Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Takao Watanabe, Mitsutoshi Nakamura, Johan M. Kros, Christoph Burkhard, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgaki

ABSTRACT

Oligodendrogliomas typically show loss of heterozygosity (LOH) on chromosomes 1p and 19q, which correlates with their response to chemotherapy, whereas low-grade astrocytomas are characterized by frequent TP53 mutations and lack of sensitivity to alkylating therapeutic agents. Unequivocal histological distinction of low-grade diffuse astrocytomas from oligodendrogliomas and oligoastrocytomas is often difficult. To elucidate the relationships between morphological phenotype and genetic profile, we screened 19 oligodendrogliomas (WHO grade II) and 23 low-grade diffuse astrocytomas (WHO grade II) for TP53 mutations and LOH on 1p and 19q. In oligodendrogliomas, LOH on chromosomes 1p and/or 19q was found in 15 cases (79%) and TP53 mutation was detected in 4 cases (21%). The presence of a typical perinuclear halo in >50% of tumour cells and a chicken-wire vascular pattern were significantly associated with LOH on 1p or 19q (93% of cases). This suggests that oligodendrogliomas with classical histologic features are likely to have a better prognosis. In low-grade diffuse astrocytomas, LOH on chromosomes 1p and/or 19q was found in three cases (13%) and TP53 mutation was detected in ten cases (43%). Histologically, five low-grade astrocytomas (22%) contained small areas with oligodendroglial differentiation, but this did not correlate with the presence of TP53 mutations or LOH on 1p and 19q. In both oligodendrogliomas and astrocytomas, LOH on chromosomes 1p or 19q and TP53 mutation were mutually exclusive. Methylation of the promoter of the gene for O (6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein, which confers resistance to chemotherapy with alkylating agents, was detected in 47% of oligodendrogliomas and 48% of low-grade diffuse astrocytomas. There was no correlation with LOH on chromosomes 1p/19q, suggesting that MGMT may not be a prognostic marker for oligodendrogliomas. More... »

