PEGylated liposomes prepared with polyborane instead of cholesterol for BNCT: characteristics and biodistribution evaluation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10

AUTHORS

Issei Takeuchi, Keishiro Tomoda, Koji Matsumoto, Hiromi Uchiro, Kimiko Makino

ABSTRACT

Recently, boron neutron capture therapy (BNCT) has been focused on, which is a cancer therapy using nuclear reaction between boron and thermal neutron. To selectively destroy cancer cells, the high accumulation and selective delivery of boron-10 (10B) into tumor tissue are required. We have developed polyborane from 1,7-dicarba-closo-dodecaborane as a boron carrier. To evaluate tumor accumulation of polyborane, PEGylated liposomes were chosen as carrier. The mean volume diameters of polyborane-embedded liposomes were 50, 100, and 200 nm, respectively. They were injected into the tail vein of tumor-bearing mice. Twenty-four hours later, mice were killed and biodistribution of boron was determined using the inductively coupled plasma atomic emission spectrometry. At 24 h after injection, 50 nm bare liposome and 100 nm PEGylated liposome were found in tumor with high boron levels. Moreover, 50 nm bare liposome showed high tumor/blood ratios of boron concentration, and their usability for BNCT was suggested. More... »

PAGES

1679-1685

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00396-016-3925-4

DOI

http://dx.doi.org/10.1007/s00396-016-3925-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008722213


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo University of Science", 
          "id": "https://www.grid.ac/institutes/grid.143643.7", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Drug Delivery Research, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Physical Pharmaceutics, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeuchi", 
        "givenName": "Issei", 
        "id": "sg:person.0755262221.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755262221.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Science", 
          "id": "https://www.grid.ac/institutes/grid.143643.7", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Drug Delivery Research, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Physical Pharmaceutics, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomoda", 
        "givenName": "Keishiro", 
        "id": "sg:person.01274020025.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274020025.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Science", 
          "id": "https://www.grid.ac/institutes/grid.143643.7", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Koji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Science", 
          "id": "https://www.grid.ac/institutes/grid.143643.7", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Drug Delivery Research, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Physical Pharmaceutics, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchiro", 
        "givenName": "Hiromi", 
        "id": "sg:person.0745720422.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745720422.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Science", 
          "id": "https://www.grid.ac/institutes/grid.143643.7", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Drug Delivery Research, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan", 
            "Center for Physical Pharmaceutics, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Makino", 
        "givenName": "Kimiko", 
        "id": "sg:person.01221563640.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221563640.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/380561a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001339131", 
          "https://doi.org/10.1038/380561a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(92)90136-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001937558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(92)90136-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001937558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2009.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006663059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2010.03.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010182394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005713113990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017564826", 
          "https://doi.org/10.1023/a:1005713113990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02699933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022993917", 
          "https://doi.org/10.1007/bf02699933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02699933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022993917", 
          "https://doi.org/10.1007/bf02699933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2010.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023208247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-5521(01)00016-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024072492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025129395", 
          "https://doi.org/10.1038/bjc.1991.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025129395", 
          "https://doi.org/10.1038/bjc.1991.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(91)90201-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026953047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(91)90201-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026953047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-328x(93)83337-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028046482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023282818409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031192731", 
          "https://doi.org/10.1023/a:1023282818409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005769214899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034105938", 
          "https://doi.org/10.1023/a:1005769214899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apradiso.2009.03.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035698163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040217282", 
          "https://doi.org/10.1038/bjc.1997.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040217282", 
          "https://doi.org/10.1038/bjc.1997.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040481924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-3659(99)00248-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044151490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0896(03)00240-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048619982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0896(03)00240-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048619982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0010-8545(02)00087-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049572302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2004.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053441075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr00010a002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054063546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc060075d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055154051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc060075d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055154051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic00112a023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055542942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm9900725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055959368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm9900725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055959368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol062840+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056248822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol062840+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056248822"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10", 
    "datePublishedReg": "2016-10-01", 
    "description": "Recently, boron neutron capture therapy (BNCT) has been focused on, which is a cancer therapy using nuclear reaction between boron and thermal neutron. To selectively destroy cancer cells, the high accumulation and selective delivery of boron-10 (10B) into tumor tissue are required. We have developed polyborane from 1,7-dicarba-closo-dodecaborane as a boron carrier. To evaluate tumor accumulation of polyborane, PEGylated liposomes were chosen as carrier. The mean volume diameters of polyborane-embedded liposomes were 50, 100, and 200 nm, respectively. They were injected into the tail vein of tumor-bearing mice. Twenty-four hours later, mice were killed and biodistribution of boron was determined using the inductively coupled plasma atomic emission spectrometry. At 24 h after injection, 50 nm bare liposome and 100 nm PEGylated liposome were found in tumor with high boron levels. Moreover, 50 nm bare liposome showed high tumor/blood ratios of boron concentration, and their usability for BNCT was suggested.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00396-016-3925-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1083512", 
        "issn": [
          "0303-402X", 
          "1435-1536"
        ], 
        "name": "Colloid and Polymer Science", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "294"
      }
    ], 
    "name": "PEGylated liposomes prepared with polyborane instead of cholesterol for BNCT: characteristics and biodistribution evaluation", 
    "pagination": "1679-1685", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "298e3018f4e27cddd9678d4cb4949d110c4624a4fcff2702f0d130e4a1ee6a3f"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00396-016-3925-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008722213"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00396-016-3925-4", 
      "https://app.dimensions.ai/details/publication/pub.1008722213"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00396-016-3925-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00396-016-3925-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00396-016-3925-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00396-016-3925-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00396-016-3925-4'


 

This table displays all metadata directly associated to this object as RDF triples.

