Contributions of cardiomyocyte–cardiac fibroblast–immune cell interactions in heart failure development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07

AUTHORS

Katsuhito Fujiu, Ryozo Nagai

ABSTRACT

The heart contains various types of cells, including cardiomyocytes, cardiac fibroblasts, many kinds of immune cells and vascular cells. Initial studies mainly focused on cardiomyocytes, which directly reflect the contractile function of the heart. Recently, pivotal functions of cardiac fibroblasts have been revealed in the maintenance of cardiac function, physiological cardiac remodeling after heart stress and pathological remodeling using genetically engineered mouse models, like the fibroblast-specific gene knockout mouse, bone marrow transplantation and immune cell-specific gene knockout. Moreover, chronic inflammation is considered to be a basic pathological mechanism that underlies various diseases, including heart failure. In the development of heart failure, the contributions of immune cells like T lymphocytes and monocyte/macrophage lineage cells have been also reported. Immune cells have diverse and multiple functions in regulating both pro-inflammatory effects and the resolution of heart failure. On the one hand, immune cells have protective effects to compensate for and overcome heart stresses. On the other hand, they also contribute to sustained inflammation and result in the development of heart failure. These observations prompted a shift in the heart-related studies to include the complex communications between cardiomyocytes and other kinds of cardiac cells, including inflammatory cells residing in or recruited to the heart. This review will summarize the current knowledge regarding cell-cell interactions during cardiac remodeling and the development of heart failure. We will especially focus on the interactions among cardiomyocytes, cardiac fibroblasts and immune cells. More... »

PAGES

357

References to SciGraph publications

  • 2012-07. Remote ischemic preconditioning confers late protection against myocardial ischemia–reperfusion injury in mice by upregulating interleukin-10 in BASIC RESEARCH IN CARDIOLOGY
  • 2013-03. Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction in BASIC RESEARCH IN CARDIOLOGY
  • 2007-09. Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis in BASIC RESEARCH IN CARDIOLOGY
  • 2000-03. Angiotensin II—Nitric Oxide Interactions in the Control of Sympathetic Outflow in Heart Failure in HEART FAILURE REVIEWS
  • 2003-09. Signalling pathways of the TNF superfamily: a double-edged sword in NATURE REVIEWS IMMUNOLOGY
  • 2012-03. S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling in BASIC RESEARCH IN CARDIOLOGY
  • 2000-05. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice in NATURE MEDICINE
  • 2005. Strategies of Conditional Gene Expression in Myocardium in MOLECULAR CARDIOLOGY
  • 2011-11. Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart in BASIC RESEARCH IN CARDIOLOGY
  • 2007-03. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload in NATURE
  • 2002-08. Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling in NATURE MEDICINE
  • 2012-03. Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway in BASIC RESEARCH IN CARDIOLOGY
  • 2012-09. The prostacyclin agonist iloprost aggravates fibrosis and enhances viral replication in enteroviral myocarditis by modulation of ERK signaling and increase of iNOS expression in BASIC RESEARCH IN CARDIOLOGY
  • 2007-03. The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease in NATURE IMMUNOLOGY
  • 2009-09. Mononuclear cells in liver fibrosis in SEMINARS IN IMMUNOPATHOLOGY
  • 2007-08. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis in NATURE MEDICINE
  • 2012-09. Role of miR-21 in the pathogenesis of atrial fibrosis in BASIC RESEARCH IN CARDIOLOGY
  • 2011-11. Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization in BASIC RESEARCH IN CARDIOLOGY
  • 2012-01. Regulatory T cells ameliorate cardiac remodeling after myocardial infarction in BASIC RESEARCH IN CARDIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00395-013-0357-x

    DOI

    http://dx.doi.org/10.1007/s00395-013-0357-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038236580

