Primary age-related tauopathy (PART): a common pathology associated with human aging View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-28

AUTHORS

John F. Crary, John Q. Trojanowski, Julie A. Schneider, Jose F. Abisambra, Erin L. Abner, Irina Alafuzoff, Steven E. Arnold, Johannes Attems, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Dennis W. Dickson, Marla Gearing, Lea T. Grinberg, Patrick R. Hof, Bradley T. Hyman, Kurt Jellinger, Gregory A. Jicha, Gabor G. Kovacs, David S. Knopman, Julia Kofler, Walter A. Kukull, Ian R. Mackenzie, Eliezer Masliah, Ann McKee, Thomas J. Montine, Melissa E. Murray, Janna H. Neltner, Ismael Santa-Maria, William W. Seeley, Alberto Serrano-Pozo, Michael L. Shelanski, Thor Stein, Masaki Takao, Dietmar R. Thal, Jonathan B. Toledo, Juan C. Troncoso, Jean Paul Vonsattel, Charles L. White, Thomas Wisniewski, Randall L. Woltjer, Masahito Yamada, Peter T. Nelson

ABSTRACT

We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer’s disease (AD), in the absence of amyloid (Aβ) plaques. For these “NFT+/Aβ−” brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as “tangle-only dementia” and “tangle-predominant senile dementia”, are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed. More... »

PAGES

755-766

References to SciGraph publications

  • 1993-08. Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report in ACTA NEUROPATHOLOGICA
  • 1994-05. Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population in ACTA NEUROPATHOLOGICA
  • 1963-01. Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease in NATURE
  • 1998-06. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 in NATURE
  • 2013-09-28. Pathology of clinical and preclinical Alzheimer’s disease in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 2001-02. Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy in ACTA NEUROPATHOLOGICA
  • 2006-08-12. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry in ACTA NEUROPATHOLOGICA
  • 2013-08-31. Globular glial tauopathies (GGT): consensus recommendations in ACTA NEUROPATHOLOGICA
  • 2007-06-20. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration in ACTA NEUROPATHOLOGICA
  • 1994-12. Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects in ACTA NEUROPATHOLOGICA
  • 2012-09-12. Neuropathologically defined subtypes of Alzheimer’s disease differ significantly from neurofibrillary tangle-predominant dementia in ACTA NEUROPATHOLOGICA
  • 2014-06-05. Differential clinicopathologic and genetic features of late-onset amnestic dementias in ACTA NEUROPATHOLOGICA
  • 2011-10-19. Neuropathological subtypes of Alzheimer’s disease in ACTA NEUROPATHOLOGICA
  • 2012-07-17. The MAPT H1 haplotype is associated with tangle-predominant dementia in ACTA NEUROPATHOLOGICA
  • 2006-11-07. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 2007-08-23. Pathological TDP-43 in parkinsonism–dementia complex and amyotrophic lateral sclerosis of Guam in ACTA NEUROPATHOLOGICA
  • 2010-12-15. The pathological process underlying Alzheimer’s disease in individuals under thirty in ACTA NEUROPATHOLOGICA
  • 1911-12. Zur Abgrenzung der sog. Alzheimerschen Krankheit in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 1978-01. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study in ACTA NEUROPATHOLOGICA
  • 2011-07-01. Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau) in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2011-03-25. A peculiar constellation of tau pathology defines a subset of dementia in the elderly in ACTA NEUROPATHOLOGICA
  • 1997-10. Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia in ACTA NEUROPATHOLOGICA
  • 2013-07-31. Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series in ACTA NEUROPATHOLOGICA
  • 1995-12. Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles in ACTA NEUROPATHOLOGICA
  • 1992-12. Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases in ACTA NEUROPATHOLOGICA
  • 2011-11-20. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach in ACTA NEUROPATHOLOGICA
  • 1991-09. Neuropathological stageing of Alzheimer-related changes in ACTA NEUROPATHOLOGICA
  • 2009-06-07. Transmission and spreading of tauopathy in transgenic mouse brain in NATURE CELL BIOLOGY
  • 2000-05. The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old in ACTA NEUROPATHOLOGICA
  • 2013-01-31. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation in ACTA NEUROPATHOLOGICA
  • 2009-12-23. Prion-like mechanisms in neurodegenerative diseases in NATURE REVIEWS NEUROSCIENCE
  • 2011-12-11. Hyperphosphorylated tau in young and middle-aged subjects in ACTA NEUROPATHOLOGICA
  • Journal

    TITLE

    Acta Neuropathologica

    ISSUE

    6

    VOLUME

    128

    Author Affiliations

  • Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA
  • Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA
  • Departments of Pathology (Neuropathology) and Neurological Sciences, Rush University Medical Center, 60612, Chicago, IL, USA
  • Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
  • Department of Public Health and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
  • Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden
  • Departments of Psychiatry and Neurology, University of Pennsylvania, 19104, Philadelphia, PA, USA
  • Institute for Ageing and Health, Newcastle University, NE45PL, Newcastle upon Tyne, UK
  • Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, 85351, Sun City, AZ, USA
  • Department of Pathology (Neuropathology), Northwestern Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA
  • Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA
  • Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA
  • Department of Pathology and Laboratory Medicine (Neuropathology), Emory University School of Medicine, 30322, Atlanta, GA, USA
  • Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil
  • Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA
  • Department of Neurology, Harvard Medical School and Massachusetts General Hospital, 02129, Charlestown, MA, USA
  • Institute of Clinical Neurobiology, 1070, Vienna, Austria
  • Department of Neurology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
  • Institute of Neurology, Medical University Vienna, 1090, Vienna, Austria
  • Department of Neurology, Mayo Clinic, 55905, Rochester, MN, USA
  • Department of Pathology (Neuropathology), University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA
  • Department of Epidemiology, University of Washington, 98104, Seattle, WA, USA
  • Department of Pathology, University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, BC, Canada
  • Departments of Neurosciences and Pathology, University of California, 92093, San Diego, La Jolla, CA, USA
  • Department of Pathology (Neuropathology), Boston University, 02118, Boston, MA, USA
  • Department of Pathology, University of Washington, 98104, Seattle, WA, USA
  • Department of Pathology, University of Kentucky, 40536, Lexington, KY, USA
  • Departments of Neurology and Pathology, University of California, 94143, San Francisco, CA, USA
  • Department of Neurology, University of Iowa Hospitals and Clinics, 52242, Iowa city, IA, USA
  • Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, 02118, Boston, MA, USA
  • Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, 173-0015, Tokyo, Japan
  • Laboratory of Neuropathology, University of Ulm, 89081, Ulm, Germany
  • Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA
  • Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, 75390, Dallas, TX, USA
  • Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, 10016, New York, NY, USA
  • Department of Pathology L113, Oregon Health Sciences University, 97239, Portland, OR, USA
  • Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, 920-8640, Kanazawa, Japan
  • Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-014-1349-0

    DOI

    http://dx.doi.org/10.1007/s00401-014-1349-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036179092

