The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-06

AUTHORS

U. Rüb, K. Del Tredici, C. Schultz, D. Thal, E. Braak, H. Braak

ABSTRACT

. The nuclei of the pontine parabrachial region (medial parabrachial nucleus, MPB; lateral parabrachial nucleus, LPB; subpeduncular nucleus, SPP) together with the intermediate zone of the medullary reticular formation (IRZ) are pivotal relay stations within central autonomic regulatory feedback systems. This study was undertaken to investigate the evolution of the Alzheimer's disease-related cytoskeletal pathology in these four sites of the lower brain stem. We examined the MPB, LPB, SPP and IRZ in 27 autopsy cases and classified the cortical Alzheimer-related cytoskeletal anomalies according to an established staging system (neurofibrillary tangle/neuropil threads [NFT/NT] stages I–VI). The lesions were visualized either with the antibody AT8, which is immunospecific for the abnormally phosphorylated form of the cytoskeletal protein tau, or with a modified Gallyas silver iodide stain. The MPB, SPB, and IRZ display cytoskeletal pathology in stage I and the LPB in stage II, whereby bothstages correspond to the preclinical phase of Alzheimer's disease (AD). In stages III–IV (incipient AD), the MPB and SPP are severely affected. In all of the stage III–IV cases, the lesions in the LPB and IRZ are well developed. In stages V and VI (clinical phase of AD), the MPB and SPP are filled with the abnormal intraneuronal material. At stages V–VI, the LPB is moderately involved and the IRZ shows severe damage. The pathogenesis of the AD-related cytoskeletal lesions in the nuclei of the pontine parabrachial region and in the IRZ conforms with the cortical NFT/NT staging sequence I–VI. In the event that the cytoskeletal pathology observed in this study impairs the function of the nerve cells involved, it is conceivable that autonomic mechanisms progressively deteriorate with advancing cortical NFT/NT stages. This relationship remains to be established, but it could provide insights into the illusive correlation between the AD-related cytoskeletal pathology and the function of affected neurons. More... »

