Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Lindsay A. Welikovitch, Sonia Do Carmo, Zsófia Maglóczky, Péter Szocsics, János Lőke, Tamás Freund, A. Claudio Cuello

ABSTRACT

Growing evidence gathered from transgenic animal models of Alzheimer's disease (AD) indicates that the intraneuronal accumulation of amyloid-β (Aβ) peptides is an early event in the AD pathogenesis, producing cognitive deficits before the deposition of insoluble plaques. Levels of soluble Aβ are also a strong indicator of synaptic deficits and concurrent AD neuropathologies in post-mortem AD brain; however, it remains poorly understood how this soluble amyloid pool builds within the brain in the decades leading up to diagnosis, when a patient is likely most amenable to early therapeutic interventions. Indeed, characterizing early intracellular Aβ accumulation in humans has been hampered by the lack of Aβ-specific antibodies, variability in the quality of available human brain tissue and the limitations of conventional microscopy. We therefore sought to investigate the development of the intraneuronal Aβ pathology using extremely high-quality post-mortem brain material obtained from a cohort of non-demented subjects with short post-mortem intervals and processed by perfusion-fixation. Using well-characterized monoclonal antibodies, we demonstrate that the age-dependent intraneuronal accumulation of soluble Aβ is pervasive throughout the entorhinal cortex and hippocampus, and that this phase of the amyloid pathology becomes established within AD-vulnerable regions before the deposition of Aβ plaques and the formation of tau neurofibrillary tangles. We also show for the first time in post-mortem human brain that Aβ oligomers do in fact accumulate intraneuronally, before the formation of extracellular plaques. Finally, we validated the origin of the Aβ-immunopositive pool by resolving Aβ- and APP/CTF-immunoreactive sites using super resolution structured illumination microscopy. Together, these findings indicate that the lifelong accrual of intraneuronal Aβ may be a potential trigger for downstream AD-related pathogenic events in early disease stages. More... »

PAGES

1-17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-018-1922-z

DOI

http://dx.doi.org/10.1007/s00401-018-1922-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107848912

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30362029


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welikovitch", 
        "givenName": "Lindsay A.", 
        "id": "sg:person.016541515215.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016541515215.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Do Carmo", 
        "givenName": "Sonia", 
        "id": "sg:person.014106414073.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014106414073.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MTA Institute of Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419012.f", 
          "name": [
            "Human Brain Research Laboratory, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magl\u00f3czky", 
        "givenName": "Zs\u00f3fia", 
        "id": "sg:person.010252251214.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010252251214.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MTA Institute of Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419012.f", 
          "name": [
            "Human Brain Research Laboratory, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szocsics", 
        "givenName": "P\u00e9ter", 
        "id": "sg:person.011235643635.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011235643635.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, Szent Borb\u00e1la Hospital, Tatab\u00e1nya, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u0151ke", 
        "givenName": "J\u00e1nos", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MTA Institute of Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419012.f", 
          "name": [
            "Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Freund", 
        "givenName": "Tam\u00e1s", 
        "id": "sg:person.01345500335.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345500335.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada", 
            "Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada", 
            "Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cuello", 
        "givenName": "A. Claudio", 
        "id": "sg:person.01206035231.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206035231.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1523/jneurosci.4970-06.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000226780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhh142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000467781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1999.0722479.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001163596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(02)00875-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001856757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(02)00875-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001856757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0679-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002603765", 
          "https://doi.org/10.1007/s00401-010-0679-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0679-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002603765", 
          "https://doi.org/10.1007/s00401-010-0679-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199807000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004605410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2014.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005412904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.141.4.1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005974937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006139983", 
          "https://doi.org/10.1038/nn842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006139983", 
          "https://doi.org/10.1038/nn842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006152248", 
          "https://doi.org/10.1038/nrn2168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(12)70291-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006207765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199107000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008166938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008214903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2011.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008278151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/emmm.201606210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009287869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(01)02444-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009607208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/305537a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010169967", 
