Post-stroke inflammation—target or tool for therapy? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-27

AUTHORS

Kate Lykke Lambertsen, Bente Finsen, Bettina Hjelm Clausen

ABSTRACT

Inflammation is currently considered a prime target for the development of new stroke therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating immune cells invade the peri-infarct and infarct core. Resident and infiltrating cells together orchestrate the post-stroke inflammatory response, communicating with each other and the ischemic neurons, through soluble and membrane-bound signaling molecules, including cytokines. Inflammation can be both detrimental and beneficial at particular stages after a stroke. While it can contribute to expansion of the infarct, it is also responsible for infarct resolution, and influences remodeling and repair. Several pre-clinical and clinical proof-of-concept studies have suggested the effectiveness of pharmacological interventions that target inflammation post-stroke. Experimental evidence shows that targeting certain inflammatory cytokines, such as tumor necrosis factor, interleukin (IL)-1, IL-6, and IL-10, holds promise. However, as these cytokines possess non-redundant protective and immunoregulatory functions, their neutralization or augmentation carries a risk of unwanted side effects, and clinical translation is, therefore, challenging. This review summarizes the cell biology of the post-stroke inflammatory response and discusses pharmacological interventions targeting inflammation in the acute phase after a stroke that may be used alone or in combination with recanalization therapies. Development of next-generation immune therapies should ideally aim at selectively neutralizing pathogenic immune signaling, enhancing tissue preservation, promoting neurological recovery and leaving normal function intact. More... »

PAGES

1-22

References to SciGraph publications

  • 2006-04. Synaptic scaling mediated by glial TNF-α in NATURE
  • 2007-07. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells in NATURE MEDICINE
  • 2012-12. Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury in CNS DRUGS
  • 2003-10. TNF-α and TNF-β gene polymorphisms in cerebral infarction in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2011-12. Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size in JOURNAL OF NEUROINFLAMMATION
  • 2004-12. Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome in BMC NEUROLOGY
  • 2013-12. The microglial sensome revealed by direct RNA sequencing in NATURE NEUROSCIENCE
  • 2014-12. Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice in JOURNAL OF NEUROINFLAMMATION
  • 2011-12. Selected acute phase CSF factors in ischemic stroke: findings and prognostic value in BMC NEUROLOGY
  • 1997-02. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells in NATURE
  • 2015-02. Neutrophil recruitment to the brain in mouse and human ischemic stroke in ACTA NEUROPATHOLOGICA
  • 2003-08. Cerebral Microvessel Responses to Focal Ischemia in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2000-02. Dynamics of Regional Brain Metabolism and Gene Expression After Middle Cerebral Artery Occlusion in Mice in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2014-12. High efficiency cell-specific targeting of cytokine activity in NATURE COMMUNICATIONS
  • 2017-12. A randomised, placebo-controlled trial of anti–interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease in RESPIRATORY RESEARCH
  • 2004-09. Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration in NATURE GENETICS
  • 2014-02. Regulated necrosis: the expanding network of non-apoptotic cell death pathways in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-06. Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2016-09. Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling in SCIENTIFIC REPORTS
  • 1999-01. The Progression and Topographic Distribution of Interleukin-1β Expression After Permanent Middle Cerebral Artery Occlusion in the Rat in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2015-07. Inflammasomes: mechanism of action, role in disease, and therapeutics in NATURE MEDICINE
  • 2014-03. Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice in METABOLIC BRAIN DISEASE
  • 2008-12. Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice in JOURNAL OF NEUROINFLAMMATION
  • 2016-12. Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2011-02. Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept in CNS DRUGS
  • 2010-08. Spatio-Temporal Distribution of Inflammatory Reaction and Expression of TLR2/4 Signaling Pathway in Rat Brain Following Permanent Focal Cerebral Ischemia in NEUROCHEMICAL RESEARCH
  • 2015-12. Sex differences and the role of IL-10 in ischemic stroke recovery in BIOLOGY OF SEX DIFFERENCES
  • 2011-12. Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice in JOURNAL OF NEUROINFLAMMATION
  • 2014-08. Stroke, IL-1ra, IL1RN, Infection and Outcome in NEUROCRITICAL CARE
  • 2015-12. Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection in JOURNAL OF NEUROINFLAMMATION
  • 2016-07. Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17 in SCIENTIFIC REPORTS
  • 2015-02. Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke in ACTA NEUROPATHOLOGICA
  • 1997-02. Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction in Mice in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2012-08. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis in NATURE
  • 2000-06. Evolution of Brain Infarction After Transient Focal Cerebral Ischemia in Mice in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 1996-09. Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 1998-02. Cerebral Interleukin-6 Is Neuroprotective During Permanent Focal Cerebral Ischemia in the Rat in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2000-06. Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine Against NMDA Receptor-Mediated Excitoxicity in the Brain in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2016-05. Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke in ACTA NEUROPATHOLOGICA
  • 2017-08. Transcriptomic analysis of purified human cortical microglia reveals age-associated changes in NATURE NEUROSCIENCE
  • 2018-12. Redefining the ancestral origins of the interleukin-1 superfamily in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-018-1930-z

    DOI

    http://dx.doi.org/10.1007/s00401-018-1930-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110226536

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30483945


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000, Odense, Denmark", 
                "Department of Clinical Research, BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, University of Southern Denmark, 5000, Odense C, Denmark", 
                "Department of Neurology, Odense University Hospital, 5000, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lambertsen", 
            "givenName": "Kate Lykke", 
            "id": "sg:person.0645406163.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645406163.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Southern Denmark", 
              "id": "https://www.grid.ac/institutes/grid.10825.3e", 
              "name": [
                "Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000, Odense, Denmark", 
                "Department of Clinical Research, BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, University of Southern Denmark, 5000, Odense C, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Finsen", 
            "givenName": "Bente", 
            "id": "sg:person.01021713024.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021713024.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Southern Denmark", 
              "id": "https://www.grid.ac/institutes/grid.10825.3e", 
              "name": [
                "Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000, Odense, Denmark", 
                "Department of Clinical Research, BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, University of Southern Denmark, 5000, Odense C, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clausen", 
            "givenName": "Bettina Hjelm", 
            "id": "sg:person.01105541111.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105541111.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature04671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381986", 
              "https://doi.org/10.1038/nature04671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381986", 
              "https://doi.org/10.1038/nature04671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381986", 
              "https://doi.org/10.1038/nature04671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000776693", 
              "https://doi.org/10.1038/ng1413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000776693", 
              "https://doi.org/10.1038/ng1413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-3940(93)90396-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001866615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-3940(93)90396-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001866615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2012.00614.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002311899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1995.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002534435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1995.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002534435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2013.155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002722721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2013.155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002722721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2012.97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002959323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2012.97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002959323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(95)00414-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003136488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/jmn:24:2:293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003189514", 
              "https://doi.org/10.1385/jmn:24:2:293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2016.03.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003784956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2014.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003839358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0854.2008.00840.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004100082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2011.01.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004208759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1520175113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004328147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/ern.10.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004515188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.1105674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004829698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbr.2014.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004984649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-3806(02)00636-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005203235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-3806(02)00636-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005203235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.68.1106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005250884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2377-11-41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005494752", 
