Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06

AUTHORS

Muneaki Takahashi, Haruka Miyata, Fuyuki Kametani, Takashi Nonaka, Haruhiko Akiyama, Shin-ichi Hisanaga, Masato Hasegawa

ABSTRACT

Alzheimer's disease (AD) is characterized by extracellular amyloid β (Aβ) deposition and intracellular tau aggregation. Many studies have indicated some association between these processes, but it remains unknown how the two pathologies are linked. In this study, we investigated whether expression of amyloid precursor protein (APP) influences extracellular seed-dependent intracellular tau accumulation in cultured cells. Treatment of tau-expressing SH-SY5Y cells with Aβ fibrils did not induce intracellular tau aggregation. On the other hand, in cells expressing both tau and APP, treatment with tau fibrils or Sarkosyl-insoluble tau from AD brains induced intracellular tau aggregation. The seed-dependent intracellular tau aggregation was not induced by expression of APP lacking the extracellular domain. The amount of phosphorylated tau aggregates in cultured cells was dose dependently elevated in response to increased levels of APP on the cell membrane. Our results indicate that the extracellular region of APP is involved in uptake of tau fibrils into cells, raising the possibility that APP, but not Aβ, influences cell-to-cell spreading of tau pathologies in AD by serving as a receptor of abnormal tau aggregates. More... »

PAGES

895-907

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-015-1415-2

DOI

http://dx.doi.org/10.1007/s00401-015-1415-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016495541

