Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

Keith A. Josephs, Melissa E. Murray, Nirubol Tosakulwong, Jennifer L. Whitwell, David S. Knopman, Mary M. Machulda, Stephen D. Weigand, Bradley F. Boeve, Kejal Kantarci, Leonard Petrucelli, Val J. Lowe, Clifford R. Jack, Ronald C. Petersen, Joseph E. Parisi, Dennis W. Dickson

ABSTRACT

We investigate whether there is any association between the Braak neurofibrillary tangle (NFT) stage and clinical and MRI features in definite primary age-related tauopathy (PART). We analysed 52 cases with a Braak NFT tangle stage >0 and ≤IV, and a Thal phase of 0 (no beta-amyloid present). Twenty-nine (56%) were female. Median age at death was 88 years (IQR 82-92 years). Fifteen (29%) were TDP-positive (75% TDP stage I), 16 (31%) had argyrophilic grain disease and three (6%) had alpha-synuclein-positive Lewy bodies. TDP-43 inclusion when present were rare and predominantly perivascular. Of the 15 with TDP-43, three showed a moderate number of inclusions and also had hippocampal sclerosis, neuronal intranuclear inclusions and fine neurites of the CA1 region of the hippocampus. Four cases (8%) had an apolipoprotein epsilon 4 (APOE4) allele. There was a significant correlation between age at death and Braak NFT stage (r = 0.32, p = 0.02). After accounting for age at clinical examination, there were significant associations between Braak NFT stage, and WAIS-R Block Design and Trail Making Tests A and B, with higher Braak stage associated with poorer performances. Thirty of the 52 cases had completed an antemortem volumetric head MRI. Two separate MRI analyses revealed an association between higher Braak NFT stage and grey matter atrophy in the head of the left hippocampus. There were no significant clinical or radiologic associations with TDP-43. Findings from this study demonstrate that aggregated tau distribution is associated with poorer cognitive performance, as well as atrophy, in the absence of beta-amyloid. These findings support the parcellation of definite PART as a useful construct. The relatively low frequencies of APOE4, TDP-43, Lewy bodies, and hippocampal sclerosis, and the rarity and morphology of TDP-43 lesions are noted contrasts to what is typically observed in Alzheimer's disease of the old. More... »

PAGES

705-715

References to SciGraph publications

  • 1997-10. Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia in ACTA NEUROPATHOLOGICA
  • 2004-10. Lewy body-related α-synucleinopathy in the aged human brain in JOURNAL OF NEURAL TRANSMISSION
  • 2007-02. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 2009-09. Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes in ACTA NEUROPATHOLOGICA
  • 2016-07. Distinct hippocampal functional networks revealed by tractography-based parcellation in BRAIN STRUCTURE AND FUNCTION
  • 2015-01. Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A in ACTA NEUROPATHOLOGICA
  • 2014-12. Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process? in ACTA NEUROPATHOLOGICA
  • 2015-05. PART is part of Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 2014-06. TDP-43 is a key player in the clinical features associated with Alzheimer’s disease in ACTA NEUROPATHOLOGICA
  • 2016-02. Suspected non-Alzheimer disease pathophysiology — concept and controversy in NATURE REVIEWS NEUROLOGY
  • 2014-03. Staging TDP-43 pathology in Alzheimer’s disease in ACTA NEUROPATHOLOGICA
  • 2015-05. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 1994-09. Hippocampal sclerosis: a common pathological feature of dementia in very old (≥80 years of age) humans in ACTA NEUROPATHOLOGICA
  • 1994-12. Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects in ACTA NEUROPATHOLOGICA
  • 2016-04. Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2009-02. Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies in ACTA NEUROPATHOLOGICA
  • 2014-12. Primary age-related tauopathy (PART): a common pathology associated with human aging in ACTA NEUROPATHOLOGICA
  • 1991-09. Neuropathological stageing of Alzheimer-related changes in ACTA NEUROPATHOLOGICA
  • 2016-04. Updated TDP-43 in Alzheimer’s disease staging scheme in ACTA NEUROPATHOLOGICA
  • 2010-01. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-017-1681-2

    DOI

    http://dx.doi.org/10.1007/s00401-017-1681-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083534962

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28160067


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Age Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloidogenic Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Atrophy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cognition", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hippocampus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Magnetic Resonance Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurofibrillary Tangles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tauopathies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "tau Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA", 
                "Movement Disorders, Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Josephs", 
            "givenName": "Keith A.", 
            "id": "sg:person.01157523461.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157523461.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murray", 
            "givenName": "Melissa E.", 
