DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

Edward C. Schwalbe, Daniel Williamson, Janet C. Lindsey, Dolores Hamilton, Sarra L. Ryan, Hisham Megahed, Miklós Garami, Peter Hauser, Bożena Dembowska-Baginska, Danuta Perek, Paul A. Northcott, Michael D. Taylor, Roger E. Taylor, David W. Ellison, Simon Bailey, Steven C. Clifford

ABSTRACT

Molecular subclassification is rapidly informing the clinical management of medulloblastoma. However, the disease remains associated with poor outcomes and therapy-associated late effects, and the majority of patients are not characterized by a validated prognostic biomarker. Here, we investigated the potential of epigenetic DNA methylation for disease subclassification, particularly in formalin-fixed biopsies, and to identify biomarkers for improved therapeutic individualization. Tumor DNA methylation profiles were assessed, alongside molecular and clinical disease features, in 230 patients primarily from the SIOP-UKCCSG PNET3 clinical trial. We demonstrate by cross-validation in frozen training and formalin-fixed test sets that medulloblastoma comprises four robust DNA methylation subgroups (termed WNT, SHH, G3 and G4), highly related to their transcriptomic counterparts, and which display distinct molecular, clinical and pathological disease characteristics. WNT patients displayed an expected favorable prognosis, while outcomes for SHH, G3 and G4 were equivalent in our cohort. MXI1 and IL8 methylation were identified as novel independent high-risk biomarkers in cross-validated survival models of non-WNT patients, and were validated using non-array methods. Incorporation of MXI1 and IL8 into current survival models significantly improved the assignment of disease risk; 46 % of patients could be classified as 'favorable risk' (>90 % survival) compared to 13 % using current models, while the high-risk group was reduced from 30 to 16 %. DNA methylation profiling enables the robust subclassification of four disease subgroups in frozen and routinely collected/archival formalin-fixed biopsy material, and the incorporation of DNA methylation biomarkers can significantly improve disease-risk stratification. These findings have important implications for future risk-adapted clinical disease management. More... »

PAGES

359-371

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-012-1077-2

DOI

http://dx.doi.org/10.1007/s00401-012-1077-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024229379

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23291781


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic Helix-Loop-Helix Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellar Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 17", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Fingerprinting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Formaldehyde", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Frozen Sections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hedgehog Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medulloblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-myc", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwalbe", 
        "givenName": "Edward C.", 
        "id": "sg:person.0715313042.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715313042.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williamson", 
        "givenName": "Daniel", 
        "id": "sg:person.01166155447.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166155447.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindsey", 
        "givenName": "Janet C.", 
        "id": "sg:person.01275011217.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275011217.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamilton", 
        "givenName": "Dolores", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ryan", 
        "givenName": "Sarra L.", 
        "id": "sg:person.0777752547.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777752547.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Megahed", 
        "givenName": "Hisham", 
        "id": "sg:person.0733746717.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733746717.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Semmelweis University", 
          "id": "https://www.grid.ac/institutes/grid.11804.3c", 
          "name": [
            "Department of Paediatrics, Semmelweis University, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garami", 
        "givenName": "Mikl\u00f3s", 
        "id": "sg:person.01022024330.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022024330.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Semmelweis University", 
          "id": "https://www.grid.ac/institutes/grid.11804.3c", 
          "name": [
            "Department of Paediatrics, Semmelweis University, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hauser", 
        "givenName": "Peter", 
        "id": "sg:person.01054467240.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054467240.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Memorial Health Institute", 
          "id": "https://www.grid.ac/institutes/grid.413923.e", 
          "name": [
            "Department of Pediatric Oncology, The Children\u2019s Memorial Health Institute, Warsaw, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dembowska-Baginska", 
        "givenName": "Bo\u017cena", 
        "id": "sg:person.01142014606.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142014606.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Memorial Health Institute", 
          "id": "https://www.grid.ac/institutes/grid.413923.e", 
          "name": [
            "Department of Pediatric Oncology, The Children\u2019s Memorial Health Institute, Warsaw, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perek", 
        "givenName": "Danuta", 
        "id": "sg:person.01265061723.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265061723.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Division of Neurosurgery and The Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Northcott", 
        "givenName": "Paul A.", 
        "id": "sg:person.010563327577.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010563327577.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Division of Neurosurgery and The Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Michael D.", 
        "id": "sg:person.012731463207.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731463207.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singleton Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415947.a", 
          "name": [
            "South Wales Cancer Centre, Singleton Hospital, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Roger E.", 
        "id": "sg:person.01036770224.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036770224.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellison", 
        "givenName": "David W.", 
        "id": "sg:person.0711352500.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bailey", 
        "givenName": "Simon", 
        "id": "sg:person.01216526625.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216526625.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clifford", 
        "givenName": "Steven C.", 
        "id": "sg:person.01346765517.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346765517.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0308531101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001366510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.5479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001500983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0899-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003857592", 
          "https://doi.org/10.1007/s00401-011-0899-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.17.9432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005423358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70867-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006867503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-012-0958-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007662906", 
          "https://doi.org/10.1007/s00401-012-0958-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009834454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.4974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011169284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btn557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012300204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0922-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012707701", 