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25869641


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Protein Precursor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Immunoelectron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "tau Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan University", 
          "id": "https://www.grid.ac/institutes/grid.265074.2", 
          "name": [
            "Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan", 
            "Department of Biological Science, Laboratory of Molecular Neuroscience, Tokyo Metropolitan University, 192-0397, Hachioji, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Muneaki", 
        "id": "sg:person.0604201274.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604201274.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyata", 
        "givenName": "Haruka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kametani", 
        "givenName": "Fuyuki", 
        "id": "sg:person.01331156562.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331156562.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nonaka", 
        "givenName": "Takashi", 
        "id": "sg:person.0707474407.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707474407.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Haruhiko", 
        "id": "sg:person.016527665577.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016527665577.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan University", 
          "id": "https://www.grid.ac/institutes/grid.265074.2", 
          "name": [
            "Department of Biological Science, Laboratory of Molecular Neuroscience, Tokyo Metropolitan University, 192-0397, Hachioji, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hisanaga", 
        "givenName": "Shin-ichi", 
        "id": "sg:person.0601061521.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601061521.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa", 
        "givenName": "Masato", 
        "id": "sg:person.01155272521.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155272521.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2011.06.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000094354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00308809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000355620", 
          "https://doi.org/10.1007/bf00308809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1999.7150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000889815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.08.181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001382392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awt037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002598055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m805627200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003304071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20112457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003310066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2013.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003344263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1139-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004016755", 
          "https://doi.org/10.1007/s00401-013-1139-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0059740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004483005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)92724-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005581723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)92724-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005581723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.06.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005941700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.148460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006862968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(98)01217-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007977315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2011.07512.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008152601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1227157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008634153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2010.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013875016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.394528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013895361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-199501000-00032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016334311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-199501000-00032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016334311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353844a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017416134", 
          "https://doi.org/10.1038/353844a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-10-84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017434545", 
          "https://doi.org/10.1186/1742-2094-10-84"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/joim.12168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018538119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/emmm.201202215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018789349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/349704a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019413791", 
          "https://doi.org/10.1038/349704a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2004.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020494720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r800019200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025032208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308243200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025270169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0308413101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027209441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1301175110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028221411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.1995.tb01025.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029464024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.515445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031240007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.2385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032110406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.12.8029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032293683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2006.113514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032336534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198906013202203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032379758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(95)90232-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032390729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(10)70119-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032880937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1301440110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033037936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033736855", 