PAGES

267-275

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010100464

DOI

http://dx.doi.org/10.1007/s004010100464

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022080349

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11907807


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligodendroglioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Takao", 
        "id": "sg:person.0654410675.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654410675.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Mitsutoshi", 
        "id": "sg:person.01070515057.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070515057.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Division of Pathology/Neuropathology, University Hospital Rotterdam-Dijkzigt, NL-3015, Rotterdam, The NetherlandsFrance"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kros", 
        "givenName": "Johan M.", 
        "id": "sg:person.0647514247.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647514247.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, University Hospital, 8091 Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burkhard", 
        "givenName": "Christoph", 
        "id": "sg:person.01067755432.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067755432.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Neurosurgery, University Hospital, 8091 Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yonekawa", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.01331563473.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331563473.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleihues", 
        "givenName": "Paul", 
        "id": "sg:person.0625346730.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625346730.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohgaki", 
        "givenName": "Hiroko", 
        "id": "sg:person.0614226574.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614226574.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00005072-199910000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002597838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199710000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004434246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65135-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005518322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19900915)66:6<1204::aid-cncr2820660621>3.0.co;2-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008149425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11940-996-0002-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010037240", 
          "https://doi.org/10.1007/s11940-996-0002-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.440150304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011834041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.440150304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011834041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004010050398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014176037", 
          "https://doi.org/10.1007/s004010050398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/59.6.539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014319411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017919182", 
          "https://doi.org/10.1038/sj.onc.1202759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017919182", 
          "https://doi.org/10.1038/sj.onc.1202759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1383-5742(00)00017-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019480839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.19.1473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020269354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00196514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021327868", 
          "https://doi.org/10.1007/bf00196514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19970401)79:7<1381::aid-cncr16>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023440807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.9.5612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025170815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199607000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027207557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004150050587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029334684", 
          "https://doi.org/10.1007/s004150050587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.18.9821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030175469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005707203596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031180847", 
          "https://doi.org/10.1023/a:1005707203596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199501000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031226686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65134-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040291106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199203000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041067553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/22.10.1715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041523796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(95)00064-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041982005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2001.tb00388.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042822725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200011093431901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045772712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199509000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046259266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/259153a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047987491", 
          "https://doi.org/10.1038/259153a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.1996.tb00848.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048755379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910640311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049752822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/60.12.1181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051875627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00126-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053423376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-199912000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060250437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.46.1.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064373601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.46.1.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064373601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.46.1.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064373601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/00006123-199501000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064433326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1991.74.3.0399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1991.74.3.0399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1991.74.3.0399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1992.76.5.0741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1992.76.5.0741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1992.76.5.0741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.3.636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074583468"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-03", 
