Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease View Full Text


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Article Info

DATE

2010-03-14

AUTHORS

Kelly Del Tredici, Christopher H. Hawkes, Estifanos Ghebremedhin, Heiko Braak

ABSTRACT

A retrospective autopsy-based study of the human submandibular gland, one of the three major salivary glands, together with anatomically related peripheral structures (cervical superior ganglion, cervical sympathetic trunk, vagal nerve at the level of the carotid bifurcation), was conducted on a cohort consisting of 33 individuals, including 9 patients with neuropathologically confirmed Parkinson’s disease (PD), three individuals with incidental Lewy body disease (iLBD), 2 individuals with neuropathologically confirmed multiple system atrophy (MSA), and 19 controls, using α-synuclein immunohistochemistry in 100 μm polyethylene glycol-embedded tissue sections. Lewy pathology (LP) was present in the submandibular glands and cervical superior ganglia in PD (9/9 cases) and iLBD (2/3 cases) but not in MSA or controls. The cervical sympathetic trunk (7/9 PD cases, 2/3 iLBD cases) and peripheral vagal nerves (9/9 PD cases, 2/3 iLBD cases) also displayed LP. The results are discussed within the context of hyposmia as well as autonomic dysfunction in PD (sialorrhea, sialopenia, dysphagia). Potential disease-related changes in salivary volume, contents, and viscosity might make it possible, in combination with other tests, to employ human saliva as a biomarker. More... »

PAGES

703-713

References to SciGraph publications

  • 1998-01. Esophageal Manometric Abnormalities in Parkinson's Disease in DYSPHAGIA
  • 2000-04. Peripheral sympathetic dysfunction in patients with Parkinson’s disease without autonomic failure is heart selective and disease specific in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1988-05. Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses in ACTA NEUROPATHOLOGICA
  • 1997-01. Pharyngo-Esophageal Dysphagia in Parkinson's Disease in DYSPHAGIA
  • 2005-05-14. α-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy in ACTA NEUROPATHOLOGICA
  • 1996-12. Prepharyngeal dysphagia in Parkinson's disease in DYSPHAGIA
  • 1990-04. Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system in ACTA NEUROPATHOLOGICA
  • 1991-09. Neuropathological stageing of Alzheimer-related changes in ACTA NEUROPATHOLOGICA
  • 1993-06. The functions of saliva in DYSPHAGIA
  • 2002-09. Impaired salivary gland function reveals autonomic dysfunction in amyotrophic lateral sclerosis in JOURNAL OF NEUROLOGY
  • 2009-10-03. Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson’s disease: an anatomical study in ACTA NEUROPATHOLOGICA
  • 1976-09. Ultrastructure of Lewy bodies in the stellate ganglion in ACTA NEUROPATHOLOGICA
  • 1993-09. Parkinson's disease with involvement of the parasympathetic ganglia in ACTA NEUROPATHOLOGICA
  • 2007-02-09. Parkinson’s disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons in ACTA NEUROPATHOLOGICA
  • 2008-02-09. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-010-0665-2

    DOI

    http://dx.doi.org/10.1007/s00401-010-0665-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051170438

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20229352


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