          "https://doi.org/10.1007/s00401-011-0922-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021622039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021622039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0923-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021993381", 
          "https://doi.org/10.1007/s00401-011-0923-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023727013", 
          "https://doi.org/10.1038/onc.2010.32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90662-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025312921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.27.4324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026297279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.5591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028769760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029207836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1198056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030704690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.4410706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033075033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0907606106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035011228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgh055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035413434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036527942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036872856", 
          "https://doi.org/10.1038/nature11329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037754285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037968545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bib/bbr001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038952556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039302414", 
          "https://doi.org/10.1038/nature11284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040240428", 
          "https://doi.org/10.1038/nature11213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2010.03.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040778422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0377-0427(87)90125-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041584630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.30.2810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041847755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.21832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042056289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btm311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042939614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0006-341x.2000.00337.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043727671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044240691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2004.12.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044354967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0800-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044440927", 
          "https://doi.org/10.1007/s00401-011-0800-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02688690903121807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044635291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.01.0454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047041320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.01.0454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047041320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0701068104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047694379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/15228517-2008-048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048919367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.5148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049260900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049915735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053708989", 
          "https://doi.org/10.1038/sj.bjc.6603852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tnb.2005.853657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061713682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2005.19.5.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071085887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2005.19.5.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071085887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2005.19.5.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071085887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2005.19.5.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071085887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2005.19.5.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071085887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2005.19.5.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071085887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.20.3360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.22.3446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4137/cin.s2846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077950823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/93.6.1351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080730833"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-03", 
    "datePublishedReg": "2013-03-01", 
    "description": "Molecular subclassification is rapidly informing the clinical management of medulloblastoma. However, the disease remains associated with poor outcomes and therapy-associated late effects, and the majority of patients are not characterized by a validated prognostic biomarker. Here, we investigated the potential of epigenetic DNA methylation for disease subclassification, particularly in formalin-fixed biopsies, and to identify biomarkers for improved therapeutic individualization. Tumor DNA methylation profiles were assessed, alongside molecular and clinical disease features, in 230 patients primarily from the SIOP-UKCCSG PNET3 clinical trial. We demonstrate by cross-validation in frozen training and formalin-fixed test sets that medulloblastoma comprises four robust DNA methylation subgroups (termed WNT, SHH, G3 and G4), highly related to their transcriptomic counterparts, and which display distinct molecular, clinical and pathological disease characteristics. WNT patients displayed an expected favorable prognosis, while outcomes for SHH, G3 and G4 were equivalent in our cohort. MXI1 and IL8 methylation were identified as novel independent high-risk biomarkers in cross-validated survival models of non-WNT patients, and were validated using non-array methods. Incorporation of MXI1 and IL8 into current survival models significantly improved the assignment of disease risk; 46 % of patients could be classified as 'favorable risk' (>90 % survival) compared to 13 % using current models, while the high-risk group was reduced from 30 to 16 %. DNA methylation profiling enables the robust subclassification of four disease subgroups in frozen and routinely collected/archival formalin-fixed biopsy material, and the incorporation of DNA methylation biomarkers can significantly improve disease-risk stratification. These findings have important implications for future risk-adapted clinical disease management.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00401-012-1077-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5134444", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "125"
      }
    ], 
    "name": "DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies", 
    "pagination": "359-371", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "736e7acbf6339c839e5a136545c69e559ffac58a4610db676d4ab18e6c2184e3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23291781"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00401-012-1077-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024229379"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00401-012-1077-2", 
      "https://app.dimensions.ai/details/publication/pub.1024229379"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000488.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00401-012-1077-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-012-1077-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-012-1077-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-012-1077-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-012-1077-2'


 

This table displays all metadata directly associated to this object as RDF triples.

