Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06

AUTHORS

Thomas G. Beach, Charles H. Adler, LihFen Lue, Lucia I. Sue, Jyothi Bachalakuri, Jonette Henry-Watson, Jeanne Sasse, Sarah Boyer, Scophil Shirohi, Reed Brooks, Jennifer Eschbacher, Charles L. White, Haru Akiyama, John Caviness, Holly A. Shill, Donald J. Connor, Marwan N. Sabbagh, Douglas G. Walker, the Arizona Parkinson’s Disease Consortium

ABSTRACT

The two current major staging systems in use for Lewy body disorders fail to classify up to 50% of subjects. Both systems do not allow for large numbers of subjects who have Lewy-type alpha-synucleinopathy (LTS) confined to the olfactory bulb or who pass through a limbic-predominant pathway that at least initially bypasses the brainstem. The results of the current study, based on examination of a standard set of ten brain regions from 417 subjects stained immunohistochemically for alpha-synuclein, suggest a new staging system that, in this study, allows for the classification of all subjects with Lewy body disorders. The autopsied subjects included elderly subjects with Parkinson's disease, dementia with Lewy bodies, incidental Lewy body disease and Alzheimer's disease with Lewy bodies, as well as comparison groups without Lewy bodies. All subjects were classifiable into one of the following stages: I. Olfactory Bulb Only; IIa Brainstem Predominant; IIb Limbic Predominant; III Brainstem and Limbic; IV Neocortical. Progression of subjects through these stages was accompanied by a generally stepwise worsening in terms of striatal tyrosine hydroxylase concentration, substantia nigra pigmented neuron loss score, Mini Mental State Examination score and score on the Unified Parkinson's Disease Rating Scale Part 3. Additionally, there were significant correlations between these measures and LTS density scores. It is suggested that the proposed staging system would improve on its predecessors by allowing classification of a much greater proportion of cases. More... »

PAGES

613-634

References to SciGraph publications

  • 2009-02. Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders in ACTA NEUROPATHOLOGICA
  • 2003-05. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen in JOURNAL OF NEURAL TRANSMISSION
  • 2002-02. α-Synuclein is phosphorylated in synucleinopathy lesions in NATURE CELL BIOLOGY
  • 2004-10. Lewy body-related α-synucleinopathy in the aged human brain in JOURNAL OF NEURAL TRANSMISSION
  • 2008-09. The Sun Health Research Institute Brain Donation Program: Description and Eexperience, 1987–2007 in CELL AND TISSUE BANKING
  • 2008-09. Evaluation of α-synuclein immunohistochemical methods used by invited experts in ACTA NEUROPATHOLOGICA
  • 1988-05. Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses in ACTA NEUROPATHOLOGICA
  • 2008-07. A critical reappraisal of current staging of Lewy-related pathology in human brain in ACTA NEUROPATHOLOGICA
  • 2008-04. Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance in ACTA NEUROPATHOLOGICA
  • 1994-12. Amygdala pathology in Parkinson's disease in ACTA NEUROPATHOLOGICA
  • 2002-07. Concurrence of α-synuclein and tau brain pathology in the Contursi kindred in ACTA NEUROPATHOLOGICA
  • 2008-04. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease in ACTA NEUROPATHOLOGICA
  • 2002-10. Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) in JOURNAL OF NEUROLOGY
  • 2004-10. Stages in the development of Parkinson’s disease-related pathology in CELL AND TISSUE RESEARCH
  • 2008-04. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease in ACTA NEUROPATHOLOGICA
  • 2003-04. Clinical and neuropathological correlates of Lewy body disease in ACTA NEUROPATHOLOGICA
  • 2002-09. Microscopic analysis of polymerization dynamics with individual actin filaments in NATURE CELL BIOLOGY
  • 2008-07. Co-localization of tau and α-synuclein in the olfactory bulb in Alzheimer’s disease with amygdala Lewy bodies in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-009-0538-8

    DOI

    http://dx.doi.org/10.1007/s00401-009-0538-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000508964

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19399512


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