            "id": "sg:person.01004204017.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004204017.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Biostatistics, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tosakulwong", 
            "givenName": "Nirubol", 
            "id": "sg:person.0740742321.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740742321.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Radiology Research, Department of Radiology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Whitwell", 
            "givenName": "Jennifer L.", 
            "id": "sg:person.01226025407.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226025407.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knopman", 
            "givenName": "David S.", 
            "id": "sg:person.0652012300.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652012300.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Machulda", 
            "givenName": "Mary M.", 
            "id": "sg:person.0606064523.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606064523.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Biostatistics, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weigand", 
            "givenName": "Stephen D.", 
            "id": "sg:person.0667230100.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667230100.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boeve", 
            "givenName": "Bradley F.", 
            "id": "sg:person.012724600657.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012724600657.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Radiology Research, Department of Radiology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kantarci", 
            "givenName": "Kejal", 
            "id": "sg:person.0746207130.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746207130.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petrucelli", 
            "givenName": "Leonard", 
            "id": "sg:person.013053751217.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013053751217.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Radiology Research, Department of Radiology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lowe", 
            "givenName": "Val J.", 
            "id": "sg:person.01051441243.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051441243.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Radiology Research, Department of Radiology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jack", 
            "givenName": "Clifford R.", 
            "id": "sg:person.01033737345.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033737345.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petersen", 
            "givenName": "Ronald C.", 
            "id": "sg:person.014432725357.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014432725357.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Neuropathology, Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parisi", 
            "givenName": "Joseph E.", 
            "id": "sg:person.010522331157.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522331157.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dickson", 
            "givenName": "Dennis W.", 
            "id": "sg:person.011647727137.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011647727137.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00308809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000355620", 
              "https://doi.org/10.1007/bf00308809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hipo.10064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001003013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/13825585.2013.795513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002041297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-016-1537-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002487851", 
              "https://doi.org/10.1007/s00401-016-1537-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.1998.tb00161.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002697999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.21154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003068291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0612-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003434425", 
              "https://doi.org/10.1007/s00401-009-0612-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0612-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003434425", 
              "https://doi.org/10.1007/s00401-009-0612-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0612-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003434425", 
              "https://doi.org/10.1007/s00401-009-0612-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aww224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004576006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(97)00057-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006788135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-004-0138-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007183146", 
              "https://doi.org/10.1007/s00702-004-0138-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1983.01790060110016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007616067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/nimg.2001.0978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008623590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1356-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008707168", 