482 TRIPLES      21 PREDICATES      109 URIs      49 LITERALS      37 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00401-012-1077-2 schema:about N02ad336b03c74631a363e3e2917eb816
2 N11b80ac8ce5549c3bf904f1eba34aa9c
3 N14b63f20ff224391995c93786f4266b5
4 N2ac700956ec64496ac0914f1da0eff19
5 N2e3c90878a654a6cb0cc60bc4f41094a
6 N355599c4cf72478fb61d8dbf56662e16
7 N3c9ff004feb24b61b0a1b2a53e9f8cf6
8 N579d7f03f6e14df38a3bd8c8696a30e4
9 N5ced77fde9024ce68b2183a29e8cfcfc
10 N6cc4355c1fa043569fbd13719f834804
11 N7be157c884e34e1dbe6c6a057299e3dd
12 N7d2c163cfcca47689ee7914eb5d80738
13 N884d0b9ce808435b8591c00b144d8909
14 N89f150839cef4b91a28102b0e63b5c30
15 N8b07beb4cb6841c49528a0412d9ee37b
16 N8d4662d86cc141fdacd76774b9e7bbfe
17 N91fd00940e0d4290b78c790ddf43dee8
18 N9ccb9877d0324e088ba855bf4184c63d
19 Nb7a1220ee86b48bcb57fd498a6120416
20 Nba00a7a833cb4e86baea121cac091e07
21 Nd92bf17c9d3d45798cf7c561c7adcfc6
22 Ndd28d03a2f8b4d64a908a34388407d49
23 Ndf644cf31ef147c0a69c2446248cbd42
24 Ne135d458dbb74067a32822d52f09ad89
25 Ne53cc04a11074a07a4f2136d93c7a068
26 Ne73a0104e8864fa389651af63eaef92c
27 Nf8229922d18a4344a3dd2f68a3b7397c
28 Nf93a6bba5982447f9130ed7b363819f8
29 anzsrc-for:11
30 anzsrc-for:1112
31 schema:author N7c786c43da6c4412955f8fd9ab733ead
32 schema:citation sg:pub.10.1007/s00401-007-0243-4
33 sg:pub.10.1007/s00401-011-0800-8
34 sg:pub.10.1007/s00401-011-0899-7
35 sg:pub.10.1007/s00401-011-0922-z
36 sg:pub.10.1007/s00401-011-0923-y
37 sg:pub.10.1007/s00401-012-0958-8
38 sg:pub.10.1038/nature11213
39 sg:pub.10.1038/nature11284
40 sg:pub.10.1038/nature11329
41 sg:pub.10.1038/onc.2010.32
42 sg:pub.10.1038/sj.bjc.6603852
43 https://doi.org/10.1002/gcc.20262
44 https://doi.org/10.1002/ijc.25562
45 https://doi.org/10.1002/pbc.21832
46 https://doi.org/10.1016/0092-8674(93)90662-a
47 https://doi.org/10.1016/0377-0427(87)90125-7
48 https://doi.org/10.1016/j.ccr.2010.03.017
49 https://doi.org/10.1016/j.ejca.2004.12.017
50 https://doi.org/10.1016/s1470-2045(06)70867-1
51 https://doi.org/10.1056/nejmoa043331
52 https://doi.org/10.1073/pnas.0308531101
53 https://doi.org/10.1073/pnas.0701068104
54 https://doi.org/10.1073/pnas.0907606106
55 https://doi.org/10.1080/02688690903121807
56 https://doi.org/10.1093/bib/bbr001
57 https://doi.org/10.1093/bioinformatics/btm311
58 https://doi.org/10.1093/bioinformatics/btn557
59 https://doi.org/10.1093/carcin/bgh055
60 https://doi.org/10.1101/gr.4410706
61 https://doi.org/10.1109/tnb.2005.853657
62 https://doi.org/10.1111/j.0006-341x.2000.00337.x
63 https://doi.org/10.1126/science.1198056
64 https://doi.org/10.1148/93.6.1351
65 https://doi.org/10.1158/0008-5472.can-11-3891
66 https://doi.org/10.1158/1078-0432.ccr-03-0721
67 https://doi.org/10.1158/1078-0432.ccr-06-1779
68 https://doi.org/10.1158/1078-0432.ccr-10-2210
69 https://doi.org/10.1200/jco.2003.05.116
70 https://doi.org/10.1200/jco.2004.01.0454
71 https://doi.org/10.1200/jco.2005.01.5479
72 https://doi.org/10.1200/jco.2005.04.4974
73 https://doi.org/10.1200/jco.2008.17.9432
74 https://doi.org/10.1200/jco.2009.27.4324
75 https://doi.org/10.1200/jco.2010.28.5148
76 https://doi.org/10.1200/jco.2010.30.2810
77 https://doi.org/10.1200/jco.2011.38.5591
78 https://doi.org/10.1215/15228517-2008-048
79 https://doi.org/10.1371/journal.pone.0003088
80 https://doi.org/10.3171/foc.2005.19.5.11
81 https://doi.org/10.4137/cin.s2846
82 https://doi.org/10.4161/cc.5.20.3360
83 https://doi.org/10.4161/cc.5.22.3446
84 schema:datePublished 2013-03
85 schema:datePublishedReg 2013-03-01
