Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-12

AUTHORS

Heiko Braak, Henrik Zetterberg, Kelly Del Tredici, Kaj Blennow

ABSTRACT

In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of Alzheimer’s disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebrospinal fluid are detectable only with the onset and progression of clinical symptoms. This sequence of events in cerebrospinal fluid (amyloid-β changes detectable prior to abnormal tau changes) contrasts with that in which both proteins develop in the brain, where intraneuronal tau inclusions (pretangles, neurofibrillary tangles, neuropil threads) appear decades before the deposition of amyloid-β plaques (diffuse plaques, neuritic plaques). This viewpoint attempts to address questions arising in connection with this apparent sequential discrepancy—questions and issues for which there are currently no clear-cut answers. More... »

PAGES

631-641

References to SciGraph publications

  • 2012-09-21. Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis in TRANSLATIONAL NEURODEGENERATION
  • 2010-02-16. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease in NATURE REVIEWS NEUROLOGY
  • 2010-12-15. The pathological process underlying Alzheimer’s disease in individuals under thirty in ACTA NEUROPATHOLOGICA
  • 2009-04-21. Classification and basic pathology of Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 2003-11. Aging, Amyloid, and Alzheimer's Disease: A Perspective in Honor of Carl Cotman in NEUROCHEMICAL RESEARCH
  • 1992-09. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids in NATURE
  • 2012-04-20. The Biology and Pathobiology of Tau Protein in CYTOSKELETON AND HUMAN DISEASE
  • 2007-03-20. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau in ACTA NEUROPATHOLOGICA
  • 2007-09. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders in NATURE REVIEWS NEUROSCIENCE
  • 2012-11-27. Advance in the pathogenesis and treatment of Wilson disease in TRANSLATIONAL NEURODEGENERATION
  • 2001-06. Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence in ACTA NEUROPATHOLOGICA
  • 2011-11-20. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach in ACTA NEUROPATHOLOGICA
  • 1991-09. Neuropathological stageing of Alzheimer-related changes in ACTA NEUROPATHOLOGICA
  • 2004-08. Pathways towards and away from Alzheimer's disease in NATURE
  • 2009-04. How can we recognize “disease modification” effects? in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2011-08-19. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics in NATURE REVIEWS DRUG DISCOVERY
  • 1995-12. tau protein in cerebrospinal fluid in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2009-01-30. Mechanisms of tau-induced neurodegeneration in ACTA NEUROPATHOLOGICA
  • 2011-04-24. Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies in ACTA NEUROPATHOLOGICA
  • 2004-04. Cerebrospinal fluid protein biomarkers for Alzheimer’s disease in NEUROTHERAPEUTICS
  • 2010-07-09. Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo in ACTA NEUROPATHOLOGICA
  • 2007-03-31. Silver diagnosis in neuropathology: principles, practice and revised interpretation in ACTA NEUROPATHOLOGICA
  • 2011-12-11. Hyperphosphorylated tau in young and middle-aged subjects in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0

    DOI

    http://dx.doi.org/10.1007/s00401-013-1139-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004016755

