Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01

AUTHORS

Andrey Korshunov, David Capper, David Reuss, Daniel Schrimpf, Marina Ryzhova, Volker Hovestadt, Dominik Sturm, Jochen Meyer, Chris Jones, Olga Zheludkova, Ella Kumirova, Andrey Golanov, Marcel Kool, Ulrich Schüller, Michel Mittelbronn, Martin Hasselblatt, Jens Schittenhelm, Guido Reifenberger, Christel Herold-Mende, Peter Lichter, Andreas von Deimling, Stefan M. Pfister, David T. W. Jones

ABSTRACT

In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of neoplasms, with microscopic characteristics typical of either glioblastoma (GBM) or central nervous system primitive neuroectodermal tumors (CNS-PNET). In the current study, we performed an integrative clinical, histopathological and molecular analysis of 81 G34-mutant CNS tumors. Routinely prepared tumor tissues were investigated for genomic and epigenomic alterations. Despite their divergent histopathological appearance, CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Comparative cytogenetic analysis with other GBM subtypes disclosed a high frequency and high specificity of 3q and 4q loss across G34-mutant tumors. PDGFRA amplification was more common in cases with GBM than with PNET morphology (36 vs. 5 %, respectively), while CCND2 amplifications showed the opposite trend (5 vs. 27 %). Survival analysis revealed the presence of amplified oncogene(s) and MGMT methylation as independent prognostic markers for poor and favorable outcomes, respectively. No difference in outcome was found between morphological variants (GBM vs. PNET). Thus, different histological variants of G34-mutant CNS tumors likely comprise a single biological entity (high-grade glioma with H3 G34 mutation, HGG_G34), which should be outlined in future diagnostic and therapeutic classifications. Screening for H3.3 G34 mutation should therefore be recommended as a routine diagnostic marker for supratentorial CNS tumors across a broad histological spectrum. More... »

PAGES

137-146

References to SciGraph publications

  • 2015-06. Histone H3 mutations—a special role for H3.3 in tumorigenesis? in CHROMOSOMA
  • 2014-02. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge in NATURE REVIEWS CANCER
  • 2012-07. Paediatric and adult malignant glioma: close relatives or distant cousins? in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2013-06. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays in ACTA NEUROPATHOLOGICA
  • 2012-10. MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status in ACTA NEUROPATHOLOGICA
  • 2015-09. Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities in ACTA NEUROPATHOLOGICA
  • 2015-01. ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma in ACTA NEUROPATHOLOGICA
  • 2013-12. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone in NATURE GENETICS
  • 2015-05. Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers in ACTA NEUROPATHOLOGICA
  • 2013-03. H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: possible diagnostic and therapeutic implications? in JOURNAL OF NEURO-ONCOLOGY
  • 2015-09. Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain in ACTA NEUROPATHOLOGICA
  • 2012-03. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas in NATURE GENETICS
  • 2012-02. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-015-1493-1

    DOI

    http://dx.doi.org/10.1007/s00401-015-1493-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047152106

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26482474


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Central Nervous System Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Supratentorial Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korshunov", 
            "givenName": "Andrey", 
            "id": "sg:person.013472071457.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013472071457.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Capper", 
            "givenName": "David", 
            "id": "sg:person.01043273753.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043273753.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reuss", 
            "givenName": "David", 
            "id": "sg:person.01074367672.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074367672.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schrimpf", 
            "givenName": "Daniel", 
            "id": "sg:person.01234464637.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234464637.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Burdenko Neurosurgery Institute", 
              "id": "https://www.grid.ac/institutes/grid.418542.e", 
              "name": [
                "Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ryzhova", 
            "givenName": "Marina", 