86 schema:description Molecular subclassification is rapidly informing the clinical management of medulloblastoma. However, the disease remains associated with poor outcomes and therapy-associated late effects, and the majority of patients are not characterized by a validated prognostic biomarker. Here, we investigated the potential of epigenetic DNA methylation for disease subclassification, particularly in formalin-fixed biopsies, and to identify biomarkers for improved therapeutic individualization. Tumor DNA methylation profiles were assessed, alongside molecular and clinical disease features, in 230 patients primarily from the SIOP-UKCCSG PNET3 clinical trial. We demonstrate by cross-validation in frozen training and formalin-fixed test sets that medulloblastoma comprises four robust DNA methylation subgroups (termed WNT, SHH, G3 and G4), highly related to their transcriptomic counterparts, and which display distinct molecular, clinical and pathological disease characteristics. WNT patients displayed an expected favorable prognosis, while outcomes for SHH, G3 and G4 were equivalent in our cohort. MXI1 and IL8 methylation were identified as novel independent high-risk biomarkers in cross-validated survival models of non-WNT patients, and were validated using non-array methods. Incorporation of MXI1 and IL8 into current survival models significantly improved the assignment of disease risk; 46 % of patients could be classified as 'favorable risk' (>90 % survival) compared to 13 % using current models, while the high-risk group was reduced from 30 to 16 %. DNA methylation profiling enables the robust subclassification of four disease subgroups in frozen and routinely collected/archival formalin-fixed biopsy material, and the incorporation of DNA methylation biomarkers can significantly improve disease-risk stratification. These findings have important implications for future risk-adapted clinical disease management.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree true
90 schema:isPartOf N7964d40934a848edb69003b4238b64ec
91 Nfbbae8f85ec2485ca22903a4e4aff99e
92 sg:journal.1019073
93 schema:name DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
94 schema:pagination 359-371
95 schema:productId N108bf4e94922492a9d384fb2a43644c7
96 N63d6a1f6578349ecb88adf3215f3ae6b
97 N9db8ce67f73e46fa84847e28d0c2d63d
98 Nfecbfef732c1407ea8786d97afd2f974
99 Nff4cb7d6a4d1445e85239d776f5be50f
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024229379
101 https://doi.org/10.1007/s00401-012-1077-2
102 schema:sdDatePublished 2019-04-10T14:03
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N008232ab66d14bfeb9d2756e8670ca7c
105 schema:url http://link.springer.com/10.1007/s00401-012-1077-2
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N008232ab66d14bfeb9d2756e8670ca7c schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N02ad336b03c74631a363e3e2917eb816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Predictive Value of Tests
113 rdf:type schema:DefinedTerm
114 N064658f3681d460fbbd7217bb8875426 rdf:first sg:person.01346765517.08
115 rdf:rest rdf:nil
116 N1024f5c30b8d449a926624e6d35fe820 rdf:first sg:person.01265061723.80
117 rdf:rest N28dbc5d51aa24c22a2c06f5bc318454c
118 N108bf4e94922492a9d384fb2a43644c7 schema:name readcube_id
119 schema:value 736e7acbf6339c839e5a136545c69e559ffac58a4610db676d4ab18e6c2184e3
120 rdf:type schema:PropertyValue
121 N11b80ac8ce5549c3bf904f1eba34aa9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Reproducibility of Results
123 rdf:type schema:DefinedTerm
124 N14b63f20ff224391995c93786f4266b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Basic Helix-Loop-Helix Transcription Factors
126 rdf:type schema:DefinedTerm
127 N24638b6eb9e64203a8b8a818934f0592 schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
128 rdf:type schema:Organization
129 N28dbc5d51aa24c22a2c06f5bc318454c rdf:first sg:person.010563327577.08
130 rdf:rest N4dc76ba09a8840fe9007a13719e59c77
131 N2a01560034ee4506ba9dec1a959069e2 rdf:first Naa7f47644d1d4e328ea3a79c4cad0826
132 rdf:rest Nb54370c73bff4852ae793a7f28627dab
