The association between GJB2 gene polymorphism and psoriasis: a verification study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08-14

AUTHORS

Que-Ping liu, Li-Sha Wu, Fang-Fang Li, Shuang Liu, Juan Su, Ye-Hong Kuang, Chen Chen, Xiao-Yun Xie, Ming-Hao Jiang, Shuang zhao, Ming-Liang Chen, Xiang Chen

ABSTRACT

Psoriasis is a chronic inflammatory skin disease with multifactorial etiology. Connexin 26 (Cx26), an important gap junction protein, has been found highly expressed in plaques of psoriasis. Recently, genome wide association studies (GWAS) identified one new single nucleotide polymorphism (SNP) in GJB2 gene coding for Cx26 protein associated with psoriasis in Chinese Han population. In this paper, we verified the GWAS data in Chinese Han population. Here we genotyped the polymorphism of GJB2 rs3751385:C>T in 371 psoriasis patients and 330 healthy controls in Chinese Han population using polymerase chain reaction restriction fragment length polymorphism assay (PCR–RFLP). Our case–control assay indicated decreased frequency of the GJB2 rs3751385 C allele in psoriasis patients compared with that in the healthy controls [p = 6.02 × 10−5, Odds ratio (OR) = 0.793, 95 % confidence interval (CI) 0.706–0.889]. The result suggested that GJB2 gene polymorphism rs3751385:C>T was associated with psoriasis susceptibility of Chinese Han population. More... »

PAGES

769-772

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00403-012-1273-x

DOI

http://dx.doi.org/10.1007/s00403-012-1273-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028278832

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22890607


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52 etiology
53 fragment length polymorphism
54 frequency
55 gap junction protein
56 gene polymorphisms
57 genes
58 healthy controls
59 important gap junction protein
60 inflammatory skin disease
61 junction proteins
62 length polymorphism
63 multifactorial etiology
64 new single nucleotide polymorphisms
65 nucleotide polymorphisms
66 paper
67 patients
68 plaques
69 plaques of psoriasis
70 polymerase chain reaction-restriction fragment length polymorphism
71 polymorphism
72 population
73 protein
74 psoriasis
75 psoriasis patients
76 psoriasis susceptibility
77 reaction-restriction fragment length polymorphism
78 restriction fragment length polymorphism
79 results
80 single nucleotide polymorphisms
81 skin diseases
82 study
83 susceptibility
84 verification study
85 wide association study
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