          "https://doi.org/10.1038/305537a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65184-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011013572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m607483200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011339265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2012.05.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011499885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013028078", 
          "https://doi.org/10.1038/nm1782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(02)00604-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013212756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201002018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014348634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-2-61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014831465", 
          "https://doi.org/10.1186/2051-5960-2-61"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(89)90164-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015431266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(89)90164-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015431266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2008.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015500639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2357-10.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015539614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2006.04157.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015598463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015973267", 
          "https://doi.org/10.1038/8438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1994.00540200048015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016614385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.12.4506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016689265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(98)01279-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017411592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64463-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017801326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-016-1632-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018695343", 
          "https://doi.org/10.1007/s00401-016-1632-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-016-1632-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018695343", 
          "https://doi.org/10.1007/s00401-016-1632-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2011.07.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019149236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.2001.01082.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021133220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/emmm.201200239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021533758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410270502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021794906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2007.02.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022754657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0127-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022911785", 
          "https://doi.org/10.1007/s00401-006-0127-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.15.8966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024075794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.11.6448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025056557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2012.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027229915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nen.0b013e318232a379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027916279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-2-23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028141072", 
          "https://doi.org/10.1186/1742-2094-2-23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awq149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028941554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awq149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028941554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5825-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029330255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.01.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030354045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-9-62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030540716", 
          "https://doi.org/10.1186/1742-2094-9-62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3672-12.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030758674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)04937-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031614765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0271678x15615132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031843339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0271678x15615132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031843339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198906013202203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032379758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/59.8.733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032485643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64700-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035501318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5167-03.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037408797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.20.9513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039524256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000446283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039794485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.103754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041289441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0572-14.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041340573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(01)01876-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043057364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00266588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044545237", 
          "https://doi.org/10.1007/bf00266588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00266588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044545237", 
          "https://doi.org/10.1007/bf00266588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(03)00434-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044948714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410430316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047026382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00509200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047336731", 
          "https://doi.org/10.1007/bf00509200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00509200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047336731", 
