Ontology type: schema:ScholarlyArticle
1996-02
AUTHORSH. Heinsen, U. Rüb, D. Gangnus, G. Jungkunz, M. Bauer, G. Ulmar, B. Bethke, M. Schüler, F. Böcker, W. Eisenmenger, M. Götz, M. Strik
ABSTRACTThe centromedian-parafascicular complex represents a nodal point in the neuronal loop comprising striatum — globulus pallidus — thalamus — striatum. Striatal neurone degeneration is a hallmark in Huntington’s disease and we were interested in estimating total neurone and glial number in this thalamic nuclear complex. Serial 500-μm-thick gallocyanin-stained frontal sections of the left hemisphere from six cases of Huntington’s disease patients (three females, three males) and six age- and sex-matched controls were investigated applying Cavalieri’s principle and the optical disector. Mean neurone number in the controls was 646,952 ± 129,668 cells versus 291,763 ± 60, 122 in Huntington’s disease patients (Mann-Whitney U-test, P < 0.001). Total glial cell number (astrocytes, oligodendrocytes, microglia, and unclassifiable glial profiles) was higher in controls with 9,544,191 ± 3,028,944 versus 6,961,989 ± 2,241,543 in Huntington’s disease patients (Mann-Whitney U-test, P < 0.021). Considerable increase of fibrous astroglia within the centromedian-parafascicular complex could be observed after Gallyas’ impregnation. Most probably this cell type enhanced the numerical ratio between glial number and neurone number (glial index: Huntington’s disease patients = 24.4 ±8.1; controls = 15.0 ± 5.2; Mann-Whitney U-test, P < 0.013). The neurone number in the centromedian-parafascicular complex correlated negatively, although statistically not significantly, with the striatal neurone number. This lack of correlation between an 80% neuronal loss in the striatum and a 55% neurone loss in the centromedian-parafascicular complex points to viable neuronal circuits connecting the centromedian-parafascicular complex with cortical and subcortical regions that are less affected in Huntington’s disease. More... »
PAGES161-168
http://scigraph.springernature.com/pub.10.1007/s004010050408
DOIhttp://dx.doi.org/10.1007/s004010050408
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8787149
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