Nerve cell loss in the thalamic centromedian-parafascicular complex in patients with Huntington’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-02

AUTHORS

H. Heinsen, U. Rüb, D. Gangnus, G. Jungkunz, M. Bauer, G. Ulmar, B. Bethke, M. Schüler, F. Böcker, W. Eisenmenger, M. Götz, M. Strik

ABSTRACT

The centromedian-parafascicular complex represents a nodal point in the neuronal loop comprising striatum — globulus pallidus — thalamus — striatum. Striatal neurone degeneration is a hallmark in Huntington’s disease and we were interested in estimating total neurone and glial number in this thalamic nuclear complex. Serial 500-μm-thick gallocyanin-stained frontal sections of the left hemisphere from six cases of Huntington’s disease patients (three females, three males) and six age- and sex-matched controls were investigated applying Cavalieri’s principle and the optical disector. Mean neurone number in the controls was 646,952 ± 129,668 cells versus 291,763 ± 60, 122 in Huntington’s disease patients (Mann-Whitney U-test, P < 0.001). Total glial cell number (astrocytes, oligodendrocytes, microglia, and unclassifiable glial profiles) was higher in controls with 9,544,191 ± 3,028,944 versus 6,961,989 ± 2,241,543 in Huntington’s disease patients (Mann-Whitney U-test, P < 0.021). Considerable increase of fibrous astroglia within the centromedian-parafascicular complex could be observed after Gallyas’ impregnation. Most probably this cell type enhanced the numerical ratio between glial number and neurone number (glial index: Huntington’s disease patients = 24.4 ±8.1; controls = 15.0 ± 5.2; Mann-Whitney U-test, P < 0.013). The neurone number in the centromedian-parafascicular complex correlated negatively, although statistically not significantly, with the striatal neurone number. This lack of correlation between an 80% neuronal loss in the striatum and a 55% neurone loss in the centromedian-parafascicular complex points to viable neuronal circuits connecting the centromedian-parafascicular complex with cortical and subcortical regions that are less affected in Huntington’s disease. More... »

PAGES

161-168

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010050408

DOI

http://dx.doi.org/10.1007/s004010050408

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023680812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8787149


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26 schema:description The centromedian-parafascicular complex represents a nodal point in the neuronal loop comprising striatum — globulus pallidus — thalamus — striatum. Striatal neurone degeneration is a hallmark in Huntington’s disease and we were interested in estimating total neurone and glial number in this thalamic nuclear complex. Serial 500-μm-thick gallocyanin-stained frontal sections of the left hemisphere from six cases of Huntington’s disease patients (three females, three males) and six age- and sex-matched controls were investigated applying Cavalieri’s principle and the optical disector. Mean neurone number in the controls was 646,952 ± 129,668 cells versus 291,763 ± 60, 122 in Huntington’s disease patients (Mann-Whitney U-test, P < 0.001). Total glial cell number (astrocytes, oligodendrocytes, microglia, and unclassifiable glial profiles) was higher in controls with 9,544,191 ± 3,028,944 versus 6,961,989 ± 2,241,543 in Huntington’s disease patients (Mann-Whitney U-test, P < 0.021). Considerable increase of fibrous astroglia within the centromedian-parafascicular complex could be observed after Gallyas’ impregnation. Most probably this cell type enhanced the numerical ratio between glial number and neurone number (glial index: Huntington’s disease patients = 24.4 ±8.1; controls = 15.0 ± 5.2; Mann-Whitney U-test, P < 0.013). The neurone number in the centromedian-parafascicular complex correlated negatively, although statistically not significantly, with the striatal neurone number. This lack of correlation between an 80% neuronal loss in the striatum and a 55% neurone loss in the centromedian-parafascicular complex points to viable neuronal circuits connecting the centromedian-parafascicular complex with cortical and subcortical regions that are less affected in Huntington’s disease.
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33 schema:keywords Cavalieri principle
34 Gallyas
35 Huntington's disease
36 Huntington's disease patients
37 age
38 astroglia
39 cases
40 cell loss
41 cell number
42 cell types
43 cells
44 centromedian-parafascicular complex
45 circuit
46 complex points
47 complexes
48 considerable increase
49 control
50 correlation
51 degeneration
52 disease
53 disease patients
54 disector
55 fibrous astroglia
56 frontal sections
57 glial cell numbers
58 glial numbers
59 hallmark
60 hemisphere
61 impregnation
62 increase
63 lack
64 lack of correlation
65 left hemisphere
66 loop
67 loss
68 nerve cell loss
69 neuronal circuits
70 neuronal loops
71 neuronal loss
72 neurone loss
73 neurone number
74 neurones
75 nodal points
76 nuclear complex
77 number
78 numerical ratio
79 optical disector
80 patients
81 point
82 principles
83 ratio
84 region
85 sections
86 sex-matched controls
87 striatum
88 subcortical regions
89 thalamic centromedian-parafascicular complex
90 total neurones
91 types
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