Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

Thomas G. Beach, Charles L. White, Christa L. Hladik, Marwan N. Sabbagh, Donald J. Connor, Holly A. Shill, Lucia I. Sue, Jeanne Sasse, Jyothi Bachalakuri, Jonette Henry-Watson, Haru Akiyama, Charles H. Adler, The Arizona Parkinson’s Disease Consortium

ABSTRACT

Involvement of the olfactory bulb by Lewy-type alpha-synucleinopathy (LTS) is known to occur at an early stage of Parkinson's disease (PD) and Lewy body disorders and is therefore of potential usefulness diagnostically. An accurate estimate of the specificity and sensitivity of this change has not previously been available. We performed immunohistochemical alpha-synuclein staining of the olfactory bulb in 328 deceased individuals. All cases had received an initial neuropathological examination that included alpha-synuclein immunohistochemical staining on sections from brainstem, limbic and neocortical regions, but excluded olfactory bulb. These cases had been classified based on their clinical characteristics and brain regional distribution and density of LTS, as PD, dementia with Lewy bodies (DLB), Alzheimer's disease with LTS (ADLS), Alzheimer's disease without LTS (ADNLS), incidental Lewy body disease (ILBD) and elderly control subjects. The numbers of cases found to be positive and negative, respectively, for olfactory bulb LTS were: PD 55/3; DLB 34/1; ADLS 37/5; ADNLS 19/84; ILBD 14/7; elderly control subjects 5/64. The sensitivities and specificities were, respectively: 95 and 91% for PD versus elderly control; 97 and 91% for DLB versus elderly control; 88 and 91% for ADLS versus elderly control; 88 and 81% for ADLS versus ADNLS; 67 and 91% for ILBD versus elderly control. Olfactory bulb synucleinopathy density scores correlated significantly with synucleinopathy scores in all other brain regions (Spearman R values between 0.46 and 0.78) as well as with scores on the Mini-Mental State Examination and Part 3 of the Unified Parkinson's Disease Rating Scale (Spearman R -0.27, 0.35, respectively). It is concluded that olfactory bulb LTS accurately predicts the presence of LTS in other brain regions. It is suggested that olfactory bulb biopsy be considered to confirm the diagnosis in PD subjects being assessed for surgical therapy. More... »

PAGES

169

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-008-0450-7

DOI

http://dx.doi.org/10.1007/s00401-008-0450-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027420062