    "datePublishedReg": "2002-03-01", 
    "description": "Oligodendrogliomas typically show loss of heterozygosity (LOH) on chromosomes 1p and 19q, which correlates with their response to chemotherapy, whereas low-grade astrocytomas are characterized by frequent TP53 mutations and lack of sensitivity to alkylating therapeutic agents. Unequivocal histological distinction of low-grade diffuse astrocytomas from oligodendrogliomas and oligoastrocytomas is often difficult. To elucidate the relationships between morphological phenotype and genetic profile, we screened 19 oligodendrogliomas (WHO grade II) and 23 low-grade diffuse astrocytomas (WHO grade II) for TP53 mutations and LOH on 1p and 19q. In oligodendrogliomas, LOH on chromosomes 1p and/or 19q was found in 15 cases (79%) and TP53 mutation was detected in 4 cases (21%). The presence of a typical perinuclear halo in >50% of tumour cells and a chicken-wire vascular pattern were significantly associated with LOH on 1p or 19q (93% of cases). This suggests that oligodendrogliomas with classical histologic features are likely to have a better prognosis. In low-grade diffuse astrocytomas, LOH on chromosomes 1p and/or 19q was found in three cases (13%) and TP53 mutation was detected in ten cases (43%). Histologically, five low-grade astrocytomas (22%) contained small areas with oligodendroglial differentiation, but this did not correlate with the presence of TP53 mutations or LOH on 1p and 19q. In both oligodendrogliomas and astrocytomas, LOH on chromosomes 1p or 19q and TP53 mutation were mutually exclusive. Methylation of the promoter of the gene for O (6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein, which confers resistance to chemotherapy with alkylating agents, was detected in 47% of oligodendrogliomas and 48% of low-grade diffuse astrocytomas. There was no correlation with LOH on chromosomes 1p/19q, suggesting that MGMT may not be a prognostic marker for oligodendrogliomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s004010100464", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "103"
      }
    ], 
    "name": "Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas", 
    "pagination": "267-275", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "693222b90ab4bf1327fbd858d33590c49627ea3482608b0cfb5acd4fd3cd24fc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11907807"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004010100464"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022080349"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004010100464", 
      "https://app.dimensions.ai/details/publication/pub.1022080349"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s004010100464"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010100464'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010100464'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010100464'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010100464'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      82 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004010100464 schema:about N186a4692cdd540a389eb12b3101a6d12
2 N1c1e3be9761148718f63441cbc5b2b2d
3 N2c057229601a455cafc122ea23943f0e
4 N3a3e9cdc46ec4dd0a1821dab9d5433a9
5 N49301b8297e54115acd45e78bfd5680d
6 N51e201dfcec8436ba510319c6b179270
7 N51f684fe4049440fb71ba03ab2d53517
8 N588f30b2d03a4baa8222336c6ebd4067
9 N61d6e2f7cdb74b3994dd847f1a5c9536
10 N61de4d2d605c4fd38eb8fe7ae64b5f84
11 N674c80bfa562462caa7ba73ec47fd254
12 N7079424f9f9840ca8ec64fe8c7c9eb8d
13 Nb82941a4c95649b8af05318a1f9d3c60
14 Nbe5bdd625ac94783b040badd6611185e
15 Nc1bdfdf9fbe14bb3bd24d48402306487
16 Ncce7a83bebf34cffbf93a05cb89368c5
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N8ea27ad81bc84c8f997382892d5f521f
20 schema:citation sg:pub.10.1007/bf00196514
21 sg:pub.10.1007/s004010050398
22 sg:pub.10.1007/s004150050587
23 sg:pub.10.1007/s11940-996-0002-1
24 sg:pub.10.1023/a:1005707203596
25 sg:pub.10.1038/259153a0
26 sg:pub.10.1038/sj.onc.1202759
27 https://doi.org/10.1002/(sici)1097-0142(19970401)79:7<1381::aid-cncr16>3.0.co;2-w
28 https://doi.org/10.1002/1097-0142(19900915)66:6<1204::aid-cncr2820660621>3.0.co;2-a
29 https://doi.org/10.1002/glia.440150304
30 https://doi.org/10.1002/ijc.2910640311
31 https://doi.org/10.1016/0165-4608(95)00064-v
32 https://doi.org/10.1016/s0002-9440(10)65134-6
33 https://doi.org/10.1016/s0002-9440(10)65135-8
34 https://doi.org/10.1016/s0360-3016(97)00126-0
35 https://doi.org/10.1016/s1383-5742(00)00017-x
36 https://doi.org/10.1056/nejm200011093431901
37 https://doi.org/10.1073/pnas.93.18.9821
38 https://doi.org/10.1093/carcin/22.10.1715
39 https://doi.org/10.1093/jnci/90.19.1473
40 https://doi.org/10.1093/jnen/59.6.539
41 https://doi.org/10.1093/jnen/60.12.1181
42 https://doi.org/10.1097/00005072-199203000-00008
43 https://doi.org/10.1097/00005072-199501000-00011
44 https://doi.org/10.1097/00005072-199509000-00002
45 https://doi.org/10.1097/00005072-199607000-00007
46 https://doi.org/10.1097/00005072-199710000-00003
47 https://doi.org/10.1097/00005072-199910000-00002
48 https://doi.org/10.1097/00006123-199912000-00001
49 https://doi.org/10.1111/j.1750-3639.1996.tb00848.x
50 https://doi.org/10.1111/j.1750-3639.2001.tb00388.x
51 https://doi.org/10.1128/mcb.17.9.5612
52 https://doi.org/10.1200/jco.2000.18.3.636
53 https://doi.org/10.1212/wnl.46.1.203
54 https://doi.org/10.1227/00006123-199501000-00001
55 https://doi.org/10.3171/jns.1991.74.3.0399
56 https://doi.org/10.3171/jns.1992.76.5.0741
57 schema:datePublished 2002-03
58 schema:datePublishedReg 2002-03-01
