Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

H. Braak, E. Braak

ABSTRACT

The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes. More... »

PAGES

197-201

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050508

DOI

http://dx.doi.org/10.1007/s004010050508

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051409290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8841666


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