Ontology type: schema:ScholarlyArticle
2001-09-04
AUTHORSN. Kemppainen, M. Röyttä, Y. Collan, S. Ma, S. Hinkka, J. Rinne
ABSTRACTThis is the first study to use the unbiased stereological method, the disector, to estimate the total number of pigmented neurons in the pars compacta of the substantia nigra (SNpc) in Alzheimer's disease (AD) patients as compared to healthy controls. The right half of the SNpc of 11 AD patients and 24 controls was studied. We also used single sections to determine the neuronal number and area in different subregions of the SNpc. The results showed that there was no significant difference in the total number of pigmented neurons in the SNpc (154415±13593 for AD and 160163±8027 for controls) or in the volume of the SNpc between the patients with AD and controls. Studies on single sections revealed that even subregionally there was no significant difference in the neuronal number or area in the SNpc between AD patients and controls. More... »
PAGES43-47
http://scigraph.springernature.com/pub.10.1007/s004010100425
DOIhttp://dx.doi.org/10.1007/s004010100425
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1043393202
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11837746
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alzheimer Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Basal Ganglia Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bias",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Count",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lewy Bodies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neurons",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Substantia Nigra",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland, Finland",
"id": "http://www.grid.ac/institutes/grid.1374.1",
"name": [
"Department of Neurology, University of Turku, 20520 Turku, Finland, Finland"
],
"type": "Organization"
},
"familyName": "Kemppainen",
"givenName": "N.",
"id": "sg:person.01122137640.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122137640.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, University of Turku, Turku, Finland, Finland",
"id": "http://www.grid.ac/institutes/grid.1374.1",
"name": [
"Department of Pathology, University of Turku, Turku, Finland, Finland"
],
"type": "Organization"
},
"familyName": "R\u00f6ytt\u00e4",
"givenName": "M.",
"id": "sg:person.061433567.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.061433567.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, University of Turku, Turku, Finland, Finland",
"id": "http://www.grid.ac/institutes/grid.1374.1",
"name": [
"Department of Pathology, University of Turku, Turku, Finland, Finland"
],
"type": "Organization"
},
"familyName": "Collan",
"givenName": "Y.",
"id": "sg:person.01216506601.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216506601.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland, Finland",
"id": "http://www.grid.ac/institutes/grid.1374.1",
"name": [
"Department of Neurology, University of Turku, 20520 Turku, Finland, Finland"
],
"type": "Organization"
},
"familyName": "Ma",
"givenName": "S.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biostatistics, University of Turku, Turku, Finland, Finland",
"id": "http://www.grid.ac/institutes/grid.1374.1",
"name": [
"Department of Biostatistics, University of Turku, Turku, Finland, Finland"
],
"type": "Organization"
},
"familyName": "Hinkka",
"givenName": "S.",
"id": "sg:person.01062630230.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062630230.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland, Finland",
"id": "http://www.grid.ac/institutes/grid.1374.1",
"name": [
"Department of Neurology, University of Turku, 20520 Turku, Finland, Finland"
],
"type": "Organization"
},
"familyName": "Rinne",
"givenName": "J.",
"id": "sg:person.012653127617.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012653127617.40"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf01249611",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023810230",
"https://doi.org/10.1007/bf01249611"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00308809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000355620",
"https://doi.org/10.1007/bf00308809"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00690198",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013142235",
"https://doi.org/10.1007/bf00690198"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00296789",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011841531",
"https://doi.org/10.1007/bf00296789"
],
"type": "CreativeWork"
}
],
"datePublished": "2001-09-04",
"datePublishedReg": "2001-09-04",
"description": "This is the first study to use the unbiased stereological method, the disector, to estimate the total number of pigmented neurons in the pars compacta of the substantia nigra (SNpc) in Alzheimer's disease (AD) patients as compared to healthy controls. The right half of the SNpc of 11 AD patients and 24 controls was studied. We also used single sections to determine the neuronal number and area in different subregions of the SNpc. The results showed that there was no significant difference in the total number of pigmented neurons in the SNpc (154415\u00b113593 for AD and 160163\u00b18027 for controls) or in the volume of the SNpc between the patients with AD and controls. Studies on single sections revealed that even subregionally there was no significant difference in the neuronal number or area in the SNpc between AD patients and controls.",
"genre": "article",
"id": "sg:pub.10.1007/s004010100425",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1019073",
"issn": [
"0001-6322",
"1432-0533"
],
"name": "Acta Neuropathologica",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "103"
}
],
"keywords": [
"pigmented neurons",
"substantia nigra",
"disease patients",
"neuronal number",
"AD patients",
"Alzheimer's disease patients",
"significant differences",
"unbiased stereological methods",
"neuronal loss",
"pars compacta",
"healthy controls",
"patients",
"Alzheimer's disease",
"SNpc",
"total number",
"single section",
"stereological methods",
"disease",
"neurons",
"nigra",
"first study",
"right half",
"control",
"compacta",
"different subregions",
"differences",
"study",
"disector",
"number",
"half",
"morphological measurements",
"subregions",
"loss",
"volume",
"area",
"sections",
"AD",
"results",
"method",
"measurements"
],
"name": "Unbiased morphological measurements show no neuronal loss in the substantia nigra in Alzheimer's disease",
"pagination": "43-47",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1043393202"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s004010100425"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11837746"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s004010100425",
"https://app.dimensions.ai/details/publication/pub.1043393202"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:21",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_329.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s004010100425"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010100425'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010100425'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010100425'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010100425'
This table displays all metadata directly associated to this object as RDF triples.
216 TRIPLES
22 PREDICATES
85 URIs
73 LITERALS
22 BLANK NODES