Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03-13

AUTHORS

Jinxia Zhou, Melissa Broe, Yue Huang, John P. Anderson, Wei-Ping Gai, Elizabeth A. Milward, Michelle Porritt, David Howells, Andrew J. Hughes, Xiaomin Wang, Glenda M. Halliday

ABSTRACT

Lewy bodies are made from insoluble, phosphorylated α-synuclein, but the earliest changes that precipitate such pathology still remain conjecture. In this study, we quantify and identify relationships between the levels of the main pathologic form of phosphorylated α-synuclein over the course of Parkinson’s disease in regions affected early through to end-stage disease. Brain tissue samples from 33 cases at different disease stages and 13 controls were collected through the Australian Network of Brain Banks. 500 mg of frozen putamen (affected preclinically) and frontal cortex (affected late) was homogenized, fractionated and α-synuclein levels evaluated using specific antibodies (syn-1, BD Transduction Laboratories; S129P phospho-α-synuclein, Elan Pharmaceuticals) and quantitative western blotting. Statistical analyses assessed the relationship between the different forms of α-synuclein, compared levels between groups, and determined any changes over the disease course. Soluble S129P was detected in controls with higher levels in putamen compared with frontal cortex. In contrast, insoluble α-synuclein occurred in Parkinson’s disease with a significant increase in soluble and lipid-associated S129P, and a decrease in soluble frontal α-synuclein over the disease course. Increasing soluble S129P in the putamen correlated with increasing S129P in other fractions and regions. These data show that soluble non-phosphorylated α-synuclein decreases over the course of Parkinson’s disease, becoming increasingly phosphorylated and insoluble. The finding that S129P α-synuclein normally occurs in vulnerable brain regions, and in Parkinson’s disease has the strongest relationships to the pathogenic forms of α-synuclein in other brain regions, suggests a propagating role for putamenal phospho-α-synuclein in disease pathogenesis. More... »

PAGES

695-704

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-011-0815-1

DOI

http://dx.doi.org/10.1007/s00401-011-0815-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048182540