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25348064


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnosis, Differential", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plaque, Amyloid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tauopathies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Terminology as Topic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.239585.0", 
              "name": [
                "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crary", 
            "givenName": "John F.", 
            "id": "sg:person.01133706223.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133706223.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trojanowski", 
            "givenName": "John Q.", 
            "id": "sg:person.01043025611.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043025611.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Pathology (Neuropathology) and Neurological Sciences, Rush University Medical Center, 60612, Chicago, IL, USA", 
              "id": "http://www.grid.ac/institutes/grid.240684.c", 
              "name": [
                "Departments of Pathology (Neuropathology) and Neurological Sciences, Rush University Medical Center, 60612, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schneider", 
            "givenName": "Julie A.", 
            "id": "sg:person.016635011667.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016635011667.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA", 
              "id": "http://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abisambra", 
            "givenName": "Jose F.", 
            "id": "sg:person.01147533121.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147533121.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA", 
              "id": "http://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Public Health and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abner", 
            "givenName": "Erin L.", 
            "id": "sg:person.010333410267.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010333410267.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.8993.b", 
              "name": [
                "Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alafuzoff", 
            "givenName": "Irina", 
            "id": "sg:person.01061660663.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061660663.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Psychiatry and Neurology, University of Pennsylvania, 19104, Philadelphia, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Departments of Psychiatry and Neurology, University of Pennsylvania, 19104, Philadelphia, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arnold", 
            "givenName": "Steven E.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Ageing and Health, Newcastle University, NE45PL, Newcastle upon Tyne, UK", 
              "id": "http://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Institute for Ageing and Health, Newcastle University, NE45PL, Newcastle upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Attems", 
            "givenName": "Johannes", 
            "id": "sg:person.0772267646.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772267646.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, 85351, Sun City, AZ, USA", 
              "id": "http://www.grid.ac/institutes/grid.414208.b", 
              "name": [
                "Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, 85351, Sun City, AZ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beach", 
            "givenName": "Thomas G.", 
            "id": "sg:person.014653302237.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014653302237.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology (Neuropathology), Northwestern Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA", 
              "id": "http://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Pathology (Neuropathology), Northwestern Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bigio", 
            "givenName": "Eileen H.", 
            "id": "sg:person.01262305573.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262305573.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cairns", 
            "givenName": "Nigel J.", 
            "id": "sg:person.01337443160.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337443160.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA", 
              "id": "http://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dickson", 
            "givenName": "Dennis W.", 
            "id": "sg:person.011647727137.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011647727137.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine (Neuropathology), Emory University School of Medicine, 30322, Atlanta, GA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine (Neuropathology), Emory University School of Medicine, 30322, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gearing", 
            "givenName": "Marla", 
            "id": "sg:person.01227450333.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227450333.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil", 
              "id": "http://www.grid.ac/institutes/grid.11899.38", 
              "name": [
                "Departments of Neurology and Pathology, UC, 94110, San Francisco, CA, USA", 
                "Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grinberg", 
            "givenName": "Lea T.", 
            "id": "sg:person.0604640573.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604640573.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hof", 
            "givenName": "Patrick R.", 
            "id": "sg:person.01245701425.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245701425.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Harvard Medical School and Massachusetts General Hospital, 02129, Charlestown, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Department of Neurology, Harvard Medical School and Massachusetts General Hospital, 02129, Charlestown, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hyman", 
            "givenName": "Bradley T.", 
            "id": "sg:person.010226313537.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010226313537.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Clinical Neurobiology, 1070, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.10420.37", 
              "name": [
                "Institute of Clinical Neurobiology, 1070, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jellinger", 
            "givenName": "Kurt", 
            "id": "sg:person.011423652677.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011423652677.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA", 
              "id": "http://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Neurology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jicha", 
            "givenName": "Gregory A.", 
            "id": "sg:person.016455760337.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016455760337.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Neurology, Medical University Vienna, 1090, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Institute of Neurology, Medical University Vienna, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kovacs", 
            "givenName": "Gabor G.", 
            "id": "sg:person.016005175252.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016005175252.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Mayo Clinic, 55905, Rochester, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Department of Neurology, Mayo Clinic, 55905, Rochester, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knopman", 
            "givenName": "David S.", 
            "id": "sg:person.0652012300.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652012300.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology (Neuropathology), University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Department of Pathology (Neuropathology), University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kofler", 
            "givenName": "Julia", 
            "id": "sg:person.0670505205.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670505205.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, University of Washington, 98104, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Epidemiology, University of Washington, 98104, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kukull", 
            "givenName": "Walter A.", 
            "id": "sg:person.015737376337.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015737376337.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, BC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Department of Pathology, University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mackenzie", 
            "givenName": "Ian R.", 
            "id": "sg:person.01055656322.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055656322.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Neurosciences and Pathology, University of California, 92093, San Diego, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Departments of Neurosciences and Pathology, University of California, 92093, San Diego, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Masliah", 
            "givenName": "Eliezer", 
            "id": "sg:person.011712740677.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011712740677.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology (Neuropathology), Boston University, 02118, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "Department of Pathology (Neuropathology), Boston University, 02118, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McKee", 
            "givenName": "Ann", 
            "id": "sg:person.01150076163.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150076163.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University of Washington, 98104, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Pathology, University of Washington, 98104, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Montine", 
            "givenName": "Thomas J.", 
