Tuberous sclerosis in a 20-week gestation fetus: immunohistochemical study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-07

AUTHORS

Sung-Hye Park, Samuel H. Pepkowitz, Christopher Kerfoot, Michael J. De Rosa, Vadims Poukens, R. Wienecke, Jeffrey E. DeClue, H. V. Vinters

ABSTRACT

We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical tubers and subependymal hamartomatous nodules. The large cells within these nodular clusters were variably immunoreactive for glial fibrillary acidic protein (GFAP) and vimentin and negative for synaptophysin and neurofilament. Subependymal radial glia expressed both vimentin and GFAP, but subpial radial glia either did not express these markers (in contrast to an age-matched control) or were absent. Tuberin expression was noted in heterotopic neurons in the white matter and brain cells consistent with Cajal Retzius cells in the neocortical molecular layer, very weakly in superficial cortical neurons, neurons in the basal ganglia, Purkinje cells and external granular cells of cerebellum, cranial nerve nuclei neurons, occasional germinal matrix cells, ependymal cells, choroid plexus epithelium, and pituitary gland neuroendocrine cells; it was not seen within the cells of subependymal nodules. The pattern of tuberin immunoreactivity was similar to that which we have observed in older TSC patients. Proliferating cell labeling indexes were comparable in the germinal matrix of the TSC patient and an age-matched control. Abnormal subpial radial glia may be responsible for some of the neuronal migration abnormalities that appear to result in neocortical tubers. More... »

PAGES

180-186

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050691

DOI

http://dx.doi.org/10.1007/s004010050691

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008209359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9255394