              "https://doi.org/10.1186/1471-2377-11-41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-4889(02)00319-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005723017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000221294.90068.c4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005750556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000221294.90068.c4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005750556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032414-112306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005978087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005995120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(05)67763-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006909756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-200006000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006997928", 
              "https://doi.org/10.1097/00004647-200006000-00008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200006000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006997928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200006000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006997928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200006000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006997928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cytogfr.2010.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007210233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.2004.054882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007648370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.115790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008284117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008343416", 
              "https://doi.org/10.1038/nrm3737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1043-4666(92)90078-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008385312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/385729a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008946714", 
              "https://doi.org/10.1038/385729a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2009.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009560087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-200006000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009726135", 
              "https://doi.org/10.1097/00004647-200006000-00006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200006000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009726135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200006000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009726135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13293-015-0035-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009815796", 
              "https://doi.org/10.1186/s13293-015-0035-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2007.03026.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009863653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2010.00684.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009904324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2014.120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010062805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2014.120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010062805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010138519", 
              "https://doi.org/10.1038/ncomms4016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2005.03227.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010148477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2005.03227.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010148477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1381-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010669304", 
              "https://doi.org/10.1007/s00401-014-1381-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011438914", 
              "https://doi.org/10.1038/nature11307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011799556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-014-0231-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011990256", 
              "https://doi.org/10.1186/s12974-014-0231-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-014-0231-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011990256", 
              "https://doi.org/10.1186/s12974-014-0231-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.10803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012106569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-8-174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012499641", 
              "https://doi.org/10.1186/1742-2094-8-174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/jmn:21:2:167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012920521", 
              "https://doi.org/10.1385/jmn:21:2:167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40263-012-0013-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013576327", 
              "https://doi.org/10.1007/s40263-012-0013-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00207454.2014.980906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013756820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2015.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013882582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.5.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014788787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0361-9230(92)90033-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014908673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0361-9230(92)90033-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014908673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jnc.13422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015245455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5505-08.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015339858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/0004-282x20130168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015970843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016133129", 
              "https://doi.org/10.1038/nn.3554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.39700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016310829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-07-273417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016762993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2015.06.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017022246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3940(98)00537-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018514689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/ijbs.4679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018906294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep25550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018946235", 
              "https://doi.org/10.1038/srep25550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.1996.0093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019393623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0271678x15610339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019879786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0271678x15610339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019879786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(03)00022-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021001228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(03)00022-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021001228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0801447105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021054562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2009.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021406780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.113.002470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021800432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.113.002470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021800432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-11-252643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021911275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000259709.16654.8f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022461728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000259709.16654.8f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022461728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000442009.06663.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022575601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000442009.06663.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022575601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2015.04.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022722157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.2006.100800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023297572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000057976.53301.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023433404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000057976.53301.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023433404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-0721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023511396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2010.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024027896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.16.1.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024065892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2006.10.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024082031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.110.036012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024151404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.38755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024549373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.2.570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024684097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2010.103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024705564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2010.103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024705564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cns.12310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024916703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0161-5890(91)90004-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025334576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0161-5890(91)90004-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025334576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.1996.0059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025490921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.295758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025754588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awr199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026435640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31816a88f9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026943115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31816a88f9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026943115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2015.08.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027230498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2015.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027623748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2015.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027623748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199901000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028493892", 
