Loss of ZNF516 protein expression is related with HR-HPV infection and cervical preneoplastic lesions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Carmen Ili, Jaime Lopez, Kurt Buchegger, Ismael Riquelme, Javier Retamal, Louise Zanella, Barbara Mora-Lagos, Carolina Vivallo, Juan C. Roa, Priscilla Brebi

ABSTRACT

PURPOSE: Cervical cancer is an important health issue among women worldwide. Cervical smear and human papillomavirus detection are the most used screening methods to detect preneoplastic and neoplastic lesions. However, as neither can predict cervical development, new markers are needed for this disease. ZNF516, a potential tumor suppressor gene, has been found altered in cervical cancer. The objective of this study was to determine ZNF516 immunohistochemistry frequency in cervical biopsies and its association with clinicopathological parameters, to evaluate its potential as marker in cervical lesions. METHODS: A retrospective series of 452 formalin-fixed, paraffin-embedded (FFPE) cervical biopsies, obtained between 2002 and 2007, were selected for immunohistochemistry of ZNF516, p16 and Ki-67 markers. Human papillomavirus genotyping was performed on 272 of these samples through reverse line blot assay. RESULTS: An inverse relation between ZNF516 expression and cervical lesions grade (P < 0.001) was observed, given this protein was found mainly expressed in normal tissues, while was decreased in cervical lesions. As expected, the proliferation markers p16 and Ki-67 were found highly expressed in cervical cancer compared to normal tissues, and inversely correlated to ZNF516 expression (P < 0.01). High oncogenic risk-Human papillomavirus presence also was related to the lack of ZNF516 expression in cervical lesions (P < 0.05), and the detection of these two parameters showed a high sensitivity (70.9%) for preneoplastic lesions detection. CONCLUSIONS: The loss of ZNF516 expression was found in cervical lesions, and its detection potentially could be used as a complementary marker of early diagnosis in cervical lesions. More... »

PAGES

1099-1108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00404-018-5012-1

DOI

http://dx.doi.org/10.1007/s00404-018-5012-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110752308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30564931