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gestational Age", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glial Fibrillary Acidic Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurofilament Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptophysin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tuberous Sclerosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vimentin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Pathology (Neuropathology),  UCLA School of Medicine, 18-170 CHS, Los Angeles,  CA 90095-1732, USA Fax: 1-310-206-5178;  e-mail: hvinters@pathology.medsch.ucla.edu, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Sung-Hye", 
        "id": "sg:person.013033476404.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013033476404.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cedars-Sinai Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.50956.3f", 
          "name": [
            "Department of Pathology, Cedars Sinai Medical center,  Los Angeles, California, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pepkowitz", 
        "givenName": "Samuel H.", 
        "id": "sg:person.01212566332.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212566332.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Pathology (Neuropathology),  UCLA School of Medicine, 18-170 CHS, Los Angeles,  CA 90095-1732, USA Fax: 1-310-206-5178;  e-mail: hvinters@pathology.medsch.ucla.edu, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerfoot", 
        "givenName": "Christopher", 
        "id": "sg:person.01147622213.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147622213.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Pathology (Neuropathology),  UCLA School of Medicine, 18-170 CHS, Los Angeles,  CA 90095-1732, USA Fax: 1-310-206-5178;  e-mail: hvinters@pathology.medsch.ucla.edu, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosa", 
        "givenName": "Michael J. De", 
        "id": "sg:person.01227255434.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227255434.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Pathology (Neuropathology),  UCLA School of Medicine, 18-170 CHS, Los Angeles,  CA 90095-1732, USA Fax: 1-310-206-5178;  e-mail: hvinters@pathology.medsch.ucla.edu, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poukens", 
        "givenName": "Vadims", 
        "id": "sg:person.01106035441.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106035441.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.417768.b", 
          "name": [
            "Laboratory of Cellular Oncology, National Cancer Institute,  Bethesda, MD 20892, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wienecke", 
        "givenName": "R.", 
        "id": "sg:person.01277432234.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277432234.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.417768.b", 
          "name": [
            "Laboratory of Cellular Oncology, National Cancer Institute,  Bethesda, MD 20892, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeClue", 
        "givenName": "Jeffrey E.", 
        "id": "sg:person.01013111055.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013111055.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Pathology (Neuropathology),  UCLA School of Medicine, 18-170 CHS, Los Angeles,  CA 90095-1732, USA Fax: 1-310-206-5178;  e-mail: hvinters@pathology.medsch.ucla.edu, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vinters", 
        "givenName": "H. V.", 
        "id": "sg:person.0660103227.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660103227.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1017/s0317167100044590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000022814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1991.tb37754.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003500332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410090211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004386589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00315012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004470027", 
          "https://doi.org/10.1007/bf00315012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00315012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004470027", 
          "https://doi.org/10.1007/bf00315012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpedi.1966.02090060123018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005377170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0294-193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005858501", 
          "https://doi.org/10.1038/ng0294-193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.27.16409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007007634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8749.1983.tb13769.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007108439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8749.1983.tb13769.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007108439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00688497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009940963", 
          "https://doi.org/10.1007/bf00688497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00691876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010080642", 
          "https://doi.org/10.1007/bf00691876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.1996.tb00866.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012467426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00688705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014079905", 
          "https://doi.org/10.1007/bf00688705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199503000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015495599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01913129309041302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019031673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(78)90721-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021702569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(78)90721-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021702569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.1990.tb01156.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023754773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01913128009141432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029105343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00691851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034855741", 