          "https://doi.org/10.1038/ng1718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033736855", 
          "https://doi.org/10.1038/ng1718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2011.11.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035932383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.17.5322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036506144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.209296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037863550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/016164108x323771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037923486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m408714200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039066074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)91422-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039680535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)91422-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039680535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awl203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039963013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042040936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042538398", 
          "https://doi.org/10.1038/ncb1901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042538398", 
          "https://doi.org/10.1038/ncb1901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(94)00851-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042629960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2008.161703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043197600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.277061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046907822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2642-12.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048551202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049752138", 
          "https://doi.org/10.1038/ncb1841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.346072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052082538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0892-345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052929734", 
          "https://doi.org/10.1038/ng0892-345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1925564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062513737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000159740.16984.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000159740.16984.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000159740.16984.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000339400.64213.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000339400.64213.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000339400.64213.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.2001.81.2.741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074791168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082613054", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-03-01083.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082858598"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "Alzheimer's disease (AD) is characterized by extracellular amyloid \u03b2 (A\u03b2) deposition and intracellular tau aggregation. Many studies have indicated some association between these processes, but it remains unknown how the two pathologies are linked. In this study, we investigated whether expression of amyloid precursor protein (APP) influences extracellular seed-dependent intracellular tau accumulation in cultured cells. Treatment of tau-expressing SH-SY5Y cells with A\u03b2 fibrils did not induce intracellular tau aggregation. On the other hand, in cells expressing both tau and APP, treatment with tau fibrils or Sarkosyl-insoluble tau from AD brains induced intracellular tau aggregation. The seed-dependent intracellular tau aggregation was not induced by expression of APP lacking the extracellular domain. The amount of phosphorylated tau aggregates in cultured cells was dose dependently elevated in response to increased levels of APP on the cell membrane. Our results indicate that the extracellular region of APP is involved in uptake of tau fibrils into cells, raising the possibility that APP, but not A\u03b2, influences cell-to-cell spreading of tau pathologies in AD by serving as a receptor of abnormal tau aggregates. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00401-015-1415-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5855713", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6133281", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6076748", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6107943", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6126566", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6083958", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6050132", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6132624", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "129"
      }
    ], 
    "name": "Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau", 
    "pagination": "895-907", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4e98d27da46c03464de841503e5bc7a257de86b19bdc31ffef4c57baee264b10"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25869641"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00401-015-1415-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016495541"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00401-015-1415-2", 
      "https://app.dimensions.ai/details/publication/pub.1016495541"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89804_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00401-015-1415-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1415-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1415-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1415-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-015-1415-2'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      21 PREDICATES      105 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00401-015-1415-2 schema:about N055c37e0aafe4e76841f5da808ff4dd3
2 N0bc182f752fb4b099f3a1ae1be825f6c
3 N0d1512eac89b4850bda38db24cee8777
4 N0efc3d659c334b9484118fd2a80d96ab
5 N147396c0311940b18fcafa1292c2fca1
6 N2d31ce21ae414222be9cb29c4acf804e