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21400129


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Frontal Lobe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Putamen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Synuclein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Jinxia", 
        "id": "sg:person.01151633652.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151633652.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broe", 
        "givenName": "Melissa", 
        "id": "sg:person.01217747052.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217747052.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Yue", 
        "id": "sg:person.01314554435.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314554435.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Elan Pharmaceuticals Inc, 94080, South San Francisco, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418772.f", 
          "name": [
            "Elan Pharmaceuticals Inc, 94080, South San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anderson", 
        "givenName": "John P.", 
        "id": "sg:person.0730274471.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730274471.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Physiology, The Centre for Neuroscience, Flinders University School of Medicine, 5042, Bedford Park, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1014.4", 
          "name": [
            "Department of Human Physiology, The Centre for Neuroscience, Flinders University School of Medicine, 5042, Bedford Park, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gai", 
        "givenName": "Wei-Ping", 
        "id": "sg:person.01351532622.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351532622.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biomedical Sciences and Pharmacy, The University of Newcastle, 2038, Callaghan, Australia", 
          "id": "http://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "School of Biomedical Sciences and Pharmacy, The University of Newcastle, 2038, Callaghan, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milward", 
        "givenName": "Elizabeth A.", 
        "id": "sg:person.01117340563.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117340563.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Porritt", 
        "givenName": "Michelle", 
        "id": "sg:person.01126426637.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126426637.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Howells", 
        "givenName": "David", 
        "id": "sg:person.01255770020.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255770020.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hughes", 
        "givenName": "Andrew J.", 
        "id": "sg:person.016537002502.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016537002502.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, 100069, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.24696.3f", 
          "name": [
            "Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, 100069, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xiaomin", 
        "id": "sg:person.01215072006.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215072006.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halliday", 
        "givenName": "Glenda M.", 
        "id": "sg:person.01003126600.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003126600.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1750-1326-4-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004113297", 
          "https://doi.org/10.1186/1750-1326-4-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0676-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017440868", 
          "https://doi.org/10.1007/s00401-010-0676-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0711-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038688391", 
          "https://doi.org/10.1007/s00401-010-0711-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015876494", 
          "https://doi.org/10.1038/nm.2165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0602-600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033109199", 
          "https://doi.org/10.1038/nm0602-600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052517087", 
          "https://doi.org/10.1038/ncb841"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-03-13", 
    "datePublishedReg": "2011-03-13", 
    "description": "Lewy bodies are made from insoluble, phosphorylated \u03b1-synuclein, but the earliest changes that precipitate such pathology still remain conjecture. In this study, we quantify and identify relationships between the levels of the main pathologic form of phosphorylated \u03b1-synuclein over the course of Parkinson\u2019s disease in regions affected early through to end-stage disease. Brain tissue samples from 33 cases at different disease stages and 13 controls were collected through the Australian Network of Brain Banks. 500\u00a0mg of frozen putamen (affected preclinically) and frontal cortex (affected late) was homogenized, fractionated and \u03b1-synuclein levels evaluated using specific antibodies (syn-1, BD Transduction Laboratories; S129P phospho-\u03b1-synuclein, Elan Pharmaceuticals) and quantitative western blotting. Statistical analyses assessed the relationship between the different forms of \u03b1-synuclein, compared levels between groups, and determined any changes over the disease course. Soluble S129P was detected in controls with higher levels in putamen compared with frontal cortex. In contrast, insoluble \u03b1-synuclein occurred in Parkinson\u2019s disease with a significant increase in soluble and lipid-associated S129P, and a decrease in soluble frontal \u03b1-synuclein over the disease course. Increasing soluble S129P in the putamen correlated with increasing S129P in other fractions and regions. These data show that soluble non-phosphorylated \u03b1-synuclein decreases over the course of Parkinson\u2019s disease, becoming increasingly phosphorylated and insoluble. The finding that S129P \u03b1-synuclein normally occurs in vulnerable brain regions, and in Parkinson\u2019s disease has the strongest relationships to the pathogenic forms of \u03b1-synuclein in other brain regions, suggests a propagating role for putamenal phospho-\u03b1-synuclein in disease pathogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00401-011-0815-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5072608", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6713471", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6728253", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6726299", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2621066", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "121"
      }
    ], 
    "keywords": [
      "Parkinson's disease", 
      "disease course", 
      "frontal cortex", 
      "brain regions", 
      "end-stage disease", 
      "vulnerable brain regions", 
      "different disease stages", 
      "disease stage", 
      "synuclein levels", 
      "Lewy bodies", 
      "Brain Bank", 
      "disease pathogenesis", 
      "early changes", 
      "brain tissue", 
      "pathologic forms", 
      "disease", 
      "quantitative Western blotting", 
      "such pathology", 
      "putamen", 
      "Western blotting", 
      "synuclein decreases", 
      "specific antibodies", 
      "synuclein", 
      "significant increase", 
      "cortex", 
      "pathogenic form", 
      "course", 
      "high levels", 
      "levels", 
      "pathogenesis", 
      "statistical analysis", 
      "pathology", 
      "antibodies", 
      "decrease", 
      "blotting", 
      "control", 
      "changes", 
      "tissue", 
      "strong relationship", 
      "group", 
      "findings", 
      "relationship", 
      "phosphorylation", 
      "phospho", 
      "study", 
      "cases", 
      "role", 
      "different forms", 
      "increase", 
      "contrast", 
      "region", 
      "body", 
      "stage", 
      "form", 
      "data", 
      "fraction", 
      "analysis", 
      "Australian network", 
      "network", 
      "solubility", 
      "banks", 
      "conjecture", 
      "main pathologic form", 
      "frozen putamen", 
      "Soluble S129P", 
      "S129P", 
      "lipid-associated S129P", 
      "S129P \u03b1", 
      "putamenal phospho"
    ], 
    "name": "Changes in the solubility and phosphorylation of \u03b1-synuclein over the course of Parkinson\u2019s disease", 
    "pagination": "695-704", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048182540"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00401-011-0815-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21400129"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00401-011-0815-1", 
      "https://app.dimensions.ai/details/publication/pub.1048182540"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_544.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00401-011-0815-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0815-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0815-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0815-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-011-0815-1'


 

This table displays all metadata directly associated to this object as RDF triples.