59 schema:description Oligodendrogliomas typically show loss of heterozygosity (LOH) on chromosomes 1p and 19q, which correlates with their response to chemotherapy, whereas low-grade astrocytomas are characterized by frequent TP53 mutations and lack of sensitivity to alkylating therapeutic agents. Unequivocal histological distinction of low-grade diffuse astrocytomas from oligodendrogliomas and oligoastrocytomas is often difficult. To elucidate the relationships between morphological phenotype and genetic profile, we screened 19 oligodendrogliomas (WHO grade II) and 23 low-grade diffuse astrocytomas (WHO grade II) for TP53 mutations and LOH on 1p and 19q. In oligodendrogliomas, LOH on chromosomes 1p and/or 19q was found in 15 cases (79%) and TP53 mutation was detected in 4 cases (21%). The presence of a typical perinuclear halo in >50% of tumour cells and a chicken-wire vascular pattern were significantly associated with LOH on 1p or 19q (93% of cases). This suggests that oligodendrogliomas with classical histologic features are likely to have a better prognosis. In low-grade diffuse astrocytomas, LOH on chromosomes 1p and/or 19q was found in three cases (13%) and TP53 mutation was detected in ten cases (43%). Histologically, five low-grade astrocytomas (22%) contained small areas with oligodendroglial differentiation, but this did not correlate with the presence of TP53 mutations or LOH on 1p and 19q. In both oligodendrogliomas and astrocytomas, LOH on chromosomes 1p or 19q and TP53 mutation were mutually exclusive. Methylation of the promoter of the gene for O (6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein, which confers resistance to chemotherapy with alkylating agents, was detected in 47% of oligodendrogliomas and 48% of low-grade diffuse astrocytomas. There was no correlation with LOH on chromosomes 1p/19q, suggesting that MGMT may not be a prognostic marker for oligodendrogliomas.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N52b50b10018f4a11851fa89cc1faaa6a
64 Na205ab94048645219f1b7fbf81696452
65 sg:journal.1019073
66 schema:name Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas
67 schema:pagination 267-275
68 schema:productId N01151a7b334d4d7f872b0279909953b1
69 N1358508d783141d294b64c48cd5abe19
70 N62449f6b74134236bd28645f36a8d586
71 N8f9313c3c5b9491391d2811ae76a8b54
72 Nfd60846115654983804bb34aeca23395
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022080349
74 https://doi.org/10.1007/s004010100464
75 schema:sdDatePublished 2019-04-10T19:01
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Nce02cbb2e0f74c6394502268ca1c5716
78 schema:url http://link.springer.com/10.1007/s004010100464
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N01151a7b334d4d7f872b0279909953b1 schema:name doi
83 schema:value 10.1007/s004010100464
84 rdf:type schema:PropertyValue
85 N109fa39d14fc44acb0e2b81b03f2b638 rdf:first sg:person.01070515057.33
86 rdf:rest N27a3da556d7649c384952e4f4e995a8f
87 N1358508d783141d294b64c48cd5abe19 schema:name dimensions_id
88 schema:value pub.1022080349
89 rdf:type schema:PropertyValue
90 N13cba6bc1b5949c188984fb3b703f8f9 schema:name Department of Neurosurgery, University Hospital, 8091 Zurich, Switzerland
91 rdf:type schema:Organization
92 N186a4692cdd540a389eb12b3101a6d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N1c1e3be9761148718f63441cbc5b2b2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Genotype
97 rdf:type schema:DefinedTerm
98 N27a3da556d7649c384952e4f4e995a8f rdf:first sg:person.0647514247.52
99 rdf:rest N6259fe9aa5c44c43b89cf3c60806b71d
100 N29d7c6496ef84176b63dd74b74af37a2 rdf:first sg:person.01331563473.90
101 rdf:rest N5bd4ab6d3cc6418c866d0c67f1c094fb
102 N2c057229601a455cafc122ea23943f0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mutation
104 rdf:type schema:DefinedTerm
105 N3a3e9cdc46ec4dd0a1821dab9d5433a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N49301b8297e54115acd45e78bfd5680d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Astrocytoma
110 rdf:type schema:DefinedTerm
111 N51e201dfcec8436ba510319c6b179270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Aged
113 rdf:type schema:DefinedTerm
114 N51f684fe4049440fb71ba03ab2d53517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Genes, p53
116 rdf:type schema:DefinedTerm
117 N52b50b10018f4a11851fa89cc1faaa6a schema:volumeNumber 103
118 rdf:type schema:PublicationVolume
119 N588f30b2d03a4baa8222336c6ebd4067 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Adult
121 rdf:type schema:DefinedTerm
122 N5bd4ab6d3cc6418c866d0c67f1c094fb rdf:first sg:person.0625346730.06
123 rdf:rest N66769859737d45fca6253b1bc549d0e6
124 N61d6e2f7cdb74b3994dd847f1a5c9536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Loss of Heterozygosity
126 rdf:type schema:DefinedTerm
127 N61de4d2d605c4fd38eb8fe7ae64b5f84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Chromosomes, Human, Pair 1
129 rdf:type schema:DefinedTerm
130 N62449f6b74134236bd28645f36a8d586 schema:name nlm_unique_id
131 schema:value 0412041
132 rdf:type schema:PropertyValue
133 N6259fe9aa5c44c43b89cf3c60806b71d rdf:first sg:person.01067755432.34
134 rdf:rest N29d7c6496ef84176b63dd74b74af37a2
135 N66769859737d45fca6253b1bc549d0e6 rdf:first sg:person.0614226574.49
136 rdf:rest rdf:nil
137 N674c80bfa562462caa7ba73ec47fd254 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Diagnosis, Differential
139 rdf:type schema:DefinedTerm
140 N7079424f9f9840ca8ec64fe8c7c9eb8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Middle Aged
142 rdf:type schema:DefinedTerm
143 N8ea27ad81bc84c8f997382892d5f521f rdf:first sg:person.0654410675.85
144 rdf:rest N109fa39d14fc44acb0e2b81b03f2b638
145 N8f9313c3c5b9491391d2811ae76a8b54 schema:name pubmed_id
146 schema:value 11907807
147 rdf:type schema:PropertyValue
148 N98817071839d449b84fdffc789f37be1 schema:name Department of Pathology, University Hospital, 8091 Zurich, Switzerland
149 rdf:type schema:Organization
150 Na205ab94048645219f1b7fbf81696452 schema:issueNumber 3
151 rdf:type schema:PublicationIssue
152 Nb82941a4c95649b8af05318a1f9d3c60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Oligodendroglioma
154 rdf:type schema:DefinedTerm
155 Nbe5bdd625ac94783b040badd6611185e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Chromosomes, Human, Pair 19
157 rdf:type schema:DefinedTerm
158 Nc1bdfdf9fbe14bb3bd24d48402306487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Female
160 rdf:type schema:DefinedTerm
161 Ncce7a83bebf34cffbf93a05cb89368c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Phenotype
163 rdf:type schema:DefinedTerm
164 Nce02cbb2e0f74c6394502268ca1c5716 schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 Nfd60846115654983804bb34aeca23395 schema:name readcube_id
167 schema:value 693222b90ab4bf1327fbd858d33590c49627ea3482608b0cfb5acd4fd3cd24fc
168 rdf:type schema:PropertyValue
169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
173 schema:name Oncology and Carcinogenesis
174 rdf:type schema:DefinedTerm
175 sg:journal.1019073 schema:issn 0001-6322
176 1432-0533
177 schema:name Acta Neuropathologica
178 rdf:type schema:Periodical
179 sg:person.01067755432.34 schema:affiliation N98817071839d449b84fdffc789f37be1
180 schema:familyName Burkhard
181 schema:givenName Christoph
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067755432.34
183 rdf:type schema:Person
184 sg:person.01070515057.33 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
185 schema:familyName Nakamura
186 schema:givenName Mitsutoshi
