α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Eva Braak, Daniele Sandmann-Keil, Udo Rüb, Wei Ping Gai, Rob A. I. de Vos, Ernst N. H. Jansen Steur, Kimihito Arai, Heiko Braak

ABSTRACT

. Advanced silver stains and immunohistochemical reactions against α-synuclein were used to detect Parkinson's disease-related cytoskeletal abnormalities in select lower brain stem nuclei. Various types of inclusion bodies including inconspicuous and heretofore unnoted granular particles and thread-like Lewy neurites were visualized. Of the nuclei investigated (gigantocellular reticular nucleus, bulbar raphe nuclei, coeruleus-subcoeruleus area), only lipofuscin- or neuromelanin-laden neuronal types showed a propensity to develop the pathological changes. Neuronal types devoid of pigment deposits remained free of the cytoskeletal abnormalities. Fine, dust-like particles and small globular Lewy bodies were encountered solely within the limits of intraneuronal lipofuscin or neuromelanin deposits. More... »

PAGES

195-201

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004010000247

DOI

http://dx.doi.org/10.1007/s004010000247

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039471223

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11307617


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