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23756600


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alzheimer Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloid beta-Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurofibrillary Tangles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "tau Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany", 
              "id": "http://www.grid.ac/institutes/grid.6582.9", 
              "name": [
                "Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braak", 
            "givenName": "Heiko", 
            "id": "sg:person.01053255500.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal Campus, 431 80, M\u00f6lndal, Sweden", 
                "UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zetterberg", 
            "givenName": "Henrik", 
            "id": "sg:person.0747372175.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747372175.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany", 
              "id": "http://www.grid.ac/institutes/grid.6582.9", 
              "name": [
                "Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Del Tredici", 
            "givenName": "Kelly", 
            "id": "sg:person.01340323332.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323332.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal Campus, 431 80, M\u00f6lndal, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.1649.a", 
              "name": [
                "Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal Campus, 431 80, M\u00f6lndal, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blennow", 
            "givenName": "Kaj", 
            "id": "sg:person.07606016437.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07606016437.66"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1023/a:1026065122854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052494683", 
              "https://doi.org/10.1023/a:1026065122854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0910-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045607293", 
              "https://doi.org/10.1007/s00401-011-0910-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009624842", 
              "https://doi.org/10.1038/nrd3505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0486-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022510509", 
              "https://doi.org/10.1007/s00401-009-0486-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0532-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022622684", 
              "https://doi.org/10.1007/s00401-009-0532-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0906-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029939986", 
              "https://doi.org/10.1007/s00401-011-0906-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-010-0789-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037411515", 
              "https://doi.org/10.1007/s00401-010-0789-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02815140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035207722", 
              "https://doi.org/10.1007/bf02815140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032680057", 
              "https://doi.org/10.1038/nrn2194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneurol.2010.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016181353", 
              "https://doi.org/10.1038/nrneurol.2010.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0207-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024620200", 
              "https://doi.org/10.1007/s00401-007-0207-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010000306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074868390", 
              "https://doi.org/10.1007/s004010000306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12603-009-0036-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020676367", 
              "https://doi.org/10.1007/s12603-009-0036-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0200-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015506622", 
              "https://doi.org/10.1007/s00401-007-0200-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2047-9158-1-18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003936353", 
              "https://doi.org/10.1186/2047-9158-1-18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1602/neurorx.1.2.213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020580249", 
              "https://doi.org/10.1602/neurorx.1.2.213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0826-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043718985", 
              "https://doi.org/10.1007/s00401-011-0826-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-788-0_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035928180", 
              "https://doi.org/10.1007/978-1-61779-788-0_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359325a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020938642", 
              "https://doi.org/10.1038/359325a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-010-0716-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029836690", 
              "https://doi.org/10.1007/s00401-010-0716-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2047-9158-1-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043662777", 