              "https://doi.org/10.1097/00004647-199901000-00010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199901000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028493892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199901000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028493892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.12.6.723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028754301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.31.7.1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029228475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2377-4-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029229764", 
              "https://doi.org/10.1186/1471-2377-4-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0703343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029691733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0271678x15606714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030408481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0271678x15606714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030408481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-016-0371-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030973377", 
              "https://doi.org/10.1186/s40478-016-0371-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-016-0371-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030973377", 
              "https://doi.org/10.1186/s40478-016-0371-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2014.05.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031254714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20151563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031992271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1308679110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033056055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.30712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033574855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1997.6436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033881627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-010-0167-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034855777", 
              "https://doi.org/10.1007/s11064-010-0167-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-010-0167-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034855777", 
              "https://doi.org/10.1007/s11064-010-0167-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep29291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035443059", 
              "https://doi.org/10.1038/srep29291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.32.5.1208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035913718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036020271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036020271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2005.09.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036098656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2005.09.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036098656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-5-46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036279804", 
              "https://doi.org/10.1186/1742-2094-5-46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5376-06.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036281180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m707933200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036306934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.115.009426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036916150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.115.009426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036916150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-013-9899-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037061484", 
              "https://doi.org/10.1007/s12028-013-9899-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(16)00114-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037508648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2009.06098.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037650109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2009.06098.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037650109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000155622.68580.dc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038683272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1081297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039169555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neulet.2014.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040682114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041187043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4901-12.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041259820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2012.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041886073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2012.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041886073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.5.933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042036585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.617787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042083922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199609000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042201473", 
              "https://doi.org/10.1097/00004647-199609000-00017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199609000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042201473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199609000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042201473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc12-1835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042204509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11011-013-9474-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042250252", 
              "https://doi.org/10.1007/s11011-013-9474-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2012-202252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042957672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(97)00981-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043102311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199702000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043285119", 
              "https://doi.org/10.1097/00004647-199702000-00013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199702000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043285119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199702000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043285119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2013.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043392004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-8-164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043512621", 
              "https://doi.org/10.1186/1742-2094-8-164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.23529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043603835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-016-1541-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044693423", 
              "https://doi.org/10.1007/s00401-016-1541-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-016-1541-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044693423", 
              "https://doi.org/10.1007/s00401-016-1541-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199802000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044965966", 
              "https://doi.org/10.1097/00004647-199802000-00008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199802000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044965966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199802000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044965966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2005.06.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045437373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2005.06.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045437373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11588400-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045735292", 
              "https://doi.org/10.2165/11588400-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046174639", 
              "https://doi.org/10.1038/nm1603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2007.09.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046374705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14728222.11.5.613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046761943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1623-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047512251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2011.03964.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047540604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2013.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048062215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2013.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048062215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-200002000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048089160", 
              "https://doi.org/10.1097/00004647-200002000-00012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200002000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048089160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200002000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048089160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1605195113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048111694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09546630410017275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048228114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/01.wcb.0000078322.96027.78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048501110", 