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18982334


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lewy Body Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropsychological Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Olfactory Bulb", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Synuclein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beach", 
        "givenName": "Thomas G.", 
        "id": "sg:person.014653302237.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014653302237.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "University of Texas Southwestern Medical Center, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "White", 
        "givenName": "Charles L.", 
        "id": "sg:person.0600212005.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600212005.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "University of Texas Southwestern Medical Center, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hladik", 
        "givenName": "Christa L.", 
        "id": "sg:person.0716247777.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716247777.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabbagh", 
        "givenName": "Marwan N.", 
        "id": "sg:person.0707625530.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707625530.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Connor", 
        "givenName": "Donald J.", 
        "id": "sg:person.0614112121.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614112121.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shill", 
        "givenName": "Holly A.", 
        "id": "sg:person.01102640170.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102640170.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sue", 
        "givenName": "Lucia I.", 
        "id": "sg:person.01126272410.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126272410.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasse", 
        "givenName": "Jeanne", 
        "id": "sg:person.0776453721.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776453721.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachalakuri", 
        "givenName": "Jyothi", 
        "id": "sg:person.0655125627.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655125627.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Banner Sun Health Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.414208.b", 
          "name": [
            "Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henry-Watson", 
        "givenName": "Jonette", 
        "id": "sg:person.01010242131.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010242131.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.417113.1", 
          "name": [
            "Tokyo Institute of Psychiatry, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Haru", 
        "id": "sg:person.012744403177.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012744403177.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417468.8", 
          "name": [
            "Mayo Clinic, Scottsdale, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adler", 
        "givenName": "Charles H.", 
        "id": "sg:person.01056363556.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056363556.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "The Arizona Parkinson\u2019s Disease Consortium", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mds.20460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000405585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0270(87)80001-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002408034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02688690601012175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005738204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(97)00057-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006788135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.20955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008855734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wco.0000137531.76491.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009167723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wco.0000137531.76491.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009167723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010944863", 
          "https://doi.org/10.1038/ncb748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010944863", 
          "https://doi.org/10.1038/ncb748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nrl.0b013e318095a4d5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011124246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nrl.0b013e318095a4d5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011124246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.2006.00727.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011645233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10561-008-9067-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012224816", 
          "https://doi.org/10.1007/s10561-008-9067-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10561-008-9067-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012224816", 
          "https://doi.org/10.1007/s10561-008-9067-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000093759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013514863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00701-007-1267-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014689843", 
          "https://doi.org/10.1007/s00701-007-1267-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00701-007-1267-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014689843", 
          "https://doi.org/10.1007/s00701-007-1267-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-008-0383-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016385682", 
          "https://doi.org/10.1007/s00401-008-0383-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-008-0383-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016385682", 
          "https://doi.org/10.1007/s00401-008-0383-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7580.2007.00748.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017981563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)93275-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019952279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)93275-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019952279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0313-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023746235", 
          "https://doi.org/10.1007/s00401-007-0313-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0313-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023746235", 
          "https://doi.org/10.1007/s00401-007-0313-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.56.1.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024222058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.21572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024638593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000285347.50028.b9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026129917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000307964.21298.fd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026129917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000109757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026529871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nrl.0b013e31815a351a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033747803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nrl.0b013e31815a351a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033747803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/brcg.1995.1261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036261125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.55.3.181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038938753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.870100309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040914837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-002-1301-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044517506", 
          "https://doi.org/10.1007/s00415-002-1301-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.21065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046627613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jme.10.1.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047315316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jme.10.1.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047315316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jme.2005.013169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050461673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jme.2005.013169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050461673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.55.7.969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051238946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.10466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051416020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052517087", 
          "https://doi.org/10.1038/ncb841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052517087", 
          "https://doi.org/10.1038/ncb841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2001-13125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057407112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.38.8.1237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064367946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.47.5.1113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064374415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.47.5.1113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064374415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.47.5.1113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064374415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.57.8.1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064380248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.57.8.1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064380248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.57.8.1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064380248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0733-8619(18)30215-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077041204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077412246", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079983924", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083196042", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-02", 
    "datePublishedReg": "2009-02-01", 
    "description": "Involvement of the olfactory bulb by Lewy-type alpha-synucleinopathy (LTS) is known to occur at an early stage of Parkinson's disease (PD) and Lewy body disorders and is therefore of potential usefulness diagnostically. An accurate estimate of the specificity and sensitivity of this change has not previously been available. We performed immunohistochemical alpha-synuclein staining of the olfactory bulb in 328 deceased individuals. All cases had received an initial neuropathological examination that included alpha-synuclein immunohistochemical staining on sections from brainstem, limbic and neocortical regions, but excluded olfactory bulb. These cases had been classified based on their clinical characteristics and brain regional distribution and density of LTS, as PD, dementia with Lewy bodies (DLB), Alzheimer's disease with LTS (ADLS), Alzheimer's disease without LTS (ADNLS), incidental Lewy body disease (ILBD) and elderly control subjects. The numbers of cases found to be positive and negative, respectively, for olfactory bulb LTS were: PD 55/3; DLB 34/1; ADLS 37/5; ADNLS 19/84; ILBD 14/7; elderly control subjects 5/64. The sensitivities and specificities were, respectively: 95 and 91% for PD versus elderly control; 97 and 91% for DLB versus elderly control; 88 and 91% for ADLS versus elderly control; 88 and 81% for ADLS versus ADNLS; 67 and 91% for ILBD versus elderly control. Olfactory bulb synucleinopathy density scores correlated significantly with synucleinopathy scores in all other brain regions (Spearman R values between 0.46 and 0.78) as well as with scores on the Mini-Mental State Examination and Part 3 of the Unified Parkinson's Disease Rating Scale (Spearman R -0.27, 0.35, respectively). It is concluded that olfactory bulb LTS accurately predicts the presence of LTS in other brain regions. It is suggested that olfactory bulb biopsy be considered to confirm the diagnosis in PD subjects being assessed for surgical therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00401-008-0450-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438625", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019073", 
        "issn": [
          "0001-6322", 
          "1432-0533"
        ], 
        "name": "Acta Neuropathologica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "117"
      }
    ], 
    "name": "Olfactory bulb \u03b1-synucleinopathy has high specificity and sensitivity for Lewy body disorders", 
    "pagination": "169", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "829eac680a2b047b7ab945218473d46586f2d04d9ed6730b4d0117d46bb92524"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18982334"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0412041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00401-008-0450-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027420062"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00401-008-0450-7", 
      "https://app.dimensions.ai/details/publication/pub.1027420062"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13109_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00401-008-0450-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00401-008-0450-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00401-008-0450-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00401-008-0450-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00401-008-0450-7'


 

This table displays all metadata directly associated to this object as RDF triples.