              "https://doi.org/10.1007/s00401-014-1356-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010354536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(07)70266-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010947337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00296494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011522454", 
              "https://doi.org/10.1007/bf00296494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0547-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012288115", 
              "https://doi.org/10.1007/s00401-009-0547-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0547-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012288115", 
              "https://doi.org/10.1007/s00401-009-0547-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0547-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012288115", 
              "https://doi.org/10.1007/s00401-009-0547-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(11)70156-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013093224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1407-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014650794", 
              "https://doi.org/10.1007/s00401-015-1407-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1390-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014972059", 
              "https://doi.org/10.1007/s00401-015-1390-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1390-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014972059", 
              "https://doi.org/10.1007/s00401-015-1390-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-150435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015041004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00293396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017937814", 
              "https://doi.org/10.1007/bf00293396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-008-0480-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019079347", 
              "https://doi.org/10.1007/s00401-008-0480-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-008-0480-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019079347", 
              "https://doi.org/10.1007/s00401-008-0480-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2010.254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019140962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1269-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021261642", 
              "https://doi.org/10.1007/s00401-014-1269-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022350341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0270(94)90168-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023002135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0270(94)90168-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023002135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jns.2008.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023493643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.23816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026607352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneurol.2015.251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027476388", 
              "https://doi.org/10.1038/nrneurol.2015.251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-016-0149-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028361715", 
              "https://doi.org/10.1007/s10654-016-0149-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-016-0149-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028361715", 
              "https://doi.org/10.1007/s10654-016-0149-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/62.11.1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029536277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nen.0b013e31816a12a6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032876283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cortex.2013.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033905466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1349-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036179092", 
              "https://doi.org/10.1007/s00401-014-1349-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/61.6.547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036906035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-1063(1999)9:1<7::aid-hipo2>3.0.co;2-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037122080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0156-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037387092", 
              "https://doi.org/10.1007/s00401-006-0156-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0156-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037387092", 
              "https://doi.org/10.1007/s00401-006-0156-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2990.1986.tb00136.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041210216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/61.11.935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043055553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awv050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043824278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00429-015-1084-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045070637", 
