Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: a physiopathologic approach View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-27

AUTHORS

José Ramón García-Berrocal, Andrés Ibáñez, Antonio Rodríguez, José Ángel González-García, José María Verdaguer, Almudena Trinidad, Rafael Ramírez-Camacho

ABSTRACT

Immune-mediated inner ear disease (IMIED) is one of the few forms of reversible sensorineural hearing loss. Corticosteroids-responsive patients are usually associated with hearing improvement. Due to the long clinical course of IMIED that frequently present recurrences (hearing loss and vertigo), alternatives to corticosteroids such as methotrexate and recently TNF-α blockers have been proposed. Likewise new procedures for delivering corticosteroids to the inner ear have been developed. The aim of this article is to assess the efficacy of methotrexate and transtympanic 6-methylprednisolone in refractory IMIED. From a database of 200 patients affected by IMIED, 16 selected patients with refractory disease were included in the present study. Five patients were treated with methotrexate and 11 by means of transtympanic injection of 6-methylprednisolone. All patients treated with methotrexate had an improvement in their vestibular symptoms. However, hearing loss did not improve. Most patients treated with local 6-methylprednisolone (68.75%) showed an improvement in hearing loss and vestibular symptoms. Methotrexate has been shown to be ineffective in maintaining long-term remissions of hearing relapses although patients presented an improvement in vestibular symptoms. However, transtympanic 6-methylprednisolone has been shown to be a safe, easy and useful therapy in refractory IMIED and it may actually become the first-line treatment for these patients based on the existence of glucocorticoid receptors and the possible targets of immune-mediated damage within the inner ear. More... »

PAGES

977-982

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00405-006-0096-9

DOI

http://dx.doi.org/10.1007/s00405-006-0096-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020268308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16802138


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucocorticoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hearing Loss, Sensorineural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylprednisolone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Round Window, Ear", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Berrocal", 
        "givenName": "Jos\u00e9 Ram\u00f3n", 
        "id": "sg:person.0653220105.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653220105.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ib\u00e1\u00f1ez", 
        "givenName": "Andr\u00e9s", 
        "id": "sg:person.01010013031.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010013031.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodr\u00edguez", 
        "givenName": "Antonio", 
        "id": "sg:person.01056126231.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056126231.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonz\u00e1lez-Garc\u00eda", 
        "givenName": "Jos\u00e9 \u00c1ngel", 
        "id": "sg:person.0606260146.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606260146.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verdaguer", 
        "givenName": "Jos\u00e9 Mar\u00eda", 
        "id": "sg:person.0760562725.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760562725.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trinidad", 
        "givenName": "Almudena", 
        "id": "sg:person.0712447525.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712447525.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Servicio de Otorrinolaringolog\u00eda, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ram\u00edrez-Camacho", 
        "givenName": "Rafael", 
        "id": "sg:person.0576221125.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576221125.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00405-006-0027-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028672662", 
          "https://doi.org/10.1007/s00405-006-0027-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-06-27", 
    "datePublishedReg": "2006-06-27", 
    "description": "Immune-mediated inner ear disease (IMIED) is one of the few forms of reversible sensorineural hearing loss. Corticosteroids-responsive patients are usually associated with hearing improvement. Due to the long clinical course of IMIED that frequently present recurrences (hearing loss and vertigo), alternatives to corticosteroids such as methotrexate and recently TNF-\u03b1 blockers have been proposed. Likewise new procedures for delivering corticosteroids to the inner ear have been developed. The aim of this article is to assess the efficacy of methotrexate and transtympanic 6-methylprednisolone in refractory IMIED. From a database of 200 patients affected by IMIED, 16 selected patients with refractory disease were included in the present study. Five patients were treated with methotrexate and 11 by means of transtympanic injection of 6-methylprednisolone. All patients treated with methotrexate had an improvement in their vestibular symptoms. However, hearing loss did not improve. Most patients treated with local 6-methylprednisolone (68.75%) showed an improvement in hearing loss and vestibular symptoms. Methotrexate has been shown to be ineffective in maintaining long-term remissions of hearing relapses although patients presented an improvement in vestibular symptoms. However, transtympanic 6-methylprednisolone has been shown to be a safe, easy and useful therapy in refractory IMIED and it may actually become the first-line treatment for these patients based on the existence of glucocorticoid receptors and the possible targets of immune-mediated damage within the inner ear.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00405-006-0096-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1004761", 
        "issn": [
          "0937-4477", 
          "1434-4726"
        ], 
        "name": "European Archives of Oto-Rhino-Laryngology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "263"
      }
    ], 
    "keywords": [
      "inner ear disease", 
      "vestibular symptoms", 
      "ear disease", 
      "immune-mediated inner ear disease", 
      "corticosteroid-responsive patients", 
      "long-term remission", 
      "first-line treatment", 
      "reversible sensorineural hearing loss", 
      "inner ear", 
      "systemic steroid therapy", 
      "long clinical course", 
      "sensorineural hearing loss", 
      "physiopathologic approach", 
      "steroid therapy", 
      "refractory disease", 
      "hearing improvement", 
      "most patients", 
      "clinical course", 
      "transtympanic injection", 
      "useful therapy", 
      "IMIED", 
      "present recurrence", 
      "hearing loss", 
      "patients", 
      "glucocorticoid receptor", 
      "symptoms", 
      "disease", 
      "corticosteroids", 
      "possible targets", 
      "methotrexate", 
      "therapy", 
      "present study", 
      "ear", 
      "remission", 
      "relapse", 
      "recurrence", 
      "blockers", 
      "TNF", 
      "Immune", 
      "receptors", 
      "efficacy", 
      "improvement", 
      "injection", 
      "treatment", 
      "loss", 
      "aim", 
      "course", 
      "damage", 
      "target", 
      "study", 
      "alternative", 
      "database", 
      "procedure", 
      "new procedure", 
      "means", 
      "form", 
      "article", 
      "approach", 
      "existence", 
      "refractory IMIED", 
      "hearing relapses", 
      "refractory immune-mediated inner ear disease"
    ], 
    "name": "Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: a physiopathologic approach", 
    "pagination": "977-982", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020268308"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00405-006-0096-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16802138"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00405-006-0096-9", 
      "https://app.dimensions.ai/details/publication/pub.1020268308"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_420.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00405-006-0096-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00405-006-0096-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00405-006-0096-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00405-006-0096-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00405-006-0096-9'


