Polymorphous adenocarcinoma of the salivary glands: reappraisal and update View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Vincent Vander Poorten, Asterios Triantafyllou, Alena Skálová, Göran Stenman, Justin A. Bishop, Esther Hauben, Jennifer L. Hunt, Henrik Hellquist, Simon Feys, Remco De Bree, Antti A. Mäkitie, Miquel Quer, Primož Strojan, Orlando Guntinas-Lichius, Alessandra Rinaldo, Alfio Ferlito

ABSTRACT

Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG. More... »

PAGES

1681-1695

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00405-018-4985-5

    DOI

    http://dx.doi.org/10.1007/s00405-018-4985-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103973744

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29761209


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