              "https://doi.org/10.1186/2047-9158-1-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00308809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000355620", 
              "https://doi.org/10.1007/bf00308809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041384090", 
              "https://doi.org/10.1038/nature02621"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-06-12", 
        "datePublishedReg": "2013-06-12", 
        "description": "In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-\u03b2 protein in cerebrospinal fluid routinely precede the onset of Alzheimer\u2019s disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebrospinal fluid are detectable only with the onset and progression of clinical symptoms. This sequence of events in cerebrospinal fluid (amyloid-\u03b2 changes detectable prior to abnormal tau changes) contrasts with that in which both proteins develop in the brain, where intraneuronal tau inclusions (pretangles, neurofibrillary tangles, neuropil threads) appear decades before the deposition of amyloid-\u03b2 plaques (diffuse plaques, neuritic plaques). This viewpoint attempts to address questions arising in connection with this apparent sequential discrepancy\u2014questions and issues for which there are currently no clear-cut answers.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00401-013-1139-0", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "126"
          }
        ], 
        "keywords": [
          "disease-related symptoms", 
          "cerebrospinal fluid", 
          "intraneuronal tau inclusions", 
          "gender-matched controls", 
          "deposition of amyloid", 
          "clinical symptoms", 
          "plaque deposition", 
          "tau inclusions", 
          "tau fraction", 
          "tau aggregation", 
          "increase of tau", 
          "amyloid", 
          "reduced levels", 
          "symptoms", 
          "onset", 
          "sequence of events", 
          "plaques", 
          "brain", 
          "progression", 
          "age", 
          "levels", 
          "fluid", 
          "tau", 
          "pathological amyloids", 
          "protein", 
          "years", 
          "control", 
          "increase", 
          "events", 
          "changes", 
          "inclusion", 
          "fraction", 
          "comparison", 
          "decades", 
          "aggregation", 
          "questions", 
          "deposition", 
          "issues", 
          "connection", 
          "answers", 
          "sequence", 
          "viewpoint", 
          "Alzheimer\u2019s disease-related symptoms", 
          "elevated soluble abnormal tau fractions", 
          "soluble abnormal tau fractions", 
          "abnormal tau fractions", 
          "Intraneuronal tau aggregation", 
          "diffuse plaque deposition"
        ], 
        "name": "Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-\u03b2 changes occur before increases of tau in cerebrospinal fluid", 
        "pagination": "631-641", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004016755"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00401-013-1139-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23756600"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00401-013-1139-0", 
          "https://app.dimensions.ai/details/publication/pub.1004016755"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_616.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00401-013-1139-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    258 TRIPLES      22 PREDICATES      104 URIs      73 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00401-013-1139-0 schema:about N2e132142c79e4b3c968e7b2420a6093a
    2 N3c26a6ab87a54c93b5799d079a8d6abc
    3 Naa198c72a56c4fcfb2e8d4582bc49190
    4 Nb231a039cb324e07ad81c055980c1b3e
    5 Nd3705f8aca954a1ba8a1fc67547e9e9a
    6 Nf8bd1cb4fd2f4a12a2208e20cf8bf8b3
    7 Nfde1c371f67548daadd7e99e9b9c900d
    8 anzsrc-for:11
    9 anzsrc-for:1109
    10 schema:author N5e832cd267424e8d835752e916b32ace
    11 schema:citation sg:pub.10.1007/978-1-61779-788-0_15
    12 sg:pub.10.1007/bf00308809
    13 sg:pub.10.1007/bf02815140
    14 sg:pub.10.1007/s00401-007-0200-2
    15 sg:pub.10.1007/s00401-007-0207-8
    16 sg:pub.10.1007/s00401-009-0486-3
    17 sg:pub.10.1007/s00401-009-0532-1
    18 sg:pub.10.1007/s00401-010-0716-8
    19 sg:pub.10.1007/s00401-010-0789-4
    20 sg:pub.10.1007/s00401-011-0826-y
    21 sg:pub.10.1007/s00401-011-0906-z
    22 sg:pub.10.1007/s00401-011-0910-3
    23 sg:pub.10.1007/s004010000306
    24 sg:pub.10.1007/s12603-009-0036-7
    25 sg:pub.10.1023/a:1026065122854
    26 sg:pub.10.1038/359325a0
    27 sg:pub.10.1038/nature02621
    28 sg:pub.10.1038/nrd3505
    29 sg:pub.10.1038/nrn2194
    30 sg:pub.10.1038/nrneurol.2010.4
    31 sg:pub.10.1186/2047-9158-1-18
    32 sg:pub.10.1186/2047-9158-1-23
    33 sg:pub.10.1602/neurorx.1.2.213
    34 schema:datePublished 2013-06-12
    35 schema:datePublishedReg 2013-06-12
