AGO Austria recommendation on screening and diagnosis of Lynch syndrome (LS) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07

AUTHORS

Alain G. Zeimet, Harald Mori, Edgar Petru, Stephan Polterauer, Alexander Reinthaller, Christian Schauer, Tonja Scholl-Firon, Christian Singer, Katharina Wimmer, Johannes Zschocke, Christian Marth

ABSTRACT

PURPOSE: This manuscript reports the consensus recommendations on screening and diagnosis of Lynch syndrome (LS) in patients with endometrial or ovarian cancer as well as on possible preventive measures in effectively LS-diagnosed women. The recommendations are issued by the Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO) of the Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) after consultation of the most recent and relevant literature and following deliberation by the Genetic Task-Force convoked May, 2015 by the AGO Council. RESULTS AND CONCLUSION: The Austrian AGO recommends immunohistochemical tissue screening for type-I and type-II endometrial cancers in all patients below the age of 70 years, and for all endometrioid and clear-cell ovarian cancers independently of the patient's age. If needed immunohistochemistry should be complemented by tissue MLH1 promotor hypermethylation testing and/or microsatellite instability (MSI) analysis. The diagnosis LS requires confirmation through identification of a germline mutation by a molecular genetic examination in the mismatch repair genes using the patient's blood. This should be performed without preceding tissue screening when in LS-associated cancer patients the family history fulfills the Amsterdam II or the revised Bethesda criteria. In LS-diagnosed women, the age for prophylactic surgery should be set flexibly based on an informed consent. Regarding the monitoring of these women, chemo-preventive measures as well as screening procedures either to avoid or to early detect LS-related tumors are discussed with a special light on their specific limitations. More... »

PAGES

123-127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00404-017-4392-y

DOI

http://dx.doi.org/10.1007/s00404-017-4392-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085422417

