N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-09-26

AUTHORS

Hiroko Ito, Masashi Akiyama, Hiroaki Nakagawa, Rie Uematsu, Kisaburo Deguchi, James R. McMillan, Shin-Ichiro Nishimura, Hiroshi Shimizu

ABSTRACT

N-Glycan oligosaccharides are thought to play multiple, important roles in a variety of biological events. However, N-glycan profiles in the stratum corneum of human skin have not yet been studied in detail. To clarify the N-glycan profiles in the stratum corneum of normal and ichthyotic epidermis, N-glycan profiles were studied by high-performance liquid chromatography using normal human epidermal samples and scales from hyperkeratotic skin of ichthyosis patients. Chromatograms of patient scale samples showed unique alterations in three peaks eluted at 15.8, 18.8 and 26.9 min. The N-glycan profiles were significantly altered in ichthyotic hyperkeratotic skin compared with normal non-hyperkeratotic controls. These findings indicate the reduction of N-acetylglucosaminyltransferase II and fucosyltransferase 8 activities. Alteration of N-glycan structures in hyperkeratotic skin suggests the biological role of N-glycans in keratinization. More... »

PAGES

403-407

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00403-006-0702-0

DOI

http://dx.doi.org/10.1007/s00403-006-0702-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004583790

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17021764


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188 Research Laboratory, Kanebo Cosmetics Inc., Odawara, Japan
189 rdf:type schema:Organization
190 grid-institutes:grid.39158.36 schema:alternateName Creative Research Initiative Sousei, Hokkaido University, Sapporo, Japan
191 Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, 060-8638, Sapporo, Japan
192 Division of Biological Sciences, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University Graduate School of Science, Sapporo, Japan
193 schema:name Creative Research Initiative Sousei, Hokkaido University, Sapporo, Japan
194 Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, 060-8638, Sapporo, Japan
195 Division of Biological Sciences, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University Graduate School of Science, Sapporo, Japan
196 rdf:type schema:Organization
 




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