Antioxidant changes in the hypertrophied heart due to energy metabolic disorder View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

Hiroki Kamiya, Kenji Okumura, Masafumi Ito, Hideo Matsui, Yoshihiro Saburi, Kazunori Hayashi, Tetsuo Hayakawa

ABSTRACT

Oxidative stress has been implicated in the pathogenesis of both heart hypertrophy and heart failure. Hypertrophied heart, in response to pressure overload, is associated with an increase in antioxidant capacity and a decrease in oxidative stress. However, in the hypertrophied heart due to energy metabolic disorder, antioxidant capacity has not been investigated. Antioxidant changes in juvenile visceral steatosis (JVS) mice, a model of heart hypertrophy due to disorder of fatty-acid oxidation, were examined at 4 weeks (developing hypertrophy stage) and 8 weeks of age (established hypertrophy stage). Superoxide dismutase activity in the JVS mice was higher than that in control mice at 4 weeks of age and was not different from that in the control mice at 8 weeks of age. Glutathione peroxidase activity in the JVS mice at 8 weeks of age was lower than that in the control mice. Catalase activity showed no significant differences between the control and the JVS mice. Lipid peroxidation in the JVS mice was significantly reduced at 4 weeks of age and increased toward control levels at 8 weeks of age. The levels of vitamin E in the heart were increased in the JVS mice at 8 weeks of age. To determine whether antioxidants affect the pathogenesis of hypertrophy in this model, long-term treatments of vitamin E and 2-mercaptopropionyl glycine were performed. Vitamin E treatment partially reduced the heart hypertrophy in these mice. The present study shows that heart hypertrophy in the JVS mice is accompanied with increased antioxidant capacity as indicated in other animal models of heart hypertrophy. The precise mechanism of heart hypertrophy in JVS mice is still unknown, but oxidative stress may play a role in the pathogenesis of heart hypertrophy. More... »

PAGES

431-438

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s003950170024

DOI

http://dx.doi.org/10.1007/s003950170024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021610263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11605989