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23740215


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Communication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblasts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Failure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Killer Cells, Natural", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macrophages", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Monocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocytes, Cardiac", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo, Tokyo, Japan", 
                "Translational Systems Biology and Medicine Initiative (TSBMI), the University of Tokyo Graduate School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujiu", 
            "givenName": "Katsuhito", 
            "id": "sg:person.01027600423.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027600423.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jichi Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo, Tokyo, Japan", 
                "Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program), Tokyo, Japan", 
                "Jichi Medical University, Tochigi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagai", 
            "givenName": "Ryozo", 
            "id": "sg:person.0772176333.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1440-1681.2007.04873.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000516368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-1097(95)00589-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000871204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00881.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001241321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmcc.1999.1007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001277217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000255031.15793.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002075187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000255031.15793.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002075187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci41080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002170430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002654168", 
              "https://doi.org/10.1038/nature05602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00166.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003733796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvp040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003798894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004288971", 
              "https://doi.org/10.1038/75037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004288971", 
              "https://doi.org/10.1038/75037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1369/jhc.4a6560.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004682861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1369/jhc.4a6560.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004682861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1369/jhc.4a6560.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004682861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0287-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006032208", 
              "https://doi.org/10.1007/s00395-012-0287-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.102.25.3060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006113302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-200201000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006644034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-200201000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006644034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmcc.1993.1104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006851400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.109.931451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006874701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.109.931451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006874701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.109.931451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006874701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-011-0228-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006979184", 
              "https://doi.org/10.1007/s00395-011-0228-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.01363.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007306930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.109.207456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007465766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.109.207456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007465766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.109.207456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007465766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.109.207456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007465766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0250-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007745831", 
              "https://doi.org/10.1007/s00395-012-0250-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000185833.42544.06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008178357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000185833.42544.06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008178357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.240820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010380276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.240820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010380276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.240820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010380276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cardfail.2005.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011089772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cardfail.2005.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011089772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0898-6568(98)00036-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011518450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci43569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012200470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci43569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012200470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0048910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012634955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2007.060547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013734622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013852261", 
              "https://doi.org/10.1038/nm738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013852261", 
              "https://doi.org/10.1038/nm738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013929852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci44824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014352067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvs320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015263106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(95)01238-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016216015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00928.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016332200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017088131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.0000227247.27111.b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018698428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.0000227247.27111.b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018698428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2010.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019197912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexmp.2010.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020425557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.211086598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020550360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2007.03356.