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28510097


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Austria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms, Hereditary Nonpolyposis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mismatch Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endometrial Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ-Line Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsatellite Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeimet", 
        "givenName": "Alain G.", 
        "id": "sg:person.01061152165.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061152165.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "MFA-Wiener Medizinische Viktor Frankl Vereinigung, Erdbrustgasse 46, 1010, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Harald", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petru", 
        "givenName": "Edgar", 
        "id": "sg:person.01063471533.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063471533.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Gynecologic Cancer Unit, Department for Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polterauer", 
        "givenName": "Stephan", 
        "id": "sg:person.0675660237.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675660237.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Gynecologic Cancer Unit, Department for Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinthaller", 
        "givenName": "Alexander", 
        "id": "sg:person.01320252335.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320252335.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gynecology, Hospital Barmherzige Br\u00fcder Graz, Marschallgasse 12, 8020, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schauer", 
        "givenName": "Christian", 
        "id": "sg:person.0665424770.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665424770.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wilhelminen Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417109.a", 
          "name": [
            "Department of Gynecology and Obstetrics, Wilhelminenspital, Montleart Stra\u00dfe 37, 1160, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scholl-Firon", 
        "givenName": "Tonja", 
        "id": "sg:person.01167551065.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167551065.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Gynecologic Cancer Unit, Department for Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singer", 
        "givenName": "Christian", 
        "id": "sg:person.0662165614.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662165614.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Division of Human Genetics, Innsbruck Medical University, Peter Mayr-Strasse 1, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wimmer", 
        "givenName": "Katharina", 
        "id": "sg:person.01343150363.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343150363.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Division of Human Genetics, Innsbruck Medical University, Peter Mayr-Strasse 1, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zschocke", 
        "givenName": "Johannes", 
        "id": "sg:person.01343344015.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343344015.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Innsbruck Medical University", 
          "id": "https://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marth", 
        "givenName": "Christian", 
        "id": "sg:person.01322407357.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322407357.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0016-5085(99)70510-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002202581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.03.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007833592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.51.2129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013319884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.50.9257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015904127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.296.12.1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019575764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2014.07.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021614822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027236341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029128387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(09)70041-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029702740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029774739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029774739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040048793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040048793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ans.13392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042099952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/genes5030497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047410217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050065627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050065627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1500596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053017729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jadpro.2013.4.5.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073583813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2014.0025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078873505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2014.0025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078873505"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07", 