          "https://doi.org/10.1007/bf00509200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nbdi.1996.0003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047599105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40478-014-0175-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048719585", 
          "https://doi.org/10.1186/s40478-014-0175-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40478-014-0175-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048719585", 
          "https://doi.org/10.1186/s40478-014-0175-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3501-06.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049211181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052597019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053594130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/protex.2013.097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056467202", 
          "https://doi.org/10.1038/protex.2013.097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.42.3.631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064370640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.58.12.1791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064380472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.58.12.1791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064380472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.58.12.1791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064380472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/0929866043407174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069157519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156720511794604561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069189014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074786528", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2000-23-403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075117827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13506120208995241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075193157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2010-1349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078050086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pin.12520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084217157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-017-0580-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085402919", 
          "https://doi.org/10.1007/s12035-017-0580-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-017-0580-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085402919", 
          "https://doi.org/10.1007/s12035-017-0580-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13195-018-0337-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100689757", 
          "https://doi.org/10.1186/s13195-018-0337-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-179941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104299492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-179941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104299492"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Growing evidence gathered from transgenic animal models of Alzheimer's disease (AD) indicates that the intraneuronal accumulation of amyloid-\u03b2 (A\u03b2) peptides is an early event in the AD pathogenesis, producing cognitive deficits before the deposition of insoluble plaques. Levels of soluble A\u03b2 are also a strong indicator of synaptic deficits and concurrent AD neuropathologies in post-mortem AD brain; however, it remains poorly understood how this soluble amyloid pool builds within the brain in the decades leading up to diagnosis, when a patient is likely most amenable to early therapeutic interventions. Indeed, characterizing early intracellular A\u03b2 accumulation in humans has been hampered by the lack of A\u03b2-specific antibodies, variability in the quality of available human brain tissue and the limitations of conventional microscopy. We therefore sought to investigate the development of the intraneuronal A\u03b2 pathology using extremely high-quality post-mortem brain material obtained from a cohort of non-demented subjects with short post-mortem intervals and processed by perfusion-fixation. Using well-characterized monoclonal antibodies, we demonstrate that the age-dependent intraneuronal accumulation of soluble A\u03b2 is pervasive throughout the entorhinal cortex and hippocampus, and that this phase of the amyloid pathology becomes established within AD-vulnerable regions before the deposition of A\u03b2 plaques and the formation of tau neurofibrillary tangles. We also show for the first time in post-mortem human brain that A\u03b2 oligomers do in fact accumulate intraneuronally, before the formation of extracellular plaques. Finally, we validated the origin of the A\u03b2-immunopositive pool by resolving A\u03b2- and APP/CTF-immunoreactive sites using super resolution structured illumination microscopy. Together, these findings indicate that the lifelong accrual of intraneuronal A\u03b2 may be a potential trigger for downstream AD-related pathogenic events in early disease stages.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00401-018-1922-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }
    ], 
    "name": "Evidence of intraneuronal A\u03b2 accumulation preceding tau pathology in the entorhinal cortex", 
    "pagination": "1-17", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "efd667595ff96dcb46f12f2d7a5134d4eee2b9339f8ad5c078d99470c039fb46"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30362029"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00401-018-1922-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107848912"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00401-018-1922-z", 
      "https://app.dimensions.ai/details/publication/pub.1107848912"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00401-018-1922-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1922-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1922-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1922-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-018-1922-z'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      110 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00401-018-1922-z schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nf59a21d3c9f746d5b7415ebb4a8c65e1
4 schema:citation sg:pub.10.1007/bf00266588
5 sg:pub.10.1007/bf00509200
6 sg:pub.10.1007/s00401-006-0127-z
7 sg:pub.10.1007/s00401-010-0679-9
8 sg:pub.10.1007/s00401-016-1632-3
9 sg:pub.10.1007/s12035-017-0580-9
10 sg:pub.10.1038/305537a0
11 sg:pub.10.1038/8438
12 sg:pub.10.1038/nm1782
13 sg:pub.10.1038/nn842
14 sg:pub.10.1038/nrn2168
15 sg:pub.10.1038/protex.2013.097
16 sg:pub.10.1186/1742-2094-2-23
17 sg:pub.10.1186/1742-2094-9-62
18 sg:pub.10.1186/2051-5960-2-61
19 sg:pub.10.1186/s13195-018-0337-3
20 sg:pub.10.1186/s40478-014-0175-x
21 https://app.dimensions.ai/details/publication/pub.1074786528
22 https://doi.org/10.1001/archneur.1994.00540200048015
23 https://doi.org/10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m
24 https://doi.org/10.1002/ana.410270502
25 https://doi.org/10.1002/ana.410430316