              "https://doi.org/10.1007/s00429-015-1084-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nen.0b013e3181baacec", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046181018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048473262", 
              "https://doi.org/10.1007/s004010050726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(12)70200-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048869471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1211-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049580963", 
              "https://doi.org/10.1007/s00401-013-1211-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-199702000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050316680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1358-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053117083", 
              "https://doi.org/10.1007/s00401-014-1358-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/13854040590945201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058388629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/nlw033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059822207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/nlw033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059822207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000150892.81839.d1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000150892.81839.d1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000150892.81839.d1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.41.4.479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064369901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.44.11.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064372130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.58.12.1791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.58.12.1791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.58.12.1791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.58.5.838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.58.5.838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.58.5.838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079248810", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.29245/2572.942x/2016/6.1059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079351635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.18-05-01841.1998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083211661"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05", 
        "datePublishedReg": "2017-05-01", 
        "description": "We investigate whether there is any association between the Braak neurofibrillary tangle (NFT) stage and clinical and MRI features in definite primary age-related tauopathy (PART). We analysed 52 cases with a Braak NFT tangle stage >0 and\u00a0\u2264IV, and a Thal phase of 0 (no beta-amyloid present). Twenty-nine (56%) were female. Median age at death was 88\u00a0years (IQR 82-92\u00a0years). Fifteen (29%) were TDP-positive (75% TDP stage I), 16 (31%) had argyrophilic grain disease and three (6%) had alpha-synuclein-positive Lewy bodies. TDP-43 inclusion when present were rare and predominantly perivascular. Of the 15 with TDP-43, three showed a moderate number of inclusions and also had hippocampal sclerosis, neuronal intranuclear inclusions and fine neurites of the CA1 region of the hippocampus. Four cases (8%) had an apolipoprotein epsilon 4 (APOE4) allele. There was a significant correlation between age at death and Braak NFT stage (r\u00a0=\u00a00.32, p\u00a0=\u00a00.02). After accounting for age at clinical examination, there were significant associations between Braak NFT stage, and WAIS-R Block Design and Trail Making Tests A and B, with higher Braak stage associated with poorer performances. Thirty of the 52 cases had completed an antemortem volumetric head MRI. Two separate MRI analyses revealed an association between higher Braak NFT stage and grey matter atrophy in the head of the left hippocampus. There were no significant clinical or radiologic associations with TDP-43. Findings from this study demonstrate that aggregated tau distribution is associated with poorer cognitive performance, as well as atrophy, in the absence of beta-amyloid. These findings support the parcellation of definite PART as a useful construct. The relatively low frequencies of APOE4, TDP-43, Lewy bodies, and hippocampal sclerosis, and the rarity and morphology of TDP-43 lesions are noted contrasts to what is typically observed in Alzheimer's disease of the old.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00401-017-1681-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2440028", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448735", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448968", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448856", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2686916", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2445992", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "133"
          }
        ], 
        "name": "Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART)", 