133 N2ac700956ec64496ac0914f1da0eff19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Adolescent
135 rdf:type schema:DefinedTerm
136 N2e3c90878a654a6cb0cc60bc4f41094a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Biopsy
138 rdf:type schema:DefinedTerm
139 N35482e7eed6f425cb4bc326a49bd9d36 schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
140 rdf:type schema:Organization
141 N355599c4cf72478fb61d8dbf56662e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cerebellar Neoplasms
143 rdf:type schema:DefinedTerm
144 N3c9ff004feb24b61b0a1b2a53e9f8cf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Male
146 rdf:type schema:DefinedTerm
147 N3dba1c21111e4d16a35e3b834c049433 rdf:first sg:person.01166155447.74
148 rdf:rest N7acb8635a837488b815757314401ff05
149 N43a3bb0ea95e4b32a254d04a6c587d2b rdf:first sg:person.0711352500.88
150 rdf:rest Na038007b746d4620842664aaf212009d
151 N4dc76ba09a8840fe9007a13719e59c77 rdf:first sg:person.012731463207.92
152 rdf:rest Nac3d4aebc735494f85c808e1a27f8b5e
153 N579d7f03f6e14df38a3bd8c8696a30e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Interleukin-8
155 rdf:type schema:DefinedTerm
156 N5ced77fde9024ce68b2183a29e8cfcfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Child, Preschool
158 rdf:type schema:DefinedTerm
159 N63d6a1f6578349ecb88adf3215f3ae6b schema:name doi
160 schema:value 10.1007/s00401-012-1077-2
161 rdf:type schema:PropertyValue
162 N63f1f07942fb4c8393948cd7448a84e7 rdf:first sg:person.0733746717.14
163 rdf:rest N7a03415e66f84c83bdc574396e6d8395
164 N6737a583a3c34f539e520044222c727e schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
165 rdf:type schema:Organization
166 N6cc4355c1fa043569fbd13719f834804 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Hedgehog Proteins
168 rdf:type schema:DefinedTerm
169 N7964d40934a848edb69003b4238b64ec schema:issueNumber 3
170 rdf:type schema:PublicationIssue
171 N7a03415e66f84c83bdc574396e6d8395 rdf:first sg:person.01022024330.02
172 rdf:rest Nea3dbc0423924ae19c5e4f2d53ffd306
173 N7acb8635a837488b815757314401ff05 rdf:first sg:person.01275011217.25
174 rdf:rest N2a01560034ee4506ba9dec1a959069e2
175 N7be157c884e34e1dbe6c6a057299e3dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Adult
177 rdf:type schema:DefinedTerm
178 N7c786c43da6c4412955f8fd9ab733ead rdf:first sg:person.0715313042.78
179 rdf:rest N3dba1c21111e4d16a35e3b834c049433
180 N7d2c163cfcca47689ee7914eb5d80738 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name DNA Methylation
182 rdf:type schema:DefinedTerm
183 N884d0b9ce808435b8591c00b144d8909 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Infant
185 rdf:type schema:DefinedTerm
186 N89f150839cef4b91a28102b0e63b5c30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Biomarkers, Tumor
188 rdf:type schema:DefinedTerm
189 N8a609fee6b3d4c419048669b62db93c6 schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
190 rdf:type schema:Organization
191 N8b07beb4cb6841c49528a0412d9ee37b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Chromosomes, Human, Pair 17
193 rdf:type schema:DefinedTerm
194 N8d4662d86cc141fdacd76774b9e7bbfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Frozen Sections
196 rdf:type schema:DefinedTerm
197 N8e0049118ace4208b6dbf1fc7820641e schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
198 rdf:type schema:Organization
199 N91fd00940e0d4290b78c790ddf43dee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Humans
201 rdf:type schema:DefinedTerm
202 N9ccb9877d0324e088ba855bf4184c63d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Tumor Suppressor Proteins
204 rdf:type schema:DefinedTerm
205 N9db8ce67f73e46fa84847e28d0c2d63d schema:name dimensions_id
206 schema:value pub.1024229379
207 rdf:type schema:PropertyValue
208 Na038007b746d4620842664aaf212009d rdf:first sg:person.01216526625.20
