Molecular subgroups of medulloblastoma: the current consensus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

Michael D. Taylor, Paul A. Northcott, Andrey Korshunov, Marc Remke, Yoon-Jae Cho, Steven C. Clifford, Charles G. Eberhart, D. Williams Parsons, Stefan Rutkowski, Amar Gajjar, David W. Ellison, Peter Lichter, Richard J. Gilbertson, Scott L. Pomeroy, Marcel Kool, Stefan M. Pfister

ABSTRACT

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology. Current mechanisms for clinical prognostication and stratification include clinical factors (age, presence of metastases, and extent of resection) as well as histological subgrouping (classic, desmoplastic, and large cell/anaplastic histology). Transcriptional profiling studies of medulloblastoma cohorts from several research groups around the globe have suggested the existence of multiple distinct molecular subgroups that differ in their demographics, transcriptomes, somatic genetic events, and clinical outcomes. Variations in the number, composition, and nature of the subgroups between studies brought about a consensus conference in Boston in the fall of 2010. Discussants at the conference came to a consensus that the evidence supported the existence of four main subgroups of medulloblastoma (Wnt, Shh, Group 3, and Group 4). Participants outlined the demographic, transcriptional, genetic, and clinical differences between the four subgroups. While it is anticipated that the molecular classification of medulloblastoma will continue to evolve and diversify in the future as larger cohorts are studied at greater depth, herein we outline the current consensus nomenclature, and the differences between the medulloblastoma subgroups. More... »

PAGES

465-472

References to SciGraph publications

  • 2009-04. An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET) in BRITISH JOURNAL OF CANCER
  • 2012-04. Biological and clinical heterogeneity of MYCN-amplified medulloblastoma in ACTA NEUROPATHOLOGICA
  • 2010-12. Subtypes of medulloblastoma have distinct developmental origins in NATURE
  • 2002-01. Prediction of central nervous system embryonal tumour outcome based on gene expression in NATURE
  • 2002-07. Mutations in SUFU predispose to medulloblastoma in NATURE GENETICS
  • 2009-04. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma in NATURE GENETICS
  • 2011-03. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups in ACTA NEUROPATHOLOGICA
  • 2011-08. Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct in ACTA NEUROPATHOLOGICA
  • 2012-04. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas in ACTA NEUROPATHOLOGICA
  • 2011-06. Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma in FAMILIAL CANCER
  • 2004-03. Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation in NATURE GENETICS
  • 2007-07-12. The 2007 WHO Classification of Tumours of the Central Nervous System in ACTA NEUROPATHOLOGICA
  • 2011-02. Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-011-0922-z

    DOI

    http://dx.doi.org/10.1007/s00401-011-0922-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012707701

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22134537


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cerebellar Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Consensus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hedgehog Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Medulloblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wnt Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada", 
                "Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taylor", 
            "givenName": "Michael D.", 
            "id": "sg:person.012731463207.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731463207.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Northcott", 
            "givenName": "Paul A.", 
            "id": "sg:person.010563327577.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010563327577.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korshunov", 
            "givenName": "Andrey", 
            "id": "sg:person.013472071457.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013472071457.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany", 
                "Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Remke", 
            "givenName": "Marc", 
            "id": "sg:person.01001656432.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001656432.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cho", 
            "givenName": "Yoon-Jae", 
            "id": "sg:person.014317474567.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014317474567.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clifford", 
            "givenName": "Steven C.", 
            "id": "sg:person.01346765517.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346765517.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Departments of Pathology, Ophthalmology and Oncology, Johns Hopkins University School of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eberhart", 
            "givenName": "Charles G.", 
            "id": "sg:person.0775321062.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775321062.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pediatrics, Texas Children\u2019s Cancer Center, Baylor College of Medicine, Houston, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parsons", 
            "givenName": "D. Williams", 
            "id": "sg:person.014131205662.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014131205662.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Hamburg-Eppendorf", 