26 https://doi.org/10.1002/emmm.201200239
27 https://doi.org/10.1006/nbdi.1996.0003
28 https://doi.org/10.1016/0006-8993(89)90164-9
29 https://doi.org/10.1016/j.ajpath.2011.07.045
30 https://doi.org/10.1016/j.lfs.2012.05.020
31 https://doi.org/10.1016/j.lfs.2012.06.004
32 https://doi.org/10.1016/j.nbd.2008.10.011
33 https://doi.org/10.1016/j.neurobiolaging.2007.02.029
34 https://doi.org/10.1016/j.neurobiolaging.2011.05.003
35 https://doi.org/10.1016/j.neurobiolaging.2014.03.026
36 https://doi.org/10.1016/j.neuron.2005.01.040
37 https://doi.org/10.1016/s0002-9440(10)64463-x
38 https://doi.org/10.1016/s0002-9440(10)64700-1
39 https://doi.org/10.1016/s0002-9440(10)65184-x
40 https://doi.org/10.1016/s0006-8993(98)01279-7
41 https://doi.org/10.1016/s0140-6736(99)04937-5
42 https://doi.org/10.1016/s0304-3940(01)01876-6
43 https://doi.org/10.1016/s0304-3940(01)02444-2
44 https://doi.org/10.1016/s0304-3940(02)00875-3
45 https://doi.org/10.1016/s0896-6273(02)00604-9
46 https://doi.org/10.1016/s0896-6273(03)00434-3
47 https://doi.org/10.1016/s1474-4422(12)70291-0
48 https://doi.org/10.1046/j.1365-2559.2001.01082.x
49 https://doi.org/10.1046/j.1471-4159.1999.0722479.x
50 https://doi.org/10.1056/nejm198906013202203
51 https://doi.org/10.1073/pnas.85.12.4506
52 https://doi.org/10.1073/pnas.90.20.9513
53 https://doi.org/10.1073/pnas.95.11.6448
54 https://doi.org/10.1074/jbc.271.15.8966
55 https://doi.org/10.1074/jbc.m607483200
56 https://doi.org/10.1083/jcb.141.4.1031
57 https://doi.org/10.1083/jcb.201002018
58 https://doi.org/10.1093/brain/awq149
59 https://doi.org/10.1093/cercor/bhh142
60 https://doi.org/10.1093/jnen/59.8.733
61 https://doi.org/10.1097/00005072-199107000-00008
62 https://doi.org/10.1097/00005072-199807000-00004
63 https://doi.org/10.1097/nen.0b013e318232a379
64 https://doi.org/10.1111/j.1471-4159.2006.04157.x
65 https://doi.org/10.1111/pin.12520
66 https://doi.org/10.1113/jphysiol.2005.103754
67 https://doi.org/10.1126/science.1072994
68 https://doi.org/10.1159/000446283
69 https://doi.org/10.1172/jci119536
70 https://doi.org/10.1177/0271678x15615132
71 https://doi.org/10.1212/wnl.42.3.631
72 https://doi.org/10.1212/wnl.58.12.1791
73 https://doi.org/10.1523/jneurosci.0572-14.2014
74 https://doi.org/10.1523/jneurosci.2357-10.2010
75 https://doi.org/10.1523/jneurosci.3501-06.2007
76 https://doi.org/10.1523/jneurosci.3672-12.2013
77 https://doi.org/10.1523/jneurosci.4970-06.2007
78 https://doi.org/10.1523/jneurosci.5167-03.2004
79 https://doi.org/10.1523/jneurosci.5825-09.2010
80 https://doi.org/10.15252/emmm.201606210
81 https://doi.org/10.2174/0929866043407174
82 https://doi.org/10.2174/156720511794604561
83 https://doi.org/10.3109/13506120208995241
84 https://doi.org/10.3233/jad-179941
85 https://doi.org/10.3233/jad-2000-23-403
86 https://doi.org/10.3233/jad-2010-1349
87 schema:datePublished 2018-12
88 schema:datePublishedReg 2018-12-01
89 schema:description Growing evidence gathered from transgenic animal models of Alzheimer's disease (AD) indicates that the intraneuronal accumulation of amyloid-β (Aβ) peptides is an early event in the AD pathogenesis, producing cognitive deficits before the deposition of insoluble plaques. Levels of soluble Aβ are also a strong indicator of synaptic deficits and concurrent AD neuropathologies in post-mortem AD brain; however, it remains poorly understood how this soluble amyloid pool builds within the brain in the decades leading up to diagnosis, when a patient is likely most amenable to early therapeutic interventions. Indeed, characterizing early intracellular Aβ accumulation in humans has been hampered by the lack of Aβ-specific antibodies, variability in the quality of available human brain tissue and the limitations of conventional microscopy. We therefore sought to investigate the development of the intraneuronal Aβ pathology using extremely high-quality post-mortem brain material obtained from a cohort of non-demented subjects with short post-mortem intervals and processed by perfusion-fixation. Using well-characterized monoclonal antibodies, we demonstrate that the age-dependent intraneuronal accumulation of soluble Aβ is pervasive throughout the entorhinal cortex and hippocampus, and that this phase of the amyloid pathology becomes established within AD-vulnerable regions before the deposition of Aβ plaques and the formation of tau neurofibrillary tangles. We also show for the first time in post-mortem human brain that Aβ oligomers do in fact accumulate intraneuronally, before the formation of extracellular plaques. Finally, we validated the origin of the Aβ-immunopositive pool by resolving Aβ- and APP/CTF-immunoreactive sites using super resolution structured illumination microscopy. Together, these findings indicate that the lifelong accrual of intraneuronal Aβ may be a potential trigger for downstream AD-related pathogenic events in early disease stages.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree false
93 schema:isPartOf sg:journal.1019073
94 schema:name Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex
95 schema:pagination 1-17
96 schema:productId N2bc5a8ebf691469f910f27f6e1370e45
97 Nb54ec13fec4b4c71b73d5285ad223bf9
98 Ncc5aa5d15f1b477ab936e5a34965cf48
99 Nee9d36af894948b09798f6ceb1378b1e
100 Nf74c7cbc2a504ec7b3849895b67ec69b
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107848912
102 https://doi.org/10.1007/s00401-018-1922-z
103 schema:sdDatePublished 2019-04-10T20:06
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N1fbb0eca56ca495eacdeaa5faa7eafed
106 schema:url https://link.springer.com/10.1007%2Fs00401-018-1922-z
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N1fbb0eca56ca495eacdeaa5faa7eafed schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N2bc5a8ebf691469f910f27f6e1370e45 schema:name nlm_unique_id
113 schema:value 0412041
114 rdf:type schema:PropertyValue
115 N348201c5058747f8ad079d7d51ec5e4d rdf:first sg:person.010252251214.41
116 rdf:rest N9bdd9486a55347aaa9ccbcaaead3c7be
117 N4a6f8222dbff4a16bcc66b2505952974 schema:affiliation Na128737a5d3e49ba85cf78262b316e51
118 schema:familyName Lőke
119 schema:givenName János
120 rdf:type schema:Person
121 N92757770fbe94c26b59aca2d21a4847d rdf:first sg:person.01206035231.10
122 rdf:rest rdf:nil
123 N9660cb47150f4b11a9ca81a3a48720aa rdf:first N4a6f8222dbff4a16bcc66b2505952974
124 rdf:rest Na45eb34bbffe45649f78c91bd9645d00
125 N9bdd9486a55347aaa9ccbcaaead3c7be rdf:first sg:person.011235643635.94
126 rdf:rest N9660cb47150f4b11a9ca81a3a48720aa
127 Na128737a5d3e49ba85cf78262b316e51 schema:name Department of Psychiatry, Szent Borbála Hospital, Tatabánya, Hungary
128 rdf:type schema:Organization
129 Na45eb34bbffe45649f78c91bd9645d00 rdf:first sg:person.01345500335.56
130 rdf:rest N92757770fbe94c26b59aca2d21a4847d
131 Na9cf0583a99e4e6fa5918ef6267e4fdd rdf:first sg:person.014106414073.87
132 rdf:rest N348201c5058747f8ad079d7d51ec5e4d
133 Nb54ec13fec4b4c71b73d5285ad223bf9 schema:name doi
134 schema:value 10.1007/s00401-018-1922-z
135 rdf:type schema:PropertyValue
136 Ncc5aa5d15f1b477ab936e5a34965cf48 schema:name dimensions_id
137 schema:value pub.1107848912
138 rdf:type schema:PropertyValue