7 N3056ba639f5849fe8e12218d36d2b578
8 N584258fe66d8456595f369ec7a99fb79
9 N7ce3ad39013f46c8a2ec68d1c979ed2e
10 N8e0a241006a0481cbb1f1939201dfe4e
11 Na0d21eee7c0d4d1493c2af8a88af4c54
12 Na14e113a894c4f5486766e42ae189c30
13 Nb90e1bc641e840c5b3d5538eb21e81f1
14 Nc1c6a60a3ba14f3482e7410b1740ad62
15 Nd97f3851264e41149257a0ffda3d2b63
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author N9a85c7caa4004248b905def405368b0e
19 schema:citation sg:pub.10.1007/bf00308809
20 sg:pub.10.1007/s00401-013-1139-0
21 sg:pub.10.1038/349704a0
22 sg:pub.10.1038/353844a0
23 sg:pub.10.1038/ncb1841
24 sg:pub.10.1038/ncb1901
25 sg:pub.10.1038/ng0892-345
26 sg:pub.10.1038/ng1718
27 sg:pub.10.1186/1742-2094-10-84
28 https://app.dimensions.ai/details/publication/pub.1082613054
29 https://doi.org/10.1002/emmm.201202215
30 https://doi.org/10.1002/pro.2385
31 https://doi.org/10.1006/exnr.1999.7150
32 https://doi.org/10.1016/0006-8993(91)91422-w
33 https://doi.org/10.1016/0014-5793(94)00851-5
34 https://doi.org/10.1016/0140-6736(91)92724-g
35 https://doi.org/10.1016/0896-6273(95)90232-5
36 https://doi.org/10.1016/j.bbadis.2004.09.008
37 https://doi.org/10.1016/j.bbrc.2006.08.181
38 https://doi.org/10.1016/j.cell.2010.06.036
39 https://doi.org/10.1016/j.febslet.2011.11.022
40 https://doi.org/10.1016/j.neurobiolaging.2010.10.010
41 https://doi.org/10.1016/j.neurobiolaging.2011.06.022
42 https://doi.org/10.1016/j.neuron.2013.02.003
43 https://doi.org/10.1016/s0014-5793(98)01217-4
44 https://doi.org/10.1016/s1474-4422(10)70119-8
45 https://doi.org/10.1056/nejm198906013202203
46 https://doi.org/10.1073/pnas.0308413101
47 https://doi.org/10.1073/pnas.1301175110
48 https://doi.org/10.1073/pnas.1301440110
49 https://doi.org/10.1074/jbc.274.12.8029
50 https://doi.org/10.1074/jbc.m110.148460
51 https://doi.org/10.1074/jbc.m110.209296
52 https://doi.org/10.1074/jbc.m111.277061
53 https://doi.org/10.1074/jbc.m112.346072
54 https://doi.org/10.1074/jbc.m112.394528
55 https://doi.org/10.1074/jbc.m113.515445
56 https://doi.org/10.1074/jbc.m308243200
57 https://doi.org/10.1074/jbc.m408714200
58 https://doi.org/10.1074/jbc.m805627200
59 https://doi.org/10.1074/jbc.r800019200
60 https://doi.org/10.1084/jem.20112457
61 https://doi.org/10.1093/brain/awl203
62 https://doi.org/10.1093/brain/awt037
63 https://doi.org/10.1093/nar/18.17.5322
64 https://doi.org/10.1097/00001756-199501000-00032
65 https://doi.org/10.1111/j.1365-2990.1995.tb01025.x
66 https://doi.org/10.1111/j.1471-4159.2011.07512.x
67 https://doi.org/10.1111/joim.12168
68 https://doi.org/10.1126/science.1227157
69 https://doi.org/10.1126/science.1925564
70 https://doi.org/10.1136/jnnp.2006.113514
71 https://doi.org/10.1136/jnnp.2008.161703
72 https://doi.org/10.1152/physrev.2001.81.2.741
73 https://doi.org/10.1179/016164108x323771
74 https://doi.org/10.1212/01.wnl.0000159740.16984.3c
75 https://doi.org/10.1212/01.wnl.0000339400.64213.56
76 https://doi.org/10.1242/jcs.01558
77 https://doi.org/10.1371/journal.pone.0059740
78 https://doi.org/10.1523/jneurosci.16-03-01083.1996
79 https://doi.org/10.1523/jneurosci.2642-12.2013
80 schema:datePublished 2015-06
81 schema:datePublishedReg 2015-06-01
82 schema:description Alzheimer's disease (AD) is characterized by extracellular amyloid β (Aβ) deposition and intracellular tau aggregation. Many studies have indicated some association between these processes, but it remains unknown how the two pathologies are linked. In this study, we investigated whether expression of amyloid precursor protein (APP) influences extracellular seed-dependent intracellular tau accumulation in cultured cells. Treatment of tau-expressing SH-SY5Y cells with Aβ fibrils did not induce intracellular tau aggregation. On the other hand, in cells expressing both tau and APP, treatment with tau fibrils or Sarkosyl-insoluble tau from AD brains induced intracellular tau aggregation. The seed-dependent intracellular tau aggregation was not induced by expression of APP lacking the extracellular domain. The amount of phosphorylated tau aggregates in cultured cells was dose dependently elevated in response to increased levels of APP on the cell membrane. Our results indicate that the extracellular region of APP is involved in uptake of tau fibrils into cells, raising the possibility that APP, but not Aβ, influences cell-to-cell spreading of tau pathologies in AD by serving as a receptor of abnormal tau aggregates.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree true
86 schema:isPartOf Nd7ee25bd66fb4cc7bbe1a8d3ff556ec6
87 Nfeb238434bd6472d993799d96a237b66
88 sg:journal.1019073
89 schema:name Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau
90 schema:pagination 895-907
91 schema:productId N2a5bbf5862a44cfbad1fd3bc628c66ee
92 N3bc0bb0f1b094e279fbd64d1bf52fc87
93 N596bc5465c5f41c4bca437b1d60fef7e
94 Ncfd296c9659941aca80b8907a85602ed
95 Nf428675543de46f98102ed5fcea00bae
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016495541
97 https://doi.org/10.1007/s00401-015-1415-2
98 schema:sdDatePublished 2019-04-11T09:56
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N0679e34ffdfb4877b908f4cccdf6563a
101 schema:url http://link.springer.com/10.1007/s00401-015-1415-2
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N055c37e0aafe4e76841f5da808ff4dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Amyloid beta-Protein Precursor
107 rdf:type schema:DefinedTerm
108 N0679e34ffdfb4877b908f4cccdf6563a schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N0bc182f752fb4b099f3a1ae1be825f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Cell Line, Tumor
112 rdf:type schema:DefinedTerm
113 N0d1512eac89b4850bda38db24cee8777 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Dose-Response Relationship, Drug
115 rdf:type schema:DefinedTerm
116 N0efc3d659c334b9484118fd2a80d96ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Microscopy, Immunoelectron
118 rdf:type schema:DefinedTerm
119 N147396c0311940b18fcafa1292c2fca1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Extracellular Fluid
121 rdf:type schema:DefinedTerm
122 N2a5bbf5862a44cfbad1fd3bc628c66ee schema:name readcube_id
123 schema:value 4e98d27da46c03464de841503e5bc7a257de86b19bdc31ffef4c57baee264b10
124 rdf:type schema:PropertyValue
125 N2d31ce21ae414222be9cb29c4acf804e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Amyloid beta-Peptides
127 rdf:type schema:DefinedTerm
128 N3056ba639f5849fe8e12218d36d2b578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Microscopy, Confocal
130 rdf:type schema:DefinedTerm
131 N3bc0bb0f1b094e279fbd64d1bf52fc87 schema:name nlm_unique_id
132 schema:value 0412041
133 rdf:type schema:PropertyValue
134 N584258fe66d8456595f369ec7a99fb79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N596bc5465c5f41c4bca437b1d60fef7e schema:name dimensions_id
138 schema:value pub.1016495541
139 rdf:type schema:PropertyValue
140 N5b111abd8fa24e62bf27c324ac98c193 rdf:first Nf9201db81f2849258b362257aecd1c29
