Choline acetyltransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-08

AUTHORS

Petri M. Mattila, Matias Röyttä, Pirkko Lönnberg, Päivi Marjamäki, Hans Helenius, Juha O. Rinne

ABSTRACT

. Brain tissue from 44 patients with Parkinson's disease (PD) and 36 age-matched controls was examined for choline acetyltransferase (ChAT) activity, and for densities of D1 and D2 dopamine receptors. Brain samples were examined for Alzheimer' disease (AD) type changes and for Lewy bodies (LBs), and for apolipoprotein E genotype. Patients were evaluated for the stage of cognitive impairment using Reisberg's global deterioration scale. ChAT activity in PD was reduced in all brain areas examined, being 51% of the control mean in the hippocampus (P<0.001), 57% in the prefrontal cortex (P<0.001) and 64% in the temporal cortex (P<0.001). The number of LBs had a significant negative correlation with ChAT activity in both prefrontal (r=–0.33, P<0.05) and temporal cortex (r=–0.32, P<0.05). The reduction in ChAT activity in the prefrontal cortex had a significant negative correlation (r=–0.38, P=0.012) with the extent of cognitive impairment. When the CERAD class 'C' was excluded, cognitive impairment correlated significantly with both prefrontal ChAT activity (r=–0.52, P=0.0051) and the density of D1 dopamine receptors in the caudate nucleus (r=–0.40, P=0.037). The number of D1 and D2 dopamine receptors was reduced in both caudate nucleus and putamen in PD patients without neuroleptics as compared to controls. An increased D2 receptor number was found in the caudate nucleus and putamen in PD patients treated with neuroleptics. The present study showed that cognitive decline in PD is associated with reduced ChAT activity in the prefrontal cortex and the D1 dopamine receptor number in the caudate nucleus, even in the absence of AD-type pathology. More... »

PAGES

160-166

References to SciGraph publications

  • 1987-01. Diffuse Lewy body disease in ACTA NEUROPATHOLOGICA
  • 1997-02. D2 dopamine receptors and personality traits in NATURE
  • 1998-05. Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson’s disease in ACTA NEUROPATHOLOGICA
  • 1981-03. Dopamine receptors in the parkinsonian brain in JOURNAL OF NEURAL TRANSMISSION
  • 1984-03. Dementia in idiopathic Parkinson's disease in ACTA NEUROPATHOLOGICA
  • 1990-06. Diffuse lewy body disease in Japan in JOURNAL OF NEUROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s004010100372