          "https://doi.org/10.1007/bf00691851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.26.1.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035458046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199605000-00040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036764294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0387-7604(12)80211-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038617567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/118.3.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059439470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/3.10.1829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059644719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/3.10.1833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059644720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.20.2.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064360385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.41.1.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064369549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/00006123-199410000-00025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064433234"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-07", 
    "datePublishedReg": "1997-07-01", 
    "description": "We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical tubers and subependymal hamartomatous nodules. The large cells within these nodular clusters were variably immunoreactive for glial fibrillary acidic protein (GFAP) and vimentin and negative for synaptophysin and neurofilament. Subependymal radial glia expressed both vimentin and GFAP, but subpial radial glia either did not express these markers (in contrast to an age-matched control) or were absent. Tuberin expression was noted in heterotopic neurons in the white matter and brain cells consistent with Cajal Retzius cells in the neocortical molecular layer, very weakly in superficial cortical neurons, neurons in the basal ganglia, Purkinje cells and external granular cells of cerebellum, cranial nerve nuclei neurons, occasional germinal matrix cells, ependymal cells, choroid plexus epithelium, and pituitary gland neuroendocrine cells; it was not seen within the cells of subependymal nodules. The pattern of tuberin immunoreactivity was similar to that which we have observed in older TSC patients. Proliferating cell labeling indexes were comparable in the germinal matrix of the TSC patient and an age-matched control. Abnormal subpial radial glia may be responsible for some of the neuronal migration abnormalities that appear to result in neocortical tubers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s004010050691", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2437347", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "94"
      }
    ], 
    "name": "Tuberous sclerosis in a 20-week gestation fetus: immunohistochemical study", 
    "pagination": "180-186", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "271c661b7e731d61c5f7093ce6766189aa77d91b753405968e6b819a4040abd2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9255394"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004010050691"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008209359"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004010050691", 
      "https://app.dimensions.ai/details/publication/pub.1008209359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000486.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s004010050691"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010050691'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010050691'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010050691'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010050691'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      70 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004010050691 schema:about N1afafd2d274c4041a8ff9d66d32a3509
2 N1e3803ce2a9548af960bfe260048f5d1
3 N1ec35835c4ec433b84d44bf580dc296f
4 N2ae2e15cd2db4966bc2c223af6ccc0dc
5 N3de66b4afa0746bf929d1b203ba286d6
6 N4573e259b6264f8fb20e6f1996eb7e82
7 N7e15563df5d54de59a76f2ba022db8d7
8 N8f3b50e2cec444509a160e01a2551a8f
9 Nbac7c29818ab4a1fbb0c84332fdbd35d
10 Nbb6414e41dcc480ea2e13c8cb23d753d
11 Nd680b97e3f934005a26c34012eb79fa6
12 Nd72c9fc3e23b4ad3b97f3b81645446d6
13 Neb5c53b93b4c48dca87715470aa1c97d
14 Nfc675cdd870a4fa3ab6a944dbe8f8877
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author Nfeb25ca1214c4ccb956e771bdf3cc238
18 schema:citation sg:pub.10.1007/bf00315012
19 sg:pub.10.1007/bf00688497
20 sg:pub.10.1007/bf00688705
21 sg:pub.10.1007/bf00691851
22 sg:pub.10.1007/bf00691876
23 sg:pub.10.1038/ng0294-193
24 https://doi.org/10.1001/archpedi.1966.02090060123018
25 https://doi.org/10.1002/ana.410090211
26 https://doi.org/10.1016/0006-8993(78)90721-7
27 https://doi.org/10.1016/s0387-7604(12)80211-7
28 https://doi.org/10.1017/s0317167100044590
29 https://doi.org/10.1074/jbc.270.27.16409
30 https://doi.org/10.1093/brain/118.3.629
31 https://doi.org/10.1093/hmg/3.10.1829
32 https://doi.org/10.1093/hmg/3.10.1833
33 https://doi.org/10.1097/00005072-199503000-00001
34 https://doi.org/10.1097/00005072-199605000-00040
35 https://doi.org/10.1111/j.1365-2990.1990.tb01156.x
36 https://doi.org/10.1111/j.1469-8749.1983.tb13769.x
37 https://doi.org/10.1111/j.1749-6632.1991.tb37754.x
38 https://doi.org/10.1111/j.1750-3639.1996.tb00866.x
39 https://doi.org/10.1136/jmg.26.1.28
40 https://doi.org/10.1212/wnl.20.2.139
41 https://doi.org/10.1212/wnl.41.1.124
42 https://doi.org/10.1227/00006123-199410000-00025
43 https://doi.org/10.3109/01913128009141432
44 https://doi.org/10.3109/01913129309041302
45 schema:datePublished 1997-07
46 schema:datePublishedReg 1997-07-01