209 rdf:rest N064658f3681d460fbbd7217bb8875426
210 Na80b8e5e561941ec95f1e6bbc1865599 schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
211 rdf:type schema:Organization
212 Naa7f47644d1d4e328ea3a79c4cad0826 schema:affiliation N24638b6eb9e64203a8b8a818934f0592
213 schema:familyName Hamilton
214 schema:givenName Dolores
215 rdf:type schema:Person
216 Nac3d4aebc735494f85c808e1a27f8b5e rdf:first sg:person.01036770224.00
217 rdf:rest N43a3bb0ea95e4b32a254d04a6c587d2b
218 Nb54370c73bff4852ae793a7f28627dab rdf:first sg:person.0777752547.21
219 rdf:rest N63f1f07942fb4c8393948cd7448a84e7
220 Nb7a1220ee86b48bcb57fd498a6120416 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Cohort Studies
222 rdf:type schema:DefinedTerm
223 Nba00a7a833cb4e86baea121cac091e07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Proto-Oncogene Proteins c-myc
225 rdf:type schema:DefinedTerm
226 Nbfd0562fe16643a79acbb3703ed8a5ac schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
227 rdf:type schema:Organization
228 Nc1fcf5299bd24a07b40a90e48274b01c schema:name Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
229 rdf:type schema:Organization
230 Nd92bf17c9d3d45798cf7c561c7adcfc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Child
232 rdf:type schema:DefinedTerm
233 Nd9689395a166460e99863e6df4ecff35 rdf:first sg:person.01142014606.50
234 rdf:rest N1024f5c30b8d449a926624e6d35fe820
235 Ndd28d03a2f8b4d64a908a34388407d49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Female
237 rdf:type schema:DefinedTerm
238 Ndf644cf31ef147c0a69c2446248cbd42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Medulloblastoma
240 rdf:type schema:DefinedTerm
241 Ne135d458dbb74067a32822d52f09ad89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Gene Expression Regulation, Neoplastic
243 rdf:type schema:DefinedTerm
244 Ne53cc04a11074a07a4f2136d93c7a068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
245 schema:name Formaldehyde
246 rdf:type schema:DefinedTerm
247 Ne73a0104e8864fa389651af63eaef92c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
248 schema:name Computational Biology
249 rdf:type schema:DefinedTerm
250 Nea3dbc0423924ae19c5e4f2d53ffd306 rdf:first sg:person.01054467240.04
251 rdf:rest Nd9689395a166460e99863e6df4ecff35
252 Nf8229922d18a4344a3dd2f68a3b7397c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
253 schema:name DNA Fingerprinting
254 rdf:type schema:DefinedTerm
255 Nf93a6bba5982447f9130ed7b363819f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Young Adult
257 rdf:type schema:DefinedTerm
258 Nfbbae8f85ec2485ca22903a4e4aff99e schema:volumeNumber 125
259 rdf:type schema:PublicationVolume
260 Nfecbfef732c1407ea8786d97afd2f974 schema:name pubmed_id
261 schema:value 23291781
262 rdf:type schema:PropertyValue
263 Nff4cb7d6a4d1445e85239d776f5be50f schema:name nlm_unique_id
264 schema:value 0412041
265 rdf:type schema:PropertyValue
266 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
267 schema:name Medical and Health Sciences
268 rdf:type schema:DefinedTerm
269 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
270 schema:name Oncology and Carcinogenesis
271 rdf:type schema:DefinedTerm
272 sg:grant.5134444 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-012-1077-2
273 rdf:type schema:MonetaryGrant
274 sg:journal.1019073 schema:issn 0001-6322
275 1432-0533
276 schema:name Acta Neuropathologica
277 rdf:type schema:Periodical
278 sg:person.01022024330.02 schema:affiliation https://www.grid.ac/institutes/grid.11804.3c
279 schema:familyName Garami
280 schema:givenName Miklós
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022024330.02
282 rdf:type schema:Person
283 sg:person.01036770224.00 schema:affiliation https://www.grid.ac/institutes/grid.415947.a
284 schema:familyName Taylor
285 schema:givenName Roger E.
