Open questions and novel concepts in oral cancer surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05-24

AUTHORS

Giancarlo Tirelli, Serena Zacchigna, Matteo Biasotto, Marco Piovesana

ABSTRACT

The persistence of cancerous cells after surgery in oral squamous cell carcinoma (OSCC) represents a major challenge, as it often leads to local recurrences and secondary primary tumors, which are eventually responsible for a large proportion of deaths. This persistence is currently evaluated by histological analyses. In this review we discuss some important pitfalls of the histopathological analysis, such as margin evaluation, specimen shrinkage and T staging. In addition, we critically analyze the appropriateness of current surgical techniques in relation to the concept of field cancerization. Finally, we describe some novel imaging and molecular approaches, which might be useful in tailoring surgical resections and encourage the use of OSCC animal models to explore and provide proof of concept of the feasibility and potential clinical utility of innovative surgical protocols. More... »

PAGES

1975-1985

References to SciGraph publications

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  • 2011-10-11. A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence in BMC CANCER
  • 2008-07-01. Quantitative methylation analyses of resection margins predict local recurrences and disease-specific deaths in patients with head and neck squamous cell carcinomas in BRITISH JOURNAL OF CANCER
  • 2013-03-16. Optical biopsy of epithelial cancers by optical coherence tomography (OCT) in LASERS IN MEDICAL SCIENCE
  • 2010-01-05. Ancient Greek and Greco–Roman Methods in Modern Surgical Treatment of Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2012-09-21. Quantitative optical coherence tomography of fluid-filled oral mucosal lesions in LASERS IN MEDICAL SCIENCE
  • 2003-06. Contribution of stem cells and differentiated cells to epidermal tumours in NATURE REVIEWS CANCER
  • 1997-07. Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer in ONCOGENE
  • 2010-03-30. Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and/or radiotherapy in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00405-015-3655-0

    DOI

    http://dx.doi.org/10.1007/s00405-015-3655-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045971437

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26003319


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