        "pagination": "705-715", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "879a17b7d859fc8e0d00804fb2b10dadf938ebda78ee4062814dbd58261f987f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28160067"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0412041"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00401-017-1681-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083534962"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00401-017-1681-2", 
          "https://app.dimensions.ai/details/publication/pub.1083534962"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:34", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113661_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00401-017-1681-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-017-1681-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-017-1681-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-017-1681-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-017-1681-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    435 TRIPLES      21 PREDICATES      101 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00401-017-1681-2 schema:about N0206e948544e4940a2747fd4b1fc146b
    2 N27bab1f8041843c5b3920d67f93f0462
    3 N6a52b868f4764f12afcc064a1713159d
    4 N798d337e6a024e1b85339423d41a83a2
    5 N96c150e00e91409e9ea69aedfcf209c5
    6 Nafccbec533774b50839bac660f4c6c6e
    7 Nbb1ecf01aa124c16875296c8ee3c6bfb
    8 Nbb985bd8d6614e3da0c26adf030d52a0
    9 Nbc51f39670d94e7790a64e9713793ae0
    10 Nca8b98f34b95453b84cf397c69794c2b
    11 Ncc398bb229f8416392ed2196045961b3
    12 Ncd90f7771ca84e359676b29c654ac02a
    13 Nd62a1c6bff6147db98fd1f6e9262a9fa
    14 anzsrc-for:11
    15 anzsrc-for:1109
    16 schema:author N18385b2b67af4b2cbfef742f5ecf17e9
    17 schema:citation sg:pub.10.1007/bf00293396
    18 sg:pub.10.1007/bf00296494
    19 sg:pub.10.1007/bf00308809
    20 sg:pub.10.1007/s00401-006-0156-7
    21 sg:pub.10.1007/s00401-008-0480-1
    22 sg:pub.10.1007/s00401-009-0547-7
    23 sg:pub.10.1007/s00401-009-0612-2
    24 sg:pub.10.1007/s00401-013-1211-9
    25 sg:pub.10.1007/s00401-014-1269-z
    26 sg:pub.10.1007/s00401-014-1349-0
    27 sg:pub.10.1007/s00401-014-1356-1
    28 sg:pub.10.1007/s00401-014-1358-z
    29 sg:pub.10.1007/s00401-015-1390-7
    30 sg:pub.10.1007/s00401-015-1407-2
    31 sg:pub.10.1007/s00401-016-1537-1
    32 sg:pub.10.1007/s004010050726
    33 sg:pub.10.1007/s00429-015-1084-x
    34 sg:pub.10.1007/s00702-004-0138-7
    35 sg:pub.10.1007/s10654-016-0149-3
    36 sg:pub.10.1038/nrneurol.2015.251
    37 https://app.dimensions.ai/details/publication/pub.1079248810
    38 https://doi.org/10.1001/archneurol.2010.254
    39 https://doi.org/10.1001/archpsyc.1983.01790060110016
    40 https://doi.org/10.1002/(sici)1098-1063(1999)9:1<7::aid-hipo2>3.0.co;2-k
    41 https://doi.org/10.1002/ana.21154
    42 https://doi.org/10.1002/ana.23816
    43 https://doi.org/10.1002/ana.24493
    44 https://doi.org/10.1002/hipo.10064
    45 https://doi.org/10.1006/nimg.2001.0978
    46 https://doi.org/10.1016/0165-0270(94)90168-6
    47 https://doi.org/10.1016/j.cortex.2013.12.012
    48 https://doi.org/10.1016/j.jns.2008.06.008
    49 https://doi.org/10.1016/s0197-4580(97)00057-2
    50 https://doi.org/10.1016/s1474-4422(07)70266-1
    51 https://doi.org/10.1016/s1474-4422(11)70156-9
    52 https://doi.org/10.1016/s1474-4422(12)70200-4
    53 https://doi.org/10.1080/13825585.2013.795513
    54 https://doi.org/10.1080/13854040590945201
    55 https://doi.org/10.1093/brain/awv050
    56 https://doi.org/10.1093/brain/aww224
    57 https://doi.org/10.1093/jnen/61.11.935
    58 https://doi.org/10.1093/jnen/61.6.547
    59 https://doi.org/10.1093/jnen/62.11.1087
    60 https://doi.org/10.1093/jnen/nlw033
    61 https://doi.org/10.1097/00005072-199702000-00006
    62 https://doi.org/10.1097/nen.0b013e31816a12a6
    63 https://doi.org/10.1097/nen.0b013e3181baacec
    64 https://doi.org/10.1111/bpa.12424
    65 https://doi.org/10.1111/j.1365-2990.1986.tb00136.x
    66 https://doi.org/10.1111/j.1750-3639.1998.tb00161.x
    67 https://doi.org/10.1212/01.wnl.0000150892.81839.d1
    68 https://doi.org/10.1212/01.wnl.0000187889.17253.b1
    69 https://doi.org/10.1212/wnl.41.4.479
    70 https://doi.org/10.1212/wnl.44.11.2015
    71 https://doi.org/10.1212/wnl.58.12.1791
    72 https://doi.org/10.1212/wnl.58.5.838
    73 https://doi.org/10.1523/jneurosci.18-05-01841.1998
    74 https://doi.org/10.29245/2572.942x/2016/6.1059
    75 https://doi.org/10.3233/jad-150435
    76 schema:datePublished 2017-05
    77 schema:datePublishedReg 2017-05-01
    78 schema:description We investigate whether there is any association between the Braak neurofibrillary tangle (NFT) stage and clinical and MRI features in definite primary age-related tauopathy (PART). We analysed 52 cases with a Braak NFT tangle stage >0 and ≤IV, and a Thal phase of 0 (no beta-amyloid present). Twenty-nine (56%) were female. Median age at death was 88 years (IQR 82-92 years). Fifteen (29%) were TDP-positive (75% TDP stage I), 16 (31%) had argyrophilic grain disease and three (6%) had alpha-synuclein-positive Lewy bodies. TDP-43 inclusion when present were rare and predominantly perivascular. Of the 15 with TDP-43, three showed a moderate number of inclusions and also had hippocampal sclerosis, neuronal intranuclear inclusions and fine neurites of the CA1 region of the hippocampus. Four cases (8%) had an apolipoprotein epsilon 4 (APOE4) allele. There was a significant correlation between age at death and Braak NFT stage (r = 0.32, p = 0.02). After accounting for age at clinical examination, there were significant associations between