            "id": "sg:person.01220632656.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220632656.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics (B060), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hovestadt", 
            "givenName": "Volker", 
            "id": "sg:person.0610463215.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610463215.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sturm", 
            "givenName": "Dominik", 
            "id": "sg:person.01124352515.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124352515.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyer", 
            "givenName": "Jochen", 
            "id": "sg:person.0720442334.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720442334.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.18886.3f", 
              "name": [
                "Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, Sutton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jones", 
            "givenName": "Chris", 
            "id": "sg:person.0707750521.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707750521.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Neuro-Oncology, Russian Scientific Center of Radiology, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheludkova", 
            "givenName": "Olga", 
            "id": "sg:person.0606224075.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606224075.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Neuro-Oncology, Federal Research Clinical Center for Pediatric Hematology, Oncology, Immunology, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumirova", 
            "givenName": "Ella", 
            "id": "sg:person.015000331624.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015000331624.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Burdenko Neurosurgery Institute", 
              "id": "https://www.grid.ac/institutes/grid.418542.e", 
              "name": [
                "Department of Neuroradiology, NN Burdenko Neurosurgical Institute, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Golanov", 
            "givenName": "Andrey", 
            "id": "sg:person.01327726046.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327726046.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kool", 
            "givenName": "Marcel", 
            "id": "sg:person.01206710443.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206710443.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Center of Neuropathology, L\u00fcdwig-Maximilians University, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sch\u00fcller", 
            "givenName": "Ulrich", 
            "id": "sg:person.0657747327.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657747327.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mittelbronn", 
            "givenName": "Michel", 
            "id": "sg:person.0750466144.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750466144.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital M\u00fcnster", 
              "id": "https://www.grid.ac/institutes/grid.16149.3b", 
              "name": [
                "Institute of Neuropathology, University Hospital M\u00fcnster, M\u00fcnster, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hasselblatt", 
            "givenName": "Martin", 
            "id": "sg:person.01137070015.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137070015.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Neuropathology, Institute of Pathology and Neuropathology, University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schittenhelm", 
            "givenName": "Jens", 
            "id": "sg:person.0607426433.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607426433.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Neuropathology, Heinrich Heine University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reifenberger", 
            "givenName": "Guido", 
            "id": "sg:person.07524506162.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07524506162.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herold-Mende", 
            "givenName": "Christel", 
            "id": "sg:person.0767624634.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767624634.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Molecular Genetics (B060), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lichter", 
            "givenName": "Peter", 
            "id": "sg:person.01243467607.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243467607.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "von Deimling", 
            "givenName": "Andreas", 
            "id": "sg:person.0627772654.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627772654.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfister", 
            "givenName": "Stefan M.", 
