Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-01-08

AUTHORS

Markus Gugatschka, Karl Kiesler, Barbara Obermayer-Pietsch, Andrea Groselj-Strele, Antonia Griesbacher, Gerhard Friedrich

ABSTRACT

Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC. More... »

PAGES

1201-1204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00405-010-1481-y

DOI

http://dx.doi.org/10.1007/s00405-010-1481-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043876574

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21221617


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