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiomegaly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carnitine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Peroxidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Peroxidation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C3H", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Mutant Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superoxide Dismutase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tiopronin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vitamin E", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Tocopherol", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamiya", 
        "givenName": "Hiroki", 
        "id": "sg:person.0616203277.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616203277.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okumura", 
        "givenName": "Kenji", 
        "id": "sg:person.012100067057.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012100067057.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Masafumi", 
        "id": "sg:person.014572226162.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014572226162.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsui", 
        "givenName": "Hideo", 
        "id": "sg:person.016661036262.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016661036262.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saburi", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.01123030641.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123030641.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Kazunori", 
        "id": "sg:person.0671463757.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671463757.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayakawa", 
        "givenName": "Tetsuo", 
        "id": "sg:person.012525572242.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525572242.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/5030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018881389", 
          "https://doi.org/10.1038/5030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003950050079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010930231", 
          "https://doi.org/10.1007/s003950050079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00944786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005823120", 
          "https://doi.org/10.1007/bf00944786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00191365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015780934", 
          "https://doi.org/10.1007/bf00191365"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-10", 
    "datePublishedReg": "2001-10-01", 
    "description": "Abstract Oxidative stress has been implicated in the pathogenesis of both heart hypertrophy and heart failure. Hypertrophied heart, in response to pressure overload, is associated with an increase in antioxidant capacity and a decrease in oxidative stress. However, in the hypertrophied heart due to energy metabolic disorder, antioxidant capacity has not been investigated. Antioxidant changes in juvenile visceral steatosis (JVS) mice, a model of heart hypertrophy due to disorder of fatty-acid oxidation, were examined at 4 weeks (developing hypertrophy stage) and 8 weeks of age (established hypertrophy stage). Superoxide dismutase activity in the JVS mice was higher than that in control mice at 4 weeks of age and was not different from that in the control mice at 8 weeks of age. Glutathione peroxidase activity in the JVS mice at 8 weeks of age was lower than that in the control mice. Catalase activity showed no significant differences between the control and the JVS mice. Lipid peroxidation in the JVS mice was significantly reduced at 4 weeks of age and increased toward control levels at 8 weeks of age. The levels of vitamin E in the heart were increased in the JVS mice at 8 weeks of age. To determine whether antioxidants affect the pathogenesis of hypertrophy in this model, long-term treatments of vitamin E and 2-mercaptopropionyl glycine were performed. Vitamin E treatment partially reduced the heart hypertrophy in these mice. The present study shows that heart hypertrophy in the JVS mice is accompanied with increased antioxidant capacity as indicated in other animal models of heart hypertrophy. The precise mechanism of heart hypertrophy in JVS mice is still unknown, but oxidative stress may play a role in the pathogenesis of heart hypertrophy.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s003950170024", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016443", 
        "issn": [
          "0300-8428", 
          "1435-1803"
        ], 
        "name": "Basic Research in Cardiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "96"
      }
    ], 
    "keywords": [
      "weeks of age", 
      "heart hypertrophy", 
      "energy metabolic disorder", 
      "control mice", 
      "JVS mice", 
      "hypertrophied hearts", 
      "metabolic disorders", 
      "oxidative stress", 
      "long-term treatment", 
      "vitamin E", 
      "Abstract Oxidative stress", 
      "juvenile visceral steatosis (JVS) mice", 
      "vitamin E treatment", 
      "pathogenesis of hypertrophy", 
      "glutathione peroxidase activity", 
      "antioxidant capacity", 
      "heart failure", 
      "fatty-acid oxidation", 
      "pressure overload", 
      "E treatment", 
      "antioxidant changes", 
      "animal models", 
      "hypertrophy", 
      "mice", 
      "weeks", 
      "control levels", 
      "pathogenesis", 
      "lipid peroxidation", 
      "dismutase activity", 
      "precise mechanism", 
      "age", 
      "disorders", 
      "significant differences", 
      "heart", 
      "catalase activity", 
      "present study", 
      "treatment", 
      "peroxidase activity", 
      "activity", 
      "peroxidation", 
      "levels", 
      "overload", 
      "failure", 
      "changes", 
      "antioxidants", 
      "stress", 
      "response", 
      "decrease", 
      "differences", 
      "control", 
      "study", 
      "role", 
      "increase", 
      "capacity", 
      "mechanism", 
      "model", 
      "oxidation", 
      "visceral steatosis (JVS) mice", 
      "steatosis (JVS) mice"
    ], 