172 TRIPLES      21 PREDICATES      52 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00396-016-3925-4 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N3ee223ebe2c04a5cb5c017e528751e70
4 schema:citation sg:pub.10.1007/bf02699933
5 sg:pub.10.1023/a:1005713113990
6 sg:pub.10.1023/a:1005769214899
7 sg:pub.10.1023/a:1023282818409
8 sg:pub.10.1038/380561a0
9 sg:pub.10.1038/bjc.1991.124
10 sg:pub.10.1038/bjc.1997.118
11 https://doi.org/10.1016/0005-2736(91)90201-i
12 https://doi.org/10.1016/0005-2736(92)90136-a
13 https://doi.org/10.1016/0022-328x(93)83337-u
14 https://doi.org/10.1016/j.apradiso.2009.03.101
15 https://doi.org/10.1016/j.bmc.2010.03.050
16 https://doi.org/10.1016/j.jconrel.2004.04.018
17 https://doi.org/10.1016/j.jconrel.2009.02.002
18 https://doi.org/10.1016/j.jconrel.2010.08.027
19 https://doi.org/10.1016/s0010-8545(02)00087-5
20 https://doi.org/10.1016/s0168-3659(99)00248-5
21 https://doi.org/10.1016/s0968-0896(03)00240-2
22 https://doi.org/10.1016/s1074-5521(01)00016-3
23 https://doi.org/10.1021/bc060075d
24 https://doi.org/10.1021/cr00010a002
25 https://doi.org/10.1021/ic00112a023
26 https://doi.org/10.1021/jm9900725
27 https://doi.org/10.1021/ol062840+
28 https://doi.org/10.1158/1078-0432.ccr-05-0035
29 schema:datePublished 2016-10
30 schema:datePublishedReg 2016-10-01
31 schema:description Recently, boron neutron capture therapy (BNCT) has been focused on, which is a cancer therapy using nuclear reaction between boron and thermal neutron. To selectively destroy cancer cells, the high accumulation and selective delivery of boron-10 (10B) into tumor tissue are required. We have developed polyborane from 1,7-dicarba-closo-dodecaborane as a boron carrier. To evaluate tumor accumulation of polyborane, PEGylated liposomes were chosen as carrier. The mean volume diameters of polyborane-embedded liposomes were 50, 100, and 200 nm, respectively. They were injected into the tail vein of tumor-bearing mice. Twenty-four hours later, mice were killed and biodistribution of boron was determined using the inductively coupled plasma atomic emission spectrometry. At 24 h after injection, 50 nm bare liposome and 100 nm PEGylated liposome were found in tumor with high boron levels. Moreover, 50 nm bare liposome showed high tumor/blood ratios of boron concentration, and their usability for BNCT was suggested.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N1052d0766ad749e6a92f7b396412c8c3
36 N8b1daed530774746addea6bd41b18614
37 sg:journal.1083512
38 schema:name PEGylated liposomes prepared with polyborane instead of cholesterol for BNCT: characteristics and biodistribution evaluation
39 schema:pagination 1679-1685
40 schema:productId N2d859ab4df23479fa3ff7f48b34bfffc
41 N812170cd733a4a55bf5a04cda44d93fd
42 Nc0372fa664c84260b6aae2c47ce79438
43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008722213
44 https://doi.org/10.1007/s00396-016-3925-4
45 schema:sdDatePublished 2019-04-11T01:59
46 schema:sdLicense https://scigraph.springernature.com/explorer/license/
47 schema:sdPublisher Nc504200f12ca455c86431abe0f4c5efc
48 schema:url http://link.springer.com/10.1007%2Fs00396-016-3925-4
49 sgo:license sg:explorer/license/
50 sgo:sdDataset articles
51 rdf:type schema:ScholarlyArticle
52 N1052d0766ad749e6a92f7b396412c8c3 schema:volumeNumber 294
53 rdf:type schema:PublicationVolume
54 N2d859ab4df23479fa3ff7f48b34bfffc schema:name readcube_id
55 schema:value 298e3018f4e27cddd9678d4cb4949d110c4624a4fcff2702f0d130e4a1ee6a3f
56 rdf:type schema:PropertyValue
57 N3ee223ebe2c04a5cb5c017e528751e70 rdf:first sg:person.0755262221.24
58 rdf:rest Ne17d13d4a54a478bbf3513fd401ec601
59 N5faf546ebef5402ebbd3a05a9e48fcf7 rdf:first sg:person.01221563640.34
60 rdf:rest rdf:nil
61 N70dad02f7d164e7382ac783a8dc7efa8 rdf:first sg:person.0745720422.71
62 rdf:rest N5faf546ebef5402ebbd3a05a9e48fcf7
63 N812170cd733a4a55bf5a04cda44d93fd schema:name dimensions_id
64 schema:value pub.1008722213
65 rdf:type schema:PropertyValue
66 N8b1daed530774746addea6bd41b18614 schema:issueNumber 10
67 rdf:type schema:PublicationIssue
68 Nc0372fa664c84260b6aae2c47ce79438 schema:name doi
69 schema:value 10.1007/s00396-016-3925-4
70 rdf:type schema:PropertyValue
71 Nc504200f12ca455c86431abe0f4c5efc schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 Ne17d13d4a54a478bbf3513fd401ec601 rdf:first sg:person.01274020025.76
74 rdf:rest Ne4b0e3b4c4434c349c73e1d717d5cae3
75 Ne4b0e3b4c4434c349c73e1d717d5cae3 rdf:first Nf58782b08bb84ce7b7bbc6177ce6fcf9
76 rdf:rest N70dad02f7d164e7382ac783a8dc7efa8
77 Nf58782b08bb84ce7b7bbc6177ce6fcf9 schema:affiliation https://www.grid.ac/institutes/grid.143643.7
78 schema:familyName Matsumoto
79 schema:givenName Koji
80 rdf:type schema:Person
81 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
82 schema:name Medical and Health Sciences
83 rdf:type schema:DefinedTerm
84 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
85 schema:name Oncology and Carcinogenesis
86 rdf:type schema:DefinedTerm
87 sg:journal.1083512 schema:issn 0303-402X
88 1435-1536
89 schema:name Colloid and Polymer Science