    36 schema:description In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of Alzheimer’s disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebrospinal fluid are detectable only with the onset and progression of clinical symptoms. This sequence of events in cerebrospinal fluid (amyloid-β changes detectable prior to abnormal tau changes) contrasts with that in which both proteins develop in the brain, where intraneuronal tau inclusions (pretangles, neurofibrillary tangles, neuropil threads) appear decades before the deposition of amyloid-β plaques (diffuse plaques, neuritic plaques). This viewpoint attempts to address questions arising in connection with this apparent sequential discrepancy—questions and issues for which there are currently no clear-cut answers.
    37 schema:genre article
    38 schema:inLanguage en
    39 schema:isAccessibleForFree false
    40 schema:isPartOf N254381aca1d449f28d4b368ea81cd50c
    41 N929b290f8dd94cc2bb3c4f552cbb8359
    42 sg:journal.1019073
    43 schema:keywords Alzheimer’s disease-related symptoms
    44 Intraneuronal tau aggregation
    45 abnormal tau fractions
    46 age
    47 aggregation
    48 amyloid
    49 answers
    50 brain
    51 cerebrospinal fluid
    52 changes
    53 clinical symptoms
    54 comparison
    55 connection
    56 control
    57 decades
    58 deposition
    59 deposition of amyloid
    60 diffuse plaque deposition
    61 disease-related symptoms
    62 elevated soluble abnormal tau fractions
    63 events
    64 fluid
    65 fraction
    66 gender-matched controls
    67 inclusion
    68 increase
    69 increase of tau
    70 intraneuronal tau inclusions
    71 issues
    72 levels
    73 onset
    74 pathological amyloids
    75 plaque deposition
    76 plaques
    77 progression
    78 protein
    79 questions
    80 reduced levels
    81 sequence
    82 sequence of events
    83 soluble abnormal tau fractions
    84 symptoms
    85 tau
    86 tau aggregation
    87 tau fraction
    88 tau inclusions
    89 viewpoint
    90 years
    91 schema:name Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
    92 schema:pagination 631-641
    93 schema:productId N153fd5f0cf404e3ba208c5e78d10b7bf
    94 N9948b3c4be8b475191b282eeee6cf2f3
    95 Na5756904307e43fcbad6a86830e608c3
    96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004016755
    97 https://doi.org/10.1007/s00401-013-1139-0
    98 schema:sdDatePublished 2021-12-01T19:30
    99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    100 schema:sdPublisher Naee20cb03ad14602a6a3f95b7483bfce
    101 schema:url https://doi.org/10.1007/s00401-013-1139-0
    102 sgo:license sg:explorer/license/
    103 sgo:sdDataset articles
    104 rdf:type schema:ScholarlyArticle
    105 N153fd5f0cf404e3ba208c5e78d10b7bf schema:name pubmed_id
    106 schema:value 23756600
    107 rdf:type schema:PropertyValue
    108 N254381aca1d449f28d4b368ea81cd50c schema:issueNumber 5
    109 rdf:type schema:PublicationIssue
    110 N286f1fbe3e8a4406ad2f01da876ce55d rdf:first sg:person.07606016437.66
    111 rdf:rest rdf:nil
    112 N2e132142c79e4b3c968e7b2420a6093a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Humans
    114 rdf:type schema:DefinedTerm
    115 N3c26a6ab87a54c93b5799d079a8d6abc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name tau Proteins
    117 rdf:type schema:DefinedTerm
    118 N4367e6ed23d341069ed102d7672500ab rdf:first sg:person.01340323332.00
    119 rdf:rest N286f1fbe3e8a4406ad2f01da876ce55d
    120 N4ebb390ece984eae9348ef0e556c8f77 rdf:first sg:person.0747372175.19
    121 rdf:rest N4367e6ed23d341069ed102d7672500ab
    122 N5e832cd267424e8d835752e916b32ace rdf:first sg:person.01053255500.71
    123 rdf:rest N4ebb390ece984eae9348ef0e556c8f77
    124 N929b290f8dd94cc2bb3c4f552cbb8359 schema:volumeNumber 126
    125 rdf:type schema:PublicationVolume
    126 N9948b3c4be8b475191b282eeee6cf2f3 schema:name doi
    127 schema:value 10.1007/s00401-013-1139-0
    128 rdf:type schema:PropertyValue
    129 Na5756904307e43fcbad6a86830e608c3 schema:name dimensions_id
    130 schema:value pub.1004016755
    131 rdf:type schema:PropertyValue
    132 Naa198c72a56c4fcfb2e8d4582bc49190 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Disease Progression
    134 rdf:type schema:DefinedTerm
    135 Naee20cb03ad14602a6a3f95b7483bfce schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 Nb231a039cb324e07ad81c055980c1b3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Neurofibrillary Tangles
    139 rdf:type schema:DefinedTerm
    140 Nd3705f8aca954a1ba8a1fc67547e9e9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Amyloid beta-Peptides
    142 rdf:type schema:DefinedTerm
    143 Nf8bd1cb4fd2f4a12a2208e20cf8bf8b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Neurons
    145 rdf:type schema:DefinedTerm
    146 Nfde1c371f67548daadd7e99e9b9c900d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Alzheimer Disease
    148 rdf:type schema:DefinedTerm
    149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Medical and Health Sciences
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Neurosciences
    154 rdf:type schema:DefinedTerm
    155 sg:journal.1019073 schema:issn 0001-6322
    156 1432-0533
    157 schema:name Acta Neuropathologica
    158 schema:publisher Springer Nature
    159 rdf:type schema:Periodical
    160 sg:person.01053255500.71 schema:affiliation grid-institutes:grid.6582.9
    161 schema:familyName Braak
    162 schema:givenName Heiko
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71
    164 rdf:type schema:Person
    165 sg:person.01340323332.00 schema:affiliation grid-institutes:grid.6582.9
    166 schema:familyName Del Tredici
    167 schema:givenName Kelly
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323332.00
