An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04

AUTHORS

Raghav C. Dwivedi, Edward J. Chisholm, Afroze S. Khan, Nicholas J. Harris, Shree A. Bhide, Suzanne St.Rose, Cyrus J. Kerawala, Peter M. Clarke, Christopher M. Nutting, Peter H. Rhys-Evans, Kevin J. Harrington, Rehan Kazi

ABSTRACT

There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (QOL) in post-surgical OC and OP cancer patients. Sixty-two consecutive OC and OP cancer patients completed the MD Anderson Dysphagia Inventory (MDADI) questionnaire. Mean scores were computed. Comparison of scores based on mean ranks were performed using Mann-Whitney U test or Kruskal-Wallis test. Level of significance was set at P ≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (P < 0.001); 50.0 (9.4) vs. 75.9 (16.3), (P < 0.0001); 57.8 (20.6) vs. 84.1 (16.7), (P < 0.001) and 55.2 (18.0) vs. 78.5 (16.3), (P < 0.001)], respectively. Patients undergoing reconstruction versus without reconstruction had worse QOL scores; 58.8 (26.9) versus 79.5 (22.8), (P < 0.01); 61.2 (15.1) versus 76.4 (17.5), (P = 0.002); 65.4 (20.5) versus 86.3 (15.9), (P < 0.0001) and 63.3 (18.8) versus 79.8 (16.3), (P < 0.01), respectively, for global, physical, functional and emotional domains. Advanced T-stage, reconstruction, younger age and base of tongue tumours have a negative impact on post-treatment swallow function and related QOL in these patients. More... »

PAGES

1233-1239

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00405-011-1756-y

DOI

http://dx.doi.org/10.1007/s00405-011-1756-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004045385

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21909656


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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282 https://www.grid.ac/institutes/grid.439471.c schema:alternateName Whipps Cross University Hospital
283 schema:name Department of ENT and Head-Neck Surgery, Whipps Cross University Hospital, E11 1NR, London, UK
284 Head and Neck Unit, Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK
285 The Institute of Cancer Research, 237 Fulham Road, SW3 6JB, London, UK
286 rdf:type schema:Organization
 




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