356 TRIPLES      21 PREDICATES      87 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00401-008-0450-7 schema:about N0ebfbf4523e6408b91627c33db3161d3
2 N1dc0004958c3413eb3f03abaa63e9fcc
3 N345bd0db5cf64d47a539226a21df10b3
4 N4316a56ce271461e8317b11486a7c76d
5 N44e8cd2d0fed4606bde0a6bfaff24d29
6 N4f7921adbe4c46319e7b312356f0bb01
7 N5c2db9293b044dd58f1242fc90d2bac0
8 N89f0aaae55774ecca6c88db4de429ccd
9 N93bb574d08a24a1187da8463d1db40cd
10 Nc2d0b9455bb042f6b1b654701f3654b8
11 Nca732291a09549a6a929f34930e240e1
12 Ndd0a5d1e30dc4c168a52bf2d277b2a71
13 Ndf87d031f9de471388715797ba743f5a
14 Ne827d06316b3469289c4bd55a434e641
15 Nf62a8c823f0647749e51f12e6e070061
16 Nfae69da978db4070a00d6f1932b47818
17 Nff80888b0742473d93e8aaef7dd76f7f
18 anzsrc-for:11
19 anzsrc-for:1109
20 schema:author Nd7bdf8a1485744e89a4922dda17957e0
21 schema:citation sg:pub.10.1007/s00401-007-0313-7
22 sg:pub.10.1007/s00401-008-0383-1
23 sg:pub.10.1007/s00415-002-1301-4
24 sg:pub.10.1007/s00701-007-1267-1
25 sg:pub.10.1007/s10561-008-9067-2
26 sg:pub.10.1038/ncb748
27 sg:pub.10.1038/ncb841
28 https://app.dimensions.ai/details/publication/pub.1077412246
29 https://app.dimensions.ai/details/publication/pub.1079983924
30 https://app.dimensions.ai/details/publication/pub.1083196042
31 https://doi.org/10.1001/archneur.55.7.969
32 https://doi.org/10.1001/archneur.56.1.33
33 https://doi.org/10.1002/mds.10466
34 https://doi.org/10.1002/mds.20460
35 https://doi.org/10.1002/mds.20955
36 https://doi.org/10.1002/mds.21065
37 https://doi.org/10.1002/mds.21572
38 https://doi.org/10.1002/mds.870100309
39 https://doi.org/10.1006/brcg.1995.1261
40 https://doi.org/10.1016/0140-6736(92)93275-r
41 https://doi.org/10.1016/s0165-0270(87)80001-8
42 https://doi.org/10.1016/s0197-4580(97)00057-2
43 https://doi.org/10.1016/s0733-8619(18)30215-9
44 https://doi.org/10.1055/s-2001-13125
45 https://doi.org/10.1080/02688690601012175
46 https://doi.org/10.1097/01.wco.0000137531.76491.c2
47 https://doi.org/10.1097/nrl.0b013e318095a4d5
48 https://doi.org/10.1097/nrl.0b013e31815a351a
49 https://doi.org/10.1111/j.1365-2990.2006.00727.x
50 https://doi.org/10.1111/j.1469-7580.2007.00748.x
51 https://doi.org/10.1136/jme.10.1.29
52 https://doi.org/10.1136/jme.2005.013169
53 https://doi.org/10.1136/jnnp.55.3.181
54 https://doi.org/10.1159/000093759
55 https://doi.org/10.1159/000109757
56 https://doi.org/10.1212/01.wnl.0000187889.17253.b1
57 https://doi.org/10.1212/wnl.38.8.1237
58 https://doi.org/10.1212/wnl.47.5.1113
59 https://doi.org/10.1212/wnl.57.8.1497
60 https://doi.org/10.1227/01.neu.0000285347.50028.b9
61 https://doi.org/10.1227/01.neu.0000307964.21298.fd
62 schema:datePublished 2009-02
63 schema:datePublishedReg 2009-02-01
64 schema:description Involvement of the olfactory bulb by Lewy-type alpha-synucleinopathy (LTS) is known to occur at an early stage of Parkinson's disease (PD) and Lewy body disorders and is therefore of potential usefulness diagnostically. An accurate estimate of the specificity and sensitivity of this change has not previously been available. We performed immunohistochemical alpha-synuclein staining of the olfactory bulb in 328 deceased individuals. All cases had received an initial neuropathological examination that included alpha-synuclein immunohistochemical staining on sections from brainstem, limbic and neocortical regions, but excluded olfactory bulb. These cases had been classified based on their clinical characteristics and brain regional distribution and density of LTS, as PD, dementia with Lewy bodies (DLB), Alzheimer's disease with LTS (ADLS), Alzheimer's disease without LTS (ADNLS), incidental Lewy body disease (ILBD) and elderly control subjects. The numbers of cases found to be positive and negative, respectively, for olfactory bulb LTS were: PD 55/3; DLB 34/1; ADLS 37/5; ADNLS 19/84; ILBD 14/7; elderly control subjects 5/64. The sensitivities and specificities were, respectively: 95 and 91% for PD versus elderly control; 97 and 91% for DLB versus elderly control; 88 and 91% for ADLS versus elderly control; 88 and 81% for ADLS versus ADNLS; 67 and 91% for ILBD versus elderly control. Olfactory bulb synucleinopathy density scores correlated significantly with synucleinopathy scores in all other brain regions (Spearman R values between 0.46 and 0.78) as well as with scores on the Mini-Mental State Examination and Part 3 of the Unified Parkinson's Disease Rating Scale (Spearman R -0.27, 0.35, respectively). It is concluded that olfactory bulb LTS accurately predicts the presence of LTS in other brain regions. It is suggested that olfactory bulb biopsy be considered to confirm the diagnosis in PD subjects being assessed for surgical therapy.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N1967c722b3244150952096e922f70f72
69 N345e1604b0fc4846b934d96037f90f5e
70 sg:journal.1019073
71 schema:name Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders
72 schema:pagination 169
