Argyrophilic grain disease is associated with apolipoprotein E ε2 allele View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-08

AUTHORS

E. Ghebremedhin, Christian Schultz, Giovannina Botez, U. Rüb, Irena Sassin, E. Braak, Heiko Braak

ABSTRACT

Argyrophilic grain disease (AGD) is a distinct degenerative disorder of the human brain associated with the formation of abnormally phosphorylated tau protein. AGD-related cytoskeletal changes are known to affect specific subsets of nerve cells and oligodendrocytes. Here we demonstrate a remarkable association between the apolipoprotein E (ApoE) ɛ2 allele and AGD. Individuals afflicted with AGD (n = 48) reveal a significantly higher frequency of the ɛ2 allele compared with controls (n = 43) (22% versus 4%, P < 0.0002). The association between AGD and ɛ2 allele of ApoE suggests that AGD can be distinguished from other neurodegenerative disorders not only neuropathologically, but also genetically. More... »

PAGES

222-224

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050886

DOI

http://dx.doi.org/10.1007/s004010050886

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041465805

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9754952


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