              "https://doi.org/10.1097/01.wcb.0000078322.96027.78"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wcb.0000078322.96027.78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048501110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cytogfr.2004.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048689348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3893", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048838933", 
              "https://doi.org/10.1038/nm.3893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90192-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049369176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-014-0159-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049529992", 
              "https://doi.org/10.1186/s12974-014-0159-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-014-0159-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049529992", 
              "https://doi.org/10.1186/s12974-014-0159-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1327.2001.01867.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049762928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2012.02.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049870647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awn109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049890613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0915018107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050009494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1355-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050583256", 
              "https://doi.org/10.1007/s00401-014-1355-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050973247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050973247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01616412.2016.1202395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051887812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(96)00026-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051971358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051987362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051987362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.23.13757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051990487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1043-4666(92)90043-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052251632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<238::aid-jnr10>3.0.co;2-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052436520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14779072.2015.1020300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052654434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/189292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053382813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.26.4.676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063341571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.28.6.1233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063342401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1615/critrevimmunol.v21.i5.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068131777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2471/blt.16.181636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070838494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.116.185975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070928682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/etm.2015.2363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071503404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/etm.2015.2363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071503404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/mabs.28612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072305765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/gmr.15027580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072395528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.21-15-05528.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074853260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.22-01-00038.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074964630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076073970", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.23-25-08692.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076571052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077228984", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077343426", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.12.8194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077817014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082381381", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jlb.56.5.542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082584943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082746033", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082885865", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083308307", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0171688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083737490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0271678x17700913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084243297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0271678x17700913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084243297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2017.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085861058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2017.06.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085937073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.omtm.2017.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086145543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090329025", 
              "https://doi.org/10.1038/nn.4597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090329025", 
              "https://doi.org/10.1038/nn.4597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12931-017-0633-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091133348", 
              "https://doi.org/10.1186/s12931-017-0633-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12931-017-0633-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091133348", 
              "https://doi.org/10.1186/s12931-017-0633-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2017.01073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091405124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2017.09.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091837915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1706442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092648288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1100671095", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-03362-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101582133", 
              "https://doi.org/10.1038/s41467-018-03362-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-03362-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101582133", 
              "https://doi.org/10.1038/s41467-018-03362-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.118.020750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101702157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.118.020750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101702157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1803856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103900358"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-11-27", 
        "datePublishedReg": "2018-11-27", 
        "description": "Inflammation is currently considered a prime target for the development of new stroke therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating immune cells invade the peri-infarct and infarct core. Resident and infiltrating cells together orchestrate the post-stroke inflammatory response, communicating with each other and the ischemic neurons, through soluble and membrane-bound signaling molecules, including cytokines. Inflammation can be both detrimental and beneficial at particular stages after a stroke. While it can contribute to expansion of the infarct, it is also responsible for infarct resolution, and influences remodeling and repair. Several pre-clinical and clinical proof-of-concept studies have suggested the effectiveness of pharmacological interventions that target inflammation post-stroke. Experimental evidence shows that targeting certain inflammatory cytokines, such as tumor necrosis factor, interleukin (IL)-1, IL-6, and IL-10, holds promise. However, as these cytokines possess non-redundant protective and immunoregulatory functions, their neutralization or augmentation carries a risk of unwanted side effects, and clinical translation is, therefore, challenging. This review summarizes the cell biology of the post-stroke inflammatory response and discusses pharmacological interventions targeting inflammation in the acute phase after a stroke that may be used alone or in combination with recanalization therapies. Development of next-generation immune therapies should ideally aim at selectively neutralizing pathogenic immune signaling, enhancing tissue preservation, promoting neurological recovery and leaving normal function intact.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00401-018-1930-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "type": "Periodical"
          }
        ], 
        "name": "Post-stroke inflammation\u2014target or tool for therapy?", 
        "pagination": "1-22", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2385752b571ef701ee5921e816058ba77f2793b79c15ed40c28b1062dce3e8eb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30483945"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0412041"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00401-018-1930-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110226536"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00401-018-1930-z", 
          "https://app.dimensions.ai/details/publication/pub.1110226536"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:16", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000278_0000000278/records_79645_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00401-018-1930-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1930-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1930-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1930-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1930-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    731 TRIPLES      21 PREDICATES      231 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00401-018-1930-z schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N7a2f9c74585a42a6ac2fd61411b8c04d
    4 schema:citation sg:pub.10.1007/s00401-014-1355-2
    5 sg:pub.10.1007/s00401-014-1381-0
    6 sg:pub.10.1007/s00401-016-1541-5
    7 sg:pub.10.1007/s11011-013-9474-3
    8 sg:pub.10.1007/s11064-010-0167-6
    9 sg:pub.10.1007/s12028-013-9899-x
    10 sg:pub.10.1007/s40263-012-0013-2
    11 sg:pub.10.1038/385729a0
    12 sg:pub.10.1038/nature04671
    13 sg:pub.10.1038/nature11307
    14 sg:pub.10.1038/ncomms4016
    15 sg:pub.10.1038/ng1413
    16 sg:pub.10.1038/nm.3893
    17 sg:pub.10.1038/nm1603