306 TRIPLES      22 PREDICATES      115 URIs      101 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00401-011-0815-1 schema:about N01a1a517942c47c299c4b99cefa0593c
2 N11f24c4a4f944f74bf4db622b183bd25
3 N28600e6170414716b4c0012f7e4d90ff
4 N5533dfba78a84971ae400850f0fdeeac
5 N5cf3b0a17ca64b6f83d7d244e9da2257
6 N5d2772e7e00a4349a49c6cb7e49dacf7
7 N62d5072a81c24cb9b29a531c8167ab74
8 N6544ab24d50c40808c5e1dc310e0732c
9 N6704ecbdef544f32a6a0efb7231ef99e
10 N73bbc0627b754352871412d681604319
11 Na5b6b499cbff41cc8da87f4fa7d71979
12 Na5c81945b88142d68596940ae5edd91a
13 Nd7398a68b5274dbdac6c760809f5273f
14 Nf012196fada84393b1c767322d8c9e37
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author N211b7fe09a70493a8bb4039c9a8ed4fe
18 schema:citation sg:pub.10.1007/s00401-010-0676-z
19 sg:pub.10.1007/s00401-010-0711-0
20 sg:pub.10.1038/ncb841
21 sg:pub.10.1038/nm.2165
22 sg:pub.10.1038/nm0602-600
23 sg:pub.10.1186/1750-1326-4-9
24 schema:datePublished 2011-03-13
25 schema:datePublishedReg 2011-03-13
26 schema:description Lewy bodies are made from insoluble, phosphorylated α-synuclein, but the earliest changes that precipitate such pathology still remain conjecture. In this study, we quantify and identify relationships between the levels of the main pathologic form of phosphorylated α-synuclein over the course of Parkinson’s disease in regions affected early through to end-stage disease. Brain tissue samples from 33 cases at different disease stages and 13 controls were collected through the Australian Network of Brain Banks. 500 mg of frozen putamen (affected preclinically) and frontal cortex (affected late) was homogenized, fractionated and α-synuclein levels evaluated using specific antibodies (syn-1, BD Transduction Laboratories; S129P phospho-α-synuclein, Elan Pharmaceuticals) and quantitative western blotting. Statistical analyses assessed the relationship between the different forms of α-synuclein, compared levels between groups, and determined any changes over the disease course. Soluble S129P was detected in controls with higher levels in putamen compared with frontal cortex. In contrast, insoluble α-synuclein occurred in Parkinson’s disease with a significant increase in soluble and lipid-associated S129P, and a decrease in soluble frontal α-synuclein over the disease course. Increasing soluble S129P in the putamen correlated with increasing S129P in other fractions and regions. These data show that soluble non-phosphorylated α-synuclein decreases over the course of Parkinson’s disease, becoming increasingly phosphorylated and insoluble. The finding that S129P α-synuclein normally occurs in vulnerable brain regions, and in Parkinson’s disease has the strongest relationships to the pathogenic forms of α-synuclein in other brain regions, suggests a propagating role for putamenal phospho-α-synuclein in disease pathogenesis.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N615fd32274f244db98e087834048b024
31 Naa10cc3f695645dd90fc37c684e9f5bd
32 sg:journal.1019073
33 schema:keywords Australian network
34 Brain Bank
35 Lewy bodies
36 Parkinson's disease
37 S129P
38 S129P α
39 Soluble S129P
40 Western blotting
41 analysis
42 antibodies
43 banks
44 blotting
45 body
46 brain regions
47 brain tissue
48 cases
49 changes
50 conjecture
51 contrast
52 control
53 cortex
54 course
55 data
56 decrease
57 different disease stages
58 different forms
59 disease
60 disease course
61 disease pathogenesis
62 disease stage
63 early changes
64 end-stage disease
65 findings
66 form
67 fraction
68 frontal cortex
69 frozen putamen
70 group
71 high levels
72 increase
73 levels
74 lipid-associated S129P
75 main pathologic form
76 network
77 pathogenesis
78 pathogenic form
79 pathologic forms
80 pathology
81 phospho
82 phosphorylation
83 putamen
84 putamenal phospho
85 quantitative Western blotting
86 region
87 relationship
88 role
89 significant increase
90 solubility
91 specific antibodies
92 stage
93 statistical analysis
94 strong relationship
95 study
96 such pathology
97 synuclein
98 synuclein decreases
99 synuclein levels
100 tissue
101 vulnerable brain regions
102 schema:name Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease
103 schema:pagination 695-704
104 schema:productId N08f247f96d8a4547abe0f1a9709d3dfd
105 N9957fd95d6114317bafbb217ebed72a1
106 Nbe55bb24594b485aafbfd06c57034fa1
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048182540
108 https://doi.org/10.1007/s00401-011-0815-1
109 schema:sdDatePublished 2021-12-01T19:25
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N4f655efc52204fd7aab7456055bfd109
112 schema:url https://doi.org/10.1007/s00401-011-0815-1
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N01a1a517942c47c299c4b99cefa0593c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 N08f247f96d8a4547abe0f1a9709d3dfd schema:name dimensions_id