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ili", 
        "givenName": "Carmen", 
        "id": "sg:person.0773013217.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773013217.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "Jaime", 
        "id": "sg:person.01137707033.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137707033.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buchegger", 
        "givenName": "Kurt", 
        "id": "sg:person.0740160036.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740160036.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Aut\u00f3noma de Chile", 
          "id": "https://www.grid.ac/institutes/grid.441837.d", 
          "name": [
            "Instituto de Ciencias Biom\u00e9dicas, Facultad de Ciencias de La Salud, Universidad Aut\u00f3noma de Chile, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riquelme", 
        "givenName": "Ismael", 
        "id": "sg:person.01014371043.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014371043.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Retamal", 
        "givenName": "Javier", 
        "id": "sg:person.01043263470.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043263470.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zanella", 
        "givenName": "Louise", 
        "id": "sg:person.015475415374.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015475415374.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mora-Lagos", 
        "givenName": "Barbara", 
        "id": "sg:person.015257637344.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015257637344.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Departamento Anatom\u00eda Patol\u00f3gica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile", 
            "Unidad de Anatom\u00eda Patol\u00f3gica, Hospital Hern\u00e1n Henr\u00edquez Aravena, Temuco, Chile", 
            "Departamento de Ciencias Precl\u00ednicas, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vivallo", 
        "givenName": "Carolina", 
        "id": "sg:person.011261545425.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011261545425.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pontifical Catholic University of Chile", 
          "id": "https://www.grid.ac/institutes/grid.7870.8", 
          "name": [
            "Department of Pathology, UC Centre for Investigational Oncology (CITO), Advanced Centre for Chronic Diseases (ACCDis), The Millennium Institute On Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roa", 
        "givenName": "Juan C.", 
        "id": "sg:person.01326154272.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326154272.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of La Frontera", 
          "id": "https://www.grid.ac/institutes/grid.412163.3", 
          "name": [
            "Laboratorio de Patolog\u00eda Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brebi", 
        "givenName": "Priscilla", 
        "id": "sg:person.0630151204.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630151204.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s13277-014-1737-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000833429", 
          "https://doi.org/10.1007/s13277-014-1737-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dc.23076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005020635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa071430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006522489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006993933", 
          "https://doi.org/10.1038/sj.onc.1209950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006993933", 
          "https://doi.org/10.1038/sj.onc.1209950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009189689", 
          "https://doi.org/10.1038/nature11935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijgo.2015.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013566809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)70481-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013826847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.h2372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014351078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181e8b2c4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019214929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181e8b2c4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019214929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2298/sarh1502042g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022272516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022284734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022284734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1940-6207.capr-16-0138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022449901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129492-200604000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024200521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129492-200604000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024200521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129492-200604000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024200521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.22057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024320144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.27828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027192509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027837046", 
          "https://doi.org/10.1038/sj.bjc.6600688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027837046", 
          "https://doi.org/10.1038/sj.bjc.6600688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.lgt200570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028371686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncy.21521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033231977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijgo.2008.12.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039741864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)04956-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045156043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00016340600604682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045314377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3287615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062604299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/epi.27120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072302721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079099150", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13304-017-0491-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091817559", 
          "https://doi.org/10.1007/s13304-017-0491-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106916204"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "PURPOSE: Cervical cancer is an important health issue among women worldwide. Cervical smear and human papillomavirus detection are the most used screening methods to detect preneoplastic and neoplastic lesions. However, as neither can predict cervical development, new markers are needed for this disease. ZNF516, a potential tumor suppressor gene, has been found altered in cervical cancer. The objective of this study was to determine ZNF516 immunohistochemistry frequency in cervical biopsies and its association with clinicopathological parameters, to evaluate its potential as marker in cervical lesions.\nMETHODS: A retrospective series of 452 formalin-fixed, paraffin-embedded (FFPE) cervical biopsies, obtained between 2002 and 2007, were selected for immunohistochemistry of ZNF516, p16 and Ki-67 markers. Human papillomavirus genotyping was performed on 272 of these samples through reverse line blot assay.\nRESULTS: An inverse relation between ZNF516 expression and cervical lesions grade (P\u2009<\u20090.001) was observed, given this protein was found mainly expressed in normal tissues, while was decreased in cervical lesions. As expected, the proliferation markers p16 and Ki-67 were found highly expressed in cervical cancer compared to normal tissues, and inversely correlated to ZNF516 expression (P\u2009<\u20090.01). High oncogenic risk-Human papillomavirus presence also was related to the lack of ZNF516 expression in cervical lesions (P\u2009<\u20090.05), and the detection of these two parameters showed a high sensitivity (70.9%) for preneoplastic lesions detection.\nCONCLUSIONS: The loss of ZNF516 expression was found in cervical lesions, and its detection potentially could be used as a complementary marker of early diagnosis in cervical lesions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00404-018-5012-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017365", 
        "issn": [
          "0932-0067", 
          "1432-0711"
        ], 
        "name": "Archives of Gynecology and Obstetrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "299"
      }
    ], 
    "name": "Loss of ZNF516 protein expression is related with HR-HPV infection and cervical preneoplastic lesions", 
    "pagination": "1099-1108", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6dee68bffb28c577a7d3d4948926996560827d65399db3b72e15eacba6978e92"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30564931"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8710213"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00404-018-5012-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110752308"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00404-018-5012-1", 
      "https://app.dimensions.ai/details/publication/pub.1110752308"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88236_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00404-018-5012-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00404-018-5012-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00404-018-5012-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00404-018-5012-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00404-018-5012-1'


 

This table displays all metadata directly associated to this object as RDF triples.