              "id": "https://www.grid.ac/institutes/grid.13648.38", 
              "name": [
                "Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rutkowski", 
            "givenName": "Stefan", 
            "id": "sg:person.01037056047.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037056047.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gajjar", 
            "givenName": "Amar", 
            "id": "sg:person.0605704743.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605704743.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ellison", 
            "givenName": "David W.", 
            "id": "sg:person.0711352500.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lichter", 
            "givenName": "Peter", 
            "id": "sg:person.01243467607.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243467607.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gilbertson", 
            "givenName": "Richard J.", 
            "id": "sg:person.01024145163.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024145163.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Neurology, Children\u2019s Hospital Boston, Harvard Medical School, Boston, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pomeroy", 
            "givenName": "Scott L.", 
            "id": "sg:person.01357716207.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357716207.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kool", 
            "givenName": "Marcel", 
            "id": "sg:person.01206710443.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206710443.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany", 
                "Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfister", 
            "givenName": "Stefan M.", 
            "id": "sg:person.01105171247.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105171247.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0912708107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000330859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0243-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001430701", 
              "https://doi.org/10.1007/s00401-007-0243-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0243-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001430701", 
              "https://doi.org/10.1007/s00401-007-0243-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.01.5479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001500983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002017147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.32944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004338893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.32944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004338893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(06)70867-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006867503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-012-0958-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007662906", 
              "https://doi.org/10.1007/s00401-012-0958-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.04.4974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011169284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-4710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011662417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.191502998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012580984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012674523", 
              "https://doi.org/10.1038/nature09587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012674523", 
              "https://doi.org/10.1038/nature09587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.31.1670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014934168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2007.00058.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016096532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415436a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019207421", 
              "https://doi.org/10.1038/415436a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415436a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019207421", 
              "https://doi.org/10.1038/415436a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019619541", 
              "https://doi.org/10.1038/ng1305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019619541", 
              "https://doi.org/10.1038/ng1305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.27.4324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026297279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1179386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028910517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.36.2798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028912740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10689-010-9411-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029324735", 
              "https://doi.org/10.1007/s10689-010-9411-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030704690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.02.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032390552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.jnen.0000196131.72302.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032741599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0918-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033236934", 
              "https://doi.org/10.1007/s00401-011-0918-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035880217", 