    18 sg:pub.10.1038/nn.3554
    19 sg:pub.10.1038/nn.4597
    20 sg:pub.10.1038/nrm3737
    21 sg:pub.10.1038/s41467-018-03362-1
    22 sg:pub.10.1038/srep25550
    23 sg:pub.10.1038/srep29291
    24 sg:pub.10.1097/00004647-199609000-00017
    25 sg:pub.10.1097/00004647-199702000-00013
    26 sg:pub.10.1097/00004647-199802000-00008
    27 sg:pub.10.1097/00004647-199901000-00010
    28 sg:pub.10.1097/00004647-200002000-00012
    29 sg:pub.10.1097/00004647-200006000-00006
    30 sg:pub.10.1097/00004647-200006000-00008
    31 sg:pub.10.1097/01.wcb.0000078322.96027.78
    32 sg:pub.10.1186/1471-2377-11-41
    33 sg:pub.10.1186/1471-2377-4-2
    34 sg:pub.10.1186/1742-2094-5-46
    35 sg:pub.10.1186/1742-2094-8-164
    36 sg:pub.10.1186/1742-2094-8-174
    37 sg:pub.10.1186/s12931-017-0633-7
    38 sg:pub.10.1186/s12974-014-0159-6
    39 sg:pub.10.1186/s12974-014-0231-2
    40 sg:pub.10.1186/s13293-015-0035-9
    41 sg:pub.10.1186/s40478-016-0371-y
    42 sg:pub.10.1385/jmn:21:2:167
    43 sg:pub.10.1385/jmn:24:2:293
    44 sg:pub.10.2165/11588400-000000000-00000
    45 https://app.dimensions.ai/details/publication/pub.1076073970
    46 https://app.dimensions.ai/details/publication/pub.1077228984
    47 https://app.dimensions.ai/details/publication/pub.1077343426
    48 https://app.dimensions.ai/details/publication/pub.1082381381
    49 https://app.dimensions.ai/details/publication/pub.1082746033
    50 https://app.dimensions.ai/details/publication/pub.1082885865
    51 https://app.dimensions.ai/details/publication/pub.1083308307
    52 https://app.dimensions.ai/details/publication/pub.1100671095
    53 https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<238::aid-jnr10>3.0.co;2-g
    54 https://doi.org/10.1002/ajmg.b.30712
    55 https://doi.org/10.1002/ana.10803
    56 https://doi.org/10.1002/ana.23529
    57 https://doi.org/10.1002/art.38755
    58 https://doi.org/10.1002/art.39700
    59 https://doi.org/10.1002/glia.22478
    60 https://doi.org/10.1002/jlb.56.5.542
    61 https://doi.org/10.1006/bbrc.1997.6436
    62 https://doi.org/10.1006/exnr.1996.0059
    63 https://doi.org/10.1006/exnr.1996.0093
    64 https://doi.org/10.1016/0092-8674(95)90192-2
    65 https://doi.org/10.1016/0161-5890(91)90004-4
    66 https://doi.org/10.1016/0304-3940(93)90396-3
    67 https://doi.org/10.1016/0306-4522(95)00414-9
    68 https://doi.org/10.1016/0361-9230(92)90033-t
    69 https://doi.org/10.1016/1043-4666(92)90043-q
    70 https://doi.org/10.1016/1043-4666(92)90078-6
    71 https://doi.org/10.1016/j.atherosclerosis.2007.09.031
    72 https://doi.org/10.1016/j.bbamcr.2011.01.034
    73 https://doi.org/10.1016/j.bbamcr.2016.03.018
    74 https://doi.org/10.1016/j.bbi.2009.02.015
    75 https://doi.org/10.1016/j.bbi.2015.08.010
    76 https://doi.org/10.1016/j.bbi.2017.05.019
    77 https://doi.org/10.1016/j.bbr.2014.05.008
    78 https://doi.org/10.1016/j.brainres.2013.02.022
    79 https://doi.org/10.1016/j.cyto.2005.09.004
    80 https://doi.org/10.1016/j.cyto.2012.02.016
    81 https://doi.org/10.1016/j.cyto.2014.05.024
    82 https://doi.org/10.1016/j.cytogfr.2004.03.011
    83 https://doi.org/10.1016/j.cytogfr.2010.09.002
    84 https://doi.org/10.1016/j.expneurol.2017.06.012
    85 https://doi.org/10.1016/j.gene.2015.04.054
    86 https://doi.org/10.1016/j.immuni.2013.01.008
    87 https://doi.org/10.1016/j.jbiotec.2010.01.011
    88 https://doi.org/10.1016/j.jneuroim.2005.06.025
    89 https://doi.org/10.1016/j.jneuroim.2009.02.003
    90 https://doi.org/10.1016/j.neulet.2014.07.003
    91 https://doi.org/10.1016/j.neurobiolaging.2015.06.015
    92 https://doi.org/10.1016/j.neuropharm.2017.09.022
    93 https://doi.org/10.1016/j.neuroscience.2006.10.046
    94 https://doi.org/10.1016/j.neuroscience.2015.08.055
    95 https://doi.org/10.1016/j.omtm.2017.06.005
    96 https://doi.org/10.1016/j.smim.2014.01.009
    97 https://doi.org/10.1016/s0006-8993(97)00981-5
    98 https://doi.org/10.1016/s0140-6736(05)67763-x
    99 https://doi.org/10.1016/s0165-3806(02)00636-3
    100 https://doi.org/10.1016/s0167-4889(02)00319-1
    101 https://doi.org/10.1016/s0304-3940(98)00537-0
    102 https://doi.org/10.1016/s1359-6101(03)00022-4
    103 https://doi.org/10.1016/s1359-6101(96)00026-3
    104 https://doi.org/10.1016/s1474-4422(16)00114-9
    105 https://doi.org/10.1038/jcbfm.1995.68
    106 https://doi.org/10.1038/jcbfm.2010.103
    107 https://doi.org/10.1038/jcbfm.2012.88
    108 https://doi.org/10.1038/jcbfm.2012.97
    109 https://doi.org/10.1038/jcbfm.2013.100
    110 https://doi.org/10.1038/jcbfm.2013.155
    111 https://doi.org/10.1038/jcbfm.2014.120
    112 https://doi.org/10.1038/jcbfm.2015.45
    113 https://doi.org/10.1038/sj.jcbfm.9600014
    114 https://doi.org/10.1038/sj.jcbfm.9600086
    115 https://doi.org/10.1038/sj.jcbfm.9600537
    116 https://doi.org/10.1046/j.1432-1327.2001.01867.x
    117 https://doi.org/10.1056/nejmc1803856
    118 https://doi.org/10.1056/nejmoa1706442
    119 https://doi.org/10.1073/pnas.0801447105
    120 https://doi.org/10.1073/pnas.0915018107
    121 https://doi.org/10.1073/pnas.1308679110
    122 https://doi.org/10.1073/pnas.1520175113
    123 https://doi.org/10.1073/pnas.1605195113
    124 https://doi.org/10.1073/pnas.94.5.2007
    125 https://doi.org/10.1073/pnas.95.2.570
    126 https://doi.org/10.1074/jbc.270.23.13757
    127 https://doi.org/10.1074/jbc.m110.115790
    128 https://doi.org/10.1074/jbc.m111.295758
    129 https://doi.org/10.1074/jbc.m114.617787
    130 https://doi.org/10.1074/jbc.m707933200
    131 https://doi.org/10.1080/01616412.2016.1202395
    132 https://doi.org/10.1080/09546630410017275
    133 https://doi.org/10.1084/jem.185.5.933
    134 https://doi.org/10.1084/jem.20151563
    135 https://doi.org/10.1093/brain/awn109
    136 https://doi.org/10.1093/brain/awr199
    137 https://doi.org/10.1097/00004647-199609000-00017
    138 https://doi.org/10.1097/00004647-199702000-00013
    139 https://doi.org/10.1097/00004647-199802000-00008
    140 https://doi.org/10.1097/00004647-199901000-00010
    141 https://doi.org/10.1097/00004647-200002000-00012
    142 https://doi.org/10.1097/00004647-200006000-00006
    143 https://doi.org/10.1097/00004647-200006000-00008
    144 https://doi.org/10.1097/01.wcb.0000078322.96027.78
    145 https://doi.org/10.1097/cji.0b013e31816a88f9
    146 https://doi.org/10.1111/cns.12310
    147 https://doi.org/10.1111/j.1365-2125.2007.03026.x
    148 https://doi.org/10.1111/j.1365-2125.2011.03964.x
    149 https://doi.org/10.1111/j.1471-4159.2005.03227.x
    150 https://doi.org/10.1111/j.1471-4159.2009.06098.x
    151 https://doi.org/10.1111/j.1476-5381.2010.00684.x
    152 https://doi.org/10.1111/j.1600-0854.2008.00840.x
    153 https://doi.org/10.1111/j.1750-3639.2012.00614.x
    154 https://doi.org/10.1111/jnc.13422
    155 https://doi.org/10.1124/dmd.110.036012
    156 https://doi.org/10.1126/science.1081297
    157 https://doi.org/10.1136/annrheumdis-2012-202252
    158 https://doi.org/10.1136/jnnp.2004.054882
    159 https://doi.org/10.1136/jnnp.2006.100800
    160 https://doi.org/10.1146/annurev-immunol-032414-112306
    161 https://doi.org/10.1146/annurev.immunol.16.1.27
    162 https://doi.org/10.1155/2015/189292
    163 https://doi.org/10.1158/0008-5472.can-12-0721
    164 https://doi.org/10.1161/01.cir.0000155622.68580.dc
    165 https://doi.org/10.1161/01.str.0000057976.53301.69
    166 https://doi.org/10.1161/01.str.0000221294.90068.c4
    167 https://doi.org/10.1161/01.str.0000259709.16654.8f
    168 https://doi.org/10.1161/01.str.0000442009.06663.48
    169 https://doi.org/10.1161/01.str.12.6.723
    170 https://doi.org/10.1161/01.str.26.4.676
    171 https://doi.org/10.1161/01.str.28.6.1233
    172 https://doi.org/10.1161/01.str.31.7.1715
    173 https://doi.org/10.1161/01.str.32.5.1208
    174 https://doi.org/10.1161/strokeaha.113.002470
    175 https://doi.org/10.1161/strokeaha.115.009426
    176 https://doi.org/10.1161/strokeaha.118.020750
    177 https://doi.org/10.1172/jci119488
    178 https://doi.org/10.1177/0271678x15606714
    179 https://doi.org/10.1177/0271678x15610339
    180 https://doi.org/10.1177/0271678x17700913
    181 https://doi.org/10.1182/blood-2009-11-252643
    182 https://doi.org/10.1182/blood-2010-07-273417
    183 https://doi.org/10.1189/jlb.0703343
    184 https://doi.org/10.1189/jlb.1105674
    185 https://doi.org/10.1200/jco.2016.68.1106
    186 https://doi.org/10.1371/journal.pone.0171688
    187 https://doi.org/10.1517/14728222.11.5.613
    188 https://doi.org/10.1523/jneurosci.1623-11.2011
    189 https://doi.org/10.1523/jneurosci.21-15-05528.2001
    190 https://doi.org/10.1523/jneurosci.22-01-00038.2002
    191 https://doi.org/10.1523/jneurosci.23-25-08692.2003
    192 https://doi.org/10.1523/jneurosci.4901-12.2013
    193 https://doi.org/10.1523/jneurosci.5376-06.2007
    194 https://doi.org/10.1523/jneurosci.5505-08.2009
    195 https://doi.org/10.1586/14779072.2015.1020300
    196 https://doi.org/10.1586/ern.10.52
    197 https://doi.org/10.1590/0004-282x20130168
    198 https://doi.org/10.1615/critrevimmunol.v21.i5.20
    199 https://doi.org/10.2337/dc12-1835
    200 https://doi.org/10.2471/blt.16.181636
    201 https://doi.org/10.2967/jnumed.116.185975
    202 https://doi.org/10.3109/00207454.2014.980906
    203 https://doi.org/10.3389/fimmu.2017.01073
    204 https://doi.org/10.3892/etm.2015.2363
    205 https://doi.org/10.4049/jimmunol.181.12.8194
    206 https://doi.org/10.4161/mabs.28612
    207 https://doi.org/10.4238/gmr.15027580
    208 https://doi.org/10.7150/ijbs.4679
    209 schema:datePublished 2018-11-27
    210 schema:datePublishedReg 2018-11-27
    211 schema:description Inflammation is currently considered a prime target for the development of new stroke therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating immune cells invade the peri-infarct and infarct core. Resident and infiltrating cells together orchestrate the post-stroke inflammatory response, communicating with each other and the ischemic neurons, through soluble and membrane-bound signaling molecules, including cytokines. Inflammation can be both detrimental and beneficial at particular stages after a stroke. While it can contribute to expansion of the infarct, it is also responsible for infarct resolution, and influences remodeling and repair. Several pre-clinical and clinical proof-of-concept studies have suggested the effectiveness of pharmacological interventions that target inflammation post-stroke. Experimental evidence shows that targeting certain inflammatory cytokines, such as tumor necrosis factor, interleukin (IL)-1, IL-6, and IL-10, holds promise. However, as these cytokines possess non-redundant protective and immunoregulatory functions, their neutralization or augmentation carries a risk of unwanted side effects, and clinical translation is, therefore, challenging. This review summarizes the cell biology of the post-stroke inflammatory response and discusses pharmacological interventions targeting inflammation in the acute phase after a stroke that may be used alone or in combination with recanalization therapies. Development of next-generation immune therapies should ideally aim at selectively neutralizing pathogenic immune signaling, enhancing tissue preservation, promoting neurological recovery and leaving normal function intact.