Braak NFT stage, and WAIS-R Block Design and Trail Making Tests A and B, with higher Braak stage associated with poorer performances. Thirty of the 52 cases had completed an antemortem volumetric head MRI. Two separate MRI analyses revealed an association between higher Braak NFT stage and grey matter atrophy in the head of the left hippocampus. There were no significant clinical or radiologic associations with TDP-43. Findings from this study demonstrate that aggregated tau distribution is associated with poorer cognitive performance, as well as atrophy, in the absence of beta-amyloid. These findings support the parcellation of definite PART as a useful construct. The relatively low frequencies of APOE4, TDP-43, Lewy bodies, and hippocampal sclerosis, and the rarity and morphology of TDP-43 lesions are noted contrasts to what is typically observed in Alzheimer's disease of the old.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree false
    82 schema:isPartOf N906227fa1c3d49ef845c656b80bd2692
    83 Nc70077ca83b549f2a04658051db9824e
    84 sg:journal.1019073
    85 schema:name Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART)
    86 schema:pagination 705-715
    87 schema:productId N1e31a7a978f64c0bbb197fa4f16749b0
    88 N3c4bd232e34c416fa48ebe9a94d29915
    89 N800520a557384371a6932e84bb7eb94c
    90 Nb1794f7344e84bfca714c3c71053e31e
    91 Necc2ce033037438783fbe05ad4f9f7f5
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083534962
    93 https://doi.org/10.1007/s00401-017-1681-2
    94 schema:sdDatePublished 2019-04-11T10:34
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher N363811da3ec84417b8ab51084b49f31f
    97 schema:url https://link.springer.com/10.1007%2Fs00401-017-1681-2
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N0206e948544e4940a2747fd4b1fc146b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Cognition
    103 rdf:type schema:DefinedTerm
    104 N049a61ae9bf54126b3e9a5b1232d168b rdf:first sg:person.01051441243.03
    105 rdf:rest Nbbb966cf6bdb449d9a9711cf422646c9
    106 N18385b2b67af4b2cbfef742f5ecf17e9 rdf:first sg:person.01157523461.64
    107 rdf:rest N672567f01f92439eb7bd1a08ea2dcb05
    108 N1e31a7a978f64c0bbb197fa4f16749b0 schema:name readcube_id
    109 schema:value 879a17b7d859fc8e0d00804fb2b10dadf938ebda78ee4062814dbd58261f987f
    110 rdf:type schema:PropertyValue
    111 N27bab1f8041843c5b3920d67f93f0462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name tau Proteins
    113 rdf:type schema:DefinedTerm
    114 N363811da3ec84417b8ab51084b49f31f schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N3901a85fcb164c73a7624658d719208b rdf:first sg:person.014432725357.54
    117 rdf:rest N413d83ce6ced4a1f8fb0eeff5c98f08f
    118 N3c4bd232e34c416fa48ebe9a94d29915 schema:name nlm_unique_id
    119 schema:value 0412041
    120 rdf:type schema:PropertyValue
    121 N413d83ce6ced4a1f8fb0eeff5c98f08f rdf:first sg:person.010522331157.67
    122 rdf:rest Nd8b401772b4d4b16ad66a8f59dbb6496
    123 N45f0213b330843e2806f374c43402f87 rdf:first sg:person.013053751217.40
    124 rdf:rest N049a61ae9bf54126b3e9a5b1232d168b
    125 N4c1839dfef2448ef901bb48796bd6fec rdf:first sg:person.012724600657.13
    126 rdf:rest Nfb292e371b92456e947810d7399d5305
    127 N5c1de38521614a1e908240c90cc87a51 rdf:first sg:person.0667230100.16
    128 rdf:rest N4c1839dfef2448ef901bb48796bd6fec
    129 N65054b7a42ae4180b630476fbcf5ffeb rdf:first sg:person.0606064523.50
    130 rdf:rest N5c1de38521614a1e908240c90cc87a51
    131 N672567f01f92439eb7bd1a08ea2dcb05 rdf:first sg:person.01004204017.25
    132 rdf:rest Nae4b352ac6bb43f28be8fb67a98e3cdf
    133 N6a52b868f4764f12afcc064a1713159d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Atrophy
    135 rdf:type schema:DefinedTerm
    136 N798d337e6a024e1b85339423d41a83a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Tauopathies
    138 rdf:type schema:DefinedTerm
    139 N800520a557384371a6932e84bb7eb94c schema:name doi
    140 schema:value 10.1007/s00401-017-1681-2
    141 rdf:type schema:PropertyValue
    142 N906227fa1c3d49ef845c656b80bd2692 schema:issueNumber 5
    143 rdf:type schema:PublicationIssue
    144 N91666e93bae94d5f8bf762457de364fe rdf:first sg:person.0652012300.82
    145 rdf:rest N65054b7a42ae4180b630476fbcf5ffeb
    146 N96c150e00e91409e9ea69aedfcf209c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Female
    148 rdf:type schema:DefinedTerm
    149 Na22d65eaabe54e27850bcd2341e9c5bf rdf:first sg:person.01226025407.86
    150 rdf:rest N91666e93bae94d5f8bf762457de364fe
    151 Nae4b352ac6bb43f28be8fb67a98e3cdf rdf:first sg:person.0740742321.46
    152 rdf:rest Na22d65eaabe54e27850bcd2341e9c5bf
    153 Nafccbec533774b50839bac660f4c6c6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Magnetic Resonance Imaging
    155 rdf:type schema:DefinedTerm
    156 Nb1794f7344e84bfca714c3c71053e31e schema:name dimensions_id
    157 schema:value pub.1083534962
    158 rdf:type schema:PropertyValue
    159 Nbb1ecf01aa124c16875296c8ee3c6bfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Age Factors
    161 rdf:type schema:DefinedTerm
    162 Nbb985bd8d6614e3da0c26adf030d52a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Hippocampus
    164 rdf:type schema:DefinedTerm
    165 Nbbb966cf6bdb449d9a9711cf422646c9 rdf:first sg:person.01033737345.96
    166 rdf:rest N3901a85fcb164c73a7624658d719208b
    167 Nbc51f39670d94e7790a64e9713793ae0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Aged, 80 and over