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036770224.00
287 rdf:type schema:Person
288 sg:person.01054467240.04 schema:affiliation https://www.grid.ac/institutes/grid.11804.3c
289 schema:familyName Hauser
290 schema:givenName Peter
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054467240.04
292 rdf:type schema:Person
293 sg:person.010563327577.08 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
294 schema:familyName Northcott
295 schema:givenName Paul A.
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010563327577.08
297 rdf:type schema:Person
298 sg:person.01142014606.50 schema:affiliation https://www.grid.ac/institutes/grid.413923.e
299 schema:familyName Dembowska-Baginska
300 schema:givenName Bożena
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142014606.50
302 rdf:type schema:Person
303 sg:person.01166155447.74 schema:affiliation N8a609fee6b3d4c419048669b62db93c6
304 schema:familyName Williamson
305 schema:givenName Daniel
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166155447.74
307 rdf:type schema:Person
308 sg:person.01216526625.20 schema:affiliation N35482e7eed6f425cb4bc326a49bd9d36
309 schema:familyName Bailey
310 schema:givenName Simon
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216526625.20
312 rdf:type schema:Person
313 sg:person.01265061723.80 schema:affiliation https://www.grid.ac/institutes/grid.413923.e
314 schema:familyName Perek
315 schema:givenName Danuta
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265061723.80
317 rdf:type schema:Person
318 sg:person.012731463207.92 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
319 schema:familyName Taylor
320 schema:givenName Michael D.
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731463207.92
322 rdf:type schema:Person
323 sg:person.01275011217.25 schema:affiliation Nbfd0562fe16643a79acbb3703ed8a5ac
324 schema:familyName Lindsey
325 schema:givenName Janet C.
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275011217.25
327 rdf:type schema:Person
328 sg:person.01346765517.08 schema:affiliation N6737a583a3c34f539e520044222c727e
329 schema:familyName Clifford
330 schema:givenName Steven C.
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346765517.08
332 rdf:type schema:Person
333 sg:person.0711352500.88 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
334 schema:familyName Ellison
335 schema:givenName David W.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88
337 rdf:type schema:Person
338 sg:person.0715313042.78 schema:affiliation Nc1fcf5299bd24a07b40a90e48274b01c
339 schema:familyName Schwalbe
340 schema:givenName Edward C.
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715313042.78
342 rdf:type schema:Person
343 sg:person.0733746717.14 schema:affiliation N8e0049118ace4208b6dbf1fc7820641e
344 schema:familyName Megahed
345 schema:givenName Hisham
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733746717.14
347 rdf:type schema:Person
348 sg:person.0777752547.21 schema:affiliation Na80b8e5e561941ec95f1e6bbc1865599
349 schema:familyName Ryan
350 schema:givenName Sarra L.