90 rdf:type schema:Periodical
91 sg:person.01221563640.34 schema:affiliation https://www.grid.ac/institutes/grid.143643.7
92 schema:familyName Makino
93 schema:givenName Kimiko
94 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221563640.34
95 rdf:type schema:Person
96 sg:person.01274020025.76 schema:affiliation https://www.grid.ac/institutes/grid.143643.7
97 schema:familyName Tomoda
98 schema:givenName Keishiro
99 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274020025.76
100 rdf:type schema:Person
101 sg:person.0745720422.71 schema:affiliation https://www.grid.ac/institutes/grid.143643.7
102 schema:familyName Uchiro
103 schema:givenName Hiromi
104 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745720422.71
105 rdf:type schema:Person
106 sg:person.0755262221.24 schema:affiliation https://www.grid.ac/institutes/grid.143643.7
107 schema:familyName Takeuchi
108 schema:givenName Issei
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755262221.24
110 rdf:type schema:Person
111 sg:pub.10.1007/bf02699933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022993917
112 https://doi.org/10.1007/bf02699933
113 rdf:type schema:CreativeWork
114 sg:pub.10.1023/a:1005713113990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017564826
115 https://doi.org/10.1023/a:1005713113990
116 rdf:type schema:CreativeWork
117 sg:pub.10.1023/a:1005769214899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034105938
118 https://doi.org/10.1023/a:1005769214899
119 rdf:type schema:CreativeWork
120 sg:pub.10.1023/a:1023282818409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031192731
121 https://doi.org/10.1023/a:1023282818409
122 rdf:type schema:CreativeWork
123 sg:pub.10.1038/380561a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001339131
124 https://doi.org/10.1038/380561a0
125 rdf:type schema:CreativeWork
126 sg:pub.10.1038/bjc.1991.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025129395
127 https://doi.org/10.1038/bjc.1991.124
128 rdf:type schema:CreativeWork
129 sg:pub.10.1038/bjc.1997.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040217282
130 https://doi.org/10.1038/bjc.1997.118
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1016/0005-2736(91)90201-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1026953047
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1016/0005-2736(92)90136-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1001937558
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1016/0022-328x(93)83337-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1028046482
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1016/j.apradiso.2009.03.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035698163
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1016/j.bmc.2010.03.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010182394
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1016/j.jconrel.2004.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053441075
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1016/j.jconrel.2009.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006663059
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/j.jconrel.2010.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023208247
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/s0010-8545(02)00087-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049572302
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/s0168-3659(99)00248-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044151490
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/s0968-0896(03)00240-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048619982
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/s1074-5521(01)00016-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024072492
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1021/bc060075d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055154051
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1021/cr00010a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054063546
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1021/ic00112a023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055542942
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1021/jm9900725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055959368
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1021/ol062840+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1056248822
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1158/1078-0432.ccr-05-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040481924
167 rdf:type schema:CreativeWork
168 https://www.grid.ac/institutes/grid.143643.7 schema:alternateName Tokyo University of Science
169 schema:name Center for Drug Delivery Research, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan
170 Center for Physical Pharmaceutics, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan
171 Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan
172 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...