Blood-nerve barrier in IgM paraproteinemic neuropathy: a clinicopathologic assessment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-01

AUTHORS

T. Kanda, Sadanari Usui, Hirokuni Beppu, Kazuhito Miyamoto, Masanaga Yamawaki, Masaya Oda

ABSTRACT

We report the pathologic findings in a patient with sensorimotor neuropathy associated with Waldenström's macroglobulinemia, particularly in relation to blood-nerve barrier defects. The monoclonal IgM was of kappa type and possessed anti-HNK-1 activity. A sural nerve biopsy specimen revealed severe loss of myelinated and unmyelinated nerve fibers and gaps between adjacent endothelial cells of small endoneurial vessels. Postmortem findings 3 years later included severe loss of myelinated nerve fibers and diffuse infiltration by lymphoplasmacytic B cells throughout the peripheral nervous system, sparing the central nervous system. Findings in this case suggest an immune attack against endoneurial endothelial cells with permeation of IgM into peripheral nerve tissue. More... »

PAGES

184-192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050785

DOI

http://dx.doi.org/10.1007/s004010050785

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004336045

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9498055


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