    DOI

    http://dx.doi.org/10.1007/s004010100372

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053236361

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11563631


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alzheimer Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apolipoprotein E4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apolipoproteins E", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caudate Nucleus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Choline O-Acetyltransferase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cognition Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hippocampus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lewy Bodies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neostriatum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parkinson Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prefrontal Cortex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Putamen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Dopamine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Dopamine D1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Dopamine D2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Temporal Lobe", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "Department of Neurology, University of Turku, 20520 Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mattila", 
            "givenName": "Petri M.", 
            "id": "sg:person.01237370004.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237370004.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University of Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "Department of Pathology, University of Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "R\u00f6ytt\u00e4", 
            "givenName": "Matias", 
            "id": "sg:person.061433567.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.061433567.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "Department of Neurology, University of Turku, 20520 Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f6nnberg", 
            "givenName": "Pirkko", 
            "id": "sg:person.0760163273.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760163273.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "Department of Neurology, University of Turku, 20520 Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marjam\u00e4ki", 
            "givenName": "P\u00e4ivi", 
            "id": "sg:person.01057277261.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057277261.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, University of Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "Department of Biostatistics, University of Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helenius", 
            "givenName": "Hans", 
            "id": "sg:person.01076571772.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076571772.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, University of Turku, 20520 Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "Department of Neurology, University of Turku, 20520 Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rinne", 
            "givenName": "Juha O.", 
            "id": "sg:person.012653127617.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012653127617.40"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/385590a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049444370", 
              "https://doi.org/10.1038/385590a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00686786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047901357", 
              "https://doi.org/10.1007/bf00686786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01664007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018570015", 
              "https://doi.org/10.1007/bf01664007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00314594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052950796", 
              "https://doi.org/10.1007/bf00314594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021492273", 
              "https://doi.org/10.1007/s004010050843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00695605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000607794", 
              "https://doi.org/10.1007/bf00695605"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2001-08", 
        "datePublishedReg": "2001-08-01", 
        "description": "Abstract. Brain tissue from 44 patients with Parkinson's disease (PD) and 36 age-matched controls was examined for choline acetyltransferase (ChAT) activity, and for densities of D1 and D2 dopamine receptors. Brain samples were examined for Alzheimer' disease (AD) type changes and for Lewy bodies (LBs), and for apolipoprotein E genotype. Patients were evaluated for the stage of cognitive impairment using Reisberg's global deterioration scale. ChAT activity in PD was reduced in all brain areas examined, being 51% of the control mean in the hippocampus (P<0.001), 57% in the prefrontal cortex (P<0.001) and 64% in the temporal cortex (P<0.001). The number of LBs had a significant negative correlation with ChAT activity in both prefrontal (r=\u20130.33, P<0.05) and temporal cortex (r=\u20130.32, P<0.05). The reduction in ChAT activity in the prefrontal cortex had a significant negative correlation (r=\u20130.38, P=0.012) with the extent of cognitive impairment. When the CERAD class 'C' was excluded, cognitive impairment correlated significantly with both prefrontal ChAT activity (r=\u20130.52, P=0.0051) and the density of D1 dopamine receptors in the caudate nucleus (r=\u20130.40, P=0.037). The number of D1 and D2 dopamine receptors was reduced in both caudate nucleus and putamen in PD patients without neuroleptics as compared to controls. An increased D2 receptor number was found in the caudate nucleus and putamen in PD patients treated with neuroleptics. The present study showed that cognitive decline in PD is associated with reduced ChAT activity in the prefrontal cortex and the D1 dopamine receptor number in the caudate nucleus, even in the absence of AD-type pathology.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s004010100372", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "102"
          }
        ], 
        "keywords": [
          "choline acetyltransferase activity", 
          "ChAT activity", 
          "D2 dopamine receptors", 
          "dopamine receptors", 
          "Parkinson's disease", 
          "caudate nucleus", 
          "Global Deterioration Scale", 
          "Lewy bodies", 
          "cognitive impairment", 
          "prefrontal cortex", 
          "PD patients", 
          "receptor number", 
          "temporal cortex", 
          "significant negative correlation", 
          "AD-type pathology", 
          "age-matched controls", 
          "density of D1", 
          "Reisberg's Global Deterioration Scale", 
          "reduced ChAT activity", 
          "dopamine receptor number", 
          "acetyltransferase activity", 
          "striatal dopamine receptors", 
          "number of D1", 
          "apolipoprotein E genotype", 
          "D2 receptor number", 
          "D1 dopamine receptors", 
          "negative correlation", 
          "brain areas", 
          "patients", 
          "brain tissue", 
          "cognitive decline", 
          "brain samples", 
          "cortex", 
          "disease", 
          "impairment", 
          "receptors", 
          "neuroleptics", 
          "putamen", 
          "present study", 
          "D1", 
          "activity", 
          "hippocampus", 
          "control", 
          "pathology", 
          "nucleus", 
          "prefrontal", 
          "tissue", 
          "correlation", 
          "number", 
          "genotypes", 
          "absence", 
          "decline", 
          "study", 
          "reduction", 
          "changes", 
          "body", 
          "stage", 
          "extent", 
          "type changes", 
          "samples", 
          "area", 
          "scale", 
          "relation", 
          "density", 
          "class", 
          "Alzheimer' disease (AD) type changes", 
          "' disease (AD) type changes", 
          "E genotype", 
          "deterioration scale", 
          "number of LBs", 
          "CERAD class", 
          "prefrontal ChAT activity", 
          "D1 dopamine receptor number"
        ], 
        "name": "Choline acetyltransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment", 
        "pagination": "160-166", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053236361"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s004010100372"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11563631"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s004010100372", 
          "https://app.dimensions.ai/details/publication/pub.1053236361"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_339.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s004010100372"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010100372'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010100372'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010100372'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010100372'


     

    This table displays all metadata directly associated to this object as RDF triples.