    "datePublishedReg": "2017-07-01", 
    "description": "PURPOSE: This manuscript reports the consensus recommendations on screening and diagnosis of Lynch syndrome (LS) in patients with endometrial or ovarian cancer as well as on possible preventive measures in effectively LS-diagnosed women. The recommendations are issued by the Austrian Arbeitsgemeinschaft f\u00fcr Gyn\u00e4kologische Onkologie (AGO) of the \u00d6sterreichischen Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe (OEGGG) after consultation of the most recent and relevant literature and following deliberation by the Genetic Task-Force convoked May, 2015 by the AGO Council.\nRESULTS AND CONCLUSION: The Austrian AGO recommends immunohistochemical tissue screening for type-I and type-II endometrial cancers in all patients below the age of 70\u00a0years, and for all endometrioid and clear-cell ovarian cancers independently of the patient's age. If needed immunohistochemistry should be complemented by tissue MLH1 promotor hypermethylation testing and/or microsatellite instability (MSI) analysis. The diagnosis LS requires confirmation through identification of a germline mutation by a molecular genetic examination in the mismatch repair genes using the patient's blood. This should be performed without preceding tissue screening when in LS-associated cancer patients the family history fulfills the Amsterdam II or the revised Bethesda criteria. In LS-diagnosed women, the age for prophylactic surgery should be set flexibly based on an informed consent. Regarding the monitoring of these women, chemo-preventive measures as well as screening procedures either to avoid or to early detect LS-related tumors are discussed with a special light on their specific limitations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00404-017-4392-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017365", 
        "issn": [
          "0932-0067", 
          "1432-0711"
        ], 
        "name": "Archives of Gynecology and Obstetrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "296"
      }
    ], 
    "name": "AGO Austria recommendation on screening and diagnosis of Lynch syndrome (LS)", 
    "pagination": "123-127", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "44663477a1d18f1c4f1fb36098a71d4db4ef941293dbc75263390ed37e882d9e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28510097"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8710213"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00404-017-4392-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085422417"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00404-017-4392-y", 
      "https://app.dimensions.ai/details/publication/pub.1085422417"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89826_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00404-017-4392-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00404-017-4392-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00404-017-4392-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00404-017-4392-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00404-017-4392-y'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      21 PREDICATES      59 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00404-017-4392-y schema:about N01ea5e26c623444e92f6b6e446d5d971
2 N04469ec0f5a648ff81c2eecf97113c65
3 N18dab5d698f342cda9643056bb64d143
4 N1ea93a30169445819f0409cb2efeceb6
5 N8036e0e1443e4560aa914bb0b9949dc3
6 Nabba261d81e049d8be33681cfd1dba92
7 Nb1668a2b32f1439d978d6c6fdb979aff
8 Nce3dfed313f945c892a324d0cb814aa2
9 Nd7765579f89b490a893415e45745cd0a
10 Ndac2d5737c3d4f16ab54477e7b647ee1
11 Ndd9d55f4ecc448db8a4d7986013f8348
12 Ne196cc5425fe4d3a951fec3d21084a66
13 Nf5a8920502f348d6b2dca3ccc107aab9
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N41e3594948f641d497590379d169974d
17 schema:citation https://doi.org/10.1001/jama.296.12.1507
18 https://doi.org/10.1016/j.ygyno.2014.07.100
19 https://doi.org/10.1016/s0016-5085(99)70510-x
20 https://doi.org/10.1016/s1470-2045(09)70041-5
21 https://doi.org/10.1053/j.gastro.2004.03.068
22 https://doi.org/10.1056/nejmoa052627
23 https://doi.org/10.1056/nejmoa1500596
24 https://doi.org/10.1093/jnci/djh034
25 https://doi.org/10.1097/pas.0000000000000298
26 https://doi.org/10.1097/pas.0000000000000425
27 https://doi.org/10.1097/pas.0000000000000606
28 https://doi.org/10.1111/ans.13392
29 https://doi.org/10.1200/jco.2013.50.9257
30 https://doi.org/10.1200/jco.2013.51.2129
31 https://doi.org/10.3390/genes5030497
32 https://doi.org/10.6004/jadpro.2013.4.5.4
33 https://doi.org/10.6004/jnccn.2014.0025
34 schema:datePublished 2017-07
35 schema:datePublishedReg 2017-07-01
36 schema:description PURPOSE: This manuscript reports the consensus recommendations on screening and diagnosis of Lynch syndrome (LS) in patients with endometrial or ovarian cancer as well as on possible preventive measures in effectively LS-diagnosed women. The recommendations are issued by the Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO) of the Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) after consultation of the most recent and relevant literature and following deliberation by the Genetic Task-Force convoked May, 2015 by the AGO Council. RESULTS AND CONCLUSION: The Austrian AGO recommends immunohistochemical tissue screening for type-I and type-II endometrial cancers in all patients below the age of 70 years, and for all endometrioid and clear-cell ovarian cancers independently of the patient's age. If needed immunohistochemistry should be complemented by tissue MLH1 promotor hypermethylation testing and/or microsatellite instability (MSI) analysis. The diagnosis LS requires confirmation through identification of a germline mutation by a molecular genetic examination in the mismatch repair genes using the patient's blood. This should be performed without preceding tissue screening when in LS-associated cancer patients the family history fulfills the Amsterdam II or the revised Bethesda criteria. In LS-diagnosed women, the age for prophylactic surgery should be set flexibly based on an informed consent. Regarding the monitoring of these women, chemo-preventive measures as well as screening procedures either to avoid or to early detect LS-related tumors are discussed with a special light on their specific limitations.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N0e8b908af2e24198a7eeb3e5de68509f