    169 rdf:type schema:DefinedTerm
    170 Nc70077ca83b549f2a04658051db9824e schema:volumeNumber 133
    171 rdf:type schema:PublicationVolume
    172 Nca8b98f34b95453b84cf397c69794c2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Male
    174 rdf:type schema:DefinedTerm
    175 Ncc398bb229f8416392ed2196045961b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Neurofibrillary Tangles
    177 rdf:type schema:DefinedTerm
    178 Ncd90f7771ca84e359676b29c654ac02a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Amyloidogenic Proteins
    180 rdf:type schema:DefinedTerm
    181 Nd62a1c6bff6147db98fd1f6e9262a9fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Humans
    183 rdf:type schema:DefinedTerm
    184 Nd8b401772b4d4b16ad66a8f59dbb6496 rdf:first sg:person.011647727137.86
    185 rdf:rest rdf:nil
    186 Necc2ce033037438783fbe05ad4f9f7f5 schema:name pubmed_id
    187 schema:value 28160067
    188 rdf:type schema:PropertyValue
    189 Nfb292e371b92456e947810d7399d5305 rdf:first sg:person.0746207130.05
    190 rdf:rest N45f0213b330843e2806f374c43402f87
    191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Medical and Health Sciences
    193 rdf:type schema:DefinedTerm
    194 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    195 schema:name Neurosciences
    196 rdf:type schema:DefinedTerm
    197 sg:grant.2440028 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-017-1681-2
    198 rdf:type schema:MonetaryGrant
    199 sg:grant.2445992 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-017-1681-2
    200 rdf:type schema:MonetaryGrant
    201 sg:grant.2448735 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-017-1681-2
    202 rdf:type schema:MonetaryGrant
    203 sg:grant.2448856 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-017-1681-2
    204 rdf:type schema:MonetaryGrant
    205 sg:grant.2448968 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-017-1681-2
    206 rdf:type schema:MonetaryGrant
    207 sg:grant.2686916 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-017-1681-2
    208 rdf:type schema:MonetaryGrant
    209 sg:journal.1019073 schema:issn 0001-6322
    210 1432-0533
    211 schema:name Acta Neuropathologica
    212 rdf:type schema:Periodical
    213 sg:person.01004204017.25 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
    214 schema:familyName Murray
    215 schema:givenName Melissa E.
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004204017.25
    217 rdf:type schema:Person
    218 sg:person.01033737345.96 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    219 schema:familyName Jack
    220 schema:givenName Clifford R.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033737345.96
    222 rdf:type schema:Person
    223 sg:person.01051441243.03 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    224 schema:familyName Lowe
    225 schema:givenName Val J.
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051441243.03
    227 rdf:type schema:Person
    228 sg:person.010522331157.67 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    229 schema:familyName Parisi
    230 schema:givenName Joseph E.
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522331157.67
    232 rdf:type schema:Person
    233 sg:person.01157523461.64 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    234 schema:familyName Josephs
    235 schema:givenName Keith A.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157523461.64
    237 rdf:type schema:Person
    238 sg:person.011647727137.86 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
    239 schema:familyName Dickson
    240 schema:givenName Dennis W.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011647727137.86
    242 rdf:type schema:Person
    243 sg:person.01226025407.86 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    244 schema:familyName Whitwell
    245 schema:givenName Jennifer L.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226025407.86
    247 rdf:type schema:Person
    248 sg:person.012724600657.13 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    249 schema:familyName Boeve
    250 schema:givenName Bradley F.
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012724600657.13
    252 rdf:type schema:Person
    253 sg:person.013053751217.40 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
    254 schema:familyName Petrucelli
    255 schema:givenName Leonard
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013053751217.40
    257 rdf:type schema:Person
    258 sg:person.014432725357.54 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    259 schema:familyName Petersen
    260 schema:givenName Ronald C.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014432725357.54
    262 rdf:type schema:Person
    263 sg:person.0606064523.50 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    264 schema:familyName Machulda
    265 schema:givenName Mary M.
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606064523.50
    267 rdf:type schema:Person
    268 sg:person.0652012300.82 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    269 schema:familyName Knopman
    270 schema:givenName David S.
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652012300.82
    272 rdf:type schema:Person
    273 sg:person.0667230100.16 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    274 schema:familyName Weigand
    275 schema:givenName Stephen D.
