Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry View Full Text


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Article Info

DATE

2006-08-12

AUTHORS

Heiko Braak, Irina Alafuzoff, Thomas Arzberger, Hans Kretzschmar, Kelly Del Tredici

ABSTRACT

Assessment of Alzheimer's disease (AD)-related neurofibrillary pathology requires a procedure that permits a sufficient differentiation between initial, intermediate, and late stages. The gradual deposition of a hyperphosphorylated tau protein within select neuronal types in specific nuclei or areas is central to the disease process. The staging of AD-related neurofibrillary pathology originally described in 1991 was performed on unconventionally thick sections (100 mum) using a modern silver technique and reflected the progress of the disease process based chiefly on the topographic expansion of the lesions. To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections (5-15 mum) and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis. It is anticipated that this revised methodological protocol will enable a more uniform application of the staging procedure. More... »

PAGES

389-404

References to SciGraph publications

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  • 2002-03-22. Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria in ACTA NEUROPATHOLOGICA
  • 1995-04. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease in ACTA NEUROPATHOLOGICA
  • 1991-09. Neuropathological stageing of Alzheimer-related changes in ACTA NEUROPATHOLOGICA
  • 2000-03. Clinical validity of Braak staging in the oldest-old in ACTA NEUROPATHOLOGICA
  • 2003-11. Plasticity and the Spread of Alzheimer's Disease-Like Changes in NEUROCHEMICAL RESEARCH
  • 2000-03. Clinical validity of Braak neuropathological staging in the oldest-old in ACTA NEUROPATHOLOGICA
  • 1992-08. Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes in ACTA NEUROPATHOLOGICA
  • 2000-01. Practical measures to simplify the Braak tangle staging method for routine pathological screening in ACTA NEUROPATHOLOGICA
  • 1994-06. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads in ACTA NEUROPATHOLOGICA
  • 1998-01. Examination of the validity of the hierarchical model of neuropathological staging in normal aging and Alzheimer’s disease in ACTA NEUROPATHOLOGICA
  • 1997. τ Protein and the Neurofibrillary Pathology of Alzheimer’s Disease in MOLECULAR MECHANISMS OF DEMENTIA
  • 1999. Temporal Sequence of Alzheimer’s Disease-Related Pathology in CEREBRAL CORTEX
  • 2001-06. Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence in ACTA NEUROPATHOLOGICA
  • 1998. The neuropathological diagnosis of Alzheimer disease in AGEING AND DEMENTIA
  • 1911-12. über eigenartige Krankheitsfälle des späteren Alters in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00401-006-0127-z

    DOI

    http://dx.doi.org/10.1007/s00401-006-0127-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022911785

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16906426


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