National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11-20

AUTHORS

Thomas J. Montine, Creighton H. Phelps, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Dennis W. Dickson, Charles Duyckaerts, Matthew P. Frosch, Eliezer Masliah, Suzanne S. Mirra, Peter T. Nelson, Julie A. Schneider, Dietmar Rudolf Thal, John Q. Trojanowski, Harry V. Vinters, Bradley T. Hyman

ABSTRACT

We present a practical guide for the implementation of recently revised National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an “ABC” score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations. More... »

PAGES

1-11

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  • Journal

    TITLE

    Acta Neuropathologica

    ISSUE

    1

    VOLUME

    123

    Author Affiliations

  • Department of Pathology, University of Washington School of Medicine, Box 359791, 98104, Seattle, WA, USA
  • National Institute on Aging, Bethesda, MD, USA
  • Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA
  • Department of Pathology and Northwestern Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  • Departments of Neurology and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA
  • Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
  • Service de Neuropathologie Raymond Escourolle, Hôpital de la Salpêtriére, Paris, France
  • C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Departments of Neurosciences and Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, USA
  • Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, USA
  • Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
  • Departments of Pathology and Neurological Sciences, Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
  • Laboratory of Neuropathology, Institute of Pathology, University of Ulm, Ulm, Germany
  • Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
  • Departments of Pathology & Laboratory Medicine (Neuropathology) and Neurology, University of California Los Angeles, Los Angeles, CA, USA
  • Neurology Department, Massachusetts General Hospital, Harvard University, Boston, MA, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-011-0910-3

    DOI

    http://dx.doi.org/10.1007/s00401-011-0910-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045607293

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22101365


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