47 schema:description We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical tubers and subependymal hamartomatous nodules. The large cells within these nodular clusters were variably immunoreactive for glial fibrillary acidic protein (GFAP) and vimentin and negative for synaptophysin and neurofilament. Subependymal radial glia expressed both vimentin and GFAP, but subpial radial glia either did not express these markers (in contrast to an age-matched control) or were absent. Tuberin expression was noted in heterotopic neurons in the white matter and brain cells consistent with Cajal Retzius cells in the neocortical molecular layer, very weakly in superficial cortical neurons, neurons in the basal ganglia, Purkinje cells and external granular cells of cerebellum, cranial nerve nuclei neurons, occasional germinal matrix cells, ependymal cells, choroid plexus epithelium, and pituitary gland neuroendocrine cells; it was not seen within the cells of subependymal nodules. The pattern of tuberin immunoreactivity was similar to that which we have observed in older TSC patients. Proliferating cell labeling indexes were comparable in the germinal matrix of the TSC patient and an age-matched control. Abnormal subpial radial glia may be responsible for some of the neuronal migration abnormalities that appear to result in neocortical tubers.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N0ae157214fac40e5ad9bd23a794e01f7
52 Nb386a66526734958831637497e7b76a5
53 sg:journal.1019073
54 schema:name Tuberous sclerosis in a 20-week gestation fetus: immunohistochemical study
55 schema:pagination 180-186
56 schema:productId N1b92adeae33448a1ac4ef7d67fef4270
57 N3d26f81fec6245a59de20e3dac281004
58 N569503d9464e4f76b13ca7e4edb67f1c
59 N7eb3872c5075403da4e7803670b81f79
60 Nf85c3b8b7a5b4c9cb96f6e623ded0c49
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008209359
62 https://doi.org/10.1007/s004010050691
63 schema:sdDatePublished 2019-04-11T00:10
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N56ac1122d2074f1f85f993a1db3ee8e2
66 schema:url http://link.springer.com/10.1007/s004010050691
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0ae157214fac40e5ad9bd23a794e01f7 schema:volumeNumber 94
71 rdf:type schema:PublicationVolume
72 N10b3f6b4f5134bc6beeb4c883e49968c rdf:first sg:person.01212566332.01
73 rdf:rest Nf31de00db3cd4aefa671b45c822e830f
74 N116bf2b458364301a36951431487a126 rdf:first sg:person.0660103227.49
75 rdf:rest rdf:nil
76 N1afafd2d274c4041a8ff9d66d32a3509 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Immunohistochemistry
78 rdf:type schema:DefinedTerm
79 N1b92adeae33448a1ac4ef7d67fef4270 schema:name doi
80 schema:value 10.1007/s004010050691
81 rdf:type schema:PropertyValue
82 N1e3803ce2a9548af960bfe260048f5d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Glial Fibrillary Acidic Protein
84 rdf:type schema:DefinedTerm
85 N1ec35835c4ec433b84d44bf580dc296f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Brain Chemistry
87 rdf:type schema:DefinedTerm
88 N2ae2e15cd2db4966bc2c223af6ccc0dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Pregnancy
90 rdf:type schema:DefinedTerm
91 N33e323e92be54ac6b446bf71973bbea3 rdf:first sg:person.01277432234.51
92 rdf:rest Ndf49a9b7de314cf8a7fc210d9532716e
93 N3d26f81fec6245a59de20e3dac281004 schema:name nlm_unique_id
94 schema:value 0412041
95 rdf:type schema:PropertyValue
96 N3de66b4afa0746bf929d1b203ba286d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Synaptophysin
98 rdf:type schema:DefinedTerm
99 N4573e259b6264f8fb20e6f1996eb7e82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Neurofilament Proteins
101 rdf:type schema:DefinedTerm
102 N569503d9464e4f76b13ca7e4edb67f1c schema:name dimensions_id
103 schema:value pub.1008209359
104 rdf:type schema:PropertyValue
105 N56ac1122d2074f1f85f993a1db3ee8e2 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N5e12f3d0a4ae456999c00cf518e78027 rdf:first sg:person.01227255434.62
108 rdf:rest Ndc9c67433c9b4bf2892b34e8e337757d
109 N7e15563df5d54de59a76f2ba022db8d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Vimentin
111 rdf:type schema:DefinedTerm
112 N7eb3872c5075403da4e7803670b81f79 schema:name pubmed_id
113 schema:value 9255394
114 rdf:type schema:PropertyValue
115 N8f3b50e2cec444509a160e01a2551a8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Female
117 rdf:type schema:DefinedTerm
118 Nb386a66526734958831637497e7b76a5 schema:issueNumber 2
119 rdf:type schema:PublicationIssue
120 Nbac7c29818ab4a1fbb0c84332fdbd35d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Neurons
122 rdf:type schema:DefinedTerm
123 Nbb6414e41dcc480ea2e13c8cb23d753d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Brain
125 rdf:type schema:DefinedTerm
126 Nd680b97e3f934005a26c34012eb79fa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Fetus
128 rdf:type schema:DefinedTerm
129 Nd72c9fc3e23b4ad3b97f3b81645446d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Gestational Age
131 rdf:type schema:DefinedTerm
132 Ndc9c67433c9b4bf2892b34e8e337757d rdf:first sg:person.01106035441.17
133 rdf:rest N33e323e92be54ac6b446bf71973bbea3
134 Ndf49a9b7de314cf8a7fc210d9532716e rdf:first sg:person.01013111055.67
135 rdf:rest N116bf2b458364301a36951431487a126
136 Neb5c53b93b4c48dca87715470aa1c97d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Tuberous Sclerosis
138 rdf:type schema:DefinedTerm
139 Nf31de00db3cd4aefa671b45c822e830f rdf:first sg:person.01147622213.80
140 rdf:rest N5e12f3d0a4ae456999c00cf518e78027
141 Nf85c3b8b7a5b4c9cb96f6e623ded0c49 schema:name readcube_id
142 schema:value 271c661b7e731d61c5f7093ce6766189aa77d91b753405968e6b819a4040abd2
143 rdf:type schema:PropertyValue
144 Nfc675cdd870a4fa3ab6a944dbe8f8877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 Nfeb25ca1214c4ccb956e771bdf3cc238 rdf:first sg:person.013033476404.22
148 rdf:rest N10b3f6b4f5134bc6beeb4c883e49968c
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
153 schema:name Neurosciences
154 rdf:type schema:DefinedTerm
155 sg:grant.2437347 http://pending.schema.org/fundedItem sg:pub.10.1007/s004010050691
156 rdf:type schema:MonetaryGrant
157 sg:journal.1019073 schema:issn 0001-6322
158 1432-0533
159 schema:name Acta Neuropathologica
160 rdf:type schema:Periodical
161 sg:person.01013111055.67 schema:affiliation https://www.grid.ac/institutes/grid.417768.b
162 schema:familyName DeClue
163 schema:givenName Jeffrey E.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013111055.67