    282 TRIPLES      22 PREDICATES      127 URIs      113 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s004010100372 schema:about N2a6b61fa80a24f569efaaa9a331fa442
    2 N2b3453cba9b14e54a7ebf6f8488504ba
    3 N30e1643ed77a4ee7a9322a4b1a0c8784
    4 N377ebf8d6306475f83dd2903f5c91354
    5 N3962203489ea4b49b28c1ad5c7477f9b
    6 N421145494dda461bbf06ca8cbe9a97a5
    7 N53395e3247854eaab0b7fb89c747805e
    8 N56b0dd1a085d4ce98d31598479fad3dc
    9 N5a3cb7525d9d4cc69b4ebed3b49736d4
    10 N773fd98758da4184bbeecf39e968a659
    11 N81c3786e50364098b36a2a62e03e2cf9
    12 N8dd561d3467a4cd29bde3562fa1796f5
    13 N94802585edec4fca9ca2d6dfc937b80d
    14 Nb14342e8ed0949d09013c53bbba7a75a
    15 Nb1c53fabaf094f3e93d6a8352e09bd60
    16 Nbd81824c23c24c90b2ad656f7a29020c
    17 Nc758286f4a514a069930f59da1871d8b
    18 Nd7ea54bd6e7649c295547ac1ae2f4748
    19 Nec0f2bbe452c469eb7c3f026d5fb3333
    20 Nf60d3fa9074d4aaeb401af60c7a806c7
    21 Nfef3b9dc11fb40919d5b8de561950503
    22 anzsrc-for:11
    23 anzsrc-for:1109
    24 schema:author N7355957e7ab2493586eda521d0619a76
    25 schema:citation sg:pub.10.1007/bf00314594
    26 sg:pub.10.1007/bf00686786
    27 sg:pub.10.1007/bf00695605
    28 sg:pub.10.1007/bf01664007
    29 sg:pub.10.1007/s004010050843
    30 sg:pub.10.1038/385590a0
    31 schema:datePublished 2001-08
    32 schema:datePublishedReg 2001-08-01
    33 schema:description Abstract. Brain tissue from 44 patients with Parkinson's disease (PD) and 36 age-matched controls was examined for choline acetyltransferase (ChAT) activity, and for densities of D1 and D2 dopamine receptors. Brain samples were examined for Alzheimer' disease (AD) type changes and for Lewy bodies (LBs), and for apolipoprotein E genotype. Patients were evaluated for the stage of cognitive impairment using Reisberg's global deterioration scale. ChAT activity in PD was reduced in all brain areas examined, being 51% of the control mean in the hippocampus (P<0.001), 57% in the prefrontal cortex (P<0.001) and 64% in the temporal cortex (P<0.001). The number of LBs had a significant negative correlation with ChAT activity in both prefrontal (r=–0.33, P<0.05) and temporal cortex (r=–0.32, P<0.05). The reduction in ChAT activity in the prefrontal cortex had a significant negative correlation (r=–0.38, P=0.012) with the extent of cognitive impairment. When the CERAD class 'C' was excluded, cognitive impairment correlated significantly with both prefrontal ChAT activity (r=–0.52, P=0.0051) and the density of D1 dopamine receptors in the caudate nucleus (r=–0.40, P=0.037). The number of D1 and D2 dopamine receptors was reduced in both caudate nucleus and putamen in PD patients without neuroleptics as compared to controls. An increased D2 receptor number was found in the caudate nucleus and putamen in PD patients treated with neuroleptics. The present study showed that cognitive decline in PD is associated with reduced ChAT activity in the prefrontal cortex and the D1 dopamine receptor number in the caudate nucleus, even in the absence of AD-type pathology.
    34 schema:genre article
    35 schema:inLanguage en
    36 schema:isAccessibleForFree false
    37 schema:isPartOf N55e8dac67d41408492429a31af9bea88
    38 Na61f704e289e48198f0c7170caa0772e
    39 sg:journal.1019073
    40 schema:keywords ' disease (AD) type changes
    41 AD-type pathology
    42 Alzheimer' disease (AD) type changes
    43 CERAD class
    44 ChAT activity
    45 D1
    46 D1 dopamine receptor number
    47 D1 dopamine receptors
    48 D2 dopamine receptors
    49 D2 receptor number
    50 E genotype
    51 Global Deterioration Scale
    52 Lewy bodies
    53 PD patients
    54 Parkinson's disease
    55 Reisberg's Global Deterioration Scale
    56 absence
    57 acetyltransferase activity
    58 activity
    59 age-matched controls
    60 apolipoprotein E genotype
    61 area
    62 body
    63 brain areas
    64 brain samples
    65 brain tissue
    66 caudate nucleus
    67 changes
    68 choline acetyltransferase activity
    69 class
    70 cognitive decline
    71 cognitive impairment
    72 control
    73 correlation
    74 cortex
    75 decline
    76 density
    77 density of D1
    78 deterioration scale
    79 disease
    80 dopamine receptor number
    81 dopamine receptors
    82 extent
    83 genotypes
    84 hippocampus
    85 impairment
    86 negative correlation
    87 neuroleptics
    88 nucleus
    89 number
    90 number of D1
    91 number of LBs
    92 pathology
    93 patients