            "id": "sg:person.0714314167.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714314167.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA", 
              "id": "http://www.grid.ac/institutes/grid.417467.7", 
              "name": [
                "Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murray", 
            "givenName": "Melissa E.", 
            "id": "sg:person.01004204017.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004204017.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University of Kentucky, 40536, Lexington, KY, USA", 
              "id": "http://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Pathology, University of Kentucky, 40536, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neltner", 
            "givenName": "Janna H.", 
            "id": "sg:person.012263062067.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012263062067.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.239585.0", 
              "name": [
                "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santa-Maria", 
            "givenName": "Ismael", 
            "id": "sg:person.0722037045.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722037045.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Neurology and Pathology, University of California, 94143, San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Departments of Neurology and Pathology, University of California, 94143, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seeley", 
            "givenName": "William W.", 
            "id": "sg:person.0636347411.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636347411.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, University of Iowa Hospitals and Clinics, 52242, Iowa city, IA, USA", 
              "id": "http://www.grid.ac/institutes/grid.412584.e", 
              "name": [
                "Department of Neurology, University of Iowa Hospitals and Clinics, 52242, Iowa city, IA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serrano-Pozo", 
            "givenName": "Alberto", 
            "id": "sg:person.01307060514.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307060514.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.239585.0", 
              "name": [
                "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shelanski", 
            "givenName": "Michael L.", 
            "id": "sg:person.01324142075.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324142075.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, 02118, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, 02118, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stein", 
            "givenName": "Thor", 
            "id": "sg:person.01062077762.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062077762.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, 173-0015, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417092.9", 
              "name": [
                "Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, 173-0015, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takao", 
            "givenName": "Masaki", 
            "id": "sg:person.01032345030.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032345030.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Neuropathology, University of Ulm, 89081, Ulm, Germany", 
              "id": "http://www.grid.ac/institutes/grid.6582.9", 
              "name": [
                "Laboratory of Neuropathology, University of Ulm, 89081, Ulm, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thal", 
            "givenName": "Dietmar R.", 
            "id": "sg:person.0617341265.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617341265.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toledo", 
            "givenName": "Jonathan B.", 
            "id": "sg:person.01244061222.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244061222.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Troncoso", 
            "givenName": "Juan C.", 
            "id": "sg:person.0677213273.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677213273.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.239585.0", 
              "name": [
                "Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vonsattel", 
            "givenName": "Jean Paul", 
            "id": "sg:person.015126147177.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015126147177.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, 75390, Dallas, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.267313.2", 
              "name": [
                "Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, 75390, Dallas, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "White", 
            "givenName": "Charles L.", 
            "id": "sg:person.0600212005.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600212005.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, 10016, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wisniewski", 
            "givenName": "Thomas", 
            "id": "sg:person.01177144156.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177144156.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology L113, Oregon Health Sciences University, 97239, Portland, OR, USA", 
              "id": "http://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Pathology L113, Oregon Health Sciences University, 97239, Portland, OR, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Woltjer", 
            "givenName": "Randall L.", 
            "id": "sg:person.011635214007.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011635214007.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, 920-8640, Kanazawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.9707.9", 
              "name": [
                "Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, 920-8640, Kanazawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamada", 
            "givenName": "Masahito", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA", 
              "id": "http://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nelson", 
            "givenName": "Peter T.", 
            "id": "sg:person.01235720500.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235720500.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s004010050726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048473262", 
              "https://doi.org/10.1007/s004010050726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1157-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013961840", 
              "https://doi.org/10.1007/s00401-013-1157-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00294172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040159608", 
              "https://doi.org/10.1007/bf00294172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0257-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028395796", 
              "https://doi.org/10.1007/s00401-007-0257-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-010-0789-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037411515", 
              "https://doi.org/10.1007/s00401-010-0789-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0819-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048400464", 
              "https://doi.org/10.1007/s00401-011-0819-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037916934", 
              "https://doi.org/10.1038/nrn2786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0906-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029939986", 
              "https://doi.org/10.1007/s00401-011-0906-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-014-1302-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045662232", 
              "https://doi.org/10.1007/s00401-014-1302-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1171-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049465792", 
              "https://doi.org/10.1007/s00401-013-1171-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12031-011-9589-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013977394", 
              "https://doi.org/10.1007/s12031-011-9589-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/197192b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039641676", 
              "https://doi.org/10.1038/197192b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010000283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012350340", 
              "https://doi.org/10.1007/s004010000283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/31508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030318669", 
              "https://doi.org/10.1038/31508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00296494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011522454", 
              "https://doi.org/10.1007/bf00296494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0127-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022911785", 
              "https://doi.org/10.1007/s00401-006-0127-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0237-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029516874", 
              "https://doi.org/10.1007/s00401-007-0237-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-012-1044-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010342082", 
              "https://doi.org/10.1007/s00401-012-1044-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00318575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023027277", 
              "https://doi.org/10.1007/bf00318575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02865132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047245703", 
              "https://doi.org/10.1007/bf02865132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010051189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051286846", 
              "https://doi.org/10.1007/s004010051189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00690970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016369234", 
              "https://doi.org/10.1007/bf00690970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-012-1017-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019337931", 
