Ontology type: schema:ScholarlyArticle
1999-05
AUTHORSH. Heinsen, U. Rüb, Manfred Bauer, Gerd Ulmar, Birgitt Bethke, Michael Schüler, Felix Böcker, Wolfgang Eisenmenger, Monika Götz, Hubert Korr, Christoph Schmitz
ABSTRACTWe estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington’s disease (HD; four males, three females, mean age 52.4 ± 13.6 years) and age- and sex-matched controls (four males, three females, mean age 53.6 ± 12.1 years) by means of a stereological protocol. The mean total neurone number (NT¯) in the MD of controls was 2,985,188 ± 174,710, the mean glial number (GT¯; astrocytes, oligodendrocytes) 21,785,008 ± 2,986,678, and the glial index 7.29 ± 0.88. In HD, the average neurone number was decreased by 23.8% to 2,275,321 ± 247,162 (Mann-Whitney U-test P < 0.05), the mean glial number by 29.7 % to 15,318,895 ± 1,722,524 (Mann-Whitney U-test P < 0.05), the glial index was slightly reduced to 6.81 ± 1.06. Gallyas’ impregnation for the demonstration of fibrous astroglia gave strongly positive results in all cases with HD and negative results in the controls. The morpho-functional correlation of the results is complicated because individual variability, presence of segregated and parallel neuronal circuits, and plasticity of the adult human CNS must be considered. More... »
PAGES613-622
http://scigraph.springernature.com/pub.10.1007/s004010051037
DOIhttp://dx.doi.org/10.1007/s004010051037
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1053422511
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10378380
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Count",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Huntington Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thalamic Nuclei",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Morphologische Hirnforschung der Psychiatrischen Klinik, Josef-Schneider-Str. 2, D-97080 W\u00fcrzburg, Germany e-mail: heinsen@mail.uni-wuerzburg.de, Tel.: +49-931-2017550, Fax: +49-931-960498, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Morphologische Hirnforschung der Psychiatrischen Klinik, Josef-Schneider-Str. 2, D-97080 W\u00fcrzburg, Germany e-mail: heinsen@mail.uni-wuerzburg.de, Tel.: +49-931-2017550, Fax: +49-931-960498, DE"
],
"type": "Organization"
},
"familyName": "Heinsen",
"givenName": "H.",
"id": "sg:person.0646606074.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646606074.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Morphologische Hirnforschung der Psychiatrischen Klinik, Josef-Schneider-Str. 2, D-97080 W\u00fcrzburg, Germany e-mail: heinsen@mail.uni-wuerzburg.de, Tel.: +49-931-2017550, Fax: +49-931-960498, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Morphologische Hirnforschung der Psychiatrischen Klinik, Josef-Schneider-Str. 2, D-97080 W\u00fcrzburg, Germany e-mail: heinsen@mail.uni-wuerzburg.de, Tel.: +49-931-2017550, Fax: +49-931-960498, DE"
],
"type": "Organization"
},
"familyName": "R\u00fcb",
"givenName": "U.",
"id": "sg:person.0637231010.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637231010.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Psychiatrisches Landeskrankenhaus, D-69155 Wiesloch, Germany, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Psychiatrisches Landeskrankenhaus, D-69155 Wiesloch, Germany, DE"
],
"type": "Organization"
},
"familyName": "Bauer",
"givenName": "Manfred",
"id": "sg:person.01307162322.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307162322.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Psychiatrisches Landeskrankenhaus, D-69155 Wiesloch, Germany, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Psychiatrisches Landeskrankenhaus, D-69155 Wiesloch, Germany, DE"
],
"type": "Organization"
},
"familyName": "Ulmar",
"givenName": "Gerd",
"id": "sg:person.0631671422.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631671422.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Pathologie, D-95445 Bayreuth, Germany, DE",
"id": "http://www.grid.ac/institutes/grid.5252.0",
"name": [
"Institut f\u00fcr Pathologie, D-95445 Bayreuth, Germany, DE"
],
"type": "Organization"
},
"familyName": "Bethke",
"givenName": "Birgitt",
"id": "sg:person.01162525176.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162525176.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nervenkrankenhaus des Bezirks Oberfranken, D-95445 Bayreuth, Germany, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Nervenkrankenhaus des Bezirks Oberfranken, D-95445 Bayreuth, Germany, DE"
],
"type": "Organization"
},
"familyName": "Sch\u00fcler",
"givenName": "Michael",
"id": "sg:person.01063577245.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063577245.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nervenkrankenhaus des Bezirks Oberfranken, D-95445 Bayreuth, Germany, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Nervenkrankenhaus des Bezirks Oberfranken, D-95445 Bayreuth, Germany, DE"
],
"type": "Organization"
},
"familyName": "B\u00f6cker",
"givenName": "Felix",
"id": "sg:person.01333241450.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333241450.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Rechtsmedizin der Universit\u00e4t, D-80337 M\u00fcnchen, Germany, DE",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Institut f\u00fcr Rechtsmedizin der Universit\u00e4t, D-80337 M\u00fcnchen, Germany, DE"
],
"type": "Organization"
},
"familyName": "Eisenmenger",
"givenName": "Wolfgang",
"id": "sg:person.0720472060.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720472060.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Pathologie, D-63739 Aschaffenburg, Germany, DE",
"id": "http://www.grid.ac/institutes/grid.5252.0",
"name": [
"Institut f\u00fcr Pathologie, D-63739 Aschaffenburg, Germany, DE"
],
"type": "Organization"
},
"familyName": "G\u00f6tz",
"givenName": "Monika",
"id": "sg:person.01200025645.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200025645.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Anatomie der RWTH, D-52057 Aachen, Germany, DE",
