Liposomal stem cell extract formulation from Coffea canephora shows outstanding anti-inflammatory activity, increased tissue repair, neocollagenesis and neoangiogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-09-17

AUTHORS

Marcio Guidoni, Antônio Domingos de Sousa Júnior, Victor Paulo Mesquita Aragão, Thiago de Melo Costa Pereira, Wedson Correa dos Santos, Flavio Cunha Monteiro, Marco Cesar Cunegundes Guimarães, Marcio Fronza

ABSTRACT

Coffea canephora plant stem cells can have bioactive compounds with tissue repairing and anti-inflammatory action. This study aimed to develop a liposomal stem cell extract formulation obtained from the leaves of C. canephora (LSCECC) and to investigate its capacity to contribute to the dynamic mechanisms of tissue repair. The liposome cream was developed and characterized through the dynamic light scattering technique, atomic force microscopy, and transmission electron microscopy. The excisional full-thickness skin wound model was used and daily topically treated with the LSCECC formulation or vehicle control. On days 2, 7, 14, and 21 after wounding, five rats from each group were euthanized and the rates of wound closure and re-epithelialization were evaluated using biochemical and histological tests. LSCECC resulted in faster re-epithelialization exhibiting a significant reduction in wound area of 36.4, 42.4, and 87.5% after 7, 10, and 14 days, respectively, when compared to vehicle control. LSCECC treated wounds exhibited an increase in granular tissue and a proper inflammatory response mediated by the reduction of pro-inflammatory cytokines like TNF-α and IL-6 and an increase of IL-10. Furthermore, wounds treated with LSCECC showed an increase in the deposition and organization of collagen fibers at the wound site and improved scar tissue quality due to the increase in transforming growth factor-beta and vascular endothelial growth factor. Our data showed that LSCECC improves wound healing, the formation of extracellular matrix, modulates inflammatory response, and promotes neovascularization being consider a promising bioactive extract to promote and support healthy skin.Graphical abstractThe graphical presents the action of LSCECC in all four phases of wound healing and tissue repair. The LSCECC can reduce the inflammatory infiltrate in the inflammatory phase by decreasing the pro-inflammatory cytokines like IL-6 and TNF-α, in addition to maintaining this modulation through lesser activation and recruitment of macrophages. The LSCECC can also increase the release of IL-10, an anti-inflammatory cytokine, decreasing local edema. The increase in VEGF provides neovascularization and the supply of nutrients to newly repaired tissue. Finally, signaling via TGF-β increases the production and organization of collagen fibers in the remodeling phase. More... »

PAGES

1-13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00403-022-02388-2

DOI

http://dx.doi.org/10.1007/s00403-022-02388-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1151101002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36114867


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15 schema:description Coffea canephora plant stem cells can have bioactive compounds with tissue repairing and anti-inflammatory action. This study aimed to develop a liposomal stem cell extract formulation obtained from the leaves of C. canephora (LSCECC) and to investigate its capacity to contribute to the dynamic mechanisms of tissue repair. The liposome cream was developed and characterized through the dynamic light scattering technique, atomic force microscopy, and transmission electron microscopy. The excisional full-thickness skin wound model was used and daily topically treated with the LSCECC formulation or vehicle control. On days 2, 7, 14, and 21 after wounding, five rats from each group were euthanized and the rates of wound closure and re-epithelialization were evaluated using biochemical and histological tests. LSCECC resulted in faster re-epithelialization exhibiting a significant reduction in wound area of 36.4, 42.4, and 87.5% after 7, 10, and 14 days, respectively, when compared to vehicle control. LSCECC treated wounds exhibited an increase in granular tissue and a proper inflammatory response mediated by the reduction of pro-inflammatory cytokines like TNF-α and IL-6 and an increase of IL-10. Furthermore, wounds treated with LSCECC showed an increase in the deposition and organization of collagen fibers at the wound site and improved scar tissue quality due to the increase in transforming growth factor-beta and vascular endothelial growth factor. Our data showed that LSCECC improves wound healing, the formation of extracellular matrix, modulates inflammatory response, and promotes neovascularization being consider a promising bioactive extract to promote and support healthy skin.Graphical abstractThe graphical presents the action of LSCECC in all four phases of wound healing and tissue repair. The LSCECC can reduce the inflammatory infiltrate in the inflammatory phase by decreasing the pro-inflammatory cytokines like IL-6 and TNF-α, in addition to maintaining this modulation through lesser activation and recruitment of macrophages. The LSCECC can also increase the release of IL-10, an anti-inflammatory cytokine, decreasing local edema. The increase in VEGF provides neovascularization and the supply of nutrients to newly repaired tissue. Finally, signaling via TGF-β increases the production and organization of collagen fibers in the remodeling phase.
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20 C. canephora
21 Coffea canephora
22 Graphical AbstractThe
23 IL-10
24 IL-6
25 TGF
26 TNF
27 VEGF
28 action
29 activation
30 activity
31 addition
32 anti-inflammatory action
33 anti-inflammatory activity
34 anti-inflammatory cytokines
35 area
36 atomic force microscopy
37 bioactive compounds
38 bioactive extracts
39 canephora
40 capacity
41 cells
42 closure
43 collagen fibers
44 compounds
45 control
46 cream
47 cytokines
48 data
49 day 2
50 days
51 deposition
52 dynamic light
53 dynamic mechanism
54 edema
55 electron microscopy
56 endothelial growth factor
57 extracellular matrix
58 extract
59 extract formulation
60 factors
61 fibers
62 force microscopy
63 formation
64 formulation
65 full-thickness skin wound model
66 granular tissue
67 group
68 growth
69 growth factor
70 healing
71 healthy skin
72 histological tests
73 increase
74 infiltrates
75 inflammatory infiltrate
76 inflammatory phase
77 inflammatory response
78 leaves
79 less activation
80 light
81 local edema
82 macrophages
83 matrix
84 mechanism
85 microscopy
86 model
87 modulation
88 neoangiogenesis
89 neocollagenesis
90 neovascularization
91 nutrients
92 organization
93 outstanding anti-inflammatory activity
94 phase
95 plant stem cells
96 pro-inflammatory cytokines
97 production
98 proper inflammatory response
99 quality
100 rate
101 rats
102 recruitment
103 recruitment of macrophages
104 reduction
105 release
106 remodeling phase
107 repair
108 repairing
109 response
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111 sites
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114 stem cells
115 study
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117 supply of nutrients
118 technique
119 test
120 tissue
121 tissue quality
122 tissue repair
123 tissue repairing
124 transmission electron microscopy
125 vascular endothelial growth factor
126 vehicle control
127 wound area
128 wound closure
129 wound healing
130 wound model
131 wound site
132 wounds
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