PAGES

555-564

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010000320

DOI

http://dx.doi.org/10.1007/s004010000320

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024103056

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11515783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autonomic Nervous System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Stem", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medulla Oblongata", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurofibrillary Tangles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reticular Formation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Fixation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00fcb", 
        "givenName": "U.", 
        "id": "sg:person.0637231010.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637231010.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Del Tredici", 
        "givenName": "K.", 
        "id": "sg:person.01340323332.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323332.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schultz", 
        "givenName": "C.", 
        "id": "sg:person.0644455256.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644455256.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thal", 
        "givenName": "D.", 
        "id": "sg:person.0617341265.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617341265.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braak", 
        "givenName": "E.", 
        "id": "sg:person.01365302117.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365302117.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braak", 
        "givenName": "H.", 
        "id": "sg:person.01053255500.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-3-662-22593-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007549857", 
          "https://doi.org/10.1007/978-3-662-22593-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00293315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015944982", 
          "https://doi.org/10.1007/bf00293315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00305867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019847482", 
          "https://doi.org/10.1007/bf00305867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00688956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034008254", 
          "https://doi.org/10.1007/bf00688956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00686763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018116215", 
          "https://doi.org/10.1007/bf00686763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00688239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035154479", 
          "https://doi.org/10.1007/bf00688239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004019900178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024399472", 
          "https://doi.org/10.1007/s004019900178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004010050508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051409290", 
          "https://doi.org/10.1007/s004010050508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004010051031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049213499", 
          "https://doi.org/10.1007/s004010051031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00308809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000355620", 
          "https://doi.org/10.1007/bf00308809"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-06", 
    "datePublishedReg": "2001-06-01", 
    "description": "Abstract. The nuclei of the pontine parabrachial region (medial parabrachial nucleus, MPB; lateral parabrachial nucleus, LPB; subpeduncular nucleus, SPP) together with the intermediate zone of the medullary reticular formation (IRZ) are pivotal relay stations within central autonomic regulatory feedback systems. This study was undertaken to investigate the evolution of the Alzheimer's disease-related cytoskeletal pathology in these four sites of the lower brain stem. We examined the MPB, LPB, SPP and IRZ in 27 autopsy cases and classified the cortical Alzheimer-related cytoskeletal anomalies according to an established staging system (neurofibrillary tangle/neuropil threads [NFT/NT] stages I\u2013VI). The lesions were visualized either with the antibody AT8, which is immunospecific for the abnormally phosphorylated form of the cytoskeletal protein tau, or with a modified Gallyas silver iodide stain. The MPB, SPB, and IRZ display cytoskeletal pathology in stage I and the LPB in stage II, whereby bothstages correspond to the preclinical phase of Alzheimer's disease (AD). In stages III\u2013IV (incipient AD), the MPB and SPP are severely affected. In all of the stage III\u2013IV cases, the lesions in the LPB and IRZ are well developed. In stages V and VI (clinical phase of AD), the MPB and SPP are filled with the abnormal intraneuronal material. At stages V\u2013VI, the LPB is moderately involved and the IRZ shows severe damage. The pathogenesis of the AD-related cytoskeletal lesions in the nuclei of the pontine parabrachial region and in the IRZ conforms with the cortical NFT/NT staging sequence I\u2013VI. In the event that the cytoskeletal pathology observed in this study impairs the function of the nerve cells involved, it is conceivable that autonomic mechanisms progressively deteriorate with advancing cortical NFT/NT stages. This relationship remains to be established, but it could provide insights into the illusive correlation between the AD-related cytoskeletal pathology and the function of affected neurons.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s004010000320", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "101"