 

This table displays all metadata directly associated to this object as RDF triples.

245 TRIPLES      22 PREDICATES      106 URIs      97 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00405-006-0096-9 schema:about N00bfc243df804010b8a0418520438241
2 N011af60f66e8414fa344a85db77f7acd
3 N09979a8166464830b6a893fe49dce7f0
4 N0a1740699f5146a391cb0e71f4b88abd
5 N1a191e4553604a62a43b5d61e90f49b6
6 N1efd92c24ba248248bc6fd6370e74e5b
7 N227b0cd0f1d446f69eff02beba4f8fb8
8 N2bf0cb0aec044859a212ce71e15ada86
9 N2e5a2757af44488cb00479e9c21cdf39
10 N5b4f0035b0c84b089f761b6ebb0b202b
11 N63041453b8ea4b18965011857f7e97e0
12 N6351245aa3e84a6ba2bd353b79526b21
13 N7cb06949cb6044a489dee806a481f9f9
14 N889c3548539749fead5109d8c9d1230e
15 N9d48046a05fa4e0cb3b97a22254d4c4c
16 Nae9e60c02b13464ba6144755d45a6866
17 Nd95175aa92cc4c799c84009c005bfd3f
18 Nf1f4ef56b2024adc95bc2333aa2dcf64
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N5d6704b9002249c39ebf0e08e8443809
22 schema:citation sg:pub.10.1007/s00405-006-0027-9
23 schema:datePublished 2006-06-27
24 schema:datePublishedReg 2006-06-27
25 schema:description Immune-mediated inner ear disease (IMIED) is one of the few forms of reversible sensorineural hearing loss. Corticosteroids-responsive patients are usually associated with hearing improvement. Due to the long clinical course of IMIED that frequently present recurrences (hearing loss and vertigo), alternatives to corticosteroids such as methotrexate and recently TNF-α blockers have been proposed. Likewise new procedures for delivering corticosteroids to the inner ear have been developed. The aim of this article is to assess the efficacy of methotrexate and transtympanic 6-methylprednisolone in refractory IMIED. From a database of 200 patients affected by IMIED, 16 selected patients with refractory disease were included in the present study. Five patients were treated with methotrexate and 11 by means of transtympanic injection of 6-methylprednisolone. All patients treated with methotrexate had an improvement in their vestibular symptoms. However, hearing loss did not improve. Most patients treated with local 6-methylprednisolone (68.75%) showed an improvement in hearing loss and vestibular symptoms. Methotrexate has been shown to be ineffective in maintaining long-term remissions of hearing relapses although patients presented an improvement in vestibular symptoms. However, transtympanic 6-methylprednisolone has been shown to be a safe, easy and useful therapy in refractory IMIED and it may actually become the first-line treatment for these patients based on the existence of glucocorticoid receptors and the possible targets of immune-mediated damage within the inner ear.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N1d7960699b474d1d9f48058edf43a13d
30 Nd1fe7dce6b72406b9f56b247a88fc5e0
31 sg:journal.1004761
32 schema:keywords IMIED
33 Immune
34 TNF
35 aim
36 alternative
37 approach
38 article
39 blockers
40 clinical course
41 corticosteroid-responsive patients
42 corticosteroids
43 course
44 damage
45 database
46 disease
47 ear
48 ear disease
49 efficacy
50 existence
51 first-line treatment
52 form
53 glucocorticoid receptor
54 hearing improvement
55 hearing loss
56 hearing relapses
57 immune-mediated inner ear disease
58 improvement
59 injection
60 inner ear
61 inner ear disease
62 long clinical course
63 long-term remission
64 loss
65 means
66 methotrexate
67 most patients
68 new procedure
69 patients
70 physiopathologic approach
71 possible targets
72 present recurrence
73 present study
74 procedure
75 receptors
76 recurrence
77 refractory IMIED
78 refractory disease
79 refractory immune-mediated inner ear disease
80 relapse
81 remission