73 schema:productId Na1f4fc053e7448328efbdd4d675afc5d
74 Nafa912b4db414b21a8d449390510c48b
75 Nc84d08314b9f4cefb25bc5745f45eae1
76 Nd70e90ba25af41bda4477402d25dc03a
77 Nd8ea515dad7247f5a1a90aedc8ce1285
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027420062
79 https://doi.org/10.1007/s00401-008-0450-7
80 schema:sdDatePublished 2019-04-11T14:34
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N940967cbdbb741858dd003ee4e1b611f
83 schema:url http://link.springer.com/10.1007/s00401-008-0450-7
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N035f1c1c71d14279b92211541933eb63 rdf:first sg:person.01126272410.46
88 rdf:rest N9c20a85c30db47ddbae5fcd09e86074e
89 N04c9c83c14cc450aa40d3803e4b5bc78 rdf:first sg:person.01010242131.16
90 rdf:rest N1f30849895a14e96800926f35ce87f96
91 N0ebfbf4523e6408b91627c33db3161d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 N1967c722b3244150952096e922f70f72 schema:volumeNumber 117
95 rdf:type schema:PublicationVolume
96 N1dc0004958c3413eb3f03abaa63e9fcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neuropsychological Tests
98 rdf:type schema:DefinedTerm
99 N1f30849895a14e96800926f35ce87f96 rdf:first sg:person.012744403177.08
100 rdf:rest N56add486279f4d5297abf7a422669556
101 N2423e680cdc14822ac6998e57a110ffb rdf:first sg:person.0707625530.62
102 rdf:rest N596e2c4aead14472aa17c274c169eafe
103 N345bd0db5cf64d47a539226a21df10b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Olfactory Bulb
105 rdf:type schema:DefinedTerm
106 N345e1604b0fc4846b934d96037f90f5e schema:issueNumber 2
107 rdf:type schema:PublicationIssue
108 N4316a56ce271461e8317b11486a7c76d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Logistic Models
110 rdf:type schema:DefinedTerm
111 N44e8cd2d0fed4606bde0a6bfaff24d29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Brain Chemistry
113 rdf:type schema:DefinedTerm
114 N4e2d1d37e2374dd8ba4029fd61697b02 rdf:first sg:person.0600212005.24
115 rdf:rest N606a4ebb257549a3a29412a69051e795
116 N4f7921adbe4c46319e7b312356f0bb01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Parkinson Disease
118 rdf:type schema:DefinedTerm
119 N56add486279f4d5297abf7a422669556 rdf:first sg:person.01056363556.30
120 rdf:rest Ne0492fbf609341b7a3b50764b4b75cff
121 N596e2c4aead14472aa17c274c169eafe rdf:first sg:person.0614112121.42
122 rdf:rest Nadb8107d25d14313b28cfa6eab04e905
123 N5c2db9293b044dd58f1242fc90d2bac0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Alzheimer Disease
125 rdf:type schema:DefinedTerm
126 N606a4ebb257549a3a29412a69051e795 rdf:first sg:person.0716247777.71
127 rdf:rest N2423e680cdc14822ac6998e57a110ffb
128 N89f0aaae55774ecca6c88db4de429ccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 N9177a7c38d484ba48d5b919ff524fc04 schema:familyName The Arizona Parkinson’s Disease Consortium
132 rdf:type schema:Person
133 N9377d799dc9447858b5d1ad1ec7fb242 rdf:first sg:person.0655125627.38
134 rdf:rest N04c9c83c14cc450aa40d3803e4b5bc78
135 N93bb574d08a24a1187da8463d1db40cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name alpha-Synuclein
137 rdf:type schema:DefinedTerm
138 N940967cbdbb741858dd003ee4e1b611f schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N9c20a85c30db47ddbae5fcd09e86074e rdf:first sg:person.0776453721.59
141 rdf:rest N9377d799dc9447858b5d1ad1ec7fb242
142 Na1f4fc053e7448328efbdd4d675afc5d schema:name dimensions_id
143 schema:value pub.1027420062
144 rdf:type schema:PropertyValue
145 Nadb8107d25d14313b28cfa6eab04e905 rdf:first sg:person.01102640170.17
146 rdf:rest N035f1c1c71d14279b92211541933eb63
147 Nafa912b4db414b21a8d449390510c48b schema:name readcube_id
148 schema:value 829eac680a2b047b7ab945218473d46586f2d04d9ed6730b4d0117d46bb92524
149 rdf:type schema:PropertyValue
150 Nc2d0b9455bb042f6b1b654701f3654b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Aged, 80 and over
152 rdf:type schema:DefinedTerm
153 Nc84d08314b9f4cefb25bc5745f45eae1 schema:name pubmed_id
154 schema:value 18982334
155 rdf:type schema:PropertyValue
156 Nca732291a09549a6a929f34930e240e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Sensitivity and Specificity
158 rdf:type schema:DefinedTerm
159 Nd70e90ba25af41bda4477402d25dc03a schema:name nlm_unique_id
160 schema:value 0412041
161 rdf:type schema:PropertyValue
162 Nd7bdf8a1485744e89a4922dda17957e0 rdf:first sg:person.014653302237.67
163 rdf:rest N4e2d1d37e2374dd8ba4029fd61697b02
164 Nd8ea515dad7247f5a1a90aedc8ce1285 schema:name doi
165 schema:value 10.1007/s00401-008-0450-7
166 rdf:type schema:PropertyValue
167 Ndd0a5d1e30dc4c168a52bf2d277b2a71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 Ndf87d031f9de471388715797ba743f5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Lewy Body Disease
172 rdf:type schema:DefinedTerm
173 Ne0492fbf609341b7a3b50764b4b75cff rdf:first N9177a7c38d484ba48d5b919ff524fc04
174 rdf:rest rdf:nil
175 Ne827d06316b3469289c4bd55a434e641 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Aged
177 rdf:type schema:DefinedTerm