            "id": "sg:person.01105171247.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105171247.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jones", 
            "givenName": "David T. W.", 
            "id": "sg:person.011536141544.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011536141544.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00401-014-1370-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000424731", 
              "https://doi.org/10.1007/s00401-014-1370-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-012-1040-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004520618", 
              "https://doi.org/10.1007/s11060-012-1040-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0113315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004751447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008445918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1126-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008994603", 
              "https://doi.org/10.1007/s00401-013-1126-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1126-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008994603", 
              "https://doi.org/10.1007/s00401-013-1126-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1454-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011884053", 
              "https://doi.org/10.1007/s00401-015-1454-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2012.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012234461", 
              "https://doi.org/10.1038/nrclinonc.2012.87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1427-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012407663", 
              "https://doi.org/10.1007/s00401-015-1427-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/noq191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020301368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-015-0510-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023430113", 
              "https://doi.org/10.1007/s00412-015-0510-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-015-0510-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023430113", 
              "https://doi.org/10.1007/s00412-015-0510-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1405-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025614916", 
              "https://doi.org/10.1007/s00401-015-1405-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-012-1016-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027095253", 
              "https://doi.org/10.1007/s00401-012-1016-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.26063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028421423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/ajcpabohbc33fvmo", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030389703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1232245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030869536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.7252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030916565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1167/iovs.06-0101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032928739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/erc-08-0241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033370270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036111867", 
              "https://doi.org/10.1038/nrc3655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/1.2.152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039524270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039575824", 
              "https://doi.org/10.1038/nature10833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043810887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.09.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044472205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)71206-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047737828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048296872", 
              "https://doi.org/10.1038/ng.1102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049677077", 
              "https://doi.org/10.1038/ng.2814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052838309"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-01", 
        "datePublishedReg": "2016-01-01", 