    94 prefrontal
    95 prefrontal ChAT activity
    96 prefrontal cortex
    97 present study
    98 putamen
    99 receptor number
    100 receptors
    101 reduced ChAT activity
    102 reduction
    103 relation
    104 samples
    105 scale
    106 significant negative correlation
    107 stage
    108 striatal dopamine receptors
    109 study
    110 temporal cortex
    111 tissue
    112 type changes
    113 schema:name Choline acetyltransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment
    114 schema:pagination 160-166
    115 schema:productId N826bb456b5f64147ba69b4c255add139
    116 Ne54d1608492b4a4abecbd49445ed50eb
    117 Ne5e605f068174e8c8a022a0dee2f4c29
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053236361
    119 https://doi.org/10.1007/s004010100372
    120 schema:sdDatePublished 2021-11-01T18:05
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher N330f1732b29943fa9dfa3a1236002587
    123 schema:url https://doi.org/10.1007/s004010100372
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N2a6b61fa80a24f569efaaa9a331fa442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Apolipoproteins E
    129 rdf:type schema:DefinedTerm
    130 N2b3453cba9b14e54a7ebf6f8488504ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Putamen
    132 rdf:type schema:DefinedTerm
    133 N30e1643ed77a4ee7a9322a4b1a0c8784 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Temporal Lobe
    135 rdf:type schema:DefinedTerm
    136 N330f1732b29943fa9dfa3a1236002587 schema:name Springer Nature - SN SciGraph project
    137 rdf:type schema:Organization
    138 N350cde5514a74e32941c8d485007cb39 rdf:first sg:person.01076571772.53
    139 rdf:rest Ncc4dd9e0995a4126ae80d944ef148810
    140 N377ebf8d6306475f83dd2903f5c91354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Neurons
    142 rdf:type schema:DefinedTerm
    143 N3962203489ea4b49b28c1ad5c7477f9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Alzheimer Disease
    145 rdf:type schema:DefinedTerm
    146 N421145494dda461bbf06ca8cbe9a97a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Lewy Bodies
    148 rdf:type schema:DefinedTerm
    149 N53395e3247854eaab0b7fb89c747805e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Male
    151 rdf:type schema:DefinedTerm
    152 N55e8dac67d41408492429a31af9bea88 schema:issueNumber 2
    153 rdf:type schema:PublicationIssue
    154 N56b0dd1a085d4ce98d31598479fad3dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Female
    156 rdf:type schema:DefinedTerm
    157 N5a3cb7525d9d4cc69b4ebed3b49736d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Neostriatum
    159 rdf:type schema:DefinedTerm
    160 N7355957e7ab2493586eda521d0619a76 rdf:first sg:person.01237370004.45
    161 rdf:rest Nede55c49aef443f3988e6d5d8eb17219
    162 N773fd98758da4184bbeecf39e968a659 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Cognition Disorders
    164 rdf:type schema:DefinedTerm
    165 N81c3786e50364098b36a2a62e03e2cf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Receptors, Dopamine
    167 rdf:type schema:DefinedTerm
    168 N826bb456b5f64147ba69b4c255add139 schema:name dimensions_id
    169 schema:value pub.1053236361
    170 rdf:type schema:PropertyValue
    171 N89fb9f1a52fa44e7a6f6b22b1238fddb rdf:first sg:person.0760163273.49
    172 rdf:rest N9535679c23a247a7b493871012b10bb6
    173 N8dd561d3467a4cd29bde3562fa1796f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Aged
    175 rdf:type schema:DefinedTerm
    176 N94802585edec4fca9ca2d6dfc937b80d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Humans
    178 rdf:type schema:DefinedTerm
    179 N9535679c23a247a7b493871012b10bb6 rdf:first sg:person.01057277261.68
    180 rdf:rest N350cde5514a74e32941c8d485007cb39
    181 Na61f704e289e48198f0c7170caa0772e schema:volumeNumber 102
    182 rdf:type schema:PublicationVolume
    183 Nb14342e8ed0949d09013c53bbba7a75a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Apolipoprotein E4
    185 rdf:type schema:DefinedTerm
    186 Nb1c53fabaf094f3e93d6a8352e09bd60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Hippocampus
    188 rdf:type schema:DefinedTerm
    189 Nbd81824c23c24c90b2ad656f7a29020c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Parkinson Disease
    191 rdf:type schema:DefinedTerm
    192 Nc758286f4a514a069930f59da1871d8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Prefrontal Cortex
    194 rdf:type schema:DefinedTerm
    195 Ncc4dd9e0995a4126ae80d944ef148810 rdf:first sg:person.012653127617.40