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667230100.16
    277 rdf:type schema:Person
    278 sg:person.0740742321.46 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    279 schema:familyName Tosakulwong
    280 schema:givenName Nirubol
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740742321.46
    282 rdf:type schema:Person
    283 sg:person.0746207130.05 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    284 schema:familyName Kantarci
    285 schema:givenName Kejal
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746207130.05
    287 rdf:type schema:Person
    288 sg:pub.10.1007/bf00293396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017937814
    289 https://doi.org/10.1007/bf00293396
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1007/bf00296494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011522454
    292 https://doi.org/10.1007/bf00296494
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
    295 https://doi.org/10.1007/bf00308809
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/s00401-006-0156-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037387092
    298 https://doi.org/10.1007/s00401-006-0156-7
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/s00401-008-0480-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019079347
    301 https://doi.org/10.1007/s00401-008-0480-1
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s00401-009-0547-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012288115
    304 https://doi.org/10.1007/s00401-009-0547-7
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s00401-009-0612-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003434425
    307 https://doi.org/10.1007/s00401-009-0612-2
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1007/s00401-013-1211-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049580963
    310 https://doi.org/10.1007/s00401-013-1211-9
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1007/s00401-014-1269-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1021261642
    313 https://doi.org/10.1007/s00401-014-1269-z
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1007/s00401-014-1349-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036179092
    316 https://doi.org/10.1007/s00401-014-1349-0
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1007/s00401-014-1356-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008707168
    319 https://doi.org/10.1007/s00401-014-1356-1
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1007/s00401-014-1358-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1053117083
    322 https://doi.org/10.1007/s00401-014-1358-z
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/s00401-015-1390-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014972059
    325 https://doi.org/10.1007/s00401-015-1390-7
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s00401-015-1407-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014650794
    328 https://doi.org/10.1007/s00401-015-1407-2
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/s00401-016-1537-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002487851
    331 https://doi.org/10.1007/s00401-016-1537-1
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/s004010050726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048473262
    334 https://doi.org/10.1007/s004010050726
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/s00429-015-1084-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045070637
    337 https://doi.org/10.1007/s00429-015-1084-x
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1007/s00702-004-0138-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007183146
    340 https://doi.org/10.1007/s00702-004-0138-7
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1007/s10654-016-0149-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028361715
    343 https://doi.org/10.1007/s10654-016-0149-3
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nrneurol.2015.251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027476388
    346 https://doi.org/10.1038/nrneurol.2015.251
    347 rdf:type schema:CreativeWork
    348 https://app.dimensions.ai/details/publication/pub.1079248810 schema:CreativeWork
    349 https://doi.org/10.1001/archneurol.2010.254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019140962
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1001/archpsyc.1983.01790060110016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007616067
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1002/(sici)1098-1063(1999)9:1<7::aid-hipo2>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1037122080
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1002/ana.21154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003068291
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1002/ana.23816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026607352
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1002/ana.24493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022350341
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1002/hipo.10064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001003013
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1006/nimg.2001.0978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008623590
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/0165-0270(94)90168-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023002135
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/j.cortex.2013.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033905466
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.jns.2008.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023493643
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/s0197-4580(97)00057-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006788135
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/s1474-4422(07)70266-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010947337
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/s1474-4422(11)70156-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013093224
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/s1474-4422(12)70200-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048869471
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1080/13825585.2013.795513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002041297
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1080/13854040590945201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058388629
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1093/brain/awv050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043824278
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1093/brain/aww224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004576006
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1093/jnen/61.11.935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043055553
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1093/jnen/61.6.547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036906035
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1093/jnen/62.11.1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029536277
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1093/jnen/nlw033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059822207
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1097/00005072-199702000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050316680
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1097/nen.0b013e31816a12a6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032876283
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1097/nen.0b013e3181baacec schema:sameAs https://app.dimensions.ai/details/publication/pub.1046181018
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1111/bpa.12424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010354536
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1111/j.1365-2990.1986.tb00136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041210216
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1111/j.1750-3639.1998.tb00161.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002697999
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1212/01.wnl.0000150892.81839.d1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346784
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1212/01.wnl.0000187889.17253.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347654
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1212/wnl.41.4.479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064369901
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1212/wnl.44.11.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064372130
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1212/wnl.58.12.1791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064380472
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1212/wnl.58.5.838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064380680
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1523/jneurosci.18-05-01841.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083211661
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.29245/2572.942x/2016/6.1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079351635
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.3233/jad-150435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015041004
    424 rdf:type schema:CreativeWork
    425 https://www.grid.ac/institutes/grid.417467.7 schema:alternateName Mayo Clinic
    426 schema:name Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    427 rdf:type schema:Organization
    428 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
    429 schema:name Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA
    430 Biostatistics, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA
    431 Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
    432 Movement Disorders, Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN, USA
    433 Neuropathology, Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    434 Radiology Research, Department of Radiology, Mayo Clinic, Rochester, MN, USA
    435 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...