              "https://doi.org/10.1007/s00401-012-1017-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00304135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043340821", 
              "https://doi.org/10.1007/bf00304135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1080-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031975363", 
              "https://doi.org/10.1007/s00401-013-1080-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0156-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037387092", 
              "https://doi.org/10.1007/s00401-006-0156-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00308809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000355620", 
              "https://doi.org/10.1007/bf00308809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0889-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046129453", 
              "https://doi.org/10.1007/s00401-011-0889-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0910-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045607293", 
              "https://doi.org/10.1007/s00401-011-0910-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00304630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041791763", 
              "https://doi.org/10.1007/bf00304630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042538398", 
              "https://doi.org/10.1038/ncb1901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00406-013-0449-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003894586", 
              "https://doi.org/10.1007/s00406-013-0449-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-10-28", 
        "datePublishedReg": "2014-10-28", 
        "description": "We recommend a new term, \u201cprimary age-related tauopathy\u201d (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer\u2019s disease (AD), in the absence of amyloid (A\u03b2) plaques. For these \u201cNFT+/A\u03b2\u2212\u201d brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as \u201ctangle-only dementia\u201d and \u201ctangle-predominant senile dementia\u201d, are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of A\u03b2 accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00401-014-1349-0", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2448790", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2781746", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440008", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440031", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448968", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438591", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434749", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438651", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2686973", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440006", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440028", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438672", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440018", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440012", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2445992", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434604", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448725", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438612", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438598", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440013", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2786665", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434589", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6138904", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438625", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440005", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2775301", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438611", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3781719", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434647", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7082210", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440009", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438585", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2686916", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2633574", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434607", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "128"
          }
        ], 
        "keywords": [
          "primary age-related tauopathy", 
          "age-related tauopathy", 
          "neurofibrillary tangles", 
          "Alzheimer's disease", 
          "common pathologic changes", 
          "neuropathological diagnostic criteria", 
          "AD neuropathologic change", 
          "temporal lobe atrophy", 
          "medial temporal lobe", 
          "A\u03b2 accumulation", 
          "neuropathologic changes", 
          "tau imaging", 
          "autopsy study", 
          "basal forebrain", 
          "lobe atrophy", 
          "pathologic entity", 
          "pathologic changes", 
          "olfactory areas", 
          "common pathology", 
          "amyloid plaques", 
          "senile dementia", 
          "temporal lobe", 
          "elderly individuals", 
          "diagnostic criteria", 
          "cognitive impairment", 
          "aged individuals", 
          "clinical setting", 
          "most subjects", 
          "profound impairment", 
          "prior reports", 
          "tauopathies", 
          "pathological processes", 
          "brain", 
          "cognitive changes", 
          "dementia", 
          "disease", 
          "pathology", 
          "impairment", 
          "human aging", 
          "future studies", 
          "tangles", 
          "Recent studies", 
          "brainstem", 
          "atrophy", 
          "symptoms", 
          "clinicians", 
          "plaques", 
          "forebrain", 
          "diagnosis", 
          "individuals", 
          "study", 
          "biomarkers", 
          "profile consisting", 
          "lobe", 
          "criteria", 
          "changes", 
          "subjects", 
          "report", 
          "imaging", 
          "persons", 
          "setting", 
          "present time", 
          "evidence", 
          "aging", 
          "absence", 
          "minority", 
          "entities", 
          "awareness", 
          "accumulation", 
          "formal criteria", 
          "nomenclature", 
          "time", 
          "area", 
          "features", 
          "designation", 
          "future", 
          "consisting", 
          "new term", 
          "terms", 
          "researchers", 
          "process", 
          "foundation", 
          "structure", 
          "conceptual foundations", 
          "amnestic cognitive changes", 
          "clinicopathologic designations", 
          "tangle-predominant senile dementia", 
          "diagnosis of PART", 
          "common biomarker profile consisting", 
          "biomarker profile consisting"
        ], 
        "name": "Primary age-related tauopathy (PART): a common pathology associated with human aging", 
        "pagination": "755-766", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036179092"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00401-014-1349-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25348064"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00401-014-1349-0", 
          "https://app.dimensions.ai/details/publication/pub.1036179092"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_622.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00401-014-1349-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-014-1349-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-014-1349-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-014-1349-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-014-1349-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    778 TRIPLES      22 PREDICATES      156 URIs      115 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00401-014-1349-0 schema:about N08cdccfc75fa4b308bd993b8c38f2470
    2 N18d911c9f4824391a2eb8d9d83ff34ab
    3 N4544d5bc830a4e548d6bee9f5cf116cb
    4 N5ac2e6fa5ca14db9981be7d15fee0e29
    5 N685bebce16b94fc2aa699546290a7487
    6 Nd13b0732adc4479bbe9272fb0fc69edb
    7 Nf692a2fa945f401dbdf80b1f915a365a
    8 anzsrc-for:11
    9 anzsrc-for:1103
    10 anzsrc-for:1109
    11 schema:author N156cf970b63f42218eabf213c161024b
    12 schema:citation sg:pub.10.1007/bf00294172
    13 sg:pub.10.1007/bf00296494
    14 sg:pub.10.1007/bf00304135
    15 sg:pub.10.1007/bf00304630
    16 sg:pub.10.1007/bf00308809
    17 sg:pub.10.1007/bf00318575
    18 sg:pub.10.1007/bf00690970
    19 sg:pub.10.1007/bf02865132
    20 sg:pub.10.1007/s00401-006-0127-z
    21 sg:pub.10.1007/s00401-006-0156-7
    22 sg:pub.10.1007/s00401-007-0237-2
    23 sg:pub.10.1007/s00401-007-0257-y
    24 sg:pub.10.1007/s00401-010-0789-4
    25 sg:pub.10.1007/s00401-011-0819-x
    26 sg:pub.10.1007/s00401-011-0889-9
    27 sg:pub.10.1007/s00401-011-0906-z
    28 sg:pub.10.1007/s00401-011-0910-3
    29 sg:pub.10.1007/s00401-012-1017-1
    30 sg:pub.10.1007/s00401-012-1044-y
    31 sg:pub.10.1007/s00401-013-1080-2
    32 sg:pub.10.1007/s00401-013-1157-y
    33 sg:pub.10.1007/s00401-013-1171-0
    34 sg:pub.10.1007/s00401-014-1302-2
    35 sg:pub.10.1007/s004010000283
    36 sg:pub.10.1007/s004010050726
    37 sg:pub.10.1007/s004010051189
    38 sg:pub.10.1007/s00406-013-0449-5
    39 sg:pub.10.1007/s12031-011-9589-0
    40 sg:pub.10.1038/197192b0
    41 sg:pub.10.1038/31508
    42 sg:pub.10.1038/ncb1901
    43 sg:pub.10.1038/nrn2786
    44 schema:datePublished 2014-10-28
    45 schema:datePublishedReg 2014-10-28
    46 schema:description We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer’s disease (AD), in the absence of amyloid (Aβ) plaques. For these “NFT+/Aβ−” brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as “tangle-only dementia” and “tangle-predominant senile dementia”, are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
    47 schema:genre article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree true
    50 schema:isPartOf N1e40f47a788f42f6848c10c8a3cae19a