223 TRIPLES      21 PREDICATES      55 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00404-018-5012-1 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N2cc708bde29e4dfcb7e21f12c33ca973
4 schema:citation sg:pub.10.1007/s13277-014-1737-z
5 sg:pub.10.1007/s13304-017-0491-3
6 sg:pub.10.1038/nature11935
7 sg:pub.10.1038/sj.bjc.6600688
8 sg:pub.10.1038/sj.onc.1209950
9 https://app.dimensions.ai/details/publication/pub.1079099150
10 https://doi.org/10.1002/cncy.21521
11 https://doi.org/10.1002/dc.23076
12 https://doi.org/10.1002/ijc.27828
13 https://doi.org/10.1002/jmv.22057
14 https://doi.org/10.1016/j.ijgo.2008.12.017
15 https://doi.org/10.1016/j.ijgo.2015.12.005
16 https://doi.org/10.1016/s0140-6736(00)04956-4
17 https://doi.org/10.1016/s1470-2045(14)70481-4
18 https://doi.org/10.1056/nejmoa071430
19 https://doi.org/10.1080/00016340600604682
20 https://doi.org/10.1097/00129492-200604000-00022
21 https://doi.org/10.1097/pas.0000000000000498
22 https://doi.org/10.1097/pas.0b013e3181e8b2c4
23 https://doi.org/10.1126/science.3287615
24 https://doi.org/10.1136/bmj.h2372
25 https://doi.org/10.1158/1940-6207.capr-16-0138
26 https://doi.org/10.2298/sarh1502042g
27 https://doi.org/10.3322/caac.21492
28 https://doi.org/10.4161/epi.27120
29 https://doi.org/10.5858/arpa.lgt200570
30 schema:datePublished 2019-04
31 schema:datePublishedReg 2019-04-01
32 schema:description PURPOSE: Cervical cancer is an important health issue among women worldwide. Cervical smear and human papillomavirus detection are the most used screening methods to detect preneoplastic and neoplastic lesions. However, as neither can predict cervical development, new markers are needed for this disease. ZNF516, a potential tumor suppressor gene, has been found altered in cervical cancer. The objective of this study was to determine ZNF516 immunohistochemistry frequency in cervical biopsies and its association with clinicopathological parameters, to evaluate its potential as marker in cervical lesions. METHODS: A retrospective series of 452 formalin-fixed, paraffin-embedded (FFPE) cervical biopsies, obtained between 2002 and 2007, were selected for immunohistochemistry of ZNF516, p16 and Ki-67 markers. Human papillomavirus genotyping was performed on 272 of these samples through reverse line blot assay. RESULTS: An inverse relation between ZNF516 expression and cervical lesions grade (P < 0.001) was observed, given this protein was found mainly expressed in normal tissues, while was decreased in cervical lesions. As expected, the proliferation markers p16 and Ki-67 were found highly expressed in cervical cancer compared to normal tissues, and inversely correlated to ZNF516 expression (P < 0.01). High oncogenic risk-Human papillomavirus presence also was related to the lack of ZNF516 expression in cervical lesions (P < 0.05), and the detection of these two parameters showed a high sensitivity (70.9%) for preneoplastic lesions detection. CONCLUSIONS: The loss of ZNF516 expression was found in cervical lesions, and its detection potentially could be used as a complementary marker of early diagnosis in cervical lesions.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf N7e168fb17ff343f4918b94617fdfa188
37 Ne7f5eef2c473443fb9f502ab82d33414
38 sg:journal.1017365
39 schema:name Loss of ZNF516 protein expression is related with HR-HPV infection and cervical preneoplastic lesions
40 schema:pagination 1099-1108
41 schema:productId N1f5ceb807c1b471c9916792fd88e52b5
42 N1f7c0dff659e4408a91ccb0e6e5bc6af
43 N44642348ff0846eb8de99607e52028d2
44 N49bcb31bf2464426ae2908192873a708
45 Na1ecfa9116674041b62273eaf7b4e754
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110752308
47 https://doi.org/10.1007/s00404-018-5012-1
48 schema:sdDatePublished 2019-04-11T13:09
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N4146d1c8ef5a4716a4ee01d8da77412d
51 schema:url https://link.springer.com/10.1007%2Fs00404-018-5012-1
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N1f5ceb807c1b471c9916792fd88e52b5 schema:name dimensions_id
56 schema:value pub.1110752308
57 rdf:type schema:PropertyValue
58 N1f7c0dff659e4408a91ccb0e6e5bc6af schema:name readcube_id
59 schema:value 6dee68bffb28c577a7d3d4948926996560827d65399db3b72e15eacba6978e92
60 rdf:type schema:PropertyValue
61 N2cc708bde29e4dfcb7e21f12c33ca973 rdf:first sg:person.0773013217.86
62 rdf:rest Nc26111e0d3f8419a80f71aeac3a0bd74
63 N4146d1c8ef5a4716a4ee01d8da77412d schema:name Springer Nature - SN SciGraph project
64 rdf:type schema:Organization
