Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

H. Braak, E. Braak

ABSTRACT

The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes. More... »

PAGES

197-201

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050508

DOI

http://dx.doi.org/10.1007/s004010050508

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051409290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8841666


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelin Sheath", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurofibrillary Tangles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Anatomy, J. W. Goethe University,  Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany Tel.: 49-69-6301-6900; Fax: 49-69-6301-6425, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braak", 
        "givenName": "H.", 
        "id": "sg:person.01053255500.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Anatomy, J. W. Goethe University,  Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany Tel.: 49-69-6301-6900; Fax: 49-69-6301-6425, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braak", 
        "givenName": "E.", 
        "id": "sg:person.01365302117.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365302117.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00308809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000355620", 
          "https://doi.org/10.1007/bf00308809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.903400206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002290799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-198805000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003874944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-6374(88)90041-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007334958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-6374(88)90041-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007334958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00293315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015944982", 
          "https://doi.org/10.1007/bf00293315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-81522-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016830478", 
          "https://doi.org/10.1007/978-3-642-81522-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-81522-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016830478", 
          "https://doi.org/10.1007/978-3-642-81522-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490360202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018978954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0301-0082(85)90001-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030137466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0301-0082(85)90001-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030137466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01276421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031670916", 
          "https://doi.org/10.1007/bf01276421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-662-34547-4_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034262020", 
          "https://doi.org/10.1007/978-3-662-34547-4_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-198705000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042319961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(90)90098-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050549818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(90)90098-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050549818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(92)90246-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052334482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01616412.1979.11739553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058295368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-6610-6_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1089803662", 
          "https://doi.org/10.1007/978-1-4615-6610-6_10"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-07", 
    "datePublishedReg": "1996-07-01", 
    "description": "The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s004010050508", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "92"
      }
    ], 
    "name": "Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis", 
    "pagination": "197-201", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f4e496ff21306d5f28796f7571d5642f6858d880643276d027b6ce1523d09c35"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8841666"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004010050508"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051409290"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004010050508", 
      "https://app.dimensions.ai/details/publication/pub.1051409290"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000483.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s004010050508"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010050508'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010050508'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010050508'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010050508'


 

This table displays all metadata directly associated to this object as RDF triples.