82 reversible sensorineural hearing loss
83 sensorineural hearing loss
84 steroid therapy
85 study
86 symptoms
87 systemic steroid therapy
88 target
89 therapy
90 transtympanic injection
91 treatment
92 useful therapy
93 vestibular symptoms
94 schema:name Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: a physiopathologic approach
95 schema:pagination 977-982
96 schema:productId N49299de2035143a1b9ebf856c057241a
97 N5b4c7d34c59e4699b2f487c5755f8402
98 Nc740c039b0ed4a968619f39b00f0f2fd
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020268308
100 https://doi.org/10.1007/s00405-006-0096-9
101 schema:sdDatePublished 2022-01-01T18:15
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher Nc980f18be87d41a88d5d58e296838ee3
104 schema:url https://doi.org/10.1007/s00405-006-0096-9
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N00bfc243df804010b8a0418520438241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Hearing Loss, Sensorineural
110 rdf:type schema:DefinedTerm
111 N011af60f66e8414fa344a85db77f7acd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Autoimmune Diseases
113 rdf:type schema:DefinedTerm
114 N09979a8166464830b6a893fe49dce7f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Adult
116 rdf:type schema:DefinedTerm
117 N0a1740699f5146a391cb0e71f4b88abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Dose-Response Relationship, Drug
119 rdf:type schema:DefinedTerm
120 N1a191e4553604a62a43b5d61e90f49b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Round Window, Ear
122 rdf:type schema:DefinedTerm
123 N1d7960699b474d1d9f48058edf43a13d schema:issueNumber 11
124 rdf:type schema:PublicationIssue
125 N1efd92c24ba248248bc6fd6370e74e5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Female
127 rdf:type schema:DefinedTerm
128 N227b0cd0f1d446f69eff02beba4f8fb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Methotrexate
130 rdf:type schema:DefinedTerm
131 N2bf0cb0aec044859a212ce71e15ada86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Drug Administration Schedule
133 rdf:type schema:DefinedTerm
134 N2e5a2757af44488cb00479e9c21cdf39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Injections
136 rdf:type schema:DefinedTerm
137 N2fe9c558d3dc4dcb85fb63ae569acf76 rdf:first sg:person.0712447525.12
138 rdf:rest N8dfeeea222514cc881a4427104662908
139 N3b4393f41d044e58ac840c91cadcdba4 rdf:first sg:person.0760562725.60
140 rdf:rest N2fe9c558d3dc4dcb85fb63ae569acf76
141 N49299de2035143a1b9ebf856c057241a schema:name pubmed_id
142 schema:value 16802138
143 rdf:type schema:PropertyValue
144 N5b4c7d34c59e4699b2f487c5755f8402 schema:name dimensions_id
145 schema:value pub.1020268308
146 rdf:type schema:PropertyValue
147 N5b4f0035b0c84b089f761b6ebb0b202b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Immunosuppressive Agents
149 rdf:type schema:DefinedTerm
150 N5d6704b9002249c39ebf0e08e8443809 rdf:first sg:person.0653220105.80
151 rdf:rest N7e51f0940d1642c5a4a9c2dde8c152d2
152 N63041453b8ea4b18965011857f7e97e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 N6351245aa3e84a6ba2bd353b79526b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Adolescent
157 rdf:type schema:DefinedTerm
158 N7cb06949cb6044a489dee806a481f9f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Methylprednisolone
160 rdf:type schema:DefinedTerm
161 N7e51f0940d1642c5a4a9c2dde8c152d2 rdf:first sg:person.01010013031.35
162 rdf:rest N8a553bd32260400bb285aeeac1c9d2db
163 N889c3548539749fead5109d8c9d1230e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Male
165 rdf:type schema:DefinedTerm
166 N8a553bd32260400bb285aeeac1c9d2db rdf:first sg:person.01056126231.79
167 rdf:rest Nae6e43fc93f2469eb8622461bd217e70
168 N8dfeeea222514cc881a4427104662908 rdf:first sg:person.0576221125.94
