Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid View Full Text


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Article Info

DATE

2013-06-12

AUTHORS

Heiko Braak, Henrik Zetterberg, Kelly Del Tredici, Kaj Blennow

ABSTRACT

In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of Alzheimer’s disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebrospinal fluid are detectable only with the onset and progression of clinical symptoms. This sequence of events in cerebrospinal fluid (amyloid-β changes detectable prior to abnormal tau changes) contrasts with that in which both proteins develop in the brain, where intraneuronal tau inclusions (pretangles, neurofibrillary tangles, neuropil threads) appear decades before the deposition of amyloid-β plaques (diffuse plaques, neuritic plaques). This viewpoint attempts to address questions arising in connection with this apparent sequential discrepancy—questions and issues for which there are currently no clear-cut answers. More... »

PAGES

631-641

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0

    DOI

    http://dx.doi.org/10.1007/s00401-013-1139-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004016755

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23756600


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