41 N14c2c92a4380448e8600ed294e333d7d
42 sg:journal.1017365
43 schema:name AGO Austria recommendation on screening and diagnosis of Lynch syndrome (LS)
44 schema:pagination 123-127
45 schema:productId N167d8591fcf24ec5a2c5040d9c75c2dd
46 N195fe9f2abc84ca2b8b43ed231487ccf
47 N33f2178c977b426ea564cb84acbd53b8
48 N58c0173c006c4a38aa6dc3bddc261f48
49 Nd30fc809155541f0b8a5318573711a3b
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085422417
51 https://doi.org/10.1007/s00404-017-4392-y
52 schema:sdDatePublished 2019-04-11T10:04
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher Neacd24f1f63a46d6a3b4c7a57d4359b4
55 schema:url https://link.springer.com/10.1007%2Fs00404-017-4392-y
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N01ea5e26c623444e92f6b6e446d5d971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Adult
61 rdf:type schema:DefinedTerm
62 N04469ec0f5a648ff81c2eecf97113c65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Middle Aged
64 rdf:type schema:DefinedTerm
65 N0e8b908af2e24198a7eeb3e5de68509f schema:volumeNumber 296
66 rdf:type schema:PublicationVolume
67 N14c2c92a4380448e8600ed294e333d7d schema:issueNumber 1
68 rdf:type schema:PublicationIssue
69 N167d8591fcf24ec5a2c5040d9c75c2dd schema:name nlm_unique_id
70 schema:value 8710213
71 rdf:type schema:PropertyValue
72 N18dab5d698f342cda9643056bb64d143 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Immunohistochemistry
74 rdf:type schema:DefinedTerm
75 N195fe9f2abc84ca2b8b43ed231487ccf schema:name doi
76 schema:value 10.1007/s00404-017-4392-y
77 rdf:type schema:PropertyValue
78 N1ea93a30169445819f0409cb2efeceb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Endometrial Neoplasms
80 rdf:type schema:DefinedTerm
81 N2391d45dd2474dc28603a184f1e9d1a0 rdf:first sg:person.01343150363.21
82 rdf:rest N86d224da167242c99d176f1b268f8621
83 N33f2178c977b426ea564cb84acbd53b8 schema:name pubmed_id
84 schema:value 28510097
85 rdf:type schema:PropertyValue
86 N3a7aa68c0bd547edbc6dc5c8a8f48cbb rdf:first sg:person.01322407357.46
87 rdf:rest rdf:nil
88 N41e3594948f641d497590379d169974d rdf:first sg:person.01061152165.48
89 rdf:rest N56fdbd625a31431b939231324eacc4af
90 N42ad668dfff9444ba5e7e7c166a46707 schema:name Department of Gynecology, Hospital Barmherzige Brüder Graz, Marschallgasse 12, 8020, Graz, Austria
91 rdf:type schema:Organization
92 N486bbf08897645f0849da468f06acfef rdf:first sg:person.01320252335.05
93 rdf:rest Nb2cad5f1ff964566be46956767fdac86
94 N4a69ab1ae81b45078442db03cd3f00f9 rdf:first sg:person.01063471533.53
95 rdf:rest N61a4b1008e8646189b0b6b801641869b
96 N56fdbd625a31431b939231324eacc4af rdf:first Nabf17abad29d43dc9312a1efae477652
97 rdf:rest N4a69ab1ae81b45078442db03cd3f00f9
98 N58c0173c006c4a38aa6dc3bddc261f48 schema:name dimensions_id
99 schema:value pub.1085422417
100 rdf:type schema:PropertyValue
101 N61a4b1008e8646189b0b6b801641869b rdf:first sg:person.0675660237.07
102 rdf:rest N486bbf08897645f0849da468f06acfef
103 N8036e0e1443e4560aa914bb0b9949dc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Microsatellite Instability
105 rdf:type schema:DefinedTerm
106 N86d224da167242c99d176f1b268f8621 rdf:first sg:person.01343344015.42
107 rdf:rest N3a7aa68c0bd547edbc6dc5c8a8f48cbb
108 Nabba261d81e049d8be33681cfd1dba92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name DNA Mismatch Repair
110 rdf:type schema:DefinedTerm
111 Nabf17abad29d43dc9312a1efae477652 schema:affiliation Nfbfd20d97e5546d4ae16df0534c1c6c4
112 schema:familyName Mori
113 schema:givenName Harald
114 rdf:type schema:Person
115 Nb1668a2b32f1439d978d6c6fdb979aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Germ-Line Mutation
117 rdf:type schema:DefinedTerm
118 Nb2cad5f1ff964566be46956767fdac86 rdf:first sg:person.0665424770.23
119 rdf:rest Nf0c35a2147b34020abf3a9fd8e388c2f
120 Nca65cd8488014a7da6186cfef973e612 rdf:first sg:person.0662165614.96
121 rdf:rest N2391d45dd2474dc28603a184f1e9d1a0
122 Nce3dfed313f945c892a324d0cb814aa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Colorectal Neoplasms, Hereditary Nonpolyposis
124 rdf:type schema:DefinedTerm
125 Nd30fc809155541f0b8a5318573711a3b schema:name readcube_id
126 schema:value 44663477a1d18f1c4f1fb36098a71d4db4ef941293dbc75263390ed37e882d9e
127 rdf:type schema:PropertyValue
128 Nd7765579f89b490a893415e45745cd0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 Ndac2d5737c3d4f16ab54477e7b647ee1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Ndd9d55f4ecc448db8a4d7986013f8348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Promoter Regions, Genetic
136 rdf:type schema:DefinedTerm
137 Ne196cc5425fe4d3a951fec3d21084a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Austria
139 rdf:type schema:DefinedTerm
140 Neacd24f1f63a46d6a3b4c7a57d4359b4 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Nf0c35a2147b34020abf3a9fd8e388c2f rdf:first sg:person.01167551065.32
143 rdf:rest Nca65cd8488014a7da6186cfef973e612
144 Nf5a8920502f348d6b2dca3ccc107aab9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ovarian Neoplasms
146 rdf:type schema:DefinedTerm
147 Nfbfd20d97e5546d4ae16df0534c1c6c4 schema:name MFA-Wiener Medizinische Viktor Frankl Vereinigung, Erdbrustgasse 46, 1010, Vienna, Austria
