Infection of human astrocytes and glioblastoma cells with Toxoplasma gondii: monocyte chemotactic protein-1 secretion and chemokine expression in vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01-14

AUTHORS

Marie-Pierre Brenier-Pinchart, Emmanuelle Blanc-Gonnet, Patrice N. Marche, François Berger, François Durand, Pierre Ambroise-Thomas, Hervé Pelloux

ABSTRACT

In immunocompromised hosts, disruption of toxoplasmic cysts and conversion from bradyzoites to tachyzoites occur in brain. In these areas, infiltrates of mononuclear cells are observed. In the murine toxoplasmosis model, recent data suggest that chemokines may play a role in leukocyte recruitment in the central nervous system (CNS). This study analyzed the monocyte chemotactic protein-1 (MCP-1) secretion and chemokine expression after Toxoplasma gondii infection of human astrocytes, glioblastoma cells (U373) and fibroblasts (MRC5) in vitro. T. gondii infection of these CNS cells, astrocytes and glioblastoma cells significantly increased MCP-1 secretion, particularly for astrocytes. In our cellular models, the pattern of chemokine gene expression is dominated by MCP-1 expression. MCP-1 mRNAs were also quantified by real-time-PCR (LightCycler). The behavior of cells studied after T. gondii infection was different (invasion and growth) and the cell mechanisms of chemokine regulation could be dependent on the type of cells infected, while MCP-1 may contribute to the cell recruitment during human cerebral reactivation of T. gondii. More... »

PAGES

245-249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00401-003-0804-0

DOI

http://dx.doi.org/10.1007/s00401-003-0804-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006828277

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14722715


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