              "https://doi.org/10.1038/ng.336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037754285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038228680", 
              "https://doi.org/10.1038/ng916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038228680", 
              "https://doi.org/10.1038/ng916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.jnen.0000199576.70923.8a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040545619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040599545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040778422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.30.2810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041847755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5439.531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042995627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2005.07.962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043459313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0800-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044440927", 
              "https://doi.org/10.1007/s00401-011-0800-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.34.9373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044636805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044881254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.25.7121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045577352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199503303321302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045772912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006123-200010000-00020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047383455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0902903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048045488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.28.5148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049260900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2009.067751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049743590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0003088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049915735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051444313", 
              "https://doi.org/10.1038/sj.bjc.6604979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0846-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051667195", 
              "https://doi.org/10.1007/s00401-011-0846-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-010-0780-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052743633", 
              "https://doi.org/10.1007/s00401-010-0780-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2011.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052969532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3001599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062686839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3001599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062686839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.5.22.3446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077006568", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083226541", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/120347549800300109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083295820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/120347549800300109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083295820"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-04", 
        "datePublishedReg": "2012-04-01", 
        "description": "Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology. Current mechanisms for clinical prognostication and stratification include clinical factors (age, presence of metastases, and extent of resection) as well as histological subgrouping (classic, desmoplastic, and large cell/anaplastic histology). Transcriptional profiling studies of medulloblastoma cohorts from several research groups around the globe have suggested the existence of multiple distinct molecular subgroups that differ in their demographics, transcriptomes, somatic genetic events, and clinical outcomes. Variations in the number, composition, and nature of the subgroups between studies brought about a consensus conference in Boston in the fall of 2010. Discussants at the conference came to a consensus that the evidence supported the existence of four main subgroups of medulloblastoma (Wnt, Shh, Group 3, and Group 4). Participants outlined the demographic, transcriptional, genetic, and clinical differences between the four subgroups. While it is anticipated that the molecular classification of medulloblastoma will continue to evolve and diversify in the future as larger cohorts are studied at greater depth, herein we outline the current consensus nomenclature, and the differences between the medulloblastoma subgroups.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00401-011-0922-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2561726", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2477649", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2479507", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1019073", 
            "issn": [
              "0001-6322", 
              "1432-0533"
            ], 
            "name": "Acta Neuropathologica", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "123"
          }
        ], 
        "name": "Molecular subgroups of medulloblastoma: the current consensus", 