178 Nf62a8c823f0647749e51f12e6e070061 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Brain
180 rdf:type schema:DefinedTerm
181 Nfae69da978db4070a00d6f1932b47818 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Middle Aged
183 rdf:type schema:DefinedTerm
184 Nff80888b0742473d93e8aaef7dd76f7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Immunohistochemistry
186 rdf:type schema:DefinedTerm
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
191 schema:name Neurosciences
192 rdf:type schema:DefinedTerm
193 sg:grant.2438625 http://pending.schema.org/fundedItem sg:pub.10.1007/s00401-008-0450-7
194 rdf:type schema:MonetaryGrant
195 sg:journal.1019073 schema:issn 0001-6322
196 1432-0533
197 schema:name Acta Neuropathologica
198 rdf:type schema:Periodical
199 sg:person.01010242131.16 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
200 schema:familyName Henry-Watson
201 schema:givenName Jonette
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010242131.16
203 rdf:type schema:Person
204 sg:person.01056363556.30 schema:affiliation https://www.grid.ac/institutes/grid.417468.8
205 schema:familyName Adler
206 schema:givenName Charles H.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056363556.30
208 rdf:type schema:Person
209 sg:person.01102640170.17 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
210 schema:familyName Shill
211 schema:givenName Holly A.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102640170.17
213 rdf:type schema:Person
214 sg:person.01126272410.46 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
215 schema:familyName Sue
216 schema:givenName Lucia I.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126272410.46
218 rdf:type schema:Person
219 sg:person.012744403177.08 schema:affiliation https://www.grid.ac/institutes/grid.417113.1
220 schema:familyName Akiyama
221 schema:givenName Haru
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012744403177.08
223 rdf:type schema:Person
224 sg:person.014653302237.67 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
225 schema:familyName Beach
226 schema:givenName Thomas G.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014653302237.67
228 rdf:type schema:Person
229 sg:person.0600212005.24 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
230 schema:familyName White
231 schema:givenName Charles L.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600212005.24
233 rdf:type schema:Person
234 sg:person.0614112121.42 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
235 schema:familyName Connor
236 schema:givenName Donald J.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614112121.42
238 rdf:type schema:Person
239 sg:person.0655125627.38 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
240 schema:familyName Bachalakuri
241 schema:givenName Jyothi
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655125627.38
243 rdf:type schema:Person
244 sg:person.0707625530.62 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
245 schema:familyName Sabbagh
246 schema:givenName Marwan N.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707625530.62
248 rdf:type schema:Person
249 sg:person.0716247777.71 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
250 schema:familyName Hladik
251 schema:givenName Christa L.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716247777.71
253 rdf:type schema:Person
254 sg:person.0776453721.59 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
255 schema:familyName Sasse
256 schema:givenName Jeanne
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776453721.59
258 rdf:type schema:Person
259 sg:pub.10.1007/s00401-007-0313-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023746235
260 https://doi.org/10.1007/s00401-007-0313-7
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s00401-008-0383-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016385682
263 https://doi.org/10.1007/s00401-008-0383-1
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s00415-002-1301-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044517506
266 https://doi.org/10.1007/s00415-002-1301-4
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s00701-007-1267-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014689843
269 https://doi.org/10.1007/s00701-007-1267-1
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s10561-008-9067-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012224816
272 https://doi.org/10.1007/s10561-008-9067-2
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/ncb748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010944863
275 https://doi.org/10.1038/ncb748
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ncb841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052517087
278 https://doi.org/10.1038/ncb841
279 rdf:type schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1077412246 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1079983924 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1083196042 schema:CreativeWork