169 rdf:rest rdf:nil
170 N9d48046a05fa4e0cb3b97a22254d4c4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Middle Aged
172 rdf:type schema:DefinedTerm
173 Nae6e43fc93f2469eb8622461bd217e70 rdf:first sg:person.0606260146.25
174 rdf:rest N3b4393f41d044e58ac840c91cadcdba4
175 Nae9e60c02b13464ba6144755d45a6866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Retrospective Studies
177 rdf:type schema:DefinedTerm
178 Nc740c039b0ed4a968619f39b00f0f2fd schema:name doi
179 schema:value 10.1007/s00405-006-0096-9
180 rdf:type schema:PropertyValue
181 Nc980f18be87d41a88d5d58e296838ee3 schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Nd1fe7dce6b72406b9f56b247a88fc5e0 schema:volumeNumber 263
184 rdf:type schema:PublicationVolume
185 Nd95175aa92cc4c799c84009c005bfd3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Glucocorticoids
187 rdf:type schema:DefinedTerm
188 Nf1f4ef56b2024adc95bc2333aa2dcf64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Administration, Oral
190 rdf:type schema:DefinedTerm
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
195 schema:name Clinical Sciences
196 rdf:type schema:DefinedTerm
197 sg:journal.1004761 schema:issn 0937-4477
198 1434-4726
199 schema:name European Archives of Oto-Rhino-Laryngology
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.01010013031.35 schema:affiliation grid-institutes:grid.73221.35
203 schema:familyName Ibáñez
204 schema:givenName Andrés
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010013031.35
206 rdf:type schema:Person
207 sg:person.01056126231.79 schema:affiliation grid-institutes:grid.73221.35
208 schema:familyName Rodríguez
209 schema:givenName Antonio
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056126231.79
211 rdf:type schema:Person
212 sg:person.0576221125.94 schema:affiliation grid-institutes:grid.73221.35
213 schema:familyName Ramírez-Camacho
214 schema:givenName Rafael
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576221125.94
216 rdf:type schema:Person
217 sg:person.0606260146.25 schema:affiliation grid-institutes:grid.73221.35
218 schema:familyName González-García
219 schema:givenName José Ángel
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606260146.25
221 rdf:type schema:Person
222 sg:person.0653220105.80 schema:affiliation grid-institutes:grid.73221.35
223 schema:familyName García-Berrocal
224 schema:givenName José Ramón
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653220105.80
226 rdf:type schema:Person
227 sg:person.0712447525.12 schema:affiliation grid-institutes:grid.73221.35
228 schema:familyName Trinidad
229 schema:givenName Almudena
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712447525.12
231 rdf:type schema:Person
232 sg:person.0760562725.60 schema:affiliation grid-institutes:None
233 schema:familyName Verdaguer
234 schema:givenName José María
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760562725.60
236 rdf:type schema:Person
237 sg:pub.10.1007/s00405-006-0027-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028672662
238 https://doi.org/10.1007/s00405-006-0027-9
239 rdf:type schema:CreativeWork
240 grid-institutes:None schema:alternateName Servicio de Otorrinolaringología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain
241 schema:name Servicio de Otorrinolaringología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain
242 rdf:type schema:Organization
243 grid-institutes:grid.73221.35 schema:alternateName Servicio de Otorrinolaringología, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain
244 schema:name Servicio de Otorrinolaringología, Hospital Universitario Puerta de Hierro, San Martin de Porres 4, 28035, Madrid, Spain
245 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...