Melanoma predilection for the lower limbs of women compared with men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-09-14

AUTHORS

M. Shakeel, Z. Jiyad, M. Grant, M. G. Cook, D. Oudit, A. C. Green

ABSTRACT

The lower limb is a common site for melanoma in women, but the reason for this is not fully understood. To investigate this phenomenon in more detail, we assessed the specific subsites of primary melanoma occurring on the lower limbs of females compared with males across age groups. In a records-based study at an oncology hospital in north-west of England, among an unselected sample of patients with primary invasive melanoma treated between 2002–2015, information was collected on patient age at diagnosis, sex, and co-morbidities, and the tumor thickness and anatomical subsite (thigh, lower leg, foot for lower limb). Of a total sample of 1,522 patients, 316 (227, 72% female) had lower limb melanoma. The most common subsite was lower leg (142 cases with F:M ratio =3.74), followed by thigh (55 cases with F:M = 1.83) and feet (30 cases with F:M = 1.15). At ages <40 years the odds of thigh to foot melanoma was 20 times higher in females than in males (OR 20.0, 95% CI 2.6-152.6) and 7.5 times higher on the lower limb (OR 7.5, 95% CI 1.1–49.2). For ages 40+ years, the odds of females developing thigh melanoma compared to foot melanoma was similar in males versus females (OR 0.8), while the corresponding odds of lower leg melanoma in females versus males remained significantly increased at ages 40–59 and 60+ (OR 4.2 and 2.8 respectively). Our study demonstrates the female predilection for lower limb melanoma persists over most but not all subsites.However, there is heterogeneity in the female to male occurence of lower limb melanoma across subsites and at different ages, which may be linked to relative influence of genetic and environmental risk factors. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00403-022-02375-7

DOI

http://dx.doi.org/10.1007/s00403-022-02375-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150997509

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36104631


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Northern Care Alliance NHS Group, Mayo Building, Salford Royal, Stott Lane, M6 8HD, Salford, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Northern Care Alliance NHS Group, Mayo Building, Salford Royal, Stott Lane, M6 8HD, Salford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shakeel", 
        "givenName": "M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, St George\u2019s Hospital, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.464688.0", 
          "name": [
            "Department of Dermatology, St George\u2019s Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiyad", 
        "givenName": "Z.", 
        "id": "sg:person.01203450600.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203450600.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, SK10 4TG, Macclesfield, Cheshire, UK", 
          "id": "http://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, SK10 4TG, Macclesfield, Cheshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grant", 
        "givenName": "M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Member of EORTC Melanoma Group, Brussels, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.418936.1", 
          "name": [
            "Department of Dermatology, St George\u2019s Hospital, London, UK", 
            "Department of Histopathology, Royal Surrey County Hospital, Egerton Road, GU2 7XX, Guildford, UK", 
            "Division of Clinical Medicine, University of Surrey, Guildford, UK", 
            "Member of EORTC Melanoma Group, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "M. G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, UK", 
          "id": "http://www.grid.ac/institutes/grid.412917.8", 
          "name": [
            "The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oudit", 
        "givenName": "D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1049.c", 
          "name": [
            "Department of Dermatology, St George\u2019s Hospital, London, UK", 
            "QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Green", 
        "givenName": "A. C.", 
        "id": "sg:person.01056300664.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056300664.37"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2022-09-14", 
    "datePublishedReg": "2022-09-14", 
    "description": "The lower limb is a common site for melanoma in women, but the reason for this is not fully understood. To investigate this phenomenon in more detail, we assessed the specific subsites of primary melanoma occurring on the lower limbs of females compared with males across age groups. In a records-based study at an oncology hospital in north-west of England, among an unselected sample of patients with primary invasive melanoma treated between 2002\u20132015, information was collected on patient age at diagnosis, sex, and co-morbidities, and the tumor thickness and anatomical subsite (thigh, lower leg, foot for lower limb). Of a total sample of 1,522 patients, 316 (227, 72% female) had lower limb melanoma. The most common subsite was lower leg (142 cases with F:M ratio =3.74), followed by thigh (55 cases with F:M = 1.83) and feet (30 cases with F:M = 1.15). At ages\u00a0<40 years the odds of thigh to foot melanoma was 20 times higher in females than in males (OR 20.0, 95% CI 2.6-152.6) and 7.5 times higher on the lower limb (OR 7.5, 95% CI 1.1\u201349.2). For ages 40+ years, the odds of females developing thigh melanoma compared to foot melanoma was similar in males versus females (OR 0.8), while the corresponding odds of lower leg melanoma in females versus males remained significantly increased at ages 40\u201359 and 60+ (OR 4.2 and 2.8 respectively). Our study demonstrates the female predilection for lower limb melanoma persists over most but not all subsites.However, there is heterogeneity in the female to male occurence of lower limb melanoma across subsites and at different ages, which may be linked to relative influence of genetic and environmental risk factors.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00403-022-02375-7", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1054393", 
        "issn": [
          "0340-3696", 
          "1432-069X"
        ], 
        "name": "Archives of Dermatological Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "lower limb melanoma", 
      "limb melanoma", 
      "lower limbs", 
      "foot melanoma", 
      "age 40", 
      "record-based study", 
      "odds of females", 
      "environmental risk factors", 
      "primary invasive melanoma", 
      "leg melanoma", 
      "anatomical subsites", 
      "melanoma occurring", 
      "patient age", 
      "oncology hospital", 
      "tumor thickness", 
      "common subsite", 
      "female predilection", 
      "risk factors", 
      "common site", 
      "invasive melanoma", 
      "lower leg", 
      "corresponding odds", 
      "melanoma", 
      "age groups", 
      "specific subsites", 
      "limb", 
      "patients", 
      "odds", 
      "age", 
      "unselected sample", 
      "males", 
      "thigh", 
      "total sample", 
      "females", 
      "predilection", 
      "women", 
      "different ages", 
      "hospital", 
      "subsites", 
      "years", 
      "diagnosis", 
      "sex", 
      "men", 
      "study", 
      "leg", 
      "foot", 
      "group", 
      "samples", 
      "factors", 
      "time", 
      "occurring", 
      "heterogeneity", 
      "sites", 
      "reasons", 
      "occurence", 
      "more detail", 
      "England", 
      "relative influence", 
      "information", 
      "influence", 
      "thickness", 
      "phenomenon", 
      "detail"
    ], 
    "name": "Melanoma predilection for the lower limbs of women compared with men", 
    "pagination": "1-4", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1150997509"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00403-022-02375-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "36104631"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00403-022-02375-7", 
      "https://app.dimensions.ai/details/publication/pub.1150997509"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_926.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00403-022-02375-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00403-022-02375-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00403-022-02375-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00403-022-02375-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00403-022-02375-7'