148 rdf:type schema:Organization
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
153 schema:name Oncology and Carcinogenesis
154 rdf:type schema:DefinedTerm
155 sg:journal.1017365 schema:issn 0932-0067
156 1432-0711
157 schema:name Archives of Gynecology and Obstetrics
158 rdf:type schema:Periodical
159 sg:person.01061152165.48 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
160 schema:familyName Zeimet
161 schema:givenName Alain G.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061152165.48
163 rdf:type schema:Person
164 sg:person.01063471533.53 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
165 schema:familyName Petru
166 schema:givenName Edgar
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063471533.53
168 rdf:type schema:Person
169 sg:person.01167551065.32 schema:affiliation https://www.grid.ac/institutes/grid.417109.a
170 schema:familyName Scholl-Firon
171 schema:givenName Tonja
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167551065.32
173 rdf:type schema:Person
174 sg:person.01320252335.05 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
175 schema:familyName Reinthaller
176 schema:givenName Alexander
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320252335.05
178 rdf:type schema:Person
179 sg:person.01322407357.46 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
180 schema:familyName Marth
181 schema:givenName Christian
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322407357.46
183 rdf:type schema:Person
184 sg:person.01343150363.21 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
185 schema:familyName Wimmer
186 schema:givenName Katharina
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343150363.21
188 rdf:type schema:Person
189 sg:person.01343344015.42 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
190 schema:familyName Zschocke
191 schema:givenName Johannes
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343344015.42
193 rdf:type schema:Person
194 sg:person.0662165614.96 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
195 schema:familyName Singer
196 schema:givenName Christian
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662165614.96
198 rdf:type schema:Person
199 sg:person.0665424770.23 schema:affiliation N42ad668dfff9444ba5e7e7c166a46707
200 schema:familyName Schauer
201 schema:givenName Christian
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665424770.23
203 rdf:type schema:Person
204 sg:person.0675660237.07 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
205 schema:familyName Polterauer
206 schema:givenName Stephan
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675660237.07
208 rdf:type schema:Person
209 https://doi.org/10.1001/jama.296.12.1507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019575764
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.ygyno.2014.07.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021614822
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0016-5085(99)70510-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002202581
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s1470-2045(09)70041-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029702740
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1053/j.gastro.2004.03.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007833592
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1056/nejmoa052627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027236341
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1056/nejmoa1500596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053017729
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1093/jnci/djh034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029128387
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1097/pas.0000000000000298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050065627
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/pas.0000000000000425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029774739
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1097/pas.0000000000000606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040048793
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1111/ans.13392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042099952
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1200/jco.2013.50.9257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015904127
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1200/jco.2013.51.2129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013319884
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3390/genes5030497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047410217
238 rdf:type schema:CreativeWork
239 https://doi.org/10.6004/jadpro.2013.4.5.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073583813
240 rdf:type schema:CreativeWork
241 https://doi.org/10.6004/jnccn.2014.0025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078873505
242 rdf:type schema:CreativeWork
243 https://www.grid.ac/institutes/grid.11598.34 schema:alternateName Medical University of Graz
244 schema:name Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
247 schema:name Gynecologic Cancer Unit, Department for Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.417109.a schema:alternateName Wilhelminen Hospital
250 schema:name Department of Gynecology and Obstetrics, Wilhelminenspital, Montleart Straße 37, 1160, Vienna, Austria
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.5361.1 schema:alternateName Innsbruck Medical University
253 schema:name Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
254 Division of Human Genetics, Innsbruck Medical University, Peter Mayr-Strasse 1, 6020, Innsbruck, Austria
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...