Bullous pemphigoid anti-BP180-NC16A autoantibody reactivity in healthy individuals is associated with marked hypovitaminosis D and Th2-like cytokine predominance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-08-12

AUTHORS

Stefan Tukaj, Katja Bieber, Wiebke Prüßmann, Jasper N. Prüßmann, Enno Schmidt, Detlef Zillikens, Ralf J. Ludwig, Michael Kasperkiewicz

ABSTRACT

Autoimmune bullous disease autoantibodies, particularly including bullous pemphigoid (BP)-related anti-BP180-NC16A IgG, have been reported in a small subset of healthy individuals, but information about associated factors is lacking. We hypothesized that an abnormal status of immunomodulatory vitamin D could play a role in anti-BP180-NC16A autoantibody reactivity in healthy persons. In addition, we aimed to evaluate the cytokine profile associated with these autoantibodies. Plasma samples from 34 anti-BP180-NC16A IgG-reactive and 85 anti-BP180-NC16A IgG-negative healthy blood donors were tested for levels of 25-hydroxyvitamin D [25(OH)D] and a wide range of cytokines (IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-21, IL-22, IFN-γ, and TNF-α). We observed that anti-BP180-NC16A IgG-reactive healthy subjects had significantly lower plasma 25(OH)D levels and about a two-fold higher rate of vitamin D deficiency (< 20 ng/ml) compared to anti-BP180-NC16A IgG-negative healthy persons. In addition, anti-BP180-NC16A IgG-positive samples were characterized by significantly higher levels of IL-2, IL-5, IL-9, IL-10, and IL-13 which were, however, not significantly associated with the vitamin D levels. Our results indicate that healthy individuals with BP autoantibody reactivity share similarities with BP patients regarding the vitamin D status and cytokine profile (i.e., marked hypovitaminosis D and Th2 predominance), which may have pathophysiologic implications. More... »

PAGES

1-6

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00403-022-02386-4

DOI

http://dx.doi.org/10.1007/s00403-022-02386-4

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https://app.dimensions.ai/details/publication/pub.1150187789

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35960354


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174 grid-institutes:grid.4562.5 schema:alternateName Department of Dermatology and Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany
175 Lübeck Institute of Experimental Dermatology and Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany
176 schema:name Department of Dermatology and Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany
177 Lübeck Institute of Experimental Dermatology and Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany
178 rdf:type schema:Organization
179 grid-institutes:grid.8585.0 schema:alternateName Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland
180 schema:name Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland
181 rdf:type schema:Organization
 




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