65 N44642348ff0846eb8de99607e52028d2 schema:name doi
66 schema:value 10.1007/s00404-018-5012-1
67 rdf:type schema:PropertyValue
68 N49bcb31bf2464426ae2908192873a708 schema:name pubmed_id
69 schema:value 30564931
70 rdf:type schema:PropertyValue
71 N588291f6defa4d7eacd363ff1cd201b4 rdf:first sg:person.015257637344.41
72 rdf:rest Nf7c4e1ba39e2454eb9fcaa7116a8024a
73 N7e168fb17ff343f4918b94617fdfa188 schema:volumeNumber 299
74 rdf:type schema:PublicationVolume
75 N7fbbd3593af44ef995edd4e200582094 rdf:first sg:person.015475415374.72
76 rdf:rest N588291f6defa4d7eacd363ff1cd201b4
77 N8ec1a554d2f044cf8ab41f91155a4aa6 rdf:first sg:person.01326154272.37
78 rdf:rest Ne7eb0ed8590749409f116b9f2debd5c0
79 Na1ecfa9116674041b62273eaf7b4e754 schema:name nlm_unique_id
80 schema:value 8710213
81 rdf:type schema:PropertyValue
82 Nc26111e0d3f8419a80f71aeac3a0bd74 rdf:first sg:person.01137707033.50
83 rdf:rest Nd92786b08e784ae98cd5db6f60baa5d4
84 Nc7acaf715dcc4bbab70083fec8884233 rdf:first sg:person.01043263470.32
85 rdf:rest N7fbbd3593af44ef995edd4e200582094
86 Ncc023d237a9d49a281d6fc2fff976bd8 rdf:first sg:person.01014371043.00
87 rdf:rest Nc7acaf715dcc4bbab70083fec8884233
88 Nd92786b08e784ae98cd5db6f60baa5d4 rdf:first sg:person.0740160036.80
89 rdf:rest Ncc023d237a9d49a281d6fc2fff976bd8
90 Ne7eb0ed8590749409f116b9f2debd5c0 rdf:first sg:person.0630151204.13
91 rdf:rest rdf:nil
92 Ne7f5eef2c473443fb9f502ab82d33414 schema:issueNumber 4
93 rdf:type schema:PublicationIssue
94 Nf7c4e1ba39e2454eb9fcaa7116a8024a rdf:first sg:person.011261545425.74
95 rdf:rest N8ec1a554d2f044cf8ab41f91155a4aa6
96 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
97 schema:name Medical and Health Sciences
98 rdf:type schema:DefinedTerm
99 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
100 schema:name Oncology and Carcinogenesis
101 rdf:type schema:DefinedTerm
102 sg:journal.1017365 schema:issn 0932-0067
103 1432-0711
104 schema:name Archives of Gynecology and Obstetrics
105 rdf:type schema:Periodical
106 sg:person.01014371043.00 schema:affiliation https://www.grid.ac/institutes/grid.441837.d
107 schema:familyName Riquelme
108 schema:givenName Ismael
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014371043.00
110 rdf:type schema:Person
111 sg:person.01043263470.32 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
112 schema:familyName Retamal
113 schema:givenName Javier
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043263470.32
115 rdf:type schema:Person
116 sg:person.011261545425.74 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
117 schema:familyName Vivallo
118 schema:givenName Carolina
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011261545425.74
120 rdf:type schema:Person
121 sg:person.01137707033.50 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
122 schema:familyName Lopez
123 schema:givenName Jaime
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137707033.50
125 rdf:type schema:Person
126 sg:person.01326154272.37 schema:affiliation https://www.grid.ac/institutes/grid.7870.8
127 schema:familyName Roa
128 schema:givenName Juan C.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326154272.37
130 rdf:type schema:Person
131 sg:person.015257637344.41 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
132 schema:familyName Mora-Lagos
133 schema:givenName Barbara
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015257637344.41
135 rdf:type schema:Person
136 sg:person.015475415374.72 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
137 schema:familyName Zanella
138 schema:givenName Louise
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015475415374.72
140 rdf:type schema:Person
141 sg:person.0630151204.13 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
142 schema:familyName Brebi
143 schema:givenName Priscilla
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630151204.13
145 rdf:type schema:Person
146 sg:person.0740160036.80 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
147 schema:familyName Buchegger
148 schema:givenName Kurt
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740160036.80
150 rdf:type schema:Person
151 sg:person.0773013217.86 schema:affiliation https://www.grid.ac/institutes/grid.412163.3
152 schema:familyName Ili
153 schema:givenName Carmen
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773013217.86
155 rdf:type schema:Person
156 sg:pub.10.1007/s13277-014-1737-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000833429
157 https://doi.org/10.1007/s13277-014-1737-z
158 rdf:type schema:CreativeWork