        "description": "In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of neoplasms, with microscopic characteristics typical of either glioblastoma (GBM) or central nervous system primitive neuroectodermal tumors (CNS-PNET). In the current study, we performed an integrative clinical, histopathological and molecular analysis of 81 G34-mutant CNS tumors. Routinely prepared tumor tissues were investigated for genomic and epigenomic alterations. Despite their divergent histopathological appearance, CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Comparative cytogenetic analysis with other GBM subtypes disclosed a high frequency and high specificity of 3q and 4q loss across G34-mutant tumors. PDGFRA amplification was more common in cases with GBM than with PNET morphology (36 vs. 5 %, respectively), while CCND2 amplifications showed the opposite trend (5 vs. 27 %). Survival analysis revealed the presence of amplified oncogene(s) and MGMT methylation as independent prognostic markers for poor and favorable outcomes, respectively. No difference in outcome was found between morphological variants (GBM vs. PNET). Thus, different histological variants of G34-mutant CNS tumors likely comprise a single biological entity (high-grade glioma with H3 G34 mutation, HGG_G34), which should be outlined in future diagnostic and therapeutic classifications. Screening for H3.3 G34 mutation should therefore be recommended as a routine diagnostic marker for supratentorial CNS tumors across a broad histological spectrum.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00401-015-1493-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4579368", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "131"
          }
        ], 
        "name": "Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity", 
        "pagination": "137-146", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e09df6cd96e51f2b007afa5b3bbc3f41fef530eb604ff8c34eea2125f396498a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26482474"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0412041"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00401-015-1493-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1047152106"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00401-015-1493-1", 
          "https://app.dimensions.ai/details/publication/pub.1047152106"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000491.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s00401-015-1493-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1493-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1493-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1493-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1493-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    417 TRIPLES      21 PREDICATES      71 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00401-015-1493-1 schema:about N02236d81cd36468cbcac723f598dd833
    2 N02c5ed91a0404bda99eaa099acf60946
    3 N26d0c6a0b1874954ba0f95529bdc6503
    4 N3e94e454912841c6b31316680d8c39e2
    5 N40f2dfc745c8440c9bf463af786bc564
    6 N6b6e89f536034b3698a7e9b0c2a5e2eb
    7 N7d50bfe7b7bd42ca916a39275198ae8c
    8 Naf5291808f9e48029b51c52354653c69
    9 Nbcf27fc032364f6497a351879181c0f0
    10 Nc47de1a73a804598a2e1bd642be2ea77
    11 Nc9a98c8d32f142a98408567caa51446e
    12 Nd6ca86b4198e46b1a28d138e1574a4bb
    13 Ndd0f99ca2cdd49ceb9112de67863e4f0
    14 Nebace9490b7b4739b6277c512abb9262
    15 Nffd6d9f1722542d2809b12cdefca7d2c
    16 anzsrc-for:06
    17 anzsrc-for:0604
    18 schema:author Nf7b2df5e79734668ad4e0fb2f94363fe
    19 schema:citation sg:pub.10.1007/s00401-012-1016-2
    20 sg:pub.10.1007/s00401-013-1126-5
    21 sg:pub.10.1007/s00401-014-1370-3
    22 sg:pub.10.1007/s00401-015-1405-4
    23 sg:pub.10.1007/s00401-015-1427-y
    24 sg:pub.10.1007/s00401-015-1454-8
    25 sg:pub.10.1007/s00412-015-0510-4
    26 sg:pub.10.1007/s11060-012-1040-z
    27 sg:pub.10.1038/nature10833
    28 sg:pub.10.1038/ng.1102
    29 sg:pub.10.1038/ng.2814
    30 sg:pub.10.1038/nrc3655
    31 sg:pub.10.1038/nrclinonc.2012.87
    32 https://doi.org/10.1002/ijc.26063
    33 https://doi.org/10.1016/j.ccr.2012.08.024
    34 https://doi.org/10.1016/j.ccr.2013.10.006
    35 https://doi.org/10.1016/j.cell.2013.09.034
    36 https://doi.org/10.1016/s1470-2045(14)71206-9
    37 https://doi.org/10.1093/neuonc/1.2.152
    38 https://doi.org/10.1093/neuonc/noq191
    39 https://doi.org/10.1126/science.1232245
    40 https://doi.org/10.1158/2159-8290.cd-12-0426
    41 https://doi.org/10.1167/iovs.06-0101
    42 https://doi.org/10.1200/jco.2009.26.7252
    43 https://doi.org/10.1309/ajcpabohbc33fvmo
    44 https://doi.org/10.1371/journal.pone.0113315
    45 https://doi.org/10.1677/erc-08-0241
    46 schema:datePublished 2016-01
    47 schema:datePublishedReg 2016-01-01
