Nerve cell loss in the thalamic mediodorsal nucleus in Huntington’s disease View Full Text


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Article Info

DATE

1999-05

AUTHORS

H. Heinsen, U. Rüb, Manfred Bauer, Gerd Ulmar, Birgitt Bethke, Michael Schüler, Felix Böcker, Wolfgang Eisenmenger, Monika Götz, Hubert Korr, Christoph Schmitz

ABSTRACT

We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington’s disease (HD; four males, three females, mean age 52.4 ± 13.6 years) and age- and sex-matched controls (four males, three females, mean age 53.6 ± 12.1 years) by means of a stereological protocol. The mean total neurone number (NT¯) in the MD of controls was 2,985,188 ± 174,710, the mean glial number (GT¯; astrocytes, oligodendrocytes) 21,785,008 ± 2,986,678, and the glial index 7.29 ± 0.88. In HD, the average neurone number was decreased by 23.8% to 2,275,321 ± 247,162 (Mann-Whitney U-test P < 0.05), the mean glial number by 29.7 % to 15,318,895 ± 1,722,524 (Mann-Whitney U-test P < 0.05), the glial index was slightly reduced to 6.81 ± 1.06. Gallyas’ impregnation for the demonstration of fibrous astroglia gave strongly positive results in all cases with HD and negative results in the controls. The morpho-functional correlation of the results is complicated because individual variability, presence of segregated and parallel neuronal circuits, and plasticity of the adult human CNS must be considered. More... »

PAGES

613-622

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s004010051037

    DOI

    http://dx.doi.org/10.1007/s004010051037

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053422511

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10378380


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    27 schema:description Abstract We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington’s disease (HD; four males, three females, mean age 52.4 ± 13.6 years) and age- and sex-matched controls (four males, three females, mean age 53.6 ± 12.1 years) by means of a stereological protocol. The mean total neurone number (NT¯) in the MD of controls was 2,985,188 ± 174,710, the mean glial number (GT¯; astrocytes, oligodendrocytes) 21,785,008 ± 2,986,678, and the glial index 7.29 ± 0.88. In HD, the average neurone number was decreased by 23.8% to 2,275,321 ± 247,162 (Mann-Whitney U-test P < 0.05), the mean glial number by 29.7 % to 15,318,895 ± 1,722,524 (Mann-Whitney U-test P < 0.05), the glial index was slightly reduced to 6.81 ± 1.06. Gallyas’ impregnation for the demonstration of fibrous astroglia gave strongly positive results in all cases with HD and negative results in the controls. The morpho-functional correlation of the results is complicated because individual variability, presence of segregated and parallel neuronal circuits, and plasticity of the adult human CNS must be considered.
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    37 HD
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    39 adult human CNS
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    41 astroglia
    42 cases
    43 cell loss
    44 circuit
    45 control
    46 correlation
    47 demonstration
    48 disease
    49 fibrous astroglia
    50 glial index
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    52 human CNS
    53 impregnation
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    55 individual variability
    56 loss
    57 means
    58 mediodorsal nucleus
    59 morpho-functional correlations
    60 negative results
    61 nerve cell loss
    62 neuronal circuits
    63 neurone number
    64 nucleus
    65 number
    66 parallel neuronal circuits
    67 patients
    68 plasticity
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    71 protocol
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