141 rdf:rest Nbd4e84ac43e4444db01b4d450ad6b0a0
142 N696a36636fd34ddb9a8b767ca9f8ef02 rdf:first sg:person.016527665577.54
143 rdf:rest N8598e1a8434744e5aaf93dd99edb4fab
144 N739a9c12d7c745fab9dc4719151f1b01 rdf:first sg:person.01155272521.20
145 rdf:rest rdf:nil
146 N7ce3ad39013f46c8a2ec68d1c979ed2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Transfection
148 rdf:type schema:DefinedTerm
149 N8598e1a8434744e5aaf93dd99edb4fab rdf:first sg:person.0601061521.94
150 rdf:rest N739a9c12d7c745fab9dc4719151f1b01
151 N8e0a241006a0481cbb1f1939201dfe4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Neuroblastoma
153 rdf:type schema:DefinedTerm
154 N9a85c7caa4004248b905def405368b0e rdf:first sg:person.0604201274.35
155 rdf:rest N5b111abd8fa24e62bf27c324ac98c193
156 Na0d21eee7c0d4d1493c2af8a88af4c54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Gene Expression Regulation
158 rdf:type schema:DefinedTerm
159 Na14e113a894c4f5486766e42ae189c30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Animals
161 rdf:type schema:DefinedTerm
162 Nb90e1bc641e840c5b3d5538eb21e81f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cytoplasm
164 rdf:type schema:DefinedTerm
165 Nbd4e84ac43e4444db01b4d450ad6b0a0 rdf:first sg:person.01331156562.18
166 rdf:rest Nffa440eccdc5463c8e5c2b33b88a31d3
167 Nc1c6a60a3ba14f3482e7410b1740ad62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name tau Proteins
169 rdf:type schema:DefinedTerm
170 Ncfd296c9659941aca80b8907a85602ed schema:name doi
171 schema:value 10.1007/s00401-015-1415-2
172 rdf:type schema:PropertyValue
173 Nd7ee25bd66fb4cc7bbe1a8d3ff556ec6 schema:volumeNumber 129
174 rdf:type schema:PublicationVolume
175 Nd97f3851264e41149257a0ffda3d2b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Mutation
177 rdf:type schema:DefinedTerm
178 Nf428675543de46f98102ed5fcea00bae schema:name pubmed_id
179 schema:value 25869641
180 rdf:type schema:PropertyValue
181 Nf9201db81f2849258b362257aecd1c29 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
182 schema:familyName Miyata
183 schema:givenName Haruka
184 rdf:type schema:Person
185 Nfeb238434bd6472d993799d96a237b66 schema:issueNumber 6
186 rdf:type schema:PublicationIssue
187 Nffa440eccdc5463c8e5c2b33b88a31d3 rdf:first sg:person.0707474407.24
188 rdf:rest N696a36636fd34ddb9a8b767ca9f8ef02
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
193 schema:name Neurosciences
194 rdf:type schema:DefinedTerm
195 sg:grant.5855713 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
196 rdf:type schema:MonetaryGrant
197 sg:grant.6050132 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
198 rdf:type schema:MonetaryGrant
199 sg:grant.6076748 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
200 rdf:type schema:MonetaryGrant
201 sg:grant.6083958 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
202 rdf:type schema:MonetaryGrant
203 sg:grant.6107943 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
204 rdf:type schema:MonetaryGrant
205 sg:grant.6126566 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
206 rdf:type schema:MonetaryGrant
207 sg:grant.6132624 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
208 rdf:type schema:MonetaryGrant
209 sg:grant.6133281 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-015-1415-2
210 rdf:type schema:MonetaryGrant
211 sg:journal.1019073 schema:issn 0001-6322
212 1432-0533
213 schema:name Acta Neuropathologica
214 rdf:type schema:Periodical
215 sg:person.01155272521.20 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
216 schema:familyName Hasegawa
217 schema:givenName Masato
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155272521.20
219 rdf:type schema:Person
220 sg:person.01331156562.18 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
221 schema:familyName Kametani
222 schema:givenName Fuyuki
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331156562.18
224 rdf:type schema:Person
225 sg:person.016527665577.54 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
226 schema:familyName Akiyama
227 schema:givenName Haruhiko
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016527665577.54
229 rdf:type schema:Person
230 sg:person.0601061521.94 schema:affiliation https://www.grid.ac/institutes/grid.265074.2
231 schema:familyName Hisanaga
232 schema:givenName Shin-ichi
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601061521.94
234 rdf:type schema:Person
235 sg:person.0604201274.35 schema:affiliation https://www.grid.ac/institutes/grid.265074.2
236 schema:familyName Takahashi
237 schema:givenName Muneaki
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604201274.35
239 rdf:type schema:Person
240 sg:person.0707474407.24 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
241 schema:familyName Nonaka
242 schema:givenName Takashi
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707474407.24
244 rdf:type schema:Person
245 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
246 https://doi.org/10.1007/bf00308809
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00401-013-1139-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004016755
249 https://doi.org/10.1007/s00401-013-1139-0
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/349704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019413791
252 https://doi.org/10.1038/349704a0
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/353844a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017416134
255 https://doi.org/10.1038/353844a0
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/ncb1841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049752138
258 https://doi.org/10.1038/ncb1841
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/ncb1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042538398
261 https://doi.org/10.1038/ncb1901
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/ng0892-345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052929734
264 https://doi.org/10.1038/ng0892-345
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/ng1718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033736855
267 https://doi.org/10.1038/ng1718
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/1742-2094-10-84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017434545
270 https://doi.org/10.1186/1742-2094-10-84
271 rdf:type schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1082613054 schema:CreativeWork
273 https://doi.org/10.1002/emmm.201202215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018789349
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/pro.2385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032110406
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1006/exnr.1999.7150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000889815
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0006-8993(91)91422-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1039680535