    48 schema:description In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of neoplasms, with microscopic characteristics typical of either glioblastoma (GBM) or central nervous system primitive neuroectodermal tumors (CNS-PNET). In the current study, we performed an integrative clinical, histopathological and molecular analysis of 81 G34-mutant CNS tumors. Routinely prepared tumor tissues were investigated for genomic and epigenomic alterations. Despite their divergent histopathological appearance, CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Comparative cytogenetic analysis with other GBM subtypes disclosed a high frequency and high specificity of 3q and 4q loss across G34-mutant tumors. PDGFRA amplification was more common in cases with GBM than with PNET morphology (36 vs. 5 %, respectively), while CCND2 amplifications showed the opposite trend (5 vs. 27 %). Survival analysis revealed the presence of amplified oncogene(s) and MGMT methylation as independent prognostic markers for poor and favorable outcomes, respectively. No difference in outcome was found between morphological variants (GBM vs. PNET). Thus, different histological variants of G34-mutant CNS tumors likely comprise a single biological entity (high-grade glioma with H3 G34 mutation, HGG_G34), which should be outlined in future diagnostic and therapeutic classifications. Screening for H3.3 G34 mutation should therefore be recommended as a routine diagnostic marker for supratentorial CNS tumors across a broad histological spectrum.
    49 schema:genre research_article
    50 schema:inLanguage en
    51 schema:isAccessibleForFree false
    52 schema:isPartOf Na452416d33554b4dbd846e66283cb993
    53 Nc2f3685f13574ff0938b093f661d30ff
    54 sg:journal.1019073
    55 schema:name Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity
    56 schema:pagination 137-146
    57 schema:productId N0b7a9ea3a2cd4390997d114b1383ab99
    58 N8ac9dba15bb04abeaf5aa6b5afad3eb0
    59 N91a632816d7c43b5837b3554620ca5ab
    60 Nb7b838598b22402493b99f268c40d8b1
    61 Ne683653c3444485bb1c32fcc28bd2d73
    62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047152106
    63 https://doi.org/10.1007/s00401-015-1493-1
    64 schema:sdDatePublished 2019-04-10T16:37
    65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    66 schema:sdPublisher N6b3ba69490324abbae1fe0ff104164da
    67 schema:url http://link.springer.com/10.1007/s00401-015-1493-1
    68 sgo:license sg:explorer/license/
    69 sgo:sdDataset articles
    70 rdf:type schema:ScholarlyArticle
    71 N02236d81cd36468cbcac723f598dd833 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    72 schema:name Male
    73 rdf:type schema:DefinedTerm
    74 N02c5ed91a0404bda99eaa099acf60946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    75 schema:name Mutation
    76 rdf:type schema:DefinedTerm
    77 N0b7a9ea3a2cd4390997d114b1383ab99 schema:name dimensions_id
    78 schema:value pub.1047152106
    79 rdf:type schema:PropertyValue
    80 N205c20fb392246f1945f2ff599129197 rdf:first sg:person.07524506162.54
    81 rdf:rest N3e3f9d2e62cb45e6b29785138d24c541
    82 N26d0c6a0b1874954ba0f95529bdc6503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Supratentorial Neoplasms
    84 rdf:type schema:DefinedTerm
    85 N2865175f3a054b70904d5d71b52aeccb rdf:first sg:person.01206710443.02
    86 rdf:rest N98db9cb0ba9847dab02f31e7f98da654
    87 N2a1a911477c64ea0b21dd33d5a46b2b5 rdf:first sg:person.01124352515.36
    88 rdf:rest N2becbe17773546449bcc66c2832bf7e8
    89 N2becbe17773546449bcc66c2832bf7e8 rdf:first sg:person.0720442334.16
    90 rdf:rest Nccc4f8cd19b3414f938ff3cbf8eb22e2
    91 N2db979f469724247a8f7df70751e7c2d rdf:first sg:person.015000331624.83
    92 rdf:rest Ne049d83888574f30bdf30c739ca5893e
    93 N39973c53d3be44528fb4239811f54f0f rdf:first sg:person.0607426433.30
    94 rdf:rest N205c20fb392246f1945f2ff599129197
    95 N3e3f9d2e62cb45e6b29785138d24c541 rdf:first sg:person.0767624634.57
    96 rdf:rest Nee04bf7034854d0bb6cce9576322e194
    97 N3e94e454912841c6b31316680d8c39e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Child
    99 rdf:type schema:DefinedTerm
    100 N40f2dfc745c8440c9bf463af786bc564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Epigenomics
    102 rdf:type schema:DefinedTerm
    103 N42be0064e6c84e68b7c0fdf71e1153ef rdf:first sg:person.01074367672.42
    104 rdf:rest N4fb1bbee344e4fc0b2cb5976333d45b9
    105 N48f65a236ee149d18c55c1366735b5d2 schema:name Department of Neuro-Oncology, Russian Scientific Center of Radiology, Moscow, Russia
    106 rdf:type schema:Organization
    107 N4fb1bbee344e4fc0b2cb5976333d45b9 rdf:first sg:person.01234464637.55
    108 rdf:rest Ndf6f7fdcdec9442ea5024b8cfdf79032
    109 N5625861b58a746f989c6c17b9d8ab7f0 rdf:first sg:person.0750466144.00
    110 rdf:rest Nb733e9a1ebdf492eb381135236c6b094
    111 N6008b462f3594a19919a06d082f6b6dc rdf:first sg:person.0627772654.33
    112 rdf:rest Nff77fc0165e246298c7f69adb2465f10
    113 N6b3ba69490324abbae1fe0ff104164da schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N6b6e89f536034b3698a7e9b0c2a5e2eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Glioblastoma
    117 rdf:type schema:DefinedTerm