    "name": "Antioxidant changes in the hypertrophied heart due to energy metabolic disorder", 
    "pagination": "431-438", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021610263"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s003950170024"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11605989"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s003950170024", 
      "https://app.dimensions.ai/details/publication/pub.1021610263"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_331.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s003950170024"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s003950170024'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s003950170024'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s003950170024'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s003950170024'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      22 PREDICATES      110 URIs      98 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s003950170024 schema:about N1360f48f74254d45bde9e6e7f69c8fc4
2 N14a2d4f445f143a69342e38a0563ea27
3 N154afb7e1a0a4638b9ce10d71e783180
4 N310920b661664d608b07ddfa2caa4608
5 N3298f6b2ef0f4136946a2d18b53e785c
6 N369082e1f4de48ea8b1acf12639bebec
7 N43432583fdad498b96a3a7a0288c160d
8 N475975f81d2d4a4c96dac0c3ee176315
9 N54508ae6640b43029740b15819b0eccf
10 N5f43379ca51b41d49911e6ec385cf6b5
11 N668c88417c804d15a43989a21f3a69fb
12 N8e9765fc81b2427db9c69e260d9262af
13 N9646f196387d42fda04c23b18bbe2b5e
14 N9d16323384924c7ba1f4c0b5e161085a
15 Nacd16595e851454090b2233c2f21dee8
16 Nc4514a2ff60d47ee917b9ead6733499c
17 Nc73ca562e5964fa7bf52616d15982420
18 Nd5b5283a2d5d4f648f5736dead4249bb
19 Nddea5cb70e9643a4b6737cae094b49e3
20 Ne2e5ca7e4fb44f0f85c68cb25db7c2ea
21 anzsrc-for:11
22 anzsrc-for:1102
23 schema:author Ndfd2751192084d7097e660e8cee6b53b
24 schema:citation sg:pub.10.1007/bf00191365
25 sg:pub.10.1007/bf00944786
26 sg:pub.10.1007/s003950050079
27 sg:pub.10.1038/5030
28 schema:datePublished 2001-10
29 schema:datePublishedReg 2001-10-01
30 schema:description Abstract Oxidative stress has been implicated in the pathogenesis of both heart hypertrophy and heart failure. Hypertrophied heart, in response to pressure overload, is associated with an increase in antioxidant capacity and a decrease in oxidative stress. However, in the hypertrophied heart due to energy metabolic disorder, antioxidant capacity has not been investigated. Antioxidant changes in juvenile visceral steatosis (JVS) mice, a model of heart hypertrophy due to disorder of fatty-acid oxidation, were examined at 4 weeks (developing hypertrophy stage) and 8 weeks of age (established hypertrophy stage). Superoxide dismutase activity in the JVS mice was higher than that in control mice at 4 weeks of age and was not different from that in the control mice at 8 weeks of age. Glutathione peroxidase activity in the JVS mice at 8 weeks of age was lower than that in the control mice. Catalase activity showed no significant differences between the control and the JVS mice. Lipid peroxidation in the JVS mice was significantly reduced at 4 weeks of age and increased toward control levels at 8 weeks of age. The levels of vitamin E in the heart were increased in the JVS mice at 8 weeks of age. To determine whether antioxidants affect the pathogenesis of hypertrophy in this model, long-term treatments of vitamin E and 2-mercaptopropionyl glycine were performed. Vitamin E treatment partially reduced the heart hypertrophy in these mice. The present study shows that heart hypertrophy in the JVS mice is accompanied with increased antioxidant capacity as indicated in other animal models of heart hypertrophy. The precise mechanism of heart hypertrophy in JVS mice is still unknown, but oxidative stress may play a role in the pathogenesis of heart hypertrophy.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N5fd3f1075a8e4e89a355e89cf69b5dfe
35 Nd5d6e25066754e2aa49e1570ca59c3dd
36 sg:journal.1016443
37 schema:keywords Abstract Oxidative stress
38 E treatment
39 JVS mice
40 activity
41 age
42 animal models
43 antioxidant capacity
44 antioxidant changes
45 antioxidants
46 capacity
47 catalase activity
48 changes
49 control
50 control levels
51 control mice
52 decrease
53 differences
54 dismutase activity
55 disorders
56 energy metabolic disorder
57 failure
58 fatty-acid oxidation
59 glutathione peroxidase activity
60 heart
61 heart failure
62 heart hypertrophy
63 hypertrophied hearts
64 hypertrophy
65 increase
66 juvenile visceral steatosis (JVS) mice
67 levels
68 lipid peroxidation
69 long-term treatment
70 mechanism
71 metabolic disorders
72 mice
73 model
74 overload
75 oxidation
76 oxidative stress
77 pathogenesis
78 pathogenesis of hypertrophy
79 peroxidase activity
80 peroxidation
81 precise mechanism
82 present study
83 pressure overload
84 response
85 role
86 significant differences
87 steatosis (JVS) mice
88 stress
89 study
90 treatment
91 visceral steatosis (JVS) mice
92 vitamin E
93 vitamin E treatment
94 weeks
95 weeks of age
96 schema:name Antioxidant changes in the hypertrophied heart due to energy metabolic disorder
97 schema:pagination 431-438
98 schema:productId N175b8711017e41b0b1fac29bfc83e2fc
99 N2c11577fc82d42809d7e083c0c42113a
100 Nf940c105dffe4fd289ba56b78632caf8
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021610263
102 https://doi.org/10.1007/s003950170024
103 schema:sdDatePublished 2022-01-01T18:11
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N56921893d0dd478a9c7fb221b65d02e4
106 schema:url https://doi.org/10.1007/s003950170024
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N1360f48f74254d45bde9e6e7f69c8fc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mice
112 rdf:type schema:DefinedTerm
113 N14a2d4f445f143a69342e38a0563ea27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Animals
115 rdf:type schema:DefinedTerm
116 N154afb7e1a0a4638b9ce10d71e783180 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Heart Rate
118 rdf:type schema:DefinedTerm
119 N175b8711017e41b0b1fac29bfc83e2fc schema:name doi
120 schema:value 10.1007/s003950170024
121 rdf:type schema:PropertyValue
122 N2c11577fc82d42809d7e083c0c42113a schema:name pubmed_id
123 schema:value 11605989
124 rdf:type schema:PropertyValue
125 N310920b661664d608b07ddfa2caa4608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cardiomegaly