159 sg:pub.10.1007/s13304-017-0491-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091817559
160 https://doi.org/10.1007/s13304-017-0491-3
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/nature11935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009189689
163 https://doi.org/10.1038/nature11935
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/sj.bjc.6600688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027837046
166 https://doi.org/10.1038/sj.bjc.6600688
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/sj.onc.1209950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006993933
169 https://doi.org/10.1038/sj.onc.1209950
170 rdf:type schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1079099150 schema:CreativeWork
172 https://doi.org/10.1002/cncy.21521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033231977
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/dc.23076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005020635
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/ijc.27828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027192509
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/jmv.22057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024320144
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.ijgo.2008.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039741864
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ijgo.2015.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013566809
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/s0140-6736(00)04956-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045156043
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/s1470-2045(14)70481-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013826847
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1056/nejmoa071430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006522489
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1080/00016340600604682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045314377
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1097/00129492-200604000-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024200521
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1097/pas.0000000000000498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022284734
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/pas.0b013e3181e8b2c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019214929
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1126/science.3287615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604299
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1136/bmj.h2372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014351078
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1158/1940-6207.capr-16-0138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022449901
203 rdf:type schema:CreativeWork
204 https://doi.org/10.2298/sarh1502042g schema:sameAs https://app.dimensions.ai/details/publication/pub.1022272516
205 rdf:type schema:CreativeWork
206 https://doi.org/10.3322/caac.21492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106916204
207 rdf:type schema:CreativeWork
208 https://doi.org/10.4161/epi.27120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302721
209 rdf:type schema:CreativeWork
210 https://doi.org/10.5858/arpa.lgt200570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028371686
211 rdf:type schema:CreativeWork
212 https://www.grid.ac/institutes/grid.412163.3 schema:alternateName University of La Frontera
213 schema:name Departamento Anatomía Patológica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
214 Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
215 Laboratorio de Patología Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile
216 Unidad de Anatomía Patológica, Hospital Hernán Henríquez Aravena, Temuco, Chile
217 rdf:type schema:Organization
218 https://www.grid.ac/institutes/grid.441837.d schema:alternateName Universidad Autónoma de Chile
219 schema:name Instituto de Ciencias Biomédicas, Facultad de Ciencias de La Salud, Universidad Autónoma de Chile, Temuco, Chile
220 rdf:type schema:Organization
221 https://www.grid.ac/institutes/grid.7870.8 schema:alternateName Pontifical Catholic University of Chile
222 schema:name Department of Pathology, UC Centre for Investigational Oncology (CITO), Advanced Centre for Chronic Diseases (ACCDis), The Millennium Institute On Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile
223 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...