    118 N7d50bfe7b7bd42ca916a39275198ae8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Adolescent
    120 rdf:type schema:DefinedTerm
    121 N7f0101d038e2443bb7c376f3a298b2aa rdf:first sg:person.0610463215.17
    122 rdf:rest N2a1a911477c64ea0b21dd33d5a46b2b5
    123 N8ac9dba15bb04abeaf5aa6b5afad3eb0 schema:name nlm_unique_id
    124 schema:value 0412041
    125 rdf:type schema:PropertyValue
    126 N91a632816d7c43b5837b3554620ca5ab schema:name doi
    127 schema:value 10.1007/s00401-015-1493-1
    128 rdf:type schema:PropertyValue
    129 N98db9cb0ba9847dab02f31e7f98da654 rdf:first sg:person.0657747327.23
    130 rdf:rest N5625861b58a746f989c6c17b9d8ab7f0
    131 Na452416d33554b4dbd846e66283cb993 schema:issueNumber 1
    132 rdf:type schema:PublicationIssue
    133 Naf5291808f9e48029b51c52354653c69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Central Nervous System Neoplasms
    135 rdf:type schema:DefinedTerm
    136 Nb733e9a1ebdf492eb381135236c6b094 rdf:first sg:person.01137070015.52
    137 rdf:rest N39973c53d3be44528fb4239811f54f0f
    138 Nb7b838598b22402493b99f268c40d8b1 schema:name readcube_id
    139 schema:value e09df6cd96e51f2b007afa5b3bbc3f41fef530eb604ff8c34eea2125f396498a
    140 rdf:type schema:PropertyValue
    141 Nbcf27fc032364f6497a351879181c0f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Female
    143 rdf:type schema:DefinedTerm
    144 Nc2f3685f13574ff0938b093f661d30ff schema:volumeNumber 131
    145 rdf:type schema:PublicationVolume
    146 Nc47de1a73a804598a2e1bd642be2ea77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Young Adult
    148 rdf:type schema:DefinedTerm
    149 Nc948604c399c4836b6ccdb2de8c1b75e rdf:first sg:person.01043273753.26
    150 rdf:rest N42be0064e6c84e68b7c0fdf71e1153ef
    151 Nc9a98c8d32f142a98408567caa51446e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Histones
    153 rdf:type schema:DefinedTerm
    154 Nccc4f8cd19b3414f938ff3cbf8eb22e2 rdf:first sg:person.0707750521.75
    155 rdf:rest Ne9d96c30009b438b8f5d11b4bd74a8c6
    156 Nd6ca86b4198e46b1a28d138e1574a4bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Adult
    158 rdf:type schema:DefinedTerm
    159 Ndd0f99ca2cdd49ceb9112de67863e4f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Middle Aged
    161 rdf:type schema:DefinedTerm
    162 Ndddd45b770fc43719aac6295e48fdefa rdf:first sg:person.011536141544.42
    163 rdf:rest rdf:nil
    164 Ndf6f7fdcdec9442ea5024b8cfdf79032 rdf:first sg:person.01220632656.30
    165 rdf:rest N7f0101d038e2443bb7c376f3a298b2aa
    166 Ne049d83888574f30bdf30c739ca5893e rdf:first sg:person.01327726046.92
    167 rdf:rest N2865175f3a054b70904d5d71b52aeccb
    168 Ne0686f1e24414bf2b9bffdd914c92822 schema:name Department of Neuro-Oncology, Federal Research Clinical Center for Pediatric Hematology, Oncology, Immunology, Moscow, Russia
    169 rdf:type schema:Organization
    170 Ne683653c3444485bb1c32fcc28bd2d73 schema:name pubmed_id
    171 schema:value 26482474
    172 rdf:type schema:PropertyValue
    173 Ne9d96c30009b438b8f5d11b4bd74a8c6 rdf:first sg:person.0606224075.50
    174 rdf:rest N2db979f469724247a8f7df70751e7c2d
    175 Nebace9490b7b4739b6277c512abb9262 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Humans
    177 rdf:type schema:DefinedTerm
    178 Nee04bf7034854d0bb6cce9576322e194 rdf:first sg:person.01243467607.83
    179 rdf:rest N6008b462f3594a19919a06d082f6b6dc
    180 Nf7b2df5e79734668ad4e0fb2f94363fe rdf:first sg:person.013472071457.40
    181 rdf:rest Nc948604c399c4836b6ccdb2de8c1b75e
    182 Nff77fc0165e246298c7f69adb2465f10 rdf:first sg:person.01105171247.76
    183 rdf:rest Ndddd45b770fc43719aac6295e48fdefa
    184 Nffd6d9f1722542d2809b12cdefca7d2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Glioma
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Biological Sciences
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Genetics
    192 rdf:type schema:DefinedTerm
    193 sg:grant.4579368 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1493-1
    194 rdf:type schema:MonetaryGrant
    195 sg:journal.1019073 schema:issn 0001-6322
    196 1432-0533
    197 schema:name Acta Neuropathologica
    198 rdf:type schema:Periodical
    199 sg:person.01043273753.26 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    200 schema:familyName Capper
    201 schema:givenName David
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043273753.26
    203 rdf:type schema:Person
    204 sg:person.01074367672.42 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    205 schema:familyName Reuss
    206 schema:givenName David
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074367672.42
    208 rdf:type schema:Person
    209 sg:person.01105171247.76 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    210 schema:familyName Pfister
    211 schema:givenName Stefan M.