    51 Ndfed056699744457b83099c94fd28135
    52 sg:journal.1019073
    53 schema:keywords AD neuropathologic change
    54 Alzheimer's disease
    55 Aβ accumulation
    56 Recent studies
    57 absence
    58 accumulation
    59 age-related tauopathy
    60 aged individuals
    61 aging
    62 amnestic cognitive changes
    63 amyloid plaques
    64 area
    65 atrophy
    66 autopsy study
    67 awareness
    68 basal forebrain
    69 biomarker profile consisting
    70 biomarkers
    71 brain
    72 brainstem
    73 changes
    74 clinical setting
    75 clinicians
    76 clinicopathologic designations
    77 cognitive changes
    78 cognitive impairment
    79 common biomarker profile consisting
    80 common pathologic changes
    81 common pathology
    82 conceptual foundations
    83 consisting
    84 criteria
    85 dementia
    86 designation
    87 diagnosis
    88 diagnosis of PART
    89 diagnostic criteria
    90 disease
    91 elderly individuals
    92 entities
    93 evidence
    94 features
    95 forebrain
    96 formal criteria
    97 foundation
    98 future
    99 future studies
    100 human aging
    101 imaging
    102 impairment
    103 individuals
    104 lobe
    105 lobe atrophy
    106 medial temporal lobe
    107 minority
    108 most subjects
    109 neurofibrillary tangles
    110 neuropathologic changes
    111 neuropathological diagnostic criteria
    112 new term
    113 nomenclature
    114 olfactory areas
    115 pathologic changes
    116 pathologic entity
    117 pathological processes
    118 pathology
    119 persons
    120 plaques
    121 present time
    122 primary age-related tauopathy
    123 prior reports
    124 process
    125 profile consisting
    126 profound impairment
    127 report
    128 researchers
    129 senile dementia
    130 setting
    131 structure
    132 study
    133 subjects
    134 symptoms
    135 tangle-predominant senile dementia
    136 tangles
    137 tau imaging
    138 tauopathies
    139 temporal lobe
    140 temporal lobe atrophy
    141 terms
    142 time
    143 schema:name Primary age-related tauopathy (PART): a common pathology associated with human aging
    144 schema:pagination 755-766
    145 schema:productId N51d8149667b143fb951e0a5453400499
    146 N7fdf28cafc464b9ea1451f1f588788ce
    147 Nb99420e5a3d24080b1c6eccdf3c20ad5
    148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036179092
    149 https://doi.org/10.1007/s00401-014-1349-0
    150 schema:sdDatePublished 2022-01-01T18:32
    151 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    152 schema:sdPublisher N6f63dcb9420b4bdf8a3d065e254884fc
    153 schema:url https://doi.org/10.1007/s00401-014-1349-0
    154 sgo:license sg:explorer/license/
    155 sgo:sdDataset articles
    156 rdf:type schema:ScholarlyArticle
    157 N0252e502e732471b8f5f5b73a387a8d7 rdf:first sg:person.01227450333.62
    158 rdf:rest N92f5be2930684c11a94a2076cdc30743
    159 N0367299c04ba4a809b8b26864fae0234 rdf:first sg:person.0714314167.12
    160 rdf:rest N34e81a39e9174686ae974106a74367df
    161 N063e2c2ebe534c698e443e4d505d1024 rdf:first sg:person.010226313537.53
    162 rdf:rest Nedcf6f82a315435d93c5d97d1559052f
    163 N088b74554de84209a8e618a7e61868aa rdf:first sg:person.0600212005.24
    164 rdf:rest N0de6e2bdeb584604bbdcce384ab38518
    165 N08cdccfc75fa4b308bd993b8c38f2470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Plaque, Amyloid
    167 rdf:type schema:DefinedTerm
    168 N0a1151706cd24198bb7feef319dea822 rdf:first sg:person.01262305573.27
    169 rdf:rest Ne21191a9ee7c490884bbb16a68b0527e
    170 N0d928b8ed0dd415a870fa0dcbd9e2439 rdf:first sg:person.01032345030.92
    171 rdf:rest Na5289f14922c455daa29d3999a0b3073
    172 N0de6e2bdeb584604bbdcce384ab38518 rdf:first sg:person.01177144156.19
    173 rdf:rest N8dc2013c71c8442db19c2a6c25faa34f
    174 N156cf970b63f42218eabf213c161024b rdf:first sg:person.01133706223.22
    175 rdf:rest N3568877ad86e49a7b198059e2ca912a4
    176 N1826636a058b46aabf22beea0f08b099 rdf:first sg:person.01324142075.05
    177 rdf:rest N6d8ff653cf2f4f959d4be4234c57e939
    178 N18d911c9f4824391a2eb8d9d83ff34ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Diagnosis, Differential
    180 rdf:type schema:DefinedTerm
    181 N1b39d6e3bc57470f946429d6c1cadeb7 rdf:first sg:person.015126147177.10
    182 rdf:rest N088b74554de84209a8e618a7e61868aa
    183 N1e40f47a788f42f6848c10c8a3cae19a schema:issueNumber 6
    184 rdf:type schema:PublicationIssue
    185 N216e6685af384b09bf1b098d7f26aa0c rdf:first sg:person.0772267646.67
    186 rdf:rest Nb748a1c9f2514002a0c16df9c6d4a04c
    187 N2e335b3ae8004e8bbd75fcfb58f46db4 rdf:first sg:person.0722037045.68
    188 rdf:rest Nfd86c97b652a4c36b5014ac41e2ec6cb
    189 N3185fe9f10674dc18842fe90969fe49c rdf:first sg:person.011647727137.86
    190 rdf:rest N0252e502e732471b8f5f5b73a387a8d7
    191 N3497996010bd45cf9a6ca85ed2b5dc43 schema:affiliation grid-institutes:grid.9707.9
    192 schema:familyName Yamada
    193 schema:givenName Masahito
    194 rdf:type schema:Person
    195 N34e81a39e9174686ae974106a74367df rdf:first sg:person.01004204017.25
    196 rdf:rest N47ea6df62942439c9b9d13f661ba3965
    197 N3568877ad86e49a7b198059e2ca912a4 rdf:first sg:person.01043025611.21
    198 rdf:rest Nbf567a72701c42609179ba8e88bd5422
    199 N4544d5bc830a4e548d6bee9f5cf116cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Aging
    201 rdf:type schema:DefinedTerm
    202 N47ea6df62942439c9b9d13f661ba3965 rdf:first sg:person.012263062067.82
    203 rdf:rest N2e335b3ae8004e8bbd75fcfb58f46db4
    204 N4a713248690144d08cfb1e2d8a222d06 rdf:first sg:person.01245701425.62
    205 rdf:rest N063e2c2ebe534c698e443e4d505d1024
    206 N4d724548125e4ef7a751984155cf3153 rdf:first sg:person.01244061222.16
    207 rdf:rest N7e49ed123f3c4ad3b703305d0ba336d0
    208 N5081280e12254ba1a8434e561491cb71 schema:affiliation grid-institutes:grid.25879.31
    209 schema:familyName Arnold
    210 schema:givenName Steven E.
    211 rdf:type schema:Person
    212 N517a3c41bf9046be89c6227b29b2608d rdf:first sg:person.015737376337.24
    213 rdf:rest Nebfc601fecd142b288524b6b4997d4f3
    214 N51d8149667b143fb951e0a5453400499 schema:name dimensions_id
    215 schema:value pub.1036179092
    216 rdf:type schema:PropertyValue
    217 N5439416b96ae4919a1713822d614f5ad rdf:first sg:person.011712740677.92
    218 rdf:rest Nf6ac407a88894b579dee9eb9dd203c48
    219 N5734e3e844784f5393b1bacf67192c82 rdf:first sg:person.01307060514.36
    220 rdf:rest N1826636a058b46aabf22beea0f08b099
    221 N5ac2e6fa5ca14db9981be7d15fee0e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Brain
    223 rdf:type schema:DefinedTerm
    224 N685bebce16b94fc2aa699546290a7487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Terminology as Topic
    226 rdf:type schema:DefinedTerm
    227 N6d8ff653cf2f4f959d4be4234c57e939 rdf:first sg:person.01062077762.19
    228 rdf:rest N0d928b8ed0dd415a870fa0dcbd9e2439
    229 N6f63dcb9420b4bdf8a3d065e254884fc schema:name Springer Nature - SN SciGraph project
    230 rdf:type schema:Organization
    231 N7e49ed123f3c4ad3b703305d0ba336d0 rdf:first sg:person.0677213273.18
    232 rdf:rest N1b39d6e3bc57470f946429d6c1cadeb7
    233 N7fdf28cafc464b9ea1451f1f588788ce schema:name doi
    234 schema:value 10.1007/s00401-014-1349-0
    235 rdf:type schema:PropertyValue
    236 N8971229390ad499d97f752558f0bb41e rdf:first sg:person.01147533121.37
    237 rdf:rest Nbc04318bf9fe481886d70312acddd19e
    238 N8dc2013c71c8442db19c2a6c25faa34f rdf:first sg:person.011635214007.54
    239 rdf:rest Na778d9545a8e4b689b9ad5b678ff25a4
    240 N8f8129f1176d4940be21e16d722a3643 rdf:first sg:person.0670505205.92
    241 rdf:rest N517a3c41bf9046be89c6227b29b2608d
    242 N92f5be2930684c11a94a2076cdc30743 rdf:first sg:person.0604640573.30
    243 rdf:rest N4a713248690144d08cfb1e2d8a222d06
    244 N95f30ea3a4864f93bf80a43ef0881f42 rdf:first sg:person.01235720500.03
    245 rdf:rest rdf:nil
    246 Na5289f14922c455daa29d3999a0b3073 rdf:first sg:person.0617341265.05
    247 rdf:rest N4d724548125e4ef7a751984155cf3153
    248 Na778d9545a8e4b689b9ad5b678ff25a4 rdf:first N3497996010bd45cf9a6ca85ed2b5dc43
    249 rdf:rest N95f30ea3a4864f93bf80a43ef0881f42
    250 Nb1d6cecfc211456881088f4a8eeb86ec rdf:first sg:person.016455760337.05
    251 rdf:rest Nf5e4ea10cb9e418995b76b11404d3e04
    252 Nb748a1c9f2514002a0c16df9c6d4a04c rdf:first sg:person.014653302237.67
    253 rdf:rest N0a1151706cd24198bb7feef319dea822
    254 Nb99420e5a3d24080b1c6eccdf3c20ad5 schema:name pubmed_id
    255 schema:value 25348064
    256 rdf:type schema:PropertyValue
    257 Nbc04318bf9fe481886d70312acddd19e rdf:first sg:person.010333410267.83
    258 rdf:rest Nc4f53c8e6b68474f8e059f1c565a360a
    259 Nbf567a72701c42609179ba8e88bd5422 rdf:first sg:person.016635011667.86
    260 rdf:rest N8971229390ad499d97f752558f0bb41e
    261 Nc4f53c8e6b68474f8e059f1c565a360a rdf:first sg:person.01061660663.93
    262 rdf:rest Nf591b7f505aa4171b36a25b7d8faadfd
    263 Nd13b0732adc4479bbe9272fb0fc69edb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Tauopathies
    265 rdf:type schema:DefinedTerm
    266 Nd5f246071d184755bede430d7bd3b4d4 rdf:first sg:person.0652012300.82
    267 rdf:rest N8f8129f1176d4940be21e16d722a3643
    268 Ndfed056699744457b83099c94fd28135 schema:volumeNumber 128
    269 rdf:type schema:PublicationVolume
    270 Ne21191a9ee7c490884bbb16a68b0527e rdf:first sg:person.01337443160.17
    271 rdf:rest N3185fe9f10674dc18842fe90969fe49c
    272 Nebfc601fecd142b288524b6b4997d4f3 rdf:first sg:person.01055656322.89
    273 rdf:rest N5439416b96ae4919a1713822d614f5ad
    274 Nedcf6f82a315435d93c5d97d1559052f rdf:first sg:person.011423652677.15
    275 rdf:rest Nb1d6cecfc211456881088f4a8eeb86ec
    276 Nf591b7f505aa4171b36a25b7d8faadfd rdf:first N5081280e12254ba1a8434e561491cb71
    277 rdf:rest N216e6685af384b09bf1b098d7f26aa0c
    278 Nf5e4ea10cb9e418995b76b11404d3e04 rdf:first sg:person.016005175252.25
    279 rdf:rest Nd5f246071d184755bede430d7bd3b4d4
    280 Nf692a2fa945f401dbdf80b1f915a365a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Humans
    282 rdf:type schema:DefinedTerm
    283 Nf6ac407a88894b579dee9eb9dd203c48 rdf:first sg:person.01150076163.89