    212 schema:genre research_article
    213 schema:inLanguage en
    214 schema:isAccessibleForFree false
    215 schema:isPartOf sg:journal.1019073
    216 schema:name Post-stroke inflammation—target or tool for therapy?
    217 schema:pagination 1-22
    218 schema:productId N266b92cd306e4297be6c87c3a4f104cc
    219 N3d483bfdf7594db291105b2256be1569
    220 N3e37a0c16a994bc3a70acbf2dc100da5
    221 N7bcf767658d6487ca96cdfa2b4569498
    222 Nc66b95c1d45c4fd2bb257cdc13664a8a
    223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110226536
    224 https://doi.org/10.1007/s00401-018-1930-z
    225 schema:sdDatePublished 2019-04-11T08:16
    226 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    227 schema:sdPublisher Nb8ea8157c59a409580c1be2017c1cd94
    228 schema:url https://link.springer.com/10.1007%2Fs00401-018-1930-z
    229 sgo:license sg:explorer/license/
    230 sgo:sdDataset articles
    231 rdf:type schema:ScholarlyArticle
    232 N266b92cd306e4297be6c87c3a4f104cc schema:name readcube_id
    233 schema:value 2385752b571ef701ee5921e816058ba77f2793b79c15ed40c28b1062dce3e8eb
    234 rdf:type schema:PropertyValue
    235 N3d483bfdf7594db291105b2256be1569 schema:name dimensions_id
    236 schema:value pub.1110226536
    237 rdf:type schema:PropertyValue
    238 N3e37a0c16a994bc3a70acbf2dc100da5 schema:name doi
    239 schema:value 10.1007/s00401-018-1930-z
    240 rdf:type schema:PropertyValue
    241 N71be84a25a81489dbe457d4d313c64d3 rdf:first sg:person.01021713024.78
    242 rdf:rest N8f1cf6f9f2ab4a518d14ceb9c441bab8
    243 N7a2f9c74585a42a6ac2fd61411b8c04d rdf:first sg:person.0645406163.64
    244 rdf:rest N71be84a25a81489dbe457d4d313c64d3
    245 N7bcf767658d6487ca96cdfa2b4569498 schema:name nlm_unique_id
    246 schema:value 0412041
    247 rdf:type schema:PropertyValue
    248 N8f1cf6f9f2ab4a518d14ceb9c441bab8 rdf:first sg:person.01105541111.00
    249 rdf:rest rdf:nil
    250 Nb8ea8157c59a409580c1be2017c1cd94 schema:name Springer Nature - SN SciGraph project
    251 rdf:type schema:Organization
    252 Nc66b95c1d45c4fd2bb257cdc13664a8a schema:name pubmed_id
    253 schema:value 30483945
    254 rdf:type schema:PropertyValue
    255 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    256 schema:name Medical and Health Sciences
    257 rdf:type schema:DefinedTerm
    258 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    259 schema:name Immunology
    260 rdf:type schema:DefinedTerm
    261 sg:journal.1019073 schema:issn 0001-6322
    262 1432-0533
    263 schema:name Acta Neuropathologica
    264 rdf:type schema:Periodical
    265 sg:person.01021713024.78 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
    266 schema:familyName Finsen
    267 schema:givenName Bente
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021713024.78
    269 rdf:type schema:Person
    270 sg:person.01105541111.00 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
    271 schema:familyName Clausen
    272 schema:givenName Bettina Hjelm
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105541111.00
    274 rdf:type schema:Person
    275 sg:person.0645406163.64 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    276 schema:familyName Lambertsen
    277 schema:givenName Kate Lykke
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645406163.64
    279 rdf:type schema:Person
    280 sg:pub.10.1007/s00401-014-1355-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050583256
    281 https://doi.org/10.1007/s00401-014-1355-2
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/s00401-014-1381-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010669304
    284 https://doi.org/10.1007/s00401-014-1381-0
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s00401-016-1541-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044693423
    287 https://doi.org/10.1007/s00401-016-1541-5
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s11011-013-9474-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042250252
    290 https://doi.org/10.1007/s11011-013-9474-3
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s11064-010-0167-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034855777
    293 https://doi.org/10.1007/s11064-010-0167-6
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s12028-013-9899-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037061484
    296 https://doi.org/10.1007/s12028-013-9899-x
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s40263-012-0013-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013576327
    299 https://doi.org/10.1007/s40263-012-0013-2
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/385729a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008946714
    302 https://doi.org/10.1038/385729a0
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/nature04671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000381986
    305 https://doi.org/10.1038/nature04671
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/nature11307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011438914
    308 https://doi.org/10.1038/nature11307
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/ncomms4016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010138519
    311 https://doi.org/10.1038/ncomms4016
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/ng1413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000776693
    314 https://doi.org/10.1038/ng1413
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nm.3893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048838933
    317 https://doi.org/10.1038/nm.3893
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nm1603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046174639
    320 https://doi.org/10.1038/nm1603
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nn.3554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016133129
    323 https://doi.org/10.1038/nn.3554
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nn.4597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090329025
    326 https://doi.org/10.1038/nn.4597
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nrm3737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008343416
    329 https://doi.org/10.1038/nrm3737
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/s41467-018-03362-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101582133
    332 https://doi.org/10.1038/s41467-018-03362-1
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/srep25550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018946235
    335 https://doi.org/10.1038/srep25550
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/srep29291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035443059
    338 https://doi.org/10.1038/srep29291
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1097/00004647-199609000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042201473
    341 https://doi.org/10.1097/00004647-199609000-00017
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1097/00004647-199702000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043285119
    344 https://doi.org/10.1097/00004647-199702000-00013
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1097/00004647-199802000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044965966
    347 https://doi.org/10.1097/00004647-199802000-00008
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1097/00004647-199901000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028493892
    350 https://doi.org/10.1097/00004647-199901000-00010
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1097/00004647-200002000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048089160
    353 https://doi.org/10.1097/00004647-200002000-00012
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1097/00004647-200006000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009726135
    356 https://doi.org/10.1097/00004647-200006000-00006
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1097/00004647-200006000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006997928
    359 https://doi.org/10.1097/00004647-200006000-00008
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1097/01.wcb.0000078322.96027.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048501110
    362 https://doi.org/10.1097/01.wcb.0000078322.96027.78
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1186/1471-2377-11-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005494752
    365 https://doi.org/10.1186/1471-2377-11-41
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1186/1471-2377-4-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029229764
    368 https://doi.org/10.1186/1471-2377-4-2
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1186/1742-2094-5-46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036279804
    371 https://doi.org/10.1186/1742-2094-5-46
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1186/1742-2094-8-164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043512621
    374 https://doi.org/10.1186/1742-2094-8-164
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1186/1742-2094-8-174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012499641
    377 https://doi.org/10.1186/1742-2094-8-174
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1186/s12931-017-0633-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091133348
    380 https://doi.org/10.1186/s12931-017-0633-7
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1186/s12974-014-0159-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049529992
    383 https://doi.org/10.1186/s12974-014-0159-6
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1186/s12974-014-0231-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011990256
    386 https://doi.org/10.1186/s12974-014-0231-2
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1186/s13293-015-0035-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009815796
    389 https://doi.org/10.1186/s13293-015-0035-9
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1186/s40478-016-0371-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1030973377
    392 https://doi.org/10.1186/s40478-016-0371-y
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1385/jmn:21:2:167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012920521
    395 https://doi.org/10.1385/jmn:21:2:167
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1385/jmn:24:2:293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003189514
    398 https://doi.org/10.1385/jmn:24:2:293
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.2165/11588400-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045735292
    401 https://doi.org/10.2165/11588400-000000000-00000
    402 rdf:type schema:CreativeWork
    403 https://app.dimensions.ai/details/publication/pub.1076073970 schema:CreativeWork
    404 https://app.dimensions.ai/details/publication/pub.1077228984 schema:CreativeWork
    405 https://app.dimensions.ai/details/publication/pub.1077343426 schema:CreativeWork
    406 https://app.dimensions.ai/details/publication/pub.1082381381 schema:CreativeWork
    407 https://app.dimensions.ai/details/publication/pub.1082746033 schema:CreativeWork
