Fiber-type-dependent expression of adenovirus-mediated transgene in mouse skeletal muscle fibers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-08

AUTHORS

Y. Hagiwara, A. Ishii, Ikuya Nonaka, Tateki Kikuchi, Shin’ichi Takeda

ABSTRACT

We show the efficient transduction and expression of the lacZ gene in the skeletal muscle of adult C57BL/10ScSn mice after adenovirus-mediated gene transfer. Of the myofibers in the tibialis anterior muscle 62% were β-galactosidase positive after injection of the lacZ gene under the control of the chicken β-actin promoter and the cytomegalovirus enhancer. The transduced gene was preferentially expressed in type IIA and IIX fibers, which were richer in oxidative enzymes than type IIB fibers. More... »

PAGES

228-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050888

DOI

http://dx.doi.org/10.1007/s004010050888

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005619830

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9754954


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