    284 rdf:rest N0367299c04ba4a809b8b26864fae0234
    285 Nfd86c97b652a4c36b5014ac41e2ec6cb rdf:first sg:person.0636347411.07
    286 rdf:rest N5734e3e844784f5393b1bacf67192c82
    287 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    288 schema:name Medical and Health Sciences
    289 rdf:type schema:DefinedTerm
    290 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    291 schema:name Clinical Sciences
    292 rdf:type schema:DefinedTerm
    293 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    294 schema:name Neurosciences
    295 rdf:type schema:DefinedTerm
    296 sg:grant.2434589 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    297 rdf:type schema:MonetaryGrant
    298 sg:grant.2434604 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    299 rdf:type schema:MonetaryGrant
    300 sg:grant.2434607 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    301 rdf:type schema:MonetaryGrant
    302 sg:grant.2434647 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    303 rdf:type schema:MonetaryGrant
    304 sg:grant.2434749 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    305 rdf:type schema:MonetaryGrant
    306 sg:grant.2438585 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    307 rdf:type schema:MonetaryGrant
    308 sg:grant.2438591 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    309 rdf:type schema:MonetaryGrant
    310 sg:grant.2438598 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    311 rdf:type schema:MonetaryGrant
    312 sg:grant.2438611 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    313 rdf:type schema:MonetaryGrant
    314 sg:grant.2438612 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    315 rdf:type schema:MonetaryGrant
    316 sg:grant.2438625 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    317 rdf:type schema:MonetaryGrant
    318 sg:grant.2438651 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    319 rdf:type schema:MonetaryGrant
    320 sg:grant.2438672 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    321 rdf:type schema:MonetaryGrant
    322 sg:grant.2440005 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    323 rdf:type schema:MonetaryGrant
    324 sg:grant.2440006 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    325 rdf:type schema:MonetaryGrant
    326 sg:grant.2440008 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    327 rdf:type schema:MonetaryGrant
    328 sg:grant.2440009 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    329 rdf:type schema:MonetaryGrant
    330 sg:grant.2440012 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    331 rdf:type schema:MonetaryGrant
    332 sg:grant.2440013 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    333 rdf:type schema:MonetaryGrant
    334 sg:grant.2440018 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    335 rdf:type schema:MonetaryGrant
    336 sg:grant.2440028 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    337 rdf:type schema:MonetaryGrant
    338 sg:grant.2440031 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    339 rdf:type schema:MonetaryGrant
    340 sg:grant.2445992 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    341 rdf:type schema:MonetaryGrant
    342 sg:grant.2448725 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    343 rdf:type schema:MonetaryGrant
    344 sg:grant.2448790 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    345 rdf:type schema:MonetaryGrant
    346 sg:grant.2448968 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    347 rdf:type schema:MonetaryGrant
    348 sg:grant.2633574 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    349 rdf:type schema:MonetaryGrant
    350 sg:grant.2686916 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    351 rdf:type schema:MonetaryGrant
    352 sg:grant.2686973 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    353 rdf:type schema:MonetaryGrant
    354 sg:grant.2775301 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    355 rdf:type schema:MonetaryGrant
    356 sg:grant.2781746 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    357 rdf:type schema:MonetaryGrant
    358 sg:grant.2786665 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    359 rdf:type schema:MonetaryGrant
    360 sg:grant.3781719 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    361 rdf:type schema:MonetaryGrant
    362 sg:grant.6138904 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    363 rdf:type schema:MonetaryGrant
    364 sg:grant.7082210 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-014-1349-0
    365 rdf:type schema:MonetaryGrant
    366 sg:journal.1019073 schema:issn 0001-6322
    367 1432-0533
    368 schema:name Acta Neuropathologica
    369 schema:publisher Springer Nature
    370 rdf:type schema:Periodical
    371 sg:person.01004204017.25 schema:affiliation grid-institutes:grid.417467.7
    372 schema:familyName Murray
    373 schema:givenName Melissa E.
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004204017.25
    375 rdf:type schema:Person
    376 sg:person.010226313537.53 schema:affiliation grid-institutes:grid.32224.35
    377 schema:familyName Hyman
    378 schema:givenName Bradley T.
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010226313537.53
    380 rdf:type schema:Person
    381 sg:person.01032345030.92 schema:affiliation grid-institutes:grid.417092.9
    382 schema:familyName Takao
    383 schema:givenName Masaki
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032345030.92
    385 rdf:type schema:Person
    386 sg:person.010333410267.83 schema:affiliation grid-institutes:grid.266539.d
    387 schema:familyName Abner
    388 schema:givenName Erin L.
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010333410267.83
    390 rdf:type schema:Person
    391 sg:person.01043025611.21 schema:affiliation grid-institutes:grid.25879.31
    392 schema:familyName Trojanowski
    393 schema:givenName John Q.
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043025611.21
    395 rdf:type schema:Person
    396 sg:person.01055656322.89 schema:affiliation grid-institutes:grid.17091.3e
    397 schema:familyName Mackenzie
    398 schema:givenName Ian R.
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055656322.89
    400 rdf:type schema:Person
    401 sg:person.01061660663.93 schema:affiliation grid-institutes:grid.8993.b
    402 schema:familyName Alafuzoff
    403 schema:givenName Irina
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061660663.93
    405 rdf:type schema:Person
    406 sg:person.01062077762.19 schema:affiliation grid-institutes:grid.189504.1
    407 schema:familyName Stein
    408 schema:givenName Thor
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062077762.19
    410 rdf:type schema:Person
    411 sg:person.01133706223.22 schema:affiliation grid-institutes:grid.239585.0
    412 schema:familyName Crary
    413 schema:givenName John F.
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133706223.22
    415 rdf:type schema:Person
    416 sg:person.011423652677.15 schema:affiliation grid-institutes:grid.10420.37
    417 schema:familyName Jellinger
    418 schema:givenName Kurt
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011423652677.15
    420 rdf:type schema:Person
    421 sg:person.01147533121.37 schema:affiliation grid-institutes:grid.266539.d
    422 schema:familyName Abisambra
    423 schema:givenName Jose F.
    424 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147533121.37
    425 rdf:type schema:Person
    426 sg:person.01150076163.89 schema:affiliation grid-institutes:grid.189504.1
    427 schema:familyName McKee
    428 schema:givenName Ann
    429 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150076163.89
    430 rdf:type schema:Person
    431 sg:person.011635214007.54 schema:affiliation grid-institutes:grid.5288.7
    432 schema:familyName Woltjer
    433 schema:givenName Randall L.
    434 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011635214007.54
    435 rdf:type schema:Person
    436 sg:person.011647727137.86 schema:affiliation grid-institutes:grid.417467.7
    437 schema:familyName Dickson
    438 schema:givenName Dennis W.
    439 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011647727137.86
    440 rdf:type schema:Person
    441 sg:person.011712740677.92 schema:affiliation grid-institutes:None
    442 schema:familyName Masliah
    443 schema:givenName Eliezer
    444 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011712740677.92
    445 rdf:type schema:Person
    446 sg:person.01177144156.19 schema:affiliation grid-institutes:grid.137628.9
    447 schema:familyName Wisniewski
    448 schema:givenName Thomas
    449 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177144156.19
    450 rdf:type schema:Person
    451 sg:person.012263062067.82 schema:affiliation grid-institutes:grid.266539.d
    452 schema:familyName Neltner
    453 schema:givenName Janna H.
    454 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012263062067.82
    455 rdf:type schema:Person
    456 sg:person.01227450333.62 schema:affiliation grid-institutes:grid.189967.8
    457 schema:familyName Gearing
    458 schema:givenName Marla
    459 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227450333.62
    460 rdf:type schema:Person
    461 sg:person.01235720500.03 schema:affiliation grid-institutes:grid.266539.d
    462 schema:familyName Nelson
    463 schema:givenName Peter T.
    464 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235720500.03
    465 rdf:type schema:Person
    466 sg:person.01244061222.16 schema:affiliation grid-institutes:grid.25879.31
    467 schema:familyName Toledo
    468 schema:givenName Jonathan B.
    469 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244061222.16
    470 rdf:type schema:Person
    471 sg:person.01245701425.62 schema:affiliation grid-institutes:grid.59734.3c
    472 schema:familyName Hof
    473 schema:givenName Patrick R.
    474 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245701425.62
    475 rdf:type schema:Person
    476 sg:person.01262305573.27 schema:affiliation grid-institutes:grid.16753.36
    477 schema:familyName Bigio
    478 schema:givenName Eileen H.