      }
    ], 
    "keywords": [
      "Alzheimer's disease-related cytoskeletal pathology", 
      "pontine parabrachial region", 
      "lower brain stem", 
      "cytoskeletal pathology", 
      "parabrachial region", 
      "brain stem", 
      "stage III", 
      "Alzheimer's disease", 
      "AD-related cytoskeletal pathology", 
      "medullary reticular formation", 
      "cytoskeletal protein tau", 
      "NT stage", 
      "staging system", 
      "autopsy cases", 
      "antibody AT8", 
      "stage V", 
      "reticular formation", 
      "cytoskeletal lesions", 
      "stage I", 
      "preclinical phase", 
      "stage II", 
      "protein tau", 
      "nerve cells", 
      "autonomic mechanisms", 
      "pathology", 
      "lesions", 
      "early target", 
      "disease", 
      "cytoskeletal anomalies", 
      "LPB", 
      "intermediate zone", 
      "phosphorylated form", 
      "pathogenesis", 
      "AT8", 
      "neurons", 
      "nucleus", 
      "regulatory feedback system", 
      "tau", 
      "Alzheimer's", 
      "cases", 
      "study", 
      "stain", 
      "spp", 
      "cells", 
      "severe damage", 
      "damage", 
      "function", 
      "target", 
      "correlation", 
      "events", 
      "stem", 
      "mechanism", 
      "anomalies", 
      "stage", 
      "region", 
      "sites", 
      "relationship", 
      "relay station", 
      "MPB", 
      "feedback system", 
      "SPB", 
      "system", 
      "insights", 
      "form", 
      "formation", 
      "materials", 
      "phase", 
      "order", 
      "sequence I", 
      "zone", 
      "IRZ", 
      "evolution", 
      "higher order", 
      "stations"
    ], 
    "name": "The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology", 
    "pagination": "555-564", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024103056"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004010000320"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11515783"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004010000320", 
      "https://app.dimensions.ai/details/publication/pub.1024103056"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_346.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s004010000320"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004010000320'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004010000320'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004010000320'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004010000320'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      22 PREDICATES      129 URIs      111 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004010000320 schema:about N0efca41ebd454d2fbba29ba4b6494854
2 N14b06d478cf741bfb35336b86c493e92
3 N24a6bc98ebbe437798fd5733ba206c7b
4 N316bd452145a4fb8b77ff292e9c3a118
5 N31ed9f5344a1497485703af5bb00e33a
6 N4890a4b0bc364f5d8f137b736ed2232d
7 N61db0557d08040c8af47379c0b661531
8 N7aa29bddab784943967c0f7bcb057640
9 N8d007157e71e4fc69bf495cd6c5de94f
10 N9a5333d66e154bfbb4860ec55d0690c6
11 N9aecc3955fd342b098666bcd6b9da3d9
12 Na855d8f16f2e4d9689a2d17529e80e1f
13 Nb0bf36cf11e64d43a2153b20cf08617a
14 Nb3dfa477eeb446d7b0fed82d1bf95e81
15 Nc24675c5bf5146fa9cc37d3f8c69855d
16 Nce9b5a3955bb4d2397be42a838f165c3
17 Ndafdff57b96f4b339869f86546d1c29b
18 Ndd18bf8c3c774325b5e468c739e69613
19 anzsrc-for:11
20 anzsrc-for:1109
21 schema:author Nccf80bf7dd87438b929d89728670b71e
22 schema:citation sg:pub.10.1007/978-3-662-22593-6
23 sg:pub.10.1007/bf00293315
24 sg:pub.10.1007/bf00305867
25 sg:pub.10.1007/bf00308809
26 sg:pub.10.1007/bf00686763
27 sg:pub.10.1007/bf00688239
28 sg:pub.10.1007/bf00688956
29 sg:pub.10.1007/s004010050508
30 sg:pub.10.1007/s004010051031
31 sg:pub.10.1007/s004019900178
32 schema:datePublished 2001-06
33 schema:datePublishedReg 2001-06-01