    169 rdf:type schema:Person
    170 sg:person.0747372175.19 schema:affiliation grid-institutes:grid.83440.3b
    171 schema:familyName Zetterberg
    172 schema:givenName Henrik
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747372175.19
    174 rdf:type schema:Person
    175 sg:person.07606016437.66 schema:affiliation grid-institutes:grid.1649.a
    176 schema:familyName Blennow
    177 schema:givenName Kaj
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07606016437.66
    179 rdf:type schema:Person
    180 sg:pub.10.1007/978-1-61779-788-0_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035928180
    181 https://doi.org/10.1007/978-1-61779-788-0_15
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
    184 https://doi.org/10.1007/bf00308809
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/bf02815140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035207722
    187 https://doi.org/10.1007/bf02815140
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s00401-007-0200-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015506622
    190 https://doi.org/10.1007/s00401-007-0200-2
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s00401-007-0207-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024620200
    193 https://doi.org/10.1007/s00401-007-0207-8
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/s00401-009-0486-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022510509
    196 https://doi.org/10.1007/s00401-009-0486-3
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/s00401-009-0532-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022622684
    199 https://doi.org/10.1007/s00401-009-0532-1
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s00401-010-0716-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029836690
    202 https://doi.org/10.1007/s00401-010-0716-8
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s00401-010-0789-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037411515
    205 https://doi.org/10.1007/s00401-010-0789-4
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/s00401-011-0826-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043718985
    208 https://doi.org/10.1007/s00401-011-0826-y
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/s00401-011-0906-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029939986
    211 https://doi.org/10.1007/s00401-011-0906-z
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/s00401-011-0910-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045607293
    214 https://doi.org/10.1007/s00401-011-0910-3
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/s004010000306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074868390
    217 https://doi.org/10.1007/s004010000306
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/s12603-009-0036-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020676367
    220 https://doi.org/10.1007/s12603-009-0036-7
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1023/a:1026065122854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052494683
    223 https://doi.org/10.1023/a:1026065122854
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/359325a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020938642
    226 https://doi.org/10.1038/359325a0
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nature02621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041384090
    229 https://doi.org/10.1038/nature02621
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nrd3505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009624842
    232 https://doi.org/10.1038/nrd3505
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nrn2194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032680057
    235 https://doi.org/10.1038/nrn2194
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nrneurol.2010.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016181353
    238 https://doi.org/10.1038/nrneurol.2010.4
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1186/2047-9158-1-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003936353
    241 https://doi.org/10.1186/2047-9158-1-18
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1186/2047-9158-1-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043662777
    244 https://doi.org/10.1186/2047-9158-1-23
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1602/neurorx.1.2.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020580249
    247 https://doi.org/10.1602/neurorx.1.2.213
    248 rdf:type schema:CreativeWork
    249 grid-institutes:grid.1649.a schema:alternateName Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, Mölndal Campus, 431 80, Mölndal, Sweden
    250 schema:name Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, Mölndal Campus, 431 80, Mölndal, Sweden
    251 rdf:type schema:Organization
    252 grid-institutes:grid.6582.9 schema:alternateName Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany
    253 schema:name Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany
    254 rdf:type schema:Organization
    255 grid-institutes:grid.83440.3b schema:alternateName UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    256 schema:name Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg, Mölndal Campus, 431 80, Mölndal, Sweden
    257 UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    258 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...