 

This table displays all metadata directly associated to this object as RDF triples.

168 TRIPLES      20 PREDICATES      86 URIs      78 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00403-022-02375-7 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N4261d4e63aab4c4fbd7ae8df5b49f78c
4 schema:datePublished 2022-09-14
5 schema:datePublishedReg 2022-09-14
6 schema:description The lower limb is a common site for melanoma in women, but the reason for this is not fully understood. To investigate this phenomenon in more detail, we assessed the specific subsites of primary melanoma occurring on the lower limbs of females compared with males across age groups. In a records-based study at an oncology hospital in north-west of England, among an unselected sample of patients with primary invasive melanoma treated between 2002–2015, information was collected on patient age at diagnosis, sex, and co-morbidities, and the tumor thickness and anatomical subsite (thigh, lower leg, foot for lower limb). Of a total sample of 1,522 patients, 316 (227, 72% female) had lower limb melanoma. The most common subsite was lower leg (142 cases with F:M ratio =3.74), followed by thigh (55 cases with F:M = 1.83) and feet (30 cases with F:M = 1.15). At ages <40 years the odds of thigh to foot melanoma was 20 times higher in females than in males (OR 20.0, 95% CI 2.6-152.6) and 7.5 times higher on the lower limb (OR 7.5, 95% CI 1.1–49.2). For ages 40+ years, the odds of females developing thigh melanoma compared to foot melanoma was similar in males versus females (OR 0.8), while the corresponding odds of lower leg melanoma in females versus males remained significantly increased at ages 40–59 and 60+ (OR 4.2 and 2.8 respectively). Our study demonstrates the female predilection for lower limb melanoma persists over most but not all subsites.However, there is heterogeneity in the female to male occurence of lower limb melanoma across subsites and at different ages, which may be linked to relative influence of genetic and environmental risk factors.
7 schema:genre article
8 schema:isAccessibleForFree false
9 schema:isPartOf sg:journal.1054393
10 schema:keywords England
11 age
12 age 40
13 age groups
14 anatomical subsites
15 common site
16 common subsite
17 corresponding odds
18 detail
19 diagnosis
20 different ages
21 environmental risk factors
22 factors
23 female predilection
24 females
25 foot
26 foot melanoma
27 group
28 heterogeneity
29 hospital
30 influence
31 information
32 invasive melanoma
33 leg
34 leg melanoma
35 limb
36 limb melanoma
37 lower leg
38 lower limb melanoma
39 lower limbs
40 males
41 melanoma
42 melanoma occurring
43 men
44 more detail
45 occurence
46 occurring
47 odds
48 odds of females
49 oncology hospital
50 patient age
51 patients
52 phenomenon
53 predilection
54 primary invasive melanoma
55 reasons
56 record-based study
57 relative influence
58 risk factors
59 samples
60 sex
61 sites
62 specific subsites
63 study
64 subsites
65 thickness
66 thigh
67 time
68 total sample
69 tumor thickness
70 unselected sample
71 women
72 years
73 schema:name Melanoma predilection for the lower limbs of women compared with men
74 schema:pagination 1-4
75 schema:productId N1d106cc302674789b06061aa54292636
76 N4cd16db048c54cae84e820010a9c7881
77 Ne30fe4bf079546ca88b404b71e17a2fb
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1150997509
79 https://doi.org/10.1007/s00403-022-02375-7
80 schema:sdDatePublished 2022-12-01T06:43
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N07440b80c3e847c7973e200b7420f530
83 schema:url https://doi.org/10.1007/s00403-022-02375-7
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N07440b80c3e847c7973e200b7420f530 schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N07f43e6996324383a69d3fcefc32f8eb schema:affiliation grid-institutes:None
90 schema:familyName Shakeel
91 schema:givenName M.
92 rdf:type schema:Person
93 N14e653b582f74281a1024f2d10ae8963 schema:affiliation grid-institutes:grid.5379.8
94 schema:familyName Grant
95 schema:givenName M.
96 rdf:type schema:Person