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021406338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2007.03356.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021406338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000014451.75415.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021426694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.108.823070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022013407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.108.823070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022013407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.101.20.2338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022791381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.20307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022998520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1253/jcj.63.951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024312791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024979688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.10251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025274359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000147233.10318.23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025483264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci40295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025982428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci40295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025982428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000057545.82749.ff", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025987601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmcc.2001.1489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025992966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0277-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026163746", 
              "https://doi.org/10.1007/s00395-012-0277-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000043825.01705.1b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026304018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4906(01)01863-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026324269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00514.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027148578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0325-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028297906", 
              "https://doi.org/10.1007/s00395-012-0325-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0325-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028297906", 
              "https://doi.org/10.1007/s00395-012-0325-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2010.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029453413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.180976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029720668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.180976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029720668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-007-0674-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030499865", 
              "https://doi.org/10.1007/s00395-007-0674-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-007-0674-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030499865", 
              "https://doi.org/10.1007/s00395-007-0674-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1009894007055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031444026", 
              "https://doi.org/10.1023/a:1009894007055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvp164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031481129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmcc.2001.1383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031533353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.112.270132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032135421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.112.270132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032135421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2008.070974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032212725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1175202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032290342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1175202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032290342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2011.10.863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033025934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033068785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.1995.tb14901.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033117620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.99.3.427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033201084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.17.6753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035089772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181b4a854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035113208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181b4a854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035113208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-011-0204-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035159409", 
              "https://doi.org/10.1007/s00395-011-0204-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.051625598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035834467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/expphysiol.2011.057612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037181993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexmp.2009.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037187878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvp208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037332168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvp208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037332168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0248-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037678994", 
              "https://doi.org/10.1007/s00395-012-0248-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.12.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038330199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2004.05.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038798282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.86.12.1259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038895525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1074248408329860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039438051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1074248408329860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039438051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59259-879-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040343879", 
              "https://doi.org/10.1007/978-1-59259-879-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59259-879-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040343879", 
              "https://doi.org/10.1007/978-1-59259-879-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.83.10.1035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041039067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.01002.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041838981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.01327.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042625731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.111.052126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045665588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.111.052126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045665588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.0000118584.33350.7d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045848863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.0000118584.33350.7d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045848863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-012-0278-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046554927", 