34 schema:description Abstract. The nuclei of the pontine parabrachial region (medial parabrachial nucleus, MPB; lateral parabrachial nucleus, LPB; subpeduncular nucleus, SPP) together with the intermediate zone of the medullary reticular formation (IRZ) are pivotal relay stations within central autonomic regulatory feedback systems. This study was undertaken to investigate the evolution of the Alzheimer's disease-related cytoskeletal pathology in these four sites of the lower brain stem. We examined the MPB, LPB, SPP and IRZ in 27 autopsy cases and classified the cortical Alzheimer-related cytoskeletal anomalies according to an established staging system (neurofibrillary tangle/neuropil threads [NFT/NT] stages I–VI). The lesions were visualized either with the antibody AT8, which is immunospecific for the abnormally phosphorylated form of the cytoskeletal protein tau, or with a modified Gallyas silver iodide stain. The MPB, SPB, and IRZ display cytoskeletal pathology in stage I and the LPB in stage II, whereby bothstages correspond to the preclinical phase of Alzheimer's disease (AD). In stages III–IV (incipient AD), the MPB and SPP are severely affected. In all of the stage III–IV cases, the lesions in the LPB and IRZ are well developed. In stages V and VI (clinical phase of AD), the MPB and SPP are filled with the abnormal intraneuronal material. At stages V–VI, the LPB is moderately involved and the IRZ shows severe damage. The pathogenesis of the AD-related cytoskeletal lesions in the nuclei of the pontine parabrachial region and in the IRZ conforms with the cortical NFT/NT staging sequence I–VI. In the event that the cytoskeletal pathology observed in this study impairs the function of the nerve cells involved, it is conceivable that autonomic mechanisms progressively deteriorate with advancing cortical NFT/NT stages. This relationship remains to be established, but it could provide insights into the illusive correlation between the AD-related cytoskeletal pathology and the function of affected neurons.
35 schema:genre article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N9d4343985c864dc7af4043f01130aa2c
39 Nc5b6955a0b404d97af82bcd0889d520e
40 sg:journal.1019073
41 schema:keywords AD-related cytoskeletal pathology
42 AT8
43 Alzheimer's
44 Alzheimer's disease
45 Alzheimer's disease-related cytoskeletal pathology
46 IRZ
47 LPB
48 MPB
49 NT stage
50 SPB
51 anomalies
52 antibody AT8
53 autonomic mechanisms
54 autopsy cases
55 brain stem
56 cases
57 cells
58 correlation
59 cytoskeletal anomalies
60 cytoskeletal lesions
61 cytoskeletal pathology
62 cytoskeletal protein tau
63 damage
64 disease
65 early target
66 events
67 evolution
68 feedback system
69 form
70 formation
71 function
72 higher order
73 insights
74 intermediate zone
75 lesions
76 lower brain stem
77 materials
78 mechanism
79 medullary reticular formation
80 nerve cells
81 neurons
82 nucleus
83 order
84 parabrachial region
85 pathogenesis
86 pathology
87 phase
88 phosphorylated form
89 pontine parabrachial region
90 preclinical phase
91 protein tau
92 region
93 regulatory feedback system
94 relationship
95 relay station
96 reticular formation
97 sequence I
98 severe damage
99 sites
100 spp
101 stage
102 stage I
103 stage II
104 stage III
105 stage V
106 staging system
107 stain
108 stations
109 stem
110 study
111 system
112 target
113 tau
114 zone
115 schema:name The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology
116 schema:pagination 555-564
117 schema:productId N37757ac8f26545afbf155da0cad82aa4
118 Nd54a1ca12f1b4a55b10d6f320802419d
119 Nda7817956c73472f9c18db44caf91c06
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024103056
121 https://doi.org/10.1007/s004010000320
122 schema:sdDatePublished 2022-05-20T07:21
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N0349355973814f47839adc48d260c66b
125 schema:url https://doi.org/10.1007/s004010000320
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N01228cba3d4c44658662e52fdfc92846 rdf:first sg:person.01340323332.00
130 rdf:rest Nb3c5070518ac432880443a33b217ed42
131 N0349355973814f47839adc48d260c66b schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N0efca41ebd454d2fbba29ba4b6494854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Amyloid beta-Peptides
135 rdf:type schema:DefinedTerm
136 N14b06d478cf741bfb35336b86c493e92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Aged, 80 and over
138 rdf:type schema:DefinedTerm
139 N24a6bc98ebbe437798fd5733ba206c7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Reticular Formation
141 rdf:type schema:DefinedTerm
142 N2cc441ec01554495a5b7784b2b73ade5 rdf:first sg:person.0617341265.05
143 rdf:rest Neda88ef07b54493e8a3927b5a499cd22
144 N316bd452145a4fb8b77ff292e9c3a118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Aged
146 rdf:type schema:DefinedTerm
147 N31ed9f5344a1497485703af5bb00e33a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Brain Stem
149 rdf:type schema:DefinedTerm
150 N37757ac8f26545afbf155da0cad82aa4 schema:name pubmed_id
151 schema:value 11515783
152 rdf:type schema:PropertyValue
153 N4890a4b0bc364f5d8f137b736ed2232d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Pons
155 rdf:type schema:DefinedTerm
156 N4f6b220d7bec4c8ab15f001dbae4510a rdf:first sg:person.01053255500.71
157 rdf:rest rdf:nil
158 N61db0557d08040c8af47379c0b661531 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Neurofibrillary Tangles
160 rdf:type schema:DefinedTerm
161 N7aa29bddab784943967c0f7bcb057640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cerebral Cortex
163 rdf:type schema:DefinedTerm
164 N8d007157e71e4fc69bf495cd6c5de94f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cytoskeleton
166 rdf:type schema:DefinedTerm
167 N9a5333d66e154bfbb4860ec55d0690c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Male
169 rdf:type schema:DefinedTerm
170 N9aecc3955fd342b098666bcd6b9da3d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Tissue Fixation