97 N1d106cc302674789b06061aa54292636 schema:name dimensions_id
98 schema:value pub.1150997509
99 rdf:type schema:PropertyValue
100 N4261d4e63aab4c4fbd7ae8df5b49f78c rdf:first N07f43e6996324383a69d3fcefc32f8eb
101 rdf:rest N522c40306d2049abbe229e1ac57504b5
102 N4cd16db048c54cae84e820010a9c7881 schema:name pubmed_id
103 schema:value 36104631
104 rdf:type schema:PropertyValue
105 N522c40306d2049abbe229e1ac57504b5 rdf:first sg:person.01203450600.31
106 rdf:rest Nec48ea0220154b4d85445e7ebbc74a65
107 N8b930085f66c4d1dbf2de78be869e276 schema:affiliation grid-institutes:grid.412917.8
108 schema:familyName Oudit
109 schema:givenName D.
110 rdf:type schema:Person
111 Nadfb74e88cc84779b748c34f8c51c4a8 schema:affiliation grid-institutes:grid.418936.1
112 schema:familyName Cook
113 schema:givenName M. G.
114 rdf:type schema:Person
115 Nb2422544971a41e9911219aff6a572ca rdf:first sg:person.01056300664.37
116 rdf:rest rdf:nil
117 Nd7e32232564d4e36894073d6072b1c99 rdf:first N8b930085f66c4d1dbf2de78be869e276
118 rdf:rest Nb2422544971a41e9911219aff6a572ca
119 Nd90fc650b6264fd991c2cf71e87855c4 rdf:first Nadfb74e88cc84779b748c34f8c51c4a8
120 rdf:rest Nd7e32232564d4e36894073d6072b1c99
121 Ne30fe4bf079546ca88b404b71e17a2fb schema:name doi
122 schema:value 10.1007/s00403-022-02375-7
123 rdf:type schema:PropertyValue
124 Nec48ea0220154b4d85445e7ebbc74a65 rdf:first N14e653b582f74281a1024f2d10ae8963
125 rdf:rest Nd90fc650b6264fd991c2cf71e87855c4
126 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
127 schema:name Medical and Health Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
130 schema:name Public Health and Health Services
131 rdf:type schema:DefinedTerm
132 sg:journal.1054393 schema:issn 0340-3696
133 1432-069X
134 schema:name Archives of Dermatological Research
135 schema:publisher Springer Nature
136 rdf:type schema:Periodical
137 sg:person.01056300664.37 schema:affiliation grid-institutes:grid.1049.c
138 schema:familyName Green
139 schema:givenName A. C.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056300664.37
141 rdf:type schema:Person
142 sg:person.01203450600.31 schema:affiliation grid-institutes:grid.464688.0
143 schema:familyName Jiyad
144 schema:givenName Z.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203450600.31
146 rdf:type schema:Person
147 grid-institutes:None schema:alternateName Northern Care Alliance NHS Group, Mayo Building, Salford Royal, Stott Lane, M6 8HD, Salford, UK
148 schema:name Northern Care Alliance NHS Group, Mayo Building, Salford Royal, Stott Lane, M6 8HD, Salford, UK
149 rdf:type schema:Organization
150 grid-institutes:grid.1049.c schema:alternateName QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
151 schema:name Department of Dermatology, St George’s Hospital, London, UK
152 QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
153 rdf:type schema:Organization
154 grid-institutes:grid.412917.8 schema:alternateName The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, UK
155 schema:name The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, UK
156 rdf:type schema:Organization
157 grid-institutes:grid.418936.1 schema:alternateName Member of EORTC Melanoma Group, Brussels, Belgium
158 schema:name Department of Dermatology, St George’s Hospital, London, UK
159 Department of Histopathology, Royal Surrey County Hospital, Egerton Road, GU2 7XX, Guildford, UK
160 Division of Clinical Medicine, University of Surrey, Guildford, UK
161 Member of EORTC Melanoma Group, Brussels, Belgium
162 rdf:type schema:Organization
163 grid-institutes:grid.464688.0 schema:alternateName Department of Dermatology, St George’s Hospital, London, UK
164 schema:name Department of Dermatology, St George’s Hospital, London, UK
165 rdf:type schema:Organization
166 grid-institutes:grid.5379.8 schema:alternateName Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, SK10 4TG, Macclesfield, Cheshire, UK
167 schema:name Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, SK10 4TG, Macclesfield, Cheshire, UK
168 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...