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070515057.33
188 rdf:type schema:Person
189 sg:person.01331563473.90 schema:affiliation N13cba6bc1b5949c188984fb3b703f8f9
190 schema:familyName Yonekawa
191 schema:givenName Yasuhiro
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331563473.90
193 rdf:type schema:Person
194 sg:person.0614226574.49 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
195 schema:familyName Ohgaki
196 schema:givenName Hiroko
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614226574.49
198 rdf:type schema:Person
199 sg:person.0625346730.06 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
200 schema:familyName Kleihues
201 schema:givenName Paul
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625346730.06
203 rdf:type schema:Person
204 sg:person.0647514247.52 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
205 schema:familyName Kros
206 schema:givenName Johan M.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647514247.52
208 rdf:type schema:Person
209 sg:person.0654410675.85 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
210 schema:familyName Watanabe
211 schema:givenName Takao
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654410675.85
213 rdf:type schema:Person
214 sg:pub.10.1007/bf00196514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021327868
215 https://doi.org/10.1007/bf00196514
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/s004010050398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014176037
218 https://doi.org/10.1007/s004010050398
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s004150050587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029334684
221 https://doi.org/10.1007/s004150050587
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s11940-996-0002-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010037240
224 https://doi.org/10.1007/s11940-996-0002-1
225 rdf:type schema:CreativeWork
226 sg:pub.10.1023/a:1005707203596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031180847
227 https://doi.org/10.1023/a:1005707203596
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/259153a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047987491
230 https://doi.org/10.1038/259153a0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.onc.1202759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017919182
233 https://doi.org/10.1038/sj.onc.1202759
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/(sici)1097-0142(19970401)79:7<1381::aid-cncr16>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1023440807
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/1097-0142(19900915)66:6<1204::aid-cncr2820660621>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1008149425
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/glia.440150304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011834041
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/ijc.2910640311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049752822
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0165-4608(95)00064-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1041982005
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0002-9440(10)65134-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040291106
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0002-9440(10)65135-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005518322
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0360-3016(97)00126-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053423376
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s1383-5742(00)00017-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019480839
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1056/nejm200011093431901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045772712
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1073/pnas.93.18.9821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030175469
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/carcin/22.10.1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041523796
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/jnci/90.19.1473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020269354
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/jnen/59.6.539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014319411
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/jnen/60.12.1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051875627
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/00005072-199203000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041067553
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/00005072-199501000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031226686
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/00005072-199509000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046259266
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/00005072-199607000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027207557
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00005072-199710000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004434246
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/00005072-199910000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002597838
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/00006123-199912000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060250437
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1750-3639.1996.tb00848.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048755379
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1750-3639.2001.tb00388.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042822725
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1128/mcb.17.9.5612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025170815
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1200/jco.2000.18.3.636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074583468
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1212/wnl.46.1.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064373601
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1227/00006123-199501000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064433326
290 rdf:type schema:CreativeWork
291 https://doi.org/10.3171/jns.1991.74.3.0399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071096021
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3171/jns.1992.76.5.0741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071096479
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.17703.32 schema:alternateName International Agency For Research On Cancer
296 schema:name Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
299 schema:name Division of Pathology/Neuropathology, University Hospital Rotterdam-Dijkzigt, NL-3015, Rotterdam, The NetherlandsFrance
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...