A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

Cheng-Ying Ho, Bret C. Mobley, Heather Gordish-Dressman, Christopher J. VandenBussche, Gary E. Mason, Miriam Bornhorst, Adam J. Esbenshade, Mahtab Tehrani, Brent A. Orr, Delecia R. LaFrance, Joseph M. Devaney, Beatrix W. Meltzer, Sean E. Hofherr, Peter C. Burger, Roger J. Packer, Fausto J. Rodriguez

ABSTRACT

Among brain tumors, the BRAF (V600E) mutation is frequently associated with pleomorphic xanthoastrocytomas (PXAs) and gangliogliomas (GGs). This oncogenic mutation is also detected in ~5 % of other pediatric low-grade gliomas (LGGs) including pilocytic astrocytomas (PAs) and diffuse astrocytomas. In the current multi-institutional study of 56 non-PXA/non-GG diencephalic pediatric LGGs, the BRAF (V600) mutation rate is 36 %. V600-mutant tumors demonstrate a predilection for infants and young children ( More... »

PAGES

575-585

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-015-1467-3

DOI

http://dx.doi.org/10.1007/s00401-015-1467-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044249572

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26264609


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