        "pagination": "465-472", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3c89a9e128557f944da1f381d8e8a4f0cd27a716a0fcfbedb68920741cdd2798"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22134537"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0412041"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00401-011-0922-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1012707701"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00401-011-0922-z", 
          "https://app.dimensions.ai/details/publication/pub.1012707701"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000546.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0922-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0922-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0922-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0922-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    407 TRIPLES      21 PREDICATES      88 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00401-011-0922-z schema:about N324e5cfc0d764784b12abe3541767ba9
    2 N4b5797fc7b73412d8dbc5e191ef636bd
    3 N73ab4e6e2efa4a858d2792b5a1f16899
    4 N8432556533fb4b0a9ee6dd58f15b4d87
    5 N9718a07a9fdb4a0ba2e824fc9712b7f3
    6 Na52b3598bfa147f1948cd16230980b17
    7 Ne6e2f8edbdad467090114d21ae9eb9d5
    8 Nfaea9fe8b43b442cb009cfc20240cf83
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author N49bc4a81416342979349737bae031301
    12 schema:citation sg:pub.10.1007/s00401-007-0243-4
    13 sg:pub.10.1007/s00401-010-0780-0
    14 sg:pub.10.1007/s00401-011-0800-8
    15 sg:pub.10.1007/s00401-011-0846-7
    16 sg:pub.10.1007/s00401-011-0918-8
    17 sg:pub.10.1007/s00401-012-0958-8
    18 sg:pub.10.1007/s10689-010-9411-0
    19 sg:pub.10.1038/415436a
    20 sg:pub.10.1038/nature09587
    21 sg:pub.10.1038/ng.336
    22 sg:pub.10.1038/ng1305
    23 sg:pub.10.1038/ng916
    24 sg:pub.10.1038/sj.bjc.6604979
    25 https://app.dimensions.ai/details/publication/pub.1077006568
    26 https://app.dimensions.ai/details/publication/pub.1083226541
    27 https://doi.org/10.1002/ajmg.a.32944
    28 https://doi.org/10.1002/cncr.21003
    29 https://doi.org/10.1002/path.2514
    30 https://doi.org/10.1016/j.ccr.2006.02.019
    31 https://doi.org/10.1016/j.ccr.2010.03.017
    32 https://doi.org/10.1016/j.ijrobp.2005.07.962
    33 https://doi.org/10.1016/j.tins.2011.01.002
    34 https://doi.org/10.1016/s1470-2045(06)70867-1
    35 https://doi.org/10.1056/nejm199503303321302
    36 https://doi.org/10.1056/nejmoa0902903
    37 https://doi.org/10.1073/pnas.0912708107
    38 https://doi.org/10.1073/pnas.191502998
    39 https://doi.org/10.1097/00006123-200010000-00020
    40 https://doi.org/10.1097/01.jnen.0000196131.72302.68
    41 https://doi.org/10.1097/01.jnen.0000199576.70923.8a
    42 https://doi.org/10.1111/j.1750-3639.2007.00058.x
    43 https://doi.org/10.1126/science.1179386
    44 https://doi.org/10.1126/science.1198056
    45 https://doi.org/10.1126/science.286.5439.531
    46 https://doi.org/10.1126/scitranslmed.3001599
    47 https://doi.org/10.1136/jmg.2009.067751
    48 https://doi.org/10.1158/0008-5472.can-08-4710
    49 https://doi.org/10.1158/0008-5472.can-09-2331
    50 https://doi.org/10.1158/1078-0432.ccr-10-2210
    51 https://doi.org/10.1177/120347549800300109
    52 https://doi.org/10.1200/jco.2005.01.5479
    53 https://doi.org/10.1200/jco.2005.04.4974
    54 https://doi.org/10.1200/jco.2009.25.7121
    55 https://doi.org/10.1200/jco.2009.27.4324
    56 https://doi.org/10.1200/jco.2010.28.5148
    57 https://doi.org/10.1200/jco.2010.30.2810
    58 https://doi.org/10.1200/jco.2010.31.1670
    59 https://doi.org/10.1200/jco.2011.34.9373
    60 https://doi.org/10.1200/jco.2011.36.2798
    61 https://doi.org/10.1371/journal.pone.0003088
    62 https://doi.org/10.4161/cc.5.22.3446
    63 schema:datePublished 2012-04
    64 schema:datePublishedReg 2012-04-01
    65 schema:description Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology. Current mechanisms for clinical prognostication and stratification include clinical factors (age, presence of metastases, and extent of resection) as well as histological subgrouping (classic, desmoplastic, and large cell/anaplastic histology). Transcriptional profiling studies of medulloblastoma cohorts from several research groups around the globe have suggested the existence of multiple distinct molecular subgroups that differ in their demographics, transcriptomes, somatic genetic events, and clinical outcomes. Variations in the number, composition, and nature of the subgroups between studies brought about a consensus conference in Boston in the fall of 2010. Discussants at the conference came to a consensus that the evidence supported the existence of four main subgroups of medulloblastoma (Wnt, Shh, Group 3, and Group 4). Participants outlined the demographic, transcriptional, genetic, and clinical differences between the four subgroups. While it is anticipated that the molecular classification of medulloblastoma will continue to evolve and diversify in the future as larger cohorts are studied at greater depth, herein we outline the current consensus nomenclature, and the differences between the medulloblastoma subgroups.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree true
    69 schema:isPartOf N3d7407825eea4a4da2b3e172d7254477
    70 Nc2cb1efdece444029bdb464d5768296d
    71 sg:journal.1019073
    72 schema:name Molecular subgroups of medulloblastoma: the current consensus
    73 schema:pagination 465-472
    74 schema:productId N34ad341142ca447d820878a761d95c2f
    75 N4dd6874269244aee84907597cc0394ad
    76 N662e87aa3c8c42a1b4e83304fc135708
    77 N69cf67b751164c42b9f5f76c4d9ef502
    78 N78907871d337479786b263f581a54e73
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012707701