151 TRIPLES      21 PREDICATES      50 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004010050508 schema:about N0571c0b2244549da9e3391a24924d541
2 N4fcda584ec1243a9b958b43c0fbf9291
3 N747611dade5e4c6c943756c48f92b88f
4 N7afb5bf487bb4e6394cf46150b59be94
5 Nb8318d5e835543e7b5091769a2413f5c
6 Ned4e89dd06734301ba9b7ff643991fda
7 anzsrc-for:11
8 anzsrc-for:1109
9 schema:author Nb6f52fb912aa4a4c9a1744c3024586d0
10 schema:citation sg:pub.10.1007/978-1-4615-6610-6_10
11 sg:pub.10.1007/978-3-642-81522-5
12 sg:pub.10.1007/978-3-662-34547-4_5
13 sg:pub.10.1007/bf00293315
14 sg:pub.10.1007/bf00308809
15 sg:pub.10.1007/bf01276421
16 https://doi.org/10.1002/cne.903400206
17 https://doi.org/10.1002/jnr.490360202
18 https://doi.org/10.1016/0014-4886(92)90246-m
19 https://doi.org/10.1016/0047-6374(88)90041-3
20 https://doi.org/10.1016/0166-2236(90)90098-u
21 https://doi.org/10.1016/0301-0082(85)90001-2
22 https://doi.org/10.1080/01616412.1979.11739553
23 https://doi.org/10.1097/00005072-198705000-00005
24 https://doi.org/10.1097/00005072-198805000-00003
25 schema:datePublished 1996-07
26 schema:datePublishedReg 1996-07-01
27 schema:description The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf N2c8bca601b1a4178bd4fcef572e81984
32 Nf8195cf6744a40b29a2820ef2cdbfb4b
33 sg:journal.1019073
34 schema:name Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis
35 schema:pagination 197-201
36 schema:productId N033f1961ea6a4ac3aa7040bfefb3d70a
37 N453e475227894cf79cb003180889616a
38 Na84d6c856e0d4d8db9a6594d83e1c7c0
39 Nf453854b18d04963b521f9728c989640
40 Nf81cd87863af424d9bc79c0aedb64136
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051409290
42 https://doi.org/10.1007/s004010050508
43 schema:sdDatePublished 2019-04-10T18:14
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher Na7e09c35a77949f49a2faf297d5283b4
46 schema:url http://link.springer.com/10.1007/s004010050508
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N033f1961ea6a4ac3aa7040bfefb3d70a schema:name dimensions_id
51 schema:value pub.1051409290
52 rdf:type schema:PropertyValue
53 N0571c0b2244549da9e3391a24924d541 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Phylogeny
55 rdf:type schema:DefinedTerm
56 N2c8bca601b1a4178bd4fcef572e81984 schema:volumeNumber 92
57 rdf:type schema:PublicationVolume
58 N3b2bc5832b344be38a680b53787cf93f rdf:first sg:person.01365302117.15
59 rdf:rest rdf:nil
60 N453e475227894cf79cb003180889616a schema:name doi
61 schema:value 10.1007/s004010050508
62 rdf:type schema:PropertyValue
63 N4fcda584ec1243a9b958b43c0fbf9291 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Myelin Sheath
65 rdf:type schema:DefinedTerm
66 N747611dade5e4c6c943756c48f92b88f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Neurofibrillary Tangles
68 rdf:type schema:DefinedTerm
69 N7afb5bf487bb4e6394cf46150b59be94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Cerebral Cortex
71 rdf:type schema:DefinedTerm
72 Na7e09c35a77949f49a2faf297d5283b4 schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 Na84d6c856e0d4d8db9a6594d83e1c7c0 schema:name pubmed_id
75 schema:value 8841666
76 rdf:type schema:PropertyValue
77 Nb6f52fb912aa4a4c9a1744c3024586d0 rdf:first sg:person.01053255500.71
78 rdf:rest N3b2bc5832b344be38a680b53787cf93f
79 Nb8318d5e835543e7b5091769a2413f5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Alzheimer Disease
81 rdf:type schema:DefinedTerm
82 Ned4e89dd06734301ba9b7ff643991fda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Humans
84 rdf:type schema:DefinedTerm
85 Nf453854b18d04963b521f9728c989640 schema:name readcube_id
86 schema:value f4e496ff21306d5f28796f7571d5642f6858d880643276d027b6ce1523d09c35
87 rdf:type schema:PropertyValue
88 Nf8195cf6744a40b29a2820ef2cdbfb4b schema:issueNumber 2
89 rdf:type schema:PublicationIssue
90 Nf81cd87863af424d9bc79c0aedb64136 schema:name nlm_unique_id
91 schema:value 0412041
92 rdf:type schema:PropertyValue
93 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
94 schema:name Medical and Health Sciences
95 rdf:type schema:DefinedTerm
96 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
97 schema:name Neurosciences
98 rdf:type schema:DefinedTerm
99 sg:journal.1019073 schema:issn 0001-6322
100 1432-0533
101 schema:name Acta Neuropathologica
102 rdf:type schema:Periodical
103 sg:person.01053255500.71 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
104 schema:familyName Braak
105 schema:givenName H.
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71
107 rdf:type schema:Person
108 sg:person.01365302117.15 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
109 schema:familyName Braak
110 schema:givenName E.
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365302117.15
112 rdf:type schema:Person
113 sg:pub.10.1007/978-1-4615-6610-6_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089803662
114 https://doi.org/10.1007/978-1-4615-6610-6_10
115 rdf:type schema:CreativeWork
116 sg:pub.10.1007/978-3-642-81522-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016830478
117 https://doi.org/10.1007/978-3-642-81522-5
118 rdf:type schema:CreativeWork
119 sg:pub.10.1007/978-3-662-34547-4_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034262020
120 https://doi.org/10.1007/978-3-662-34547-4_5
121 rdf:type schema:CreativeWork
122 sg:pub.10.1007/bf00293315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015944982
123 https://doi.org/10.1007/bf00293315
124 rdf:type schema:CreativeWork
125 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
126 https://doi.org/10.1007/bf00308809
127 rdf:type schema:CreativeWork
128 sg:pub.10.1007/bf01276421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031670916
129 https://doi.org/10.1007/bf01276421
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1002/cne.903400206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002290799
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1002/jnr.490360202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018978954
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1016/0014-4886(92)90246-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1052334482
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1016/0047-6374(88)90041-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007334958
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1016/0166-2236(90)90098-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1050549818
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/0301-0082(85)90001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030137466
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1080/01616412.1979.11739553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058295368
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1097/00005072-198705000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042319961
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1097/00005072-198805000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003874944
148 rdf:type schema:CreativeWork
149 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
150 schema:name Department of Anatomy, J. W. Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany Tel.: 49-69-6301-6900; Fax: 49-69-6301-6425, DE
151 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...