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/0014-5793(94)00851-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042629960
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/0140-6736(91)92724-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1005581723
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0896-6273(95)90232-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032390729
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.bbadis.2004.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020494720
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.bbrc.2006.08.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001382392
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.cell.2010.06.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005941700
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.febslet.2011.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035932383
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.neurobiolaging.2010.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013875016
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.neurobiolaging.2011.06.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000094354
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.neuron.2013.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003344263
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0014-5793(98)01217-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007977315
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s1474-4422(10)70119-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032880937
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1056/nejm198906013202203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032379758
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.0308413101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027209441
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.1301175110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028221411
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.1301440110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033037936
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.274.12.8029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032293683
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1074/jbc.m110.148460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006862968
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.m110.209296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037863550
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.m111.277061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046907822
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1074/jbc.m112.346072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052082538
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1074/jbc.m112.394528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013895361
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.m113.515445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031240007
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1074/jbc.m308243200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025270169
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1074/jbc.m408714200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039066074
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1074/jbc.m805627200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003304071
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1074/jbc.r800019200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025032208
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1084/jem.20112457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003310066
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/brain/awl203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039963013
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/brain/awt037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002598055
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/nar/18.17.5322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036506144
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1097/00001756-199501000-00032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016334311
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1365-2990.1995.tb01025.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029464024
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/j.1471-4159.2011.07512.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008152601
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1111/joim.12168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018538119
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1227157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008634153
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1126/science.1925564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062513737
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1136/jnnp.2006.113514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032336534
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1136/jnnp.2008.161703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043197600
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1152/physrev.2001.81.2.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074791168
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1179/016164108x323771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037923486
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1212/01.wnl.0000159740.16984.3c schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347025
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1212/01.wnl.0000339400.64213.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350848
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1242/jcs.01558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042040936
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1371/journal.pone.0059740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004483005
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1523/jneurosci.16-03-01083.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082858598
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1523/jneurosci.2642-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048551202
374 rdf:type schema:CreativeWork
375 https://www.grid.ac/institutes/grid.265074.2 schema:alternateName Tokyo Metropolitan University
376 schema:name Department of Biological Science, Laboratory of Molecular Neuroscience, Tokyo Metropolitan University, 192-0397, Hachioji, Tokyo, Japan
377 Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.272456.0 schema:alternateName Tokyo Metropolitan Institute of Medical Science
380 schema:name Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, 156-8506, Tokyo, Japan
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...