165 rdf:type schema:Person
166 sg:person.01106035441.17 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
167 schema:familyName Poukens
168 schema:givenName Vadims
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106035441.17
170 rdf:type schema:Person
171 sg:person.01147622213.80 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
172 schema:familyName Kerfoot
173 schema:givenName Christopher
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147622213.80
175 rdf:type schema:Person
176 sg:person.01212566332.01 schema:affiliation https://www.grid.ac/institutes/grid.50956.3f
177 schema:familyName Pepkowitz
178 schema:givenName Samuel H.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212566332.01
180 rdf:type schema:Person
181 sg:person.01227255434.62 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
182 schema:familyName Rosa
183 schema:givenName Michael J. De
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227255434.62
185 rdf:type schema:Person
186 sg:person.01277432234.51 schema:affiliation https://www.grid.ac/institutes/grid.417768.b
187 schema:familyName Wienecke
188 schema:givenName R.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277432234.51
190 rdf:type schema:Person
191 sg:person.013033476404.22 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
192 schema:familyName Park
193 schema:givenName Sung-Hye
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013033476404.22
195 rdf:type schema:Person
196 sg:person.0660103227.49 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
197 schema:familyName Vinters
198 schema:givenName H. V.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660103227.49
200 rdf:type schema:Person
201 sg:pub.10.1007/bf00315012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004470027
202 https://doi.org/10.1007/bf00315012
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/bf00688497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009940963
205 https://doi.org/10.1007/bf00688497
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/bf00688705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014079905
208 https://doi.org/10.1007/bf00688705
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/bf00691851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034855741
211 https://doi.org/10.1007/bf00691851
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/bf00691876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010080642
214 https://doi.org/10.1007/bf00691876
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/ng0294-193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005858501
217 https://doi.org/10.1038/ng0294-193
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1001/archpedi.1966.02090060123018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005377170
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/ana.410090211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004386589
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0006-8993(78)90721-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021702569
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0387-7604(12)80211-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038617567
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1017/s0317167100044590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000022814
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1074/jbc.270.27.16409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007007634
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/brain/118.3.629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059439470
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/hmg/3.10.1829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059644719
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/hmg/3.10.1833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059644720
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/00005072-199503000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015495599
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/00005072-199605000-00040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036764294
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/j.1365-2990.1990.tb01156.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023754773
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/j.1469-8749.1983.tb13769.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007108439
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1111/j.1749-6632.1991.tb37754.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003500332
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1111/j.1750-3639.1996.tb00866.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012467426
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1136/jmg.26.1.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035458046
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1212/wnl.20.2.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064360385
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1212/wnl.41.1.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064369549
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1227/00006123-199410000-00025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064433234
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3109/01913128009141432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029105343
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3109/01913129309041302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019031673
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
262 schema:name Department of Pathology (Neuropathology), UCLA School of Medicine, 18-170 CHS, Los Angeles, CA 90095-1732, USA Fax: 1-310-206-5178; e-mail: hvinters@pathology.medsch.ucla.edu, US
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.417768.b schema:alternateName Center for Cancer Research
265 schema:name Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892, USA, US
266 rdf:type schema:Organization
267 https://www.grid.ac/institutes/grid.50956.3f schema:alternateName Cedars-Sinai Medical Center
268 schema:name Department of Pathology, Cedars Sinai Medical center, Los Angeles, California, USA, US
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...