127 rdf:type schema:DefinedTerm
128 N3298f6b2ef0f4136946a2d18b53e785c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Fatty Liver
130 rdf:type schema:DefinedTerm
131 N33f9812544b74774a522ea088893132f rdf:first sg:person.016661036262.27
132 rdf:rest N9a078f70e4504801b47ae4d9c3cab498
133 N369082e1f4de48ea8b1acf12639bebec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Antioxidants
135 rdf:type schema:DefinedTerm
136 N3e0d9c133fc64bdcb743e577375c8397 rdf:first sg:person.014572226162.89
137 rdf:rest N33f9812544b74774a522ea088893132f
138 N43432583fdad498b96a3a7a0288c160d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Mice, Inbred C3H
140 rdf:type schema:DefinedTerm
141 N475975f81d2d4a4c96dac0c3ee176315 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Carnitine
143 rdf:type schema:DefinedTerm
144 N54508ae6640b43029740b15819b0eccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Glutathione Peroxidase
146 rdf:type schema:DefinedTerm
147 N56921893d0dd478a9c7fb221b65d02e4 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 N5f43379ca51b41d49911e6ec385cf6b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Superoxide Dismutase
151 rdf:type schema:DefinedTerm
152 N5fd3f1075a8e4e89a355e89cf69b5dfe schema:volumeNumber 96
153 rdf:type schema:PublicationVolume
154 N668c88417c804d15a43989a21f3a69fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Myocardium
156 rdf:type schema:DefinedTerm
157 N7e6ae2f85ea944738bf087f31fd21a2d rdf:first sg:person.012525572242.18
158 rdf:rest rdf:nil
159 N8da07690d7db4cf99f83b88ff55cd839 rdf:first sg:person.012100067057.97
160 rdf:rest N3e0d9c133fc64bdcb743e577375c8397
161 N8e9765fc81b2427db9c69e260d9262af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name alpha-Tocopherol
163 rdf:type schema:DefinedTerm
164 N9646f196387d42fda04c23b18bbe2b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Blood Pressure
166 rdf:type schema:DefinedTerm
167 N9a078f70e4504801b47ae4d9c3cab498 rdf:first sg:person.01123030641.08
168 rdf:rest Nf32447b0b2e241239bbe821c1fdf1b0d
169 N9d16323384924c7ba1f4c0b5e161085a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Oxidative Stress
171 rdf:type schema:DefinedTerm
172 Nacd16595e851454090b2233c2f21dee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Lipid Peroxidation
174 rdf:type schema:DefinedTerm
175 Nc4514a2ff60d47ee917b9ead6733499c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Organ Size
177 rdf:type schema:DefinedTerm
178 Nc73ca562e5964fa7bf52616d15982420 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Energy Metabolism
180 rdf:type schema:DefinedTerm
181 Nd5b5283a2d5d4f648f5736dead4249bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Mice, Mutant Strains
183 rdf:type schema:DefinedTerm
184 Nd5d6e25066754e2aa49e1570ca59c3dd schema:issueNumber 5
185 rdf:type schema:PublicationIssue
186 Nddea5cb70e9643a4b6737cae094b49e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Tiopronin
188 rdf:type schema:DefinedTerm
189 Ndfd2751192084d7097e660e8cee6b53b rdf:first sg:person.0616203277.21
190 rdf:rest N8da07690d7db4cf99f83b88ff55cd839
191 Ne2e5ca7e4fb44f0f85c68cb25db7c2ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Vitamin E
193 rdf:type schema:DefinedTerm
194 Nf32447b0b2e241239bbe821c1fdf1b0d rdf:first sg:person.0671463757.19
195 rdf:rest N7e6ae2f85ea944738bf087f31fd21a2d
196 Nf940c105dffe4fd289ba56b78632caf8 schema:name dimensions_id
197 schema:value pub.1021610263
198 rdf:type schema:PropertyValue
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
203 schema:name Cardiorespiratory Medicine and Haematology
204 rdf:type schema:DefinedTerm
205 sg:journal.1016443 schema:issn 0300-8428
206 1435-1803
207 schema:name Basic Research in Cardiology
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01123030641.08 schema:affiliation grid-institutes:grid.27476.30
211 schema:familyName Saburi
212 schema:givenName Yoshihiro
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123030641.08
214 rdf:type schema:Person
215 sg:person.012100067057.97 schema:affiliation grid-institutes:grid.27476.30
216 schema:familyName Okumura
217 schema:givenName Kenji
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012100067057.97
219 rdf:type schema:Person
220 sg:person.012525572242.18 schema:affiliation grid-institutes:grid.27476.30
221 schema:familyName Hayakawa
222 schema:givenName Tetsuo
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525572242.18
224 rdf:type schema:Person
225 sg:person.014572226162.89 schema:affiliation grid-institutes:grid.27476.30
226 schema:familyName Ito
227 schema:givenName Masafumi
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014572226162.89
229 rdf:type schema:Person
230 sg:person.016661036262.27 schema:affiliation grid-institutes:grid.27476.30
231 schema:familyName Matsui
232 schema:givenName Hideo
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016661036262.27
234 rdf:type schema:Person
235 sg:person.0616203277.21 schema:affiliation grid-institutes:grid.27476.30
236 schema:familyName Kamiya
237 schema:givenName Hiroki
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616203277.21
239 rdf:type schema:Person
240 sg:person.0671463757.19 schema:affiliation grid-institutes:grid.27476.30
241 schema:familyName Hayashi
242 schema:givenName Kazunori
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671463757.19
244 rdf:type schema:Person
245 sg:pub.10.1007/bf00191365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015780934
246 https://doi.org/10.1007/bf00191365
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/bf00944786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005823120
249 https://doi.org/10.1007/bf00944786
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s003950050079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010930231
252 https://doi.org/10.1007/s003950050079
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/5030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018881389
255 https://doi.org/10.1038/5030
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.27476.30 schema:alternateName Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP
258 schema:name Internal Medicine II and First Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan, JP
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...