Ontology type: schema:ScholarlyArticle
1999-05
AUTHORSH. Heinsen, U. Rüb, Manfred Bauer, Gerd Ulmar, Birgitt Bethke, Michael Schüler, Felix Böcker, Wolfgang Eisenmenger, Monika Götz, Hubert Korr, Christoph Schmitz
ABSTRACTWe estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington’s disease (HD; four males, three females, mean age 52.4 ± 13.6 years) and age- and sex-matched controls (four males, three females, mean age 53.6 ± 12.1 years) by means of a stereological protocol. The mean total neurone number (NT¯) in the MD of controls was 2,985,188 ± 174,710, the mean glial number (GT¯; astrocytes, oligodendrocytes) 21,785,008 ± 2,986,678, and the glial index 7.29 ± 0.88. In HD, the average neurone number was decreased by 23.8% to 2,275,321 ± 247,162 (Mann-Whitney U-test P < 0.05), the mean glial number by 29.7 % to 15,318,895 ± 1,722,524 (Mann-Whitney U-test P < 0.05), the glial index was slightly reduced to 6.81 ± 1.06. Gallyas’ impregnation for the demonstration of fibrous astroglia gave strongly positive results in all cases with HD and negative results in the controls. The morpho-functional correlation of the results is complicated because individual variability, presence of segregated and parallel neuronal circuits, and plasticity of the adult human CNS must be considered. More... »
PAGES613-622
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DOIhttp://dx.doi.org/10.1007/s004010051037
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10378380
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