Microglial cell loss after ischemic stroke favors brain neutrophil accumulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Amaia Otxoa-de-Amezaga, Francesc Miró-Mur, Jordi Pedragosa, Mattia Gallizioli, Carles Justicia, Núria Gaja-Capdevila, Francisca Ruíz-Jaen, Angélica Salas-Perdomo, Anna Bosch, Maria Calvo, Leonardo Márquez-Kisinousky, Adam Denes, Matthias Gunzer, Anna M. Planas

ABSTRACT

Stroke attracts neutrophils to the injured brain tissue where they can damage the integrity of the blood-brain barrier and exacerbate the lesion. However, the mechanisms involved in neutrophil transmigration, location and accumulation in the ischemic brain are not fully elucidated. Neutrophils can reach the perivascular spaces of brain vessels after crossing the endothelial cell layer and endothelial basal lamina of post-capillary venules, or migrating from the leptomeninges following pial vessel extravasation and/or a suggested translocation from the skull bone marrow. Based on previous observations of microglia phagocytosing neutrophils recruited to the ischemic brain lesion, we hypothesized that microglial cells might control neutrophil accumulation in the injured brain. We studied a model of permanent occlusion of the middle cerebral artery in mice, including microglia- and neutrophil-reporter mice. Using various in vitro and in vivo strategies to impair microglial function or to eliminate microglia by targeting colony stimulating factor 1 receptor (CSF1R), this study demonstrates that microglial phagocytosis of neutrophils has fundamental consequences for the ischemic tissue. We found that reactive microglia engulf neutrophils at the periphery of the ischemic lesion, whereas local microglial cell loss and dystrophy occurring in the ischemic core are associated with the accumulation of neutrophils first in perivascular spaces and later in the parenchyma. Accordingly, microglia depletion by long-term treatment with a CSF1R inhibitor increased the numbers of neutrophils and enlarged the ischemic lesion. Hence, microglial phagocytic function sets a critical line of defense against the vascular and tissue damaging capacity of neutrophils in brain ischemia. More... »

PAGES

1-21

References to SciGraph publications

  • 2015-02. Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke in ACTA NEUROPATHOLOGICA
  • 2014-04. Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation in CELL DEATH & DISEASE
  • 2013-12. M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia in JOURNAL OF NEUROINFLAMMATION
  • 2013-03. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury in ACTA NEUROPATHOLOGICA
  • 2015-02. Neutrophil recruitment to the brain in mouse and human ischemic stroke in ACTA NEUROPATHOLOGICA
  • 2010-01. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain in NATURE NEUROSCIENCE
  • 2014-10. Neuronal morphometry directly from bitmap images in NATURE METHODS
  • 2014-04. Microglial phagocytosis of live neurons in NATURE REVIEWS NEUROSCIENCE
  • 2015-05. Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes in NATURE METHODS
  • 2013-12. The microglial sensome revealed by direct RNA sequencing in NATURE NEUROSCIENCE
  • 2018-09. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration in NATURE NEUROSCIENCE
  • 2018-12. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction in NATURE COMMUNICATIONS
  • 1998-05. Oligodendrocytes and Microglia Are Selectively Vulnerable to Combined Hypoxia and Hypoglycemia Injury in Vitro in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2014-01. Identification of a unique TGF-β–dependent molecular and functional signature in microglia in NATURE NEUROSCIENCE
  • 2006-12. The P2Y12 receptor regulates microglial activation by extracellular nucleotides in NATURE NEUROSCIENCE
  • 2003-12. Neutrophil Infiltration Increases Matrix Metalloproteinase-9 in the Ischemic Brain after Occlusion/Reperfusion of the Middle Cerebral Artery in Rats in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2016-05-03. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke in NATURE COMMUNICATIONS
  • 2018-09. Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-018-1954-4

    DOI

    http://dx.doi.org/10.1007/s00401-018-1954-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110833839

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30580383


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