Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

Benedikt Wiestler, David Capper, Martin Sill, David T. W. Jones, Volker Hovestadt, Dominik Sturm, Christian Koelsche, Anna Bertoni, Leonille Schweizer, Andrey Korshunov, Elisa K. Weiß, Maximilian G. Schliesser, Alexander Radbruch, Christel Herold-Mende, Patrick Roth, Andreas Unterberg, Christian Hartmann, Torsten Pietsch, Guido Reifenberger, Peter Lichter, Bernhard Radlwimmer, Michael Platten, Stefan M. Pfister, Andreas von Deimling, Michael Weller, Wolfgang Wick

ABSTRACT

The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation analysis, using a platform which also allows the detection of copy-number aberrations, was performed in a cohort of 228 patients with anaplastic gliomas (astrocytomas, oligoastrocytomas, and oligodendrogliomas), including 115 patients of the NOA-04 trial. We further compared these tumors with a group of 55 glioblastomas. Unsupervised clustering of DNA methylation patterns revealed two main groups correlated with IDH status: CpG island methylator phenotype (CIMP) positive (77.5 %) or negative (22.5 %). CIMP(pos) (IDH mutant) tumors showed a further separation based on copy-number status of chromosome arms 1p and 19q. CIMP(neg) (IDH wild type) tumors showed hallmark copy-number alterations of glioblastomas, and clustered together with CIMP(neg) glioblastomas without forming separate groups based on WHO grade. Notably, there was no molecular evidence for a distinct biological entity representing anaplastic oligoastrocytoma. Tumor classification based on CIMP and 1p/19q status was significantly associated with survival, allowing a better prediction of outcome than the current histopathological classification: patients with CIMP(pos) tumors with 1p/19q codeletion (CIMP-codel) had the best prognosis, followed by patients with CIMP(pos) tumors but intact 1p/19q status (CIMP-non-codel). Patients with CIMP(neg) anaplastic gliomas (GBM-like) had the worst prognosis. Collectively, our data suggest that anaplastic gliomas can be grouped by IDH and 1p/19q status into three molecular groups that show clear links to underlying biology and a significant association with clinical outcome in a prospective trial cohort. More... »

PAGES

561-571

References to SciGraph publications

  • 2014-02. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge in NATURE REVIEWS CANCER
  • 2012-11. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations in ACTA NEUROPATHOLOGICA
  • 2013-12. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system in ACTA NEUROPATHOLOGICA
  • 2012-03. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype in NATURE
  • 2014-07. MGMT testing—the challenges for biomarker-based glioma treatment in NATURE REVIEWS NEUROLOGY
  • 2013-09. ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis in ACTA NEUROPATHOLOGICA
  • 2010-12. Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas in ACTA NEUROPATHOLOGICA
  • 2013-08. Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors in ACTA NEUROPATHOLOGICA
  • 2013-10. The integrated landscape of driver genomic alterations in glioblastoma in NATURE GENETICS
  • 2012-10. MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status in ACTA NEUROPATHOLOGICA
  • 2007-07-12. The 2007 WHO Classification of Tumours of the Central Nervous System in ACTA NEUROPATHOLOGICA
  • 2012-02. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-014-1315-x

    DOI

    http://dx.doi.org/10.1007/s00401-014-1315-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015534862

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25008768


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