    80 https://doi.org/10.1007/s00401-011-0922-z
    81 schema:sdDatePublished 2019-04-10T17:37
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher Nd8956766be62474d857cf4c7336c95ca
    84 schema:url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N05da716458be49b09f35c355144f172d rdf:first sg:person.01024145163.14
    89 rdf:rest Ne377efa6dc8e47848019db742ee094d6
    90 N1fdfea300cf8498696089843fb9e319c rdf:first sg:person.013472071457.40
    91 rdf:rest N89f0db2379ed4051b04e5fad071284a5
    92 N2e5be996b6ba43fd8da2b5150b2ee5e3 rdf:first sg:person.010563327577.08
    93 rdf:rest N1fdfea300cf8498696089843fb9e319c
    94 N324e5cfc0d764784b12abe3541767ba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Hedgehog Proteins
    96 rdf:type schema:DefinedTerm
    97 N34ad341142ca447d820878a761d95c2f schema:name nlm_unique_id
    98 schema:value 0412041
    99 rdf:type schema:PropertyValue
    100 N3d7407825eea4a4da2b3e172d7254477 schema:volumeNumber 123
    101 rdf:type schema:PublicationVolume
    102 N4118c9c150a7425c9be06307361022d2 rdf:first sg:person.01105171247.76
    103 rdf:rest rdf:nil
    104 N422132fd06fe44968d52c72a6e122c9c rdf:first sg:person.0711352500.88
    105 rdf:rest Nf70dc4a90cb447e7a7fd79b769a63e97
    106 N4885d083a1be47df8de2f3c614735125 rdf:first sg:person.014131205662.35
    107 rdf:rest N8c2d036a49ac44db959768b0a13ff851
    108 N49bc4a81416342979349737bae031301 rdf:first sg:person.012731463207.92
    109 rdf:rest N2e5be996b6ba43fd8da2b5150b2ee5e3
    110 N4b5797fc7b73412d8dbc5e191ef636bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Cerebellar Neoplasms
    112 rdf:type schema:DefinedTerm
    113 N4dd6874269244aee84907597cc0394ad schema:name doi
    114 schema:value 10.1007/s00401-011-0922-z
    115 rdf:type schema:PropertyValue
    116 N4ebe5eac020c4638bf1e7abc502080fa rdf:first sg:person.01346765517.08
    117 rdf:rest N91dbf6159066406ca11702b5e6ce7dee
    118 N662e87aa3c8c42a1b4e83304fc135708 schema:name dimensions_id
    119 schema:value pub.1012707701
    120 rdf:type schema:PropertyValue
    121 N69cf67b751164c42b9f5f76c4d9ef502 schema:name readcube_id
    122 schema:value 3c89a9e128557f944da1f381d8e8a4f0cd27a716a0fcfbedb68920741cdd2798
    123 rdf:type schema:PropertyValue
    124 N6d218671ddc94ff7a7084c9ad27e7a67 rdf:first sg:person.01206710443.02
    125 rdf:rest N4118c9c150a7425c9be06307361022d2
    126 N73ab4e6e2efa4a858d2792b5a1f16899 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Consensus
    128 rdf:type schema:DefinedTerm
    129 N78907871d337479786b263f581a54e73 schema:name pubmed_id
    130 schema:value 22134537
    131 rdf:type schema:PropertyValue
    132 N7ac4ed8235a042a3839e7b705e8ac245 schema:name Department of Neurology, Children’s Hospital Boston, Harvard Medical School, Boston, USA
    133 rdf:type schema:Organization
    134 N8432556533fb4b0a9ee6dd58f15b4d87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Gene Expression Profiling
    136 rdf:type schema:DefinedTerm
    137 N89f0db2379ed4051b04e5fad071284a5 rdf:first sg:person.01001656432.42
    138 rdf:rest Nd0bc37c223c34505b7a207de01a03903
    139 N8c2d036a49ac44db959768b0a13ff851 rdf:first sg:person.01037056047.34
    140 rdf:rest N9f6fc671dc014026afa266af5b060153
    141 N91dbf6159066406ca11702b5e6ce7dee rdf:first sg:person.0775321062.58
    142 rdf:rest N4885d083a1be47df8de2f3c614735125
    143 N9718a07a9fdb4a0ba2e824fc9712b7f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Wnt Proteins
    145 rdf:type schema:DefinedTerm
    146 N9f6fc671dc014026afa266af5b060153 rdf:first sg:person.0605704743.40
    147 rdf:rest N422132fd06fe44968d52c72a6e122c9c
    148 Na52b3598bfa147f1948cd16230980b17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Transcriptome
    150 rdf:type schema:DefinedTerm
    151 Nc2cb1efdece444029bdb464d5768296d schema:issueNumber 4
    152 rdf:type schema:PublicationIssue
    153 Nd0bc37c223c34505b7a207de01a03903 rdf:first sg:person.014317474567.18
    154 rdf:rest N4ebe5eac020c4638bf1e7abc502080fa
    155 Nd8956766be62474d857cf4c7336c95ca schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 Ne377efa6dc8e47848019db742ee094d6 rdf:first sg:person.01357716207.14
    158 rdf:rest N6d218671ddc94ff7a7084c9ad27e7a67
    159 Ne6e2f8edbdad467090114d21ae9eb9d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Humans
    161 rdf:type schema:DefinedTerm
    162 Nf70dc4a90cb447e7a7fd79b769a63e97 rdf:first sg:person.01243467607.83
    163 rdf:rest N05da716458be49b09f35c355144f172d
    164 Nfaea9fe8b43b442cb009cfc20240cf83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Medulloblastoma
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Biological Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Genetics
    172 rdf:type schema:DefinedTerm
    173 sg:grant.2477649 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0922-z
    174 rdf:type schema:MonetaryGrant
    175 sg:grant.2479507 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0922-z
    176 rdf:type schema:MonetaryGrant
    177 sg:grant.2561726 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0922-z
    178 rdf:type schema:MonetaryGrant
    179 sg:journal.1019073 schema:issn 0001-6322
    180 1432-0533
    181 schema:name Acta Neuropathologica
    182 rdf:type schema:Periodical
    183 sg:person.01001656432.42 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    184 schema:familyName Remke
    185 schema:givenName Marc
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001656432.42
    187 rdf:type schema:Person
    188 sg:person.01024145163.14 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    189 schema:familyName Gilbertson
    190 schema:givenName Richard J.