283 https://doi.org/10.1001/archneur.55.7.969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051238946
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1001/archneur.56.1.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024222058
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/mds.10466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051416020
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/mds.20460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000405585
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/mds.20955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008855734
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/mds.21065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046627613
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1002/mds.21572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024638593
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/mds.870100309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040914837
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1006/brcg.1995.1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036261125
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/0140-6736(92)93275-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1019952279
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s0165-0270(87)80001-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002408034
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s0197-4580(97)00057-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006788135
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0733-8619(18)30215-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077041204
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1055/s-2001-13125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057407112
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1080/02688690601012175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005738204
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1097/01.wco.0000137531.76491.c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009167723
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/nrl.0b013e318095a4d5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011124246
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/nrl.0b013e31815a351a schema:sameAs https://app.dimensions.ai/details/publication/pub.1033747803
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1365-2990.2006.00727.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011645233
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/j.1469-7580.2007.00748.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017981563
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1136/jme.10.1.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047315316
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1136/jme.2005.013169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050461673
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1136/jnnp.55.3.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038938753
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1159/000093759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013514863
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1159/000109757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026529871
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1212/01.wnl.0000187889.17253.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347654
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1212/wnl.38.8.1237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064367946
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1212/wnl.47.5.1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064374415
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1212/wnl.57.8.1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064380248
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1227/01.neu.0000285347.50028.b9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026129917
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1227/01.neu.0000307964.21298.fd schema:sameAs https://app.dimensions.ai/details/publication/pub.1026129917
344 rdf:type schema:CreativeWork
345 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
346 schema:name University of Texas Southwestern Medical Center, Dallas, TX, USA
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.414208.b schema:alternateName Banner Sun Health Research Institute
349 schema:name Sun Health Research Institute, 10515 West Santa Fe Drive, 85351, Sun City, AZ, USA
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.417113.1 schema:alternateName Tokyo Institute of Psychiatry
352 schema:name Tokyo Institute of Psychiatry, Tokyo, Japan
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.417468.8 schema:alternateName Mayo Clinic
355 schema:name Mayo Clinic, Scottsdale, AZ, USA
356 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...