    479 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262305573.27
    480 rdf:type schema:Person
    481 sg:person.01307060514.36 schema:affiliation grid-institutes:grid.412584.e
    482 schema:familyName Serrano-Pozo
    483 schema:givenName Alberto
    484 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307060514.36
    485 rdf:type schema:Person
    486 sg:person.01324142075.05 schema:affiliation grid-institutes:grid.239585.0
    487 schema:familyName Shelanski
    488 schema:givenName Michael L.
    489 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324142075.05
    490 rdf:type schema:Person
    491 sg:person.01337443160.17 schema:affiliation grid-institutes:grid.4367.6
    492 schema:familyName Cairns
    493 schema:givenName Nigel J.
    494 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337443160.17
    495 rdf:type schema:Person
    496 sg:person.014653302237.67 schema:affiliation grid-institutes:grid.414208.b
    497 schema:familyName Beach
    498 schema:givenName Thomas G.
    499 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014653302237.67
    500 rdf:type schema:Person
    501 sg:person.015126147177.10 schema:affiliation grid-institutes:grid.239585.0
    502 schema:familyName Vonsattel
    503 schema:givenName Jean Paul
    504 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015126147177.10
    505 rdf:type schema:Person
    506 sg:person.015737376337.24 schema:affiliation grid-institutes:grid.34477.33
    507 schema:familyName Kukull
    508 schema:givenName Walter A.
    509 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015737376337.24
    510 rdf:type schema:Person
    511 sg:person.016005175252.25 schema:affiliation grid-institutes:grid.22937.3d
    512 schema:familyName Kovacs
    513 schema:givenName Gabor G.
    514 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016005175252.25
    515 rdf:type schema:Person
    516 sg:person.016455760337.05 schema:affiliation grid-institutes:grid.266539.d
    517 schema:familyName Jicha
    518 schema:givenName Gregory A.
    519 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016455760337.05
    520 rdf:type schema:Person
    521 sg:person.016635011667.86 schema:affiliation grid-institutes:grid.240684.c
    522 schema:familyName Schneider
    523 schema:givenName Julie A.
    524 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016635011667.86
    525 rdf:type schema:Person
    526 sg:person.0600212005.24 schema:affiliation grid-institutes:grid.267313.2
    527 schema:familyName White
    528 schema:givenName Charles L.
    529 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600212005.24
    530 rdf:type schema:Person
    531 sg:person.0604640573.30 schema:affiliation grid-institutes:grid.11899.38
    532 schema:familyName Grinberg
    533 schema:givenName Lea T.
    534 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604640573.30
    535 rdf:type schema:Person
    536 sg:person.0617341265.05 schema:affiliation grid-institutes:grid.6582.9
    537 schema:familyName Thal
    538 schema:givenName Dietmar R.
    539 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617341265.05
    540 rdf:type schema:Person
    541 sg:person.0636347411.07 schema:affiliation grid-institutes:grid.266102.1
    542 schema:familyName Seeley
    543 schema:givenName William W.
    544 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636347411.07
    545 rdf:type schema:Person
    546 sg:person.0652012300.82 schema:affiliation grid-institutes:grid.66875.3a
    547 schema:familyName Knopman
    548 schema:givenName David S.
    549 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652012300.82
    550 rdf:type schema:Person
    551 sg:person.0670505205.92 schema:affiliation grid-institutes:grid.412689.0
    552 schema:familyName Kofler
    553 schema:givenName Julia
    554 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670505205.92
    555 rdf:type schema:Person
    556 sg:person.0677213273.18 schema:affiliation grid-institutes:grid.25879.31
    557 schema:familyName Troncoso
    558 schema:givenName Juan C.
    559 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677213273.18
    560 rdf:type schema:Person
    561 sg:person.0714314167.12 schema:affiliation grid-institutes:grid.34477.33
    562 schema:familyName Montine
    563 schema:givenName Thomas J.
    564 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714314167.12
    565 rdf:type schema:Person
    566 sg:person.0722037045.68 schema:affiliation grid-institutes:grid.239585.0
    567 schema:familyName Santa-Maria
    568 schema:givenName Ismael
    569 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722037045.68
    570 rdf:type schema:Person
    571 sg:person.0772267646.67 schema:affiliation grid-institutes:grid.1006.7
    572 schema:familyName Attems
    573 schema:givenName Johannes
    574 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772267646.67
    575 rdf:type schema:Person
    576 sg:pub.10.1007/bf00294172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040159608
    577 https://doi.org/10.1007/bf00294172
    578 rdf:type schema:CreativeWork
    579 sg:pub.10.1007/bf00296494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011522454
    580 https://doi.org/10.1007/bf00296494
    581 rdf:type schema:CreativeWork
    582 sg:pub.10.1007/bf00304135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043340821
    583 https://doi.org/10.1007/bf00304135
    584 rdf:type schema:CreativeWork
    585 sg:pub.10.1007/bf00304630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041791763
    586 https://doi.org/10.1007/bf00304630
    587 rdf:type schema:CreativeWork
    588 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
    589 https://doi.org/10.1007/bf00308809
    590 rdf:type schema:CreativeWork
    591 sg:pub.10.1007/bf00318575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023027277
    592 https://doi.org/10.1007/bf00318575
    593 rdf:type schema:CreativeWork
    594 sg:pub.10.1007/bf00690970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016369234
    595 https://doi.org/10.1007/bf00690970
    596 rdf:type schema:CreativeWork
    597 sg:pub.10.1007/bf02865132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047245703
    598 https://doi.org/10.1007/bf02865132
    599 rdf:type schema:CreativeWork
    600 sg:pub.10.1007/s00401-006-0127-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1022911785
    601 https://doi.org/10.1007/s00401-006-0127-z
    602 rdf:type schema:CreativeWork
    603 sg:pub.10.1007/s00401-006-0156-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037387092
    604 https://doi.org/10.1007/s00401-006-0156-7
    605 rdf:type schema:CreativeWork
    606 sg:pub.10.1007/s00401-007-0237-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029516874
    607 https://doi.org/10.1007/s00401-007-0237-2
    608 rdf:type schema:CreativeWork
    609 sg:pub.10.1007/s00401-007-0257-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028395796
    610 https://doi.org/10.1007/s00401-007-0257-y
    611 rdf:type schema:CreativeWork
    612 sg:pub.10.1007/s00401-010-0789-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037411515
    613 https://doi.org/10.1007/s00401-010-0789-4
    614 rdf:type schema:CreativeWork
    615 sg:pub.10.1007/s00401-011-0819-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048400464
    616 https://doi.org/10.1007/s00401-011-0819-x
    617 rdf:type schema:CreativeWork
    618 sg:pub.10.1007/s00401-011-0889-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046129453
    619 https://doi.org/10.1007/s00401-011-0889-9
    620 rdf:type schema:CreativeWork
    621 sg:pub.10.1007/s00401-011-0906-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029939986
    622 https://doi.org/10.1007/s00401-011-0906-z
    623 rdf:type schema:CreativeWork
    624 sg:pub.10.1007/s00401-011-0910-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045607293
    625 https://doi.org/10.1007/s00401-011-0910-3
    626 rdf:type schema:CreativeWork
    627 sg:pub.10.1007/s00401-012-1017-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019337931
    628 https://doi.org/10.1007/s00401-012-1017-1
    629 rdf:type schema:CreativeWork
    630 sg:pub.10.1007/s00401-012-1044-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1010342082
    631 https://doi.org/10.1007/s00401-012-1044-y
    632 rdf:type schema:CreativeWork
    633 sg:pub.10.1007/s00401-013-1080-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031975363
    634 https://doi.org/10.1007/s00401-013-1080-2
    635 rdf:type schema:CreativeWork
    636 sg:pub.10.1007/s00401-013-1157-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1013961840
    637 https://doi.org/10.1007/s00401-013-1157-y
    638 rdf:type schema:CreativeWork
    639 sg:pub.10.1007/s00401-013-1171-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049465792
    640 https://doi.org/10.1007/s00401-013-1171-0
    641 rdf:type schema:CreativeWork
    642 sg:pub.10.1007/s00401-014-1302-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045662232
    643 https://doi.org/10.1007/s00401-014-1302-2
    644 rdf:type schema:CreativeWork
    645 sg:pub.10.1007/s004010000283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012350340
    646 https://doi.org/10.1007/s004010000283
    647 rdf:type schema:CreativeWork
    648 sg:pub.10.1007/s004010050726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048473262
    649 https://doi.org/10.1007/s004010050726
    650 rdf:type schema:CreativeWork
    651 sg:pub.10.1007/s004010051189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051286846
    652 https://doi.org/10.1007/s004010051189
    653 rdf:type schema:CreativeWork
    654 sg:pub.10.1007/s00406-013-0449-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003894586
    655 https://doi.org/10.1007/s00406-013-0449-5
    656 rdf:type schema:CreativeWork
    657 sg:pub.10.1007/s12031-011-9589-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013977394
    658 https://doi.org/10.1007/s12031-011-9589-0
    659 rdf:type schema:CreativeWork
    660 sg:pub.10.1038/197192b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039641676
    661 https://doi.org/10.1038/197192b0
    662 rdf:type schema:CreativeWork