    196 rdf:rest rdf:nil
    197 Nd7ea54bd6e7649c295547ac1ae2f4748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Choline O-Acetyltransferase
    199 rdf:type schema:DefinedTerm
    200 Ne54d1608492b4a4abecbd49445ed50eb schema:name doi
    201 schema:value 10.1007/s004010100372
    202 rdf:type schema:PropertyValue
    203 Ne5e605f068174e8c8a022a0dee2f4c29 schema:name pubmed_id
    204 schema:value 11563631
    205 rdf:type schema:PropertyValue
    206 Nec0f2bbe452c469eb7c3f026d5fb3333 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Receptors, Dopamine D1
    208 rdf:type schema:DefinedTerm
    209 Nede55c49aef443f3988e6d5d8eb17219 rdf:first sg:person.061433567.50
    210 rdf:rest N89fb9f1a52fa44e7a6f6b22b1238fddb
    211 Nf60d3fa9074d4aaeb401af60c7a806c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Receptors, Dopamine D2
    213 rdf:type schema:DefinedTerm
    214 Nfef3b9dc11fb40919d5b8de561950503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Caudate Nucleus
    216 rdf:type schema:DefinedTerm
    217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Medical and Health Sciences
    219 rdf:type schema:DefinedTerm
    220 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    221 schema:name Neurosciences
    222 rdf:type schema:DefinedTerm
    223 sg:journal.1019073 schema:issn 0001-6322
    224 1432-0533
    225 schema:name Acta Neuropathologica
    226 schema:publisher Springer Nature
    227 rdf:type schema:Periodical
    228 sg:person.01057277261.68 schema:affiliation grid-institutes:grid.1374.1
    229 schema:familyName Marjamäki
    230 schema:givenName Päivi
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057277261.68
    232 rdf:type schema:Person
    233 sg:person.01076571772.53 schema:affiliation grid-institutes:grid.1374.1
    234 schema:familyName Helenius
    235 schema:givenName Hans
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076571772.53
    237 rdf:type schema:Person
    238 sg:person.01237370004.45 schema:affiliation grid-institutes:grid.1374.1
    239 schema:familyName Mattila
    240 schema:givenName Petri M.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237370004.45
    242 rdf:type schema:Person
    243 sg:person.012653127617.40 schema:affiliation grid-institutes:grid.1374.1
    244 schema:familyName Rinne
    245 schema:givenName Juha O.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012653127617.40
    247 rdf:type schema:Person
    248 sg:person.061433567.50 schema:affiliation grid-institutes:grid.1374.1
    249 schema:familyName Röyttä
    250 schema:givenName Matias
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.061433567.50
    252 rdf:type schema:Person
    253 sg:person.0760163273.49 schema:affiliation grid-institutes:grid.1374.1
    254 schema:familyName Lönnberg
    255 schema:givenName Pirkko
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760163273.49
    257 rdf:type schema:Person
    258 sg:pub.10.1007/bf00314594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052950796
    259 https://doi.org/10.1007/bf00314594
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1007/bf00686786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047901357
    262 https://doi.org/10.1007/bf00686786
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/bf00695605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000607794
    265 https://doi.org/10.1007/bf00695605
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/bf01664007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018570015
    268 https://doi.org/10.1007/bf01664007
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s004010050843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021492273
    271 https://doi.org/10.1007/s004010050843
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/385590a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049444370
    274 https://doi.org/10.1038/385590a0
    275 rdf:type schema:CreativeWork
    276 grid-institutes:grid.1374.1 schema:alternateName Department of Biostatistics, University of Turku, Finland
    277 Department of Neurology, University of Turku, 20520 Turku, Finland
    278 Department of Pathology, University of Turku, Finland
    279 schema:name Department of Biostatistics, University of Turku, Finland
    280 Department of Neurology, University of Turku, 20520 Turku, Finland
    281 Department of Pathology, University of Turku, Finland
    282 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...