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105171247.76
    213 rdf:type schema:Person
    214 sg:person.01124352515.36 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    215 schema:familyName Sturm
    216 schema:givenName Dominik
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124352515.36
    218 rdf:type schema:Person
    219 sg:person.01137070015.52 schema:affiliation https://www.grid.ac/institutes/grid.16149.3b
    220 schema:familyName Hasselblatt
    221 schema:givenName Martin
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137070015.52
    223 rdf:type schema:Person
    224 sg:person.011536141544.42 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    225 schema:familyName Jones
    226 schema:givenName David T. W.
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011536141544.42
    228 rdf:type schema:Person
    229 sg:person.01206710443.02 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    230 schema:familyName Kool
    231 schema:givenName Marcel
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206710443.02
    233 rdf:type schema:Person
    234 sg:person.01220632656.30 schema:affiliation https://www.grid.ac/institutes/grid.418542.e
    235 schema:familyName Ryzhova
    236 schema:givenName Marina
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220632656.30
    238 rdf:type schema:Person
    239 sg:person.01234464637.55 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    240 schema:familyName Schrimpf
    241 schema:givenName Daniel
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234464637.55
    243 rdf:type schema:Person
    244 sg:person.01243467607.83 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    245 schema:familyName Lichter
    246 schema:givenName Peter
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243467607.83
    248 rdf:type schema:Person
    249 sg:person.01327726046.92 schema:affiliation https://www.grid.ac/institutes/grid.418542.e
    250 schema:familyName Golanov
    251 schema:givenName Andrey
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327726046.92
    253 rdf:type schema:Person
    254 sg:person.013472071457.40 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    255 schema:familyName Korshunov
    256 schema:givenName Andrey
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013472071457.40
    258 rdf:type schema:Person
    259 sg:person.015000331624.83 schema:affiliation Ne0686f1e24414bf2b9bffdd914c92822
    260 schema:familyName Kumirova
    261 schema:givenName Ella
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015000331624.83
    263 rdf:type schema:Person
    264 sg:person.0606224075.50 schema:affiliation N48f65a236ee149d18c55c1366735b5d2
    265 schema:familyName Zheludkova
    266 schema:givenName Olga
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606224075.50
    268 rdf:type schema:Person
    269 sg:person.0607426433.30 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    270 schema:familyName Schittenhelm
    271 schema:givenName Jens
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607426433.30
    273 rdf:type schema:Person
    274 sg:person.0610463215.17 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    275 schema:familyName Hovestadt
    276 schema:givenName Volker
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610463215.17
    278 rdf:type schema:Person
    279 sg:person.0627772654.33 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    280 schema:familyName von Deimling
    281 schema:givenName Andreas
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627772654.33
    283 rdf:type schema:Person
    284 sg:person.0657747327.23 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    285 schema:familyName Schüller
    286 schema:givenName Ulrich
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657747327.23
    288 rdf:type schema:Person
    289 sg:person.0707750521.75 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
    290 schema:familyName Jones
    291 schema:givenName Chris
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707750521.75
    293 rdf:type schema:Person
    294 sg:person.0720442334.16 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    295 schema:familyName Meyer
    296 schema:givenName Jochen
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720442334.16
    298 rdf:type schema:Person
    299 sg:person.0750466144.00 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    300 schema:familyName Mittelbronn
    301 schema:givenName Michel
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750466144.00
    303 rdf:type schema:Person
    304 sg:person.07524506162.54 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    305 schema:familyName Reifenberger
    306 schema:givenName Guido
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07524506162.54
    308 rdf:type schema:Person
    309 sg:person.0767624634.57 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    310 schema:familyName Herold-Mende
    311 schema:givenName Christel
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767624634.57
    313 rdf:type schema:Person
    314 sg:pub.10.1007/s00401-012-1016-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027095253
    315 https://doi.org/10.1007/s00401-012-1016-2
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1007/s00401-013-1126-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008994603
    318 https://doi.org/10.1007/s00401-013-1126-5
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1007/s00401-014-1370-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000424731
    321 https://doi.org/10.1007/s00401-014-1370-3
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1007/s00401-015-1405-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025614916
    324 https://doi.org/10.1007/s00401-015-1405-4
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1007/s00401-015-1427-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1012407663