              "https://doi.org/10.1007/s00395-012-0278-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-009-0169-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047305303", 
              "https://doi.org/10.1007/s00281-009-0169-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-009-0169-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047305303", 
              "https://doi.org/10.1007/s00281-009-0169-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-009-0169-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047305303", 
              "https://doi.org/10.1007/s00281-009-0169-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.20197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048332476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64824-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049303912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049337093", 
              "https://doi.org/10.1038/ni1439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049455189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.107.692764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049817998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m003128200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049857990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2009.05094.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050326839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2009.05094.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050326839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.108.832782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050326941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050416284", 
              "https://doi.org/10.1038/nm1613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4067/s0716-97602012000200012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052206046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000117070.86556.9f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052420241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000117070.86556.9f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052420241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000124490.27666.b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053255841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-011-0232-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053455835", 
              "https://doi.org/10.1007/s00395-011-0232-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199007263230405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053487433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(02)00413-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054578144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(02)00729-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054578361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(98)00121-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054580087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1230719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062467744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8140422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00902.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063194671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.93.4.704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063336984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.95.5.1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063337892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.81.2.187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063341114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.81.4.493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063341150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci14190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.5.2798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074685498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.2000.279.6.h3020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074731316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077519931", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082398346", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083228936", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "The heart contains various types of cells, including cardiomyocytes, cardiac fibroblasts, many kinds of immune cells and vascular cells. Initial studies mainly focused on cardiomyocytes, which directly reflect the contractile function of the heart. Recently, pivotal functions of cardiac fibroblasts have been revealed in the maintenance of cardiac function, physiological cardiac remodeling after heart stress and pathological remodeling using genetically engineered mouse models, like the fibroblast-specific gene knockout mouse, bone marrow transplantation and immune cell-specific gene knockout. Moreover, chronic inflammation is considered to be a basic pathological mechanism that underlies various diseases, including heart failure. In the development of heart failure, the contributions of immune cells like T lymphocytes and monocyte/macrophage lineage cells have been also reported. Immune cells have diverse and multiple functions in regulating both pro-inflammatory effects and the resolution of heart failure. On the one hand, immune cells have protective effects to compensate for and overcome heart stresses. On the other hand, they also contribute to sustained inflammation and result in the development of heart failure. These observations prompted a shift in the heart-related studies to include the complex communications between cardiomyocytes and other kinds of cardiac cells, including inflammatory cells residing in or recruited to the heart. This review will summarize the current knowledge regarding cell-cell interactions during cardiac remodeling and the development of heart failure. We will especially focus on the interactions among cardiomyocytes, cardiac fibroblasts and immune cells.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00395-013-0357-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6078532", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1016443", 
            "issn": [
              "0300-8428", 
              "1435-1803"
            ], 
            "name": "Basic Research in Cardiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "108"
          }
        ], 
        "name": "Contributions of cardiomyocyte\u2013cardiac fibroblast\u2013immune cell interactions in heart failure development", 
        "pagination": "357", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b625946b254f01350349888a351e33e2f216bd0dcd321a4576cbb1bb1485983a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23740215"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0360342"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00395-013-0357-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038236580"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00395-013-0357-x", 
          "https://app.dimensions.ai/details/publication/pub.1038236580"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000514.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00395-013-0357-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00395-013-0357-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00395-013-0357-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00395-013-0357-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00395-013-0357-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    505 TRIPLES      21 PREDICATES      160 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00395-013-0357-x schema:about N0db15ed089614b4295858efc43ead1d4
    2 N28960312c386485ea082868e0c531ac1
    3 N293127b78df14c83bce287024d733aad
    4 N354c3aa528b34b4c97be74d7fa873720
    5 N7ad891000d614bc1b27cac126a3481e9
    6 N946c19b665a641b38ebc083fc5bf3b67
    7 N951d563c8f0148aea640d521b7ce364f
    8 Na3e521f046854d8fbfce8569118fefa0
    9 Ncd74934d87ef4a828b64edfc63c4f77e