139 Nee9d36af894948b09798f6ceb1378b1e schema:name pubmed_id
140 schema:value 30362029
141 rdf:type schema:PropertyValue
142 Nf59a21d3c9f746d5b7415ebb4a8c65e1 rdf:first sg:person.016541515215.39
143 rdf:rest Na9cf0583a99e4e6fa5918ef6267e4fdd
144 Nf74c7cbc2a504ec7b3849895b67ec69b schema:name readcube_id
145 schema:value efd667595ff96dcb46f12f2d7a5134d4eee2b9339f8ad5c078d99470c039fb46
146 rdf:type schema:PropertyValue
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
151 schema:name Neurosciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1019073 schema:issn 0001-6322
154 1432-0533
155 schema:name Acta Neuropathologica
156 rdf:type schema:Periodical
157 sg:person.010252251214.41 schema:affiliation https://www.grid.ac/institutes/grid.419012.f
158 schema:familyName Maglóczky
159 schema:givenName Zsófia
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010252251214.41
161 rdf:type schema:Person
162 sg:person.011235643635.94 schema:affiliation https://www.grid.ac/institutes/grid.419012.f
163 schema:familyName Szocsics
164 schema:givenName Péter
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011235643635.94
166 rdf:type schema:Person
167 sg:person.01206035231.10 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
168 schema:familyName Cuello
169 schema:givenName A. Claudio
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206035231.10
171 rdf:type schema:Person
172 sg:person.01345500335.56 schema:affiliation https://www.grid.ac/institutes/grid.419012.f
173 schema:familyName Freund
174 schema:givenName Tamás
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345500335.56
176 rdf:type schema:Person
177 sg:person.014106414073.87 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
178 schema:familyName Do Carmo
179 schema:givenName Sonia
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014106414073.87
181 rdf:type schema:Person
182 sg:person.016541515215.39 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
183 schema:familyName Welikovitch
184 schema:givenName Lindsay A.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016541515215.39
186 rdf:type schema:Person
187 sg:pub.10.1007/bf00266588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044545237
188 https://doi.org/10.1007/bf00266588
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/bf00509200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047336731
191 https://doi.org/10.1007/bf00509200
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00401-006-0127-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1022911785
194 https://doi.org/10.1007/s00401-006-0127-z
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s00401-010-0679-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002603765
197 https://doi.org/10.1007/s00401-010-0679-9
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s00401-016-1632-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018695343
200 https://doi.org/10.1007/s00401-016-1632-3
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s12035-017-0580-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085402919
203 https://doi.org/10.1007/s12035-017-0580-9
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/305537a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010169967
206 https://doi.org/10.1038/305537a0
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/8438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015973267
209 https://doi.org/10.1038/8438
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/nm1782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013028078
212 https://doi.org/10.1038/nm1782
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/nn842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006139983
215 https://doi.org/10.1038/nn842
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/nrn2168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006152248
218 https://doi.org/10.1038/nrn2168
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/protex.2013.097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056467202
221 https://doi.org/10.1038/protex.2013.097
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/1742-2094-2-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028141072
224 https://doi.org/10.1186/1742-2094-2-23
225 rdf:type schema:CreativeWork
226 sg:pub.10.1186/1742-2094-9-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030540716
227 https://doi.org/10.1186/1742-2094-9-62
228 rdf:type schema:CreativeWork
229 sg:pub.10.1186/2051-5960-2-61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014831465
230 https://doi.org/10.1186/2051-5960-2-61
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/s13195-018-0337-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100689757
233 https://doi.org/10.1186/s13195-018-0337-3
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/s40478-014-0175-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048719585
236 https://doi.org/10.1186/s40478-014-0175-x
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1074786528 schema:CreativeWork
239 https://doi.org/10.1001/archneur.1994.00540200048015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016614385
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1053594130
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/ana.410270502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021794906
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/ana.410430316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047026382
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/emmm.201200239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021533758
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1006/nbdi.1996.0003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047599105
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0006-8993(89)90164-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015431266
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.ajpath.2011.07.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019149236
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.lfs.2012.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011499885
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.lfs.2012.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027229915
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.nbd.2008.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015500639
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.neurobiolaging.2007.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022754657
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.neurobiolaging.2011.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008278151
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.neurobiolaging.2014.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005412904
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.neuron.2005.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030354045
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0002-9440(10)64463-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017801326