    327 https://doi.org/10.1007/s00401-015-1427-y
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1007/s00401-015-1454-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011884053
    330 https://doi.org/10.1007/s00401-015-1454-8
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1007/s00412-015-0510-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023430113
    333 https://doi.org/10.1007/s00412-015-0510-4
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1007/s11060-012-1040-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004520618
    336 https://doi.org/10.1007/s11060-012-1040-z
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/nature10833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039575824
    339 https://doi.org/10.1038/nature10833
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/ng.1102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048296872
    342 https://doi.org/10.1038/ng.1102
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/ng.2814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049677077
    345 https://doi.org/10.1038/ng.2814
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nrc3655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036111867
    348 https://doi.org/10.1038/nrc3655
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nrclinonc.2012.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012234461
    351 https://doi.org/10.1038/nrclinonc.2012.87
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1002/ijc.26063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028421423
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.ccr.2012.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052838309
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/j.ccr.2013.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008445918
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/j.cell.2013.09.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044472205
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s1470-2045(14)71206-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047737828
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1093/neuonc/1.2.152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039524270
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1093/neuonc/noq191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020301368
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/science.1232245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030869536
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1158/2159-8290.cd-12-0426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043810887
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1167/iovs.06-0101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032928739
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1200/jco.2009.26.7252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030916565
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1309/ajcpabohbc33fvmo schema:sameAs https://app.dimensions.ai/details/publication/pub.1030389703
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1371/journal.pone.0113315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004751447
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1677/erc-08-0241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033370270
    380 rdf:type schema:CreativeWork
    381 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
    382 schema:name Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen, Tübingen, Germany
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.16149.3b schema:alternateName University Hospital Münster
    385 schema:name Institute of Neuropathology, University Hospital Münster, Münster, Germany
    386 rdf:type schema:Organization
    387 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
    388 schema:name Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, Sutton, UK
    389 rdf:type schema:Organization
    390 https://www.grid.ac/institutes/grid.411327.2 schema:alternateName Heinrich Heine University Düsseldorf
    391 schema:name Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany
    392 rdf:type schema:Organization
    393 https://www.grid.ac/institutes/grid.418542.e schema:alternateName Burdenko Neurosurgery Institute
    394 schema:name Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia
    395 Department of Neuroradiology, NN Burdenko Neurosurgical Institute, Moscow, Russia
    396 rdf:type schema:Organization
    397 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
    398 schema:name Center of Neuropathology, Lüdwig-Maximilians University, Munich, Germany
    399 rdf:type schema:Organization
    400 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
    401 schema:name Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    402 Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany
    403 Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
    404 Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany
    405 Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Heidelberg, Germany
    406 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
    407 rdf:type schema:Organization
    408 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
    409 schema:name Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    410 Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany
    411 Division of Molecular Genetics (B060), German Cancer Research Center (DKFZ), Heidelberg, Germany
    412 Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ), Heidelberg, Germany
    413 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
    414 rdf:type schema:Organization
    415 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
    416 schema:name Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany
    417 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...