    10 Ndb41e6cfb6a847c983e9f664e88d7a80
    11 Ndff3b64deadf45de9d8c4592554f0363
    12 Nfd9b856ca3d74d26bae383f2dcc6f46f
    13 anzsrc-for:11
    14 anzsrc-for:1102
    15 schema:author N01ee5b820bf840358e2c223b0c4d8a6d
    16 schema:citation sg:pub.10.1007/978-1-59259-879-3_8
    17 sg:pub.10.1007/s00281-009-0169-0
    18 sg:pub.10.1007/s00395-007-0674-z
    19 sg:pub.10.1007/s00395-011-0204-x
    20 sg:pub.10.1007/s00395-011-0228-2
    21 sg:pub.10.1007/s00395-011-0232-6
    22 sg:pub.10.1007/s00395-012-0248-6
    23 sg:pub.10.1007/s00395-012-0250-z
    24 sg:pub.10.1007/s00395-012-0277-1
    25 sg:pub.10.1007/s00395-012-0278-0
    26 sg:pub.10.1007/s00395-012-0287-z
    27 sg:pub.10.1007/s00395-012-0325-x
    28 sg:pub.10.1023/a:1009894007055
    29 sg:pub.10.1038/75037
    30 sg:pub.10.1038/nature05602
    31 sg:pub.10.1038/ni1439
    32 sg:pub.10.1038/nm1613
    33 sg:pub.10.1038/nm738
    34 sg:pub.10.1038/nri1184
    35 https://app.dimensions.ai/details/publication/pub.1077519931
    36 https://app.dimensions.ai/details/publication/pub.1082398346
    37 https://app.dimensions.ai/details/publication/pub.1083228936
    38 https://doi.org/10.1002/jcp.10251
    39 https://doi.org/10.1002/jcp.20197
    40 https://doi.org/10.1002/jcp.20307
    41 https://doi.org/10.1006/jmcc.1993.1104
    42 https://doi.org/10.1006/jmcc.1999.1007
    43 https://doi.org/10.1006/jmcc.2001.1383
    44 https://doi.org/10.1006/jmcc.2001.1489
    45 https://doi.org/10.1016/0014-5793(95)01238-5
    46 https://doi.org/10.1016/0735-1097(95)00589-7
    47 https://doi.org/10.1016/j.cardfail.2005.05.005
    48 https://doi.org/10.1016/j.ccr.2008.01.003
    49 https://doi.org/10.1016/j.cell.2006.12.036
    50 https://doi.org/10.1016/j.devcel.2008.12.007
    51 https://doi.org/10.1016/j.jacc.2011.10.863
    52 https://doi.org/10.1016/j.pharmthera.2010.05.002
    53 https://doi.org/10.1016/j.yexmp.2009.06.001
    54 https://doi.org/10.1016/j.yexmp.2010.10.004
    55 https://doi.org/10.1016/j.yjmcc.2004.05.012
    56 https://doi.org/10.1016/j.yjmcc.2010.04.010
    57 https://doi.org/10.1016/s0002-9440(10)64824-9
    58 https://doi.org/10.1016/s0008-6363(02)00413-3
    59 https://doi.org/10.1016/s0008-6363(02)00729-0
    60 https://doi.org/10.1016/s0008-6363(98)00121-7
    61 https://doi.org/10.1016/s0898-6568(98)00036-9
    62 https://doi.org/10.1016/s1471-4906(01)01863-4
    63 https://doi.org/10.1056/nejm199007263230405
    64 https://doi.org/10.1073/pnas.051625598
    65 https://doi.org/10.1073/pnas.211086598
    66 https://doi.org/10.1073/pnas.86.17.6753
    67 https://doi.org/10.1074/jbc.m003128200
    68 https://doi.org/10.1093/cvr/cvp040
    69 https://doi.org/10.1093/cvr/cvp164
    70 https://doi.org/10.1093/cvr/cvp208
    71 https://doi.org/10.1093/cvr/cvs320
    72 https://doi.org/10.1097/00005344-200201000-00003
    73 https://doi.org/10.1097/ccm.0b013e3181b4a854
    74 https://doi.org/10.1111/j.1365-2249.2007.03356.x
    75 https://doi.org/10.1111/j.1440-1681.2007.04873.x
    76 https://doi.org/10.1111/j.1476-5381.1995.tb14901.x
    77 https://doi.org/10.1111/j.1749-6632.2009.05094.x
    78 https://doi.org/10.1113/expphysiol.2011.057612
    79 https://doi.org/10.1126/science.1175202
    80 https://doi.org/10.1126/science.1230719
    81 https://doi.org/10.1126/science.8140422
    82 https://doi.org/10.1152/ajpcell.00166.2006
    83 https://doi.org/10.1152/ajpheart.00514.2007
    84 https://doi.org/10.1152/ajpheart.00881.2005
    85 https://doi.org/10.1152/ajpheart.00902.2002
    86 https://doi.org/10.1152/ajpheart.00928.2007
    87 https://doi.org/10.1152/ajpheart.01002.2010
    88 https://doi.org/10.1152/ajpheart.01327.2005
    89 https://doi.org/10.1152/ajpheart.01363.2007
    90 https://doi.org/10.1152/ajpheart.2000.279.6.h3020
    91 https://doi.org/10.1161/01.cir.0000057545.82749.ff
    92 https://doi.org/10.1161/01.cir.0000124490.27666.b2
    93 https://doi.org/10.1161/01.cir.0000147233.10318.23
    94 https://doi.org/10.1161/01.cir.101.20.2338
    95 https://doi.org/10.1161/01.cir.102.25.3060
    96 https://doi.org/10.1161/01.cir.93.4.704
    97 https://doi.org/10.1161/01.cir.95.5.1247
    98 https://doi.org/10.1161/01.cir.99.3.427
    99 https://doi.org/10.1161/01.hyp.0000118584.33350.7d
    100 https://doi.org/10.1161/01.hyp.0000227247.27111.b2
    101 https://doi.org/10.1161/01.res.0000014451.75415.36
    102 https://doi.org/10.1161/01.res.0000043825.01705.1b
    103 https://doi.org/10.1161/01.res.0000117070.86556.9f
    104 https://doi.org/10.1161/01.res.0000185833.42544.06
    105 https://doi.org/10.1161/01.res.0000255031.15793.86
    106 https://doi.org/10.1161/01.res.81.2.187
    107 https://doi.org/10.1161/01.res.81.4.493
    108 https://doi.org/10.1161/01.res.83.10.1035
    109 https://doi.org/10.1161/01.res.86.12.1259
    110 https://doi.org/10.1161/circheartfailure.108.823070
    111 https://doi.org/10.1161/circheartfailure.109.931451
    112 https://doi.org/10.1161/circresaha.108.180976
    113 https://doi.org/10.1161/circresaha.109.207456
    114 https://doi.org/10.1161/circresaha.111.240820
    115 https://doi.org/10.1161/circresaha.112.270132
    116 https://doi.org/10.1161/circulationaha.107.692764
    117 https://doi.org/10.1161/circulationaha.108.832782
    118 https://doi.org/10.1161/circulationaha.111.052126
    119 https://doi.org/10.1172/jci119114
    120 https://doi.org/10.1172/jci119509
    121 https://doi.org/10.1172/jci14190
    122 https://doi.org/10.1172/jci39942
    123 https://doi.org/10.1172/jci40295
    124 https://doi.org/10.1172/jci41080
    125 https://doi.org/10.1172/jci43569
    126 https://doi.org/10.1172/jci44824
    127 https://doi.org/10.1177/1074248408329860
    128 https://doi.org/10.1253/jcj.63.951
    129 https://doi.org/10.1369/jhc.4a6560.2005
    130 https://doi.org/10.1371/journal.pone.0048910
    131 https://doi.org/10.2353/ajpath.2007.060547
    132 https://doi.org/10.2353/ajpath.2008.070974
    133 https://doi.org/10.4049/jimmunol.165.5.2798
    134 https://doi.org/10.4067/s0716-97602012000200012
    135 schema:datePublished 2013-07
    136 schema:datePublishedReg 2013-07-01
    137 schema:description The heart contains various types of cells, including cardiomyocytes, cardiac fibroblasts, many kinds of immune cells and vascular cells. Initial studies mainly focused on cardiomyocytes, which directly reflect the contractile function of the heart. Recently, pivotal functions of cardiac fibroblasts have been revealed in the maintenance of cardiac function, physiological cardiac remodeling after heart stress and pathological remodeling using genetically engineered mouse models, like the fibroblast-specific gene knockout mouse, bone marrow transplantation and immune cell-specific gene knockout. Moreover, chronic inflammation is considered to be a basic pathological mechanism that underlies various diseases, including heart failure. In the development of heart failure, the contributions of immune cells like T lymphocytes and monocyte/macrophage lineage cells have been also reported. Immune cells have diverse and multiple functions in regulating both pro-inflammatory effects and the resolution of heart failure. On the one hand, immune cells have protective effects to compensate for and overcome heart stresses. On the other hand, they also contribute to sustained inflammation and result in the development of heart failure. These observations prompted a shift in the heart-related studies to include the complex communications between cardiomyocytes and other kinds of cardiac cells, including inflammatory cells residing in or recruited to the heart. This review will summarize the current knowledge regarding cell-cell interactions during cardiac remodeling and the development of heart failure. We will especially focus on the interactions among cardiomyocytes, cardiac fibroblasts and immune cells.
    138 schema:genre research_article
    139 schema:inLanguage en
    140 schema:isAccessibleForFree false
    141 schema:isPartOf N05278c3431854329b6c0c5cf115c78aa
    142 Nb0e69057a7664339aceaa63c33772f65
    143 sg:journal.1016443
    144 schema:name Contributions of cardiomyocyte–cardiac fibroblast–immune cell interactions in heart failure development
    145