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0002-9440(10)64700-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035501318
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0002-9440(10)65184-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011013572
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0006-8993(98)01279-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017411592
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0140-6736(99)04937-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031614765
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0304-3940(01)01876-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043057364
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0304-3940(01)02444-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009607208
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0304-3940(02)00875-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001856757
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0896-6273(02)00604-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013212756
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0896-6273(03)00434-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044948714
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s1474-4422(12)70291-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006207765
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1046/j.1365-2559.2001.01082.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021133220
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1046/j.1471-4159.1999.0722479.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001163596
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1056/nejm198906013202203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032379758
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.85.12.4506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016689265
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.90.20.9513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039524256
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.95.11.6448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025056557
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1074/jbc.271.15.8966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024075794
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m607483200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011339265
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1083/jcb.141.4.1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005974937
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1083/jcb.201002018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014348634
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/brain/awq149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028941554
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/cercor/bhh142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000467781
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/jnen/59.8.733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032485643
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/00005072-199107000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008166938
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1097/00005072-199807000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004605410
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/nen.0b013e318232a379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027916279
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1111/j.1471-4159.2006.04157.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015598463
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/pin.12520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084217157
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1113/jphysiol.2005.103754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041289441
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1072994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052597019
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1159/000446283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039794485
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1172/jci119536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008214903
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1177/0271678x15615132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031843339
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1212/wnl.42.3.631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064370640
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1212/wnl.58.12.1791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064380472
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1523/jneurosci.0572-14.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041340573
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1523/jneurosci.2357-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015539614
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1523/jneurosci.3501-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049211181
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1523/jneurosci.3672-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030758674
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1523/jneurosci.4970-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000226780
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1523/jneurosci.5167-03.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037408797
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1523/jneurosci.5825-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029330255
354 rdf:type schema:CreativeWork
355 https://doi.org/10.15252/emmm.201606210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009287869
356 rdf:type schema:CreativeWork
357 https://doi.org/10.2174/0929866043407174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069157519
358 rdf:type schema:CreativeWork
359 https://doi.org/10.2174/156720511794604561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069189014
360 rdf:type schema:CreativeWork
361 https://doi.org/10.3109/13506120208995241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075193157
362 rdf:type schema:CreativeWork
363 https://doi.org/10.3233/jad-179941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104299492
364 rdf:type schema:CreativeWork
365 https://doi.org/10.3233/jad-2000-23-403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075117827
366 rdf:type schema:CreativeWork
367 https://doi.org/10.3233/jad-2010-1349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078050086
368 rdf:type schema:CreativeWork
369 https://www.grid.ac/institutes/grid.14709.3b schema:alternateName McGill University
370 schema:name Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada
371 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
372 Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.419012.f schema:alternateName MTA Institute of Experimental Medicine
375 schema:name Human Brain Research Laboratory, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
376 Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, Hungary
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...