APP involvement in retinogenesis of mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10-27

AUTHORS

Virginie Dinet, Na An, Giuseppe D. Ciccotosto, Julien Bruban, Agathe Maoui, Shayne A. Bellingham, Andrew F. Hill, Olav M. Andersen, Anders Nykjaer, Laurent Jonet, Roberto Cappai, Frédéric Mascarelli

ABSTRACT

Very few studies have examined expression and function of amyloid precursor protein (APP) in the retina. We showed that APP mRNA and protein are expressed according to the different waves of retinal differentiation. Depletion of App led to an absence of amacrine cells, a 50% increase in the number of horizontal cells and alteration of the synapses. The retinas of adult APP−/− mice showed only half as many glycinergic amacrine cells as wild-type retinas. We identified Ptf1a, which plays a role in controlling both amacrine and horizontal cell fates, as a downstream effector of APP. The observation of a similar phenotype in sorLA knockout mice, a major regulator of APP processing, suggests that regulation of APP functions via sorLA controls the determination of amacrine and horizontal cell fate. These findings provide novel insights that indicate that APP plays an important role in retinal differentiation. More... »

PAGES

351-363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-010-0762-2

DOI

http://dx.doi.org/10.1007/s00401-010-0762-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002506997

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20978902


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