120 schema:value pub.1048182540
121 rdf:type schema:PropertyValue
122 N11f24c4a4f944f74bf4db622b183bd25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Aged
124 rdf:type schema:DefinedTerm
125 N1ae8780655af467fa285a5b195e58ee1 rdf:first sg:person.01255770020.91
126 rdf:rest N57e730b3e5bd43bc940bf99e1fb031ae
127 N211b7fe09a70493a8bb4039c9a8ed4fe rdf:first sg:person.01151633652.19
128 rdf:rest Nd84b7030e5944042a7cf4c366e00d0df
129 N28600e6170414716b4c0012f7e4d90ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Putamen
131 rdf:type schema:DefinedTerm
132 N4f655efc52204fd7aab7456055bfd109 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N5533dfba78a84971ae400850f0fdeeac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N57e730b3e5bd43bc940bf99e1fb031ae rdf:first sg:person.016537002502.24
138 rdf:rest Nf65068b5fb034183a6d03a1a69f4adfb
139 N5cf3b0a17ca64b6f83d7d244e9da2257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Statistics, Nonparametric
141 rdf:type schema:DefinedTerm
142 N5d2772e7e00a4349a49c6cb7e49dacf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name alpha-Synuclein
144 rdf:type schema:DefinedTerm
145 N615fd32274f244db98e087834048b024 schema:issueNumber 6
146 rdf:type schema:PublicationIssue
147 N62794dc28760470a879c2e736ed9c882 rdf:first sg:person.01126426637.43
148 rdf:rest N1ae8780655af467fa285a5b195e58ee1
149 N62d5072a81c24cb9b29a531c8167ab74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Parkinson Disease
151 rdf:type schema:DefinedTerm
152 N6544ab24d50c40808c5e1dc310e0732c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Analysis of Variance
154 rdf:type schema:DefinedTerm
155 N6704ecbdef544f32a6a0efb7231ef99e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Disease Progression
157 rdf:type schema:DefinedTerm
158 N73bbc0627b754352871412d681604319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Frontal Lobe
160 rdf:type schema:DefinedTerm
161 N7e7f1cd21cfc4ebab08aefaf9724d830 rdf:first sg:person.01314554435.23
162 rdf:rest Nf917f083e07f45e0be02aac48dddcb41
163 N9957fd95d6114317bafbb217ebed72a1 schema:name doi
164 schema:value 10.1007/s00401-011-0815-1
165 rdf:type schema:PropertyValue
166 N9efd4898c94f4151bc6be8cf90d4a5d7 rdf:first sg:person.01117340563.00
167 rdf:rest N62794dc28760470a879c2e736ed9c882
168 Na1822122757648e0b66c31fa3449909a rdf:first sg:person.01003126600.09
169 rdf:rest rdf:nil
170 Na5b6b499cbff41cc8da87f4fa7d71979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Aged, 80 and over
172 rdf:type schema:DefinedTerm
173 Na5c81945b88142d68596940ae5edd91a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Phosphorylation
175 rdf:type schema:DefinedTerm
176 Naa10cc3f695645dd90fc37c684e9f5bd schema:volumeNumber 121
177 rdf:type schema:PublicationVolume
178 Nbe55bb24594b485aafbfd06c57034fa1 schema:name pubmed_id
179 schema:value 21400129
180 rdf:type schema:PropertyValue
181 Nd7398a68b5274dbdac6c760809f5273f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Female
183 rdf:type schema:DefinedTerm
184 Nd84b7030e5944042a7cf4c366e00d0df rdf:first sg:person.01217747052.41
185 rdf:rest N7e7f1cd21cfc4ebab08aefaf9724d830
186 Ndad71ddf244944a18dd762eded1bd3f2 rdf:first sg:person.01351532622.13
187 rdf:rest N9efd4898c94f4151bc6be8cf90d4a5d7
188 Nf012196fada84393b1c767322d8c9e37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Serine
190 rdf:type schema:DefinedTerm
191 Nf65068b5fb034183a6d03a1a69f4adfb rdf:first sg:person.01215072006.34
192 rdf:rest Na1822122757648e0b66c31fa3449909a
193 Nf917f083e07f45e0be02aac48dddcb41 rdf:first sg:person.0730274471.06
194 rdf:rest Ndad71ddf244944a18dd762eded1bd3f2
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
199 schema:name Neurosciences
200 rdf:type schema:DefinedTerm
201 sg:grant.2621066 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0815-1
202 rdf:type schema:MonetaryGrant
203 sg:grant.5072608 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0815-1
204 rdf:type schema:MonetaryGrant
205 sg:grant.6713471 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0815-1
206 rdf:type schema:MonetaryGrant
207 sg:grant.6726299 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0815-1
208 rdf:type schema:MonetaryGrant
209 sg:grant.6728253 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-011-0815-1
210 rdf:type schema:MonetaryGrant
211 sg:journal.1019073 schema:issn 0001-6322
212 1432-0533
213 schema:name Acta Neuropathologica
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01003126600.09 schema:affiliation grid-institutes:grid.1005.4
217 schema:familyName Halliday
218 schema:givenName Glenda M.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003126600.09
220 rdf:type schema:Person
221 sg:person.01117340563.00 schema:affiliation grid-institutes:grid.266842.c
222 schema:familyName Milward