    408 https://app.dimensions.ai/details/publication/pub.1082885865 schema:CreativeWork
    409 https://app.dimensions.ai/details/publication/pub.1083308307 schema:CreativeWork
    410 https://app.dimensions.ai/details/publication/pub.1100671095 schema:CreativeWork
    411 https://doi.org/10.1002/(sici)1097-4547(20000115)59:2<238::aid-jnr10>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1052436520
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1002/ajmg.b.30712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033574855
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1002/ana.10803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012106569
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1002/ana.23529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043603835
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1002/art.38755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024549373
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1002/art.39700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016310829
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1002/glia.22478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011799556
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1002/jlb.56.5.542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082584943
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1006/bbrc.1997.6436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033881627
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1006/exnr.1996.0059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025490921
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1006/exnr.1996.0093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019393623
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/0092-8674(95)90192-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049369176
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/0161-5890(91)90004-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025334576
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/0304-3940(93)90396-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001866615
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/0306-4522(95)00414-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003136488
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/0361-9230(92)90033-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1014908673
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/1043-4666(92)90043-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1052251632
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/1043-4666(92)90078-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008385312
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.atherosclerosis.2007.09.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046374705
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.bbamcr.2011.01.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004208759
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.bbamcr.2016.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003784956
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.bbi.2009.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009560087
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.bbi.2015.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013882582
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.bbi.2017.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085861058
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/j.bbr.2014.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004984649
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.brainres.2013.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043392004
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.cyto.2005.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036098656
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.cyto.2012.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049870647
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.cyto.2014.05.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254714
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.cytogfr.2004.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048689348
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.cytogfr.2010.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007210233
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.expneurol.2017.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085937073
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/j.gene.2015.04.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022722157
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/j.immuni.2013.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041187043
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/j.jbiotec.2010.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024027896
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1016/j.jneuroim.2005.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045437373
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1016/j.jneuroim.2009.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021406780
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1016/j.neulet.2014.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040682114
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1016/j.neurobiolaging.2015.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017022246
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1016/j.neuropharm.2017.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091837915
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1016/j.neuroscience.2006.10.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024082031
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1016/j.neuroscience.2015.08.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027230498
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1016/j.omtm.2017.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086145543
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1016/j.smim.2014.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003839358
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1016/s0006-8993(97)00981-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043102311
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1016/s0140-6736(05)67763-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006909756
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1016/s0165-3806(02)00636-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005203235
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1016/s0167-4889(02)00319-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005723017
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1016/s0304-3940(98)00537-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018514689
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1016/s1359-6101(03)00022-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021001228
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1016/s1359-6101(96)00026-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051971358
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1016/s1474-4422(16)00114-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037508648
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1038/jcbfm.1995.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002534435
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1038/jcbfm.2010.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024705564
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1038/jcbfm.2012.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041886073
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1038/jcbfm.2012.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002959323
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1038/jcbfm.2013.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048062215
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1038/jcbfm.2013.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002722721
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1038/jcbfm.2014.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010062805
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1038/jcbfm.2015.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027623748
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1038/sj.jcbfm.9600014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050973247
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1038/sj.jcbfm.9600086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051987362
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1038/sj.jcbfm.9600537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036020271
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1046/j.1432-1327.2001.01867.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049762928
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1056/nejmc1803856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103900358
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1056/nejmoa1706442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092648288
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1073/pnas.0801447105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021054562
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1073/pnas.0915018107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050009494
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1073/pnas.1308679110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033056055
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1073/pnas.1520175113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004328147
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1073/pnas.1605195113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048111694
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1073/pnas.94.5.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014788787
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1073/pnas.95.2.570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024684097
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1074/jbc.270.23.13757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051990487
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1074/jbc.m110.115790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008284117
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1074/jbc.m111.295758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025754588
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1074/jbc.m114.617787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042083922
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1074/jbc.m707933200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036306934
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1080/01616412.2016.1202395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051887812
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1080/09546630410017275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048228114
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1084/jem.185.5.933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042036585
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1084/jem.20151563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031992271