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024145163.14
    192 rdf:type schema:Person
    193 sg:person.01037056047.34 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
    194 schema:familyName Rutkowski
    195 schema:givenName Stefan
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037056047.34
    197 rdf:type schema:Person
    198 sg:person.010563327577.08 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    199 schema:familyName Northcott
    200 schema:givenName Paul A.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010563327577.08
    202 rdf:type schema:Person
    203 sg:person.01105171247.76 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    204 schema:familyName Pfister
    205 schema:givenName Stefan M.
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105171247.76
    207 rdf:type schema:Person
    208 sg:person.01206710443.02 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    209 schema:familyName Kool
    210 schema:givenName Marcel
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206710443.02
    212 rdf:type schema:Person
    213 sg:person.01243467607.83 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    214 schema:familyName Lichter
    215 schema:givenName Peter
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243467607.83
    217 rdf:type schema:Person
    218 sg:person.012731463207.92 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    219 schema:familyName Taylor
    220 schema:givenName Michael D.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731463207.92
    222 rdf:type schema:Person
    223 sg:person.01346765517.08 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    224 schema:familyName Clifford
    225 schema:givenName Steven C.
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346765517.08
    227 rdf:type schema:Person
    228 sg:person.013472071457.40 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    229 schema:familyName Korshunov
    230 schema:givenName Andrey
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013472071457.40
    232 rdf:type schema:Person
    233 sg:person.01357716207.14 schema:affiliation N7ac4ed8235a042a3839e7b705e8ac245
    234 schema:familyName Pomeroy
    235 schema:givenName Scott L.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357716207.14
    237 rdf:type schema:Person
    238 sg:person.014131205662.35 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    239 schema:familyName Parsons
    240 schema:givenName D. Williams
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014131205662.35
    242 rdf:type schema:Person
    243 sg:person.014317474567.18 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    244 schema:familyName Cho
    245 schema:givenName Yoon-Jae
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014317474567.18
    247 rdf:type schema:Person
    248 sg:person.0605704743.40 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    249 schema:familyName Gajjar
    250 schema:givenName Amar
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605704743.40
    252 rdf:type schema:Person
    253 sg:person.0711352500.88 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    254 schema:familyName Ellison
    255 schema:givenName David W.