"id": "http://www.grid.ac/institutes/grid.1957.a",
"name": [
"Institut f\u00fcr Anatomie der RWTH, D-52057 Aachen, Germany, DE"
],
"type": "Organization"
},
"familyName": "Korr",
"givenName": "Hubert",
"id": "sg:person.01141663323.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141663323.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Anatomie der RWTH, D-52057 Aachen, Germany, DE",
"id": "http://www.grid.ac/institutes/grid.1957.a",
"name": [
"Institut f\u00fcr Anatomie der RWTH, D-52057 Aachen, Germany, DE"
],
"type": "Organization"
},
"familyName": "Schmitz",
"givenName": "Christoph",
"id": "sg:person.010642640112.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010642640112.94"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00343806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1081753129",
"https://doi.org/10.1007/bf00343806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4757-9619-3_4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043749507",
"https://doi.org/10.1007/978-1-4757-9619-3_4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4684-4148-2_10",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011744332",
"https://doi.org/10.1007/978-1-4684-4148-2_10"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00193414",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041700098",
"https://doi.org/10.1007/bf00193414"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-662-22593-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007549857",
"https://doi.org/10.1007/978-3-662-22593-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00228975",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048116221",
"https://doi.org/10.1007/bf00228975"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/263244a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031681971",
"https://doi.org/10.1038/263244a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02206615",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040722114",
"https://doi.org/10.1007/bf02206615"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004010051038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017476458",
"https://doi.org/10.1007/s004010051038"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4613-2149-1_12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030072183",
"https://doi.org/10.1007/978-1-4613-2149-1_12"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00310376",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034265207",
"https://doi.org/10.1007/bf00310376"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004010050408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023680812",
"https://doi.org/10.1007/s004010050408"
],
"type": "CreativeWork"
}
],
"datePublished": "1999-05",
"datePublishedReg": "1999-05-01",
"description": "Abstract We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington\u2019s disease (HD; four males, three females, mean age 52.4 \u00b1 13.6 years) and age- and sex-matched controls (four males, three females, mean age 53.6 \u00b1 12.1 years) by means of a stereological protocol. The mean total neurone number (NT\u00af) in the MD of controls was 2,985,188 \u00b1 174,710, the mean glial number (GT\u00af; astrocytes, oligodendrocytes) 21,785,008 \u00b1 2,986,678, and the glial index 7.29 \u00b1 0.88. In HD, the average neurone number was decreased by 23.8% to 2,275,321 \u00b1 247,162 (Mann-Whitney U-test P < 0.05), the mean glial number by 29.7 % to 15,318,895 \u00b1 1,722,524 (Mann-Whitney U-test P < 0.05), the glial index was slightly reduced to 6.81 \u00b1 1.06. Gallyas\u2019 impregnation for the demonstration of fibrous astroglia gave strongly positive results in all cases with HD and negative results in the controls. The morpho-functional correlation of the results is complicated because individual variability, presence of segregated and parallel neuronal circuits, and plasticity of the adult human CNS must be considered.",
"genre": "article",
"id": "sg:pub.10.1007/s004010051037",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1019073",
"issn": [
"0001-6322",
"1432-0533"
],
"name": "Acta Neuropathologica",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "97"
}
],
"keywords": [
"mediodorsal nucleus",
"thalamic mediodorsal nucleus",
"glial numbers",
"neurone number",
"glial index",
"Huntington's disease",
"morpho-functional correlations",
"parallel neuronal circuits",
"nerve cell loss",
"sex-matched controls",
"adult human CNS",
"fibrous astroglia",
"human CNS",
"neuronal circuits",
"cell loss",
"disease",
"negative results",
"positive results",
"individual variability",
"stereological protocol",
"HD",
"patients",
"astroglia",
"Gallyas",
"CNS",
"control",
"index",
"age",
"nucleus",
"number",
"plasticity",
"cases",
"protocol",
"results",
"correlation",
"loss",
"presence",
"demonstration",
"variability",
"means",
"Abstract",
"circuit",
"impregnation"
],
"name": "Nerve cell loss in the thalamic mediodorsal nucleus in Huntington\u2019s disease",
"pagination": "613-622",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1053422511"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s004010051037"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10378380"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s004010051037",
"https://app.dimensions.ai/details/publication/pub.1053422511"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_311.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s004010051037"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010051037'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010051037'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010051037'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010051037'
This table displays all metadata directly associated to this object as RDF triples.
273 TRIPLES
22 PREDICATES
91 URIs
71 LITERALS
16 BLANK NODES