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1093/brain/awn109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049890613
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1093/brain/awr199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026435640
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1097/00004647-199609000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042201473
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1097/00004647-199702000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043285119
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1097/00004647-199802000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044965966
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1097/00004647-199901000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028493892
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1097/00004647-200002000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048089160
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1097/00004647-200006000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009726135
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1097/00004647-200006000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006997928
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1097/01.wcb.0000078322.96027.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048501110
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1097/cji.0b013e31816a88f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026943115
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1111/cns.12310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024916703
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1111/j.1365-2125.2007.03026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009863653
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1111/j.1365-2125.2011.03964.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047540604
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1111/j.1471-4159.2005.03227.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010148477
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1111/j.1471-4159.2009.06098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037650109
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1111/j.1476-5381.2010.00684.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009904324
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1111/j.1600-0854.2008.00840.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004100082
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1111/j.1750-3639.2012.00614.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002311899
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1111/jnc.13422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015245455
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1124/dmd.110.036012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024151404
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1126/science.1081297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039169555
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1136/annrheumdis-2012-202252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042957672
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1136/jnnp.2004.054882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007648370
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1136/jnnp.2006.100800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023297572
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1146/annurev-immunol-032414-112306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005978087
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1146/annurev.immunol.16.1.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024065892
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1155/2015/189292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053382813
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1158/0008-5472.can-12-0721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023511396
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1161/01.cir.0000155622.68580.dc schema:sameAs https://app.dimensions.ai/details/publication/pub.1038683272
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1161/01.str.0000057976.53301.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023433404
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1161/01.str.0000221294.90068.c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005750556
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1161/01.str.0000259709.16654.8f schema:sameAs https://app.dimensions.ai/details/publication/pub.1022461728
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1161/01.str.0000442009.06663.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022575601
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1161/01.str.12.6.723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028754301
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1161/01.str.26.4.676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341571
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1161/01.str.28.6.1233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063342401
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1161/01.str.31.7.1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029228475
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1161/01.str.32.5.1208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035913718
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1161/strokeaha.113.002470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021800432
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1161/strokeaha.115.009426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036916150
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1161/strokeaha.118.020750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101702157
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1172/jci119488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005995120
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1177/0271678x15606714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030408481
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1177/0271678x15610339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019879786
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1177/0271678x17700913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084243297
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1182/blood-2009-11-252643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021911275
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1182/blood-2010-07-273417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016762993
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1189/jlb.0703343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029691733
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1189/jlb.1105674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004829698
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1200/jco.2016.68.1106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005250884
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1371/journal.pone.0171688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083737490
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1517/14728222.11.5.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046761943
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1523/jneurosci.1623-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047512251
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.1523/jneurosci.21-15-05528.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074853260
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.1523/jneurosci.22-01-00038.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074964630
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.1523/jneurosci.23-25-08692.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076571052
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.1523/jneurosci.4901-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041259820
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.1523/jneurosci.5376-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036281180
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.1523/jneurosci.5505-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015339858
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.1586/14779072.2015.1020300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052654434
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.1586/ern.10.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004515188
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.1590/0004-282x20130168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015970843
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.1615/critrevimmunol.v21.i5.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131777
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.2337/dc12-1835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042204509
    704 rdf:type schema:CreativeWork
    705 https://doi.org/10.2471/blt.16.181636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070838494
    706 rdf:type schema:CreativeWork
    707 https://doi.org/10.2967/jnumed.116.185975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070928682
    708 rdf:type schema:CreativeWork
    709 https://doi.org/10.3109/00207454.2014.980906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013756820
    710 rdf:type schema:CreativeWork
    711 https://doi.org/10.3389/fimmu.2017.01073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091405124
    712 rdf:type schema:CreativeWork
    713 https://doi.org/10.3892/etm.2015.2363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071503404
    714 rdf:type schema:CreativeWork
    715 https://doi.org/10.4049/jimmunol.181.12.8194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077817014
    716 rdf:type schema:CreativeWork
    717 https://doi.org/10.4161/mabs.28612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305765
    718 rdf:type schema:CreativeWork
    719 https://doi.org/10.4238/gmr.15027580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072395528
    720 rdf:type schema:CreativeWork
    721 https://doi.org/10.7150/ijbs.4679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018906294
    722 rdf:type schema:CreativeWork
    723 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
    724 schema:name Department of Clinical Research, BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, University of Southern Denmark, 5000, Odense C, Denmark
    725 Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000, Odense, Denmark
    726 rdf:type schema:Organization
    727 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
    728 schema:name Department of Clinical Research, BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, University of Southern Denmark, 5000, Odense C, Denmark
    729 Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000, Odense, Denmark
    730 Department of Neurology, Odense University Hospital, 5000, Odense, Denmark
    731 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...