172 rdf:type schema:DefinedTerm
173 N9d4343985c864dc7af4043f01130aa2c schema:volumeNumber 101
174 rdf:type schema:PublicationVolume
175 Na855d8f16f2e4d9689a2d17529e80e1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Female
177 rdf:type schema:DefinedTerm
178 Nb0bf36cf11e64d43a2153b20cf08617a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Nb3c5070518ac432880443a33b217ed42 rdf:first sg:person.0644455256.91
182 rdf:rest N2cc441ec01554495a5b7784b2b73ade5
183 Nb3dfa477eeb446d7b0fed82d1bf95e81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Antibodies, Monoclonal
185 rdf:type schema:DefinedTerm
186 Nc24675c5bf5146fa9cc37d3f8c69855d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Alzheimer Disease
188 rdf:type schema:DefinedTerm
189 Nc5b6955a0b404d97af82bcd0889d520e schema:issueNumber 6
190 rdf:type schema:PublicationIssue
191 Nccf80bf7dd87438b929d89728670b71e rdf:first sg:person.0637231010.55
192 rdf:rest N01228cba3d4c44658662e52fdfc92846
193 Nce9b5a3955bb4d2397be42a838f165c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Autonomic Nervous System
195 rdf:type schema:DefinedTerm
196 Nd54a1ca12f1b4a55b10d6f320802419d schema:name doi
197 schema:value 10.1007/s004010000320
198 rdf:type schema:PropertyValue
199 Nda7817956c73472f9c18db44caf91c06 schema:name dimensions_id
200 schema:value pub.1024103056
201 rdf:type schema:PropertyValue
202 Ndafdff57b96f4b339869f86546d1c29b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Medulla Oblongata
204 rdf:type schema:DefinedTerm
205 Ndd18bf8c3c774325b5e468c739e69613 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Immunohistochemistry
207 rdf:type schema:DefinedTerm
208 Neda88ef07b54493e8a3927b5a499cd22 rdf:first sg:person.01365302117.15
209 rdf:rest N4f6b220d7bec4c8ab15f001dbae4510a
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
214 schema:name Neurosciences
215 rdf:type schema:DefinedTerm
216 sg:journal.1019073 schema:issn 0001-6322
217 1432-0533
218 schema:name Acta Neuropathologica
219 schema:publisher Springer Nature
220 rdf:type schema:Periodical
221 sg:person.01053255500.71 schema:affiliation grid-institutes:grid.7839.5
222 schema:familyName Braak
223 schema:givenName H.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71
225 rdf:type schema:Person
226 sg:person.01340323332.00 schema:affiliation grid-institutes:grid.7839.5
227 schema:familyName Del Tredici
228 schema:givenName K.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323332.00
230 rdf:type schema:Person
231 sg:person.01365302117.15 schema:affiliation grid-institutes:grid.7839.5
232 schema:familyName Braak
233 schema:givenName E.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365302117.15
235 rdf:type schema:Person
236 sg:person.0617341265.05 schema:affiliation grid-institutes:grid.7839.5
237 schema:familyName Thal
238 schema:givenName D.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617341265.05
240 rdf:type schema:Person
241 sg:person.0637231010.55 schema:affiliation grid-institutes:grid.7839.5
242 schema:familyName Rüb
243 schema:givenName U.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637231010.55
245 rdf:type schema:Person
246 sg:person.0644455256.91 schema:affiliation grid-institutes:grid.7839.5
247 schema:familyName Schultz
248 schema:givenName C.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644455256.91
250 rdf:type schema:Person
251 sg:pub.10.1007/978-3-662-22593-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007549857
252 https://doi.org/10.1007/978-3-662-22593-6
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/bf00293315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015944982
255 https://doi.org/10.1007/bf00293315
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/bf00305867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019847482
258 https://doi.org/10.1007/bf00305867
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
261 https://doi.org/10.1007/bf00308809
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/bf00686763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018116215
264 https://doi.org/10.1007/bf00686763
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/bf00688239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035154479
267 https://doi.org/10.1007/bf00688239
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/bf00688956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034008254
270 https://doi.org/10.1007/bf00688956
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s004010050508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051409290
273 https://doi.org/10.1007/s004010050508
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s004010051031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049213499
276 https://doi.org/10.1007/s004010051031
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s004019900178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024399472
279 https://doi.org/10.1007/s004019900178
280 rdf:type schema:CreativeWork
281 grid-institutes:grid.7839.5 schema:alternateName Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany
282 schema:name Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...