    663 sg:pub.10.1038/31508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030318669
    664 https://doi.org/10.1038/31508
    665 rdf:type schema:CreativeWork
    666 sg:pub.10.1038/ncb1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042538398
    667 https://doi.org/10.1038/ncb1901
    668 rdf:type schema:CreativeWork
    669 sg:pub.10.1038/nrn2786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037916934
    670 https://doi.org/10.1038/nrn2786
    671 rdf:type schema:CreativeWork
    672 grid-institutes:None schema:alternateName Departments of Neurosciences and Pathology, University of California, 92093, San Diego, La Jolla, CA, USA
    673 schema:name Departments of Neurosciences and Pathology, University of California, 92093, San Diego, La Jolla, CA, USA
    674 rdf:type schema:Organization
    675 grid-institutes:grid.1006.7 schema:alternateName Institute for Ageing and Health, Newcastle University, NE45PL, Newcastle upon Tyne, UK
    676 schema:name Institute for Ageing and Health, Newcastle University, NE45PL, Newcastle upon Tyne, UK
    677 rdf:type schema:Organization
    678 grid-institutes:grid.10420.37 schema:alternateName Institute of Clinical Neurobiology, 1070, Vienna, Austria
    679 schema:name Institute of Clinical Neurobiology, 1070, Vienna, Austria
    680 rdf:type schema:Organization
    681 grid-institutes:grid.11899.38 schema:alternateName Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil
    682 schema:name Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil
    683 Departments of Neurology and Pathology, UC, 94110, San Francisco, CA, USA
    684 rdf:type schema:Organization
    685 grid-institutes:grid.137628.9 schema:alternateName Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, 10016, New York, NY, USA
    686 schema:name Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, 10016, New York, NY, USA
    687 rdf:type schema:Organization
    688 grid-institutes:grid.16753.36 schema:alternateName Department of Pathology (Neuropathology), Northwestern Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA
    689 schema:name Department of Pathology (Neuropathology), Northwestern Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA
    690 rdf:type schema:Organization
    691 grid-institutes:grid.17091.3e schema:alternateName Department of Pathology, University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, BC, Canada
    692 schema:name Department of Pathology, University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, BC, Canada
    693 rdf:type schema:Organization
    694 grid-institutes:grid.189504.1 schema:alternateName Department of Pathology (Neuropathology), Boston University, 02118, Boston, MA, USA
    695 Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, 02118, Boston, MA, USA
    696 schema:name Department of Pathology (Neuropathology), Boston University, 02118, Boston, MA, USA
    697 Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, 02118, Boston, MA, USA
    698 rdf:type schema:Organization
    699 grid-institutes:grid.189967.8 schema:alternateName Department of Pathology and Laboratory Medicine (Neuropathology), Emory University School of Medicine, 30322, Atlanta, GA, USA
    700 schema:name Department of Pathology and Laboratory Medicine (Neuropathology), Emory University School of Medicine, 30322, Atlanta, GA, USA
    701 rdf:type schema:Organization
    702 grid-institutes:grid.22937.3d schema:alternateName Institute of Neurology, Medical University Vienna, 1090, Vienna, Austria
    703 schema:name Institute of Neurology, Medical University Vienna, 1090, Vienna, Austria
    704 rdf:type schema:Organization
    705 grid-institutes:grid.239585.0 schema:alternateName Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA
    706 schema:name Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 10032, New York, NY, USA
    707 rdf:type schema:Organization
    708 grid-institutes:grid.240684.c schema:alternateName Departments of Pathology (Neuropathology) and Neurological Sciences, Rush University Medical Center, 60612, Chicago, IL, USA
    709 schema:name Departments of Pathology (Neuropathology) and Neurological Sciences, Rush University Medical Center, 60612, Chicago, IL, USA
    710 rdf:type schema:Organization
    711 grid-institutes:grid.25879.31 schema:alternateName Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA
    712 Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA
    713 Departments of Psychiatry and Neurology, University of Pennsylvania, 19104, Philadelphia, PA, USA
    714 schema:name Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA
    715 Department of Pathology, Division of Neuropathology, University of Pennsylvania, 19104, Philadelphia, PA, USA
    716 Departments of Psychiatry and Neurology, University of Pennsylvania, 19104, Philadelphia, PA, USA
    717 rdf:type schema:Organization
    718 grid-institutes:grid.266102.1 schema:alternateName Departments of Neurology and Pathology, University of California, 94143, San Francisco, CA, USA
    719 schema:name Departments of Neurology and Pathology, University of California, 94143, San Francisco, CA, USA
    720 rdf:type schema:Organization
    721 grid-institutes:grid.266539.d schema:alternateName Department of Neurology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    722 Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
    723 Department of Pathology, University of Kentucky, 40536, Lexington, KY, USA
    724 Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
    725 Department of Public Health and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
    726 schema:name Department of Neurology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    727 Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
    728 Department of Pathology, University of Kentucky, 40536, Lexington, KY, USA
    729 Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
    730 Department of Public Health and Sanders-Brown Center on Aging, University of Kentucky, 40536, Lexington, KY, USA
    731 rdf:type schema:Organization
    732 grid-institutes:grid.267313.2 schema:alternateName Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, 75390, Dallas, TX, USA
    733 schema:name Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, 75390, Dallas, TX, USA
    734 rdf:type schema:Organization
    735 grid-institutes:grid.32224.35 schema:alternateName Department of Neurology, Harvard Medical School and Massachusetts General Hospital, 02129, Charlestown, MA, USA
    736 schema:name Department of Neurology, Harvard Medical School and Massachusetts General Hospital, 02129, Charlestown, MA, USA
    737 rdf:type schema:Organization
    738 grid-institutes:grid.34477.33 schema:alternateName Department of Epidemiology, University of Washington, 98104, Seattle, WA, USA
    739 Department of Pathology, University of Washington, 98104, Seattle, WA, USA
    740 schema:name Department of Epidemiology, University of Washington, 98104, Seattle, WA, USA
    741 Department of Pathology, University of Washington, 98104, Seattle, WA, USA
    742 rdf:type schema:Organization
    743 grid-institutes:grid.412584.e schema:alternateName Department of Neurology, University of Iowa Hospitals and Clinics, 52242, Iowa city, IA, USA
    744 schema:name Department of Neurology, University of Iowa Hospitals and Clinics, 52242, Iowa city, IA, USA
    745 rdf:type schema:Organization
    746 grid-institutes:grid.412689.0 schema:alternateName Department of Pathology (Neuropathology), University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA
    747 schema:name Department of Pathology (Neuropathology), University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA
    748 rdf:type schema:Organization
    749 grid-institutes:grid.414208.b schema:alternateName Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, 85351, Sun City, AZ, USA
    750 schema:name Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, 85351, Sun City, AZ, USA
    751 rdf:type schema:Organization
    752 grid-institutes:grid.417092.9 schema:alternateName Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, 173-0015, Tokyo, Japan
    753 schema:name Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, 173-0015, Tokyo, Japan
    754 rdf:type schema:Organization
    755 grid-institutes:grid.417467.7 schema:alternateName Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA
    756 schema:name Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA
    757 rdf:type schema:Organization
    758 grid-institutes:grid.4367.6 schema:alternateName Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA
    759 schema:name Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA
    760 rdf:type schema:Organization
    761 grid-institutes:grid.5288.7 schema:alternateName Department of Pathology L113, Oregon Health Sciences University, 97239, Portland, OR, USA
    762 schema:name Department of Pathology L113, Oregon Health Sciences University, 97239, Portland, OR, USA
    763 rdf:type schema:Organization
    764 grid-institutes:grid.59734.3c schema:alternateName Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA
    765 schema:name Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA
    766 rdf:type schema:Organization
    767 grid-institutes:grid.6582.9 schema:alternateName Laboratory of Neuropathology, University of Ulm, 89081, Ulm, Germany
    768 schema:name Laboratory of Neuropathology, University of Ulm, 89081, Ulm, Germany
    769 rdf:type schema:Organization
    770 grid-institutes:grid.66875.3a schema:alternateName Department of Neurology, Mayo Clinic, 55905, Rochester, MN, USA
    771 schema:name Department of Neurology, Mayo Clinic, 55905, Rochester, MN, USA
    772 rdf:type schema:Organization
    773 grid-institutes:grid.8993.b schema:alternateName Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden
    774 schema:name Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85, Uppsala, Sweden
    775 rdf:type schema:Organization
    776 grid-institutes:grid.9707.9 schema:alternateName Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, 920-8640, Kanazawa, Japan
    777 schema:name Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, 920-8640, Kanazawa, Japan
    778 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...