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88
    257 rdf:type schema:Person
    258 sg:person.0775321062.58 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    259 schema:familyName Eberhart
    260 schema:givenName Charles G.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775321062.58
    262 rdf:type schema:Person
    263 sg:pub.10.1007/s00401-007-0243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430701
    264 https://doi.org/10.1007/s00401-007-0243-4
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s00401-010-0780-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052743633
    267 https://doi.org/10.1007/s00401-010-0780-0
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s00401-011-0800-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044440927
    270 https://doi.org/10.1007/s00401-011-0800-8
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s00401-011-0846-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051667195
    273 https://doi.org/10.1007/s00401-011-0846-7
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s00401-011-0918-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033236934
    276 https://doi.org/10.1007/s00401-011-0918-8
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s00401-012-0958-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007662906
    279 https://doi.org/10.1007/s00401-012-0958-8
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s10689-010-9411-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029324735
    282 https://doi.org/10.1007/s10689-010-9411-0
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/415436a schema:sameAs https://app.dimensions.ai/details/publication/pub.1019207421
    285 https://doi.org/10.1038/415436a
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nature09587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012674523
    288 https://doi.org/10.1038/nature09587
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ng.336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035880217
    291 https://doi.org/10.1038/ng.336
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/ng1305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019619541
    294 https://doi.org/10.1038/ng1305
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/ng916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038228680
    297 https://doi.org/10.1038/ng916
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/sj.bjc.6604979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051444313
    300 https://doi.org/10.1038/sj.bjc.6604979
    301 rdf:type schema:CreativeWork
    302 https://app.dimensions.ai/details/publication/pub.1077006568 schema:CreativeWork
    303 https://app.dimensions.ai/details/publication/pub.1083226541 schema:CreativeWork
    304 https://doi.org/10.1002/ajmg.a.32944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004338893
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1002/cncr.21003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040599545
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1002/path.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044881254
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.ccr.2006.02.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032390552
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.ccr.2010.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040778422
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.ijrobp.2005.07.962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043459313
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.tins.2011.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052969532
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s1470-2045(06)70867-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006867503
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1056/nejm199503303321302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045772912
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1056/nejmoa0902903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048045488
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1073/pnas.0912708107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000330859
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1073/pnas.191502998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012580984
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1097/00006123-200010000-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047383455
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1097/01.jnen.0000196131.72302.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032741599
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1097/01.jnen.0000199576.70923.8a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040545619
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1111/j.1750-3639.2007.00058.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016096532
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1126/science.1179386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028910517
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1126/science.1198056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030704690
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1126/science.286.5439.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042995627
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1126/scitranslmed.3001599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062686839
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1136/jmg.2009.067751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049743590
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1158/0008-5472.can-08-4710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011662417
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1158/0008-5472.can-09-2331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002017147
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1158/1078-0432.ccr-10-2210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037754285
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1177/120347549800300109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083295820
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1200/jco.2005.01.5479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001500983
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1200/jco.2005.04.4974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011169284
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1200/jco.2009.25.7121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045577352
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1200/jco.2009.27.4324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026297279
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1200/jco.2010.28.5148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049260900
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1200/jco.2010.30.2810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041847755
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1200/jco.2010.31.1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014934168
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1200/jco.2011.34.9373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044636805
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1200/jco.2011.36.2798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028912740
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1371/journal.pone.0003088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049915735
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.4161/cc.5.22.3446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298705
    375 rdf:type schema:CreativeWork
    376 https://www.grid.ac/institutes/grid.1006.7 schema:alternateName Newcastle University
    377 schema:name Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    378 rdf:type schema:Organization
    379 https://www.grid.ac/institutes/grid.13648.38 schema:alternateName University Medical Center Hamburg-Eppendorf
    380 schema:name Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    381 rdf:type schema:Organization
    382 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
    383 schema:name Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, USA
    384 rdf:type schema:Organization
    385 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
    386 schema:name Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    387 Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Canada
    388 rdf:type schema:Organization
    389 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    390 schema:name Departments of Pathology, Ophthalmology and Oncology, Johns Hopkins University School of Medicine, Baltimore, USA
    391 rdf:type schema:Organization
    392 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
    393 schema:name Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, USA
    394 Department of Oncology, St. Jude Children’s Research Hospital, Memphis, USA
    395 Department of Pathology, St. Jude Children’s Research Hospital, Memphis, USA
    396 rdf:type schema:Organization
    397 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
    398 schema:name Department of Pediatrics, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, USA
    399 rdf:type schema:Organization
    400 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
    401 schema:name Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany
    402 Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
    403 rdf:type schema:Organization
    404 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
    405 schema:name Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany
    406 Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
    407 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...