223 schema:givenName Elizabeth A.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117340563.00
225 rdf:type schema:Person
226 sg:person.01126426637.43 schema:affiliation grid-institutes:None
227 schema:familyName Porritt
228 schema:givenName Michelle
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126426637.43
230 rdf:type schema:Person
231 sg:person.01151633652.19 schema:affiliation grid-institutes:grid.1005.4
232 schema:familyName Zhou
233 schema:givenName Jinxia
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151633652.19
235 rdf:type schema:Person
236 sg:person.01215072006.34 schema:affiliation grid-institutes:grid.24696.3f
237 schema:familyName Wang
238 schema:givenName Xiaomin
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215072006.34
240 rdf:type schema:Person
241 sg:person.01217747052.41 schema:affiliation grid-institutes:grid.1005.4
242 schema:familyName Broe
243 schema:givenName Melissa
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217747052.41
245 rdf:type schema:Person
246 sg:person.01255770020.91 schema:affiliation grid-institutes:None
247 schema:familyName Howells
248 schema:givenName David
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255770020.91
250 rdf:type schema:Person
251 sg:person.01314554435.23 schema:affiliation grid-institutes:grid.1005.4
252 schema:familyName Huang
253 schema:givenName Yue
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314554435.23
255 rdf:type schema:Person
256 sg:person.01351532622.13 schema:affiliation grid-institutes:grid.1014.4
257 schema:familyName Gai
258 schema:givenName Wei-Ping
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351532622.13
260 rdf:type schema:Person
261 sg:person.016537002502.24 schema:affiliation grid-institutes:None
262 schema:familyName Hughes
263 schema:givenName Andrew J.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016537002502.24
265 rdf:type schema:Person
266 sg:person.0730274471.06 schema:affiliation grid-institutes:grid.418772.f
267 schema:familyName Anderson
268 schema:givenName John P.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730274471.06
270 rdf:type schema:Person
271 sg:pub.10.1007/s00401-010-0676-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1017440868
272 https://doi.org/10.1007/s00401-010-0676-z
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s00401-010-0711-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038688391
275 https://doi.org/10.1007/s00401-010-0711-0
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ncb841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052517087
278 https://doi.org/10.1038/ncb841
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nm.2165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015876494
281 https://doi.org/10.1038/nm.2165
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nm0602-600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033109199
284 https://doi.org/10.1038/nm0602-600
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/1750-1326-4-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004113297
287 https://doi.org/10.1186/1750-1326-4-9
288 rdf:type schema:CreativeWork
289 grid-institutes:None schema:alternateName Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia
290 schema:name Department of Medicine, Florey Neuroscience Institutes, The University of Melbourne, Austin Health, 3084, Heidelberg, Australia
291 rdf:type schema:Organization
292 grid-institutes:grid.1005.4 schema:alternateName Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia
293 schema:name Neuroscience Research Australia, The University of New South Wales, Barker Street, Randwick, 2031, Sydney, Australia
294 rdf:type schema:Organization
295 grid-institutes:grid.1014.4 schema:alternateName Department of Human Physiology, The Centre for Neuroscience, Flinders University School of Medicine, 5042, Bedford Park, Australia
296 schema:name Department of Human Physiology, The Centre for Neuroscience, Flinders University School of Medicine, 5042, Bedford Park, Australia
297 rdf:type schema:Organization
298 grid-institutes:grid.24696.3f schema:alternateName Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, 100069, Beijing, China
299 schema:name Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, 100069, Beijing, China
300 rdf:type schema:Organization
301 grid-institutes:grid.266842.c schema:alternateName School of Biomedical Sciences and Pharmacy, The University of Newcastle, 2038, Callaghan, Australia
302 schema:name School of Biomedical Sciences and Pharmacy, The University of Newcastle, 2038, Callaghan, Australia
303 rdf:type schema:Organization
304 grid-institutes:grid.418772.f schema:alternateName Elan Pharmaceuticals Inc, 94080, South San Francisco, CA, USA
305 schema:name Elan Pharmaceuticals Inc, 94080, South San Francisco, CA, USA
306 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...