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777752547.21
352 rdf:type schema:Person
353 sg:pub.10.1007/s00401-007-0243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430701
354 https://doi.org/10.1007/s00401-007-0243-4
355 rdf:type schema:CreativeWork
356 sg:pub.10.1007/s00401-011-0800-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044440927
357 https://doi.org/10.1007/s00401-011-0800-8
358 rdf:type schema:CreativeWork
359 sg:pub.10.1007/s00401-011-0899-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003857592
360 https://doi.org/10.1007/s00401-011-0899-7
361 rdf:type schema:CreativeWork
362 sg:pub.10.1007/s00401-011-0922-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1012707701
363 https://doi.org/10.1007/s00401-011-0922-z
364 rdf:type schema:CreativeWork
365 sg:pub.10.1007/s00401-011-0923-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1021993381
366 https://doi.org/10.1007/s00401-011-0923-y
367 rdf:type schema:CreativeWork
368 sg:pub.10.1007/s00401-012-0958-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007662906
369 https://doi.org/10.1007/s00401-012-0958-8
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/nature11213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040240428
372 https://doi.org/10.1038/nature11213
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/nature11284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039302414
375 https://doi.org/10.1038/nature11284
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/nature11329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036872856
378 https://doi.org/10.1038/nature11329
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/onc.2010.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023727013
381 https://doi.org/10.1038/onc.2010.32
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/sj.bjc.6603852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053708989
384 https://doi.org/10.1038/sj.bjc.6603852
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1002/gcc.20262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021622039
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1002/ijc.25562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009834454
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1002/pbc.21832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042056289
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1016/0092-8674(93)90662-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1025312921
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1016/0377-0427(87)90125-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041584630
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1016/j.ccr.2010.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040778422
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1016/j.ejca.2004.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044354967
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1016/s1470-2045(06)70867-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006867503
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1056/nejmoa043331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029207836
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1073/pnas.0308531101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001366510
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1073/pnas.0701068104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047694379
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1073/pnas.0907606106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035011228
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1080/02688690903121807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044635291
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1093/bib/bbr001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038952556
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1093/bioinformatics/btm311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042939614
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1093/bioinformatics/btn557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012300204
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1093/carcin/bgh055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035413434
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1101/gr.4410706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033075033
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1109/tnb.2005.853657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061713682
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1111/j.0006-341x.2000.00337.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043727671
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1126/science.1198056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030704690
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1148/93.6.1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080730833
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1158/0008-5472.can-11-3891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036527942
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1158/1078-0432.ccr-03-0721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037968545
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1158/1078-0432.ccr-06-1779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044240691
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1158/1078-0432.ccr-10-2210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037754285
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1200/jco.2003.05.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203613
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1200/jco.2004.01.0454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047041320
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1200/jco.2005.01.5479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001500983
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1200/jco.2005.04.4974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011169284
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1200/jco.2008.17.9432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005423358
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1200/jco.2009.27.4324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026297279
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1200/jco.2010.28.5148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049260900
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1200/jco.2010.30.2810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041847755
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1200/jco.2011.38.5591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028769760
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1215/15228517-2008-048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048919367
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1371/journal.pone.0003088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049915735
459 rdf:type schema:CreativeWork
460 https://doi.org/10.3171/foc.2005.19.5.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071085887
461 rdf:type schema:CreativeWork
462 https://doi.org/10.4137/cin.s2846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077950823
463 rdf:type schema:CreativeWork
464 https://doi.org/10.4161/cc.5.20.3360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298666
465 rdf:type schema:CreativeWork
466 https://doi.org/10.4161/cc.5.22.3446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298705
467 rdf:type schema:CreativeWork
468 https://www.grid.ac/institutes/grid.11804.3c schema:alternateName Semmelweis University
469 schema:name Department of Paediatrics, Semmelweis University, Budapest, Hungary
470 rdf:type schema:Organization
471 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
472 schema:name Department of Pathology, St. Jude Children’s Research Hospital, Memphis, USA
473 rdf:type schema:Organization
474 https://www.grid.ac/institutes/grid.413923.e schema:alternateName Children's Memorial Health Institute
475 schema:name Department of Pediatric Oncology, The Children’s Memorial Health Institute, Warsaw, Poland
476 rdf:type schema:Organization
477 https://www.grid.ac/institutes/grid.415947.a schema:alternateName Singleton Hospital
478 schema:name South Wales Cancer Centre, Singleton Hospital, Swansea, UK
479 rdf:type schema:Organization
480 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
481 schema:name Division of Neurosurgery and The Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada
482 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...