Ontology type: schema:ScholarlyArticle
2018-07
AUTHORSVincent Vander Poorten, Asterios Triantafyllou, Alena Skálová, Göran Stenman, Justin A. Bishop, Esther Hauben, Jennifer L. Hunt, Henrik Hellquist, Simon Feys, Remco De Bree, Antti A. Mäkitie, Miquel Quer, Primož Strojan, Orlando Guntinas-Lichius, Alessandra Rinaldo, Alfio Ferlito
ABSTRACTAlthough relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG. More... »
PAGES1681-1695
http://scigraph.springernature.com/pub.10.1007/s00405-018-4985-5
DOIhttp://dx.doi.org/10.1007/s00405-018-4985-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1103973744
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29761209
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"description": "Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy\u00a0of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours\u00a0has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy,\u00a0predominantly\u00a0because\u00a0of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG \u00a0often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.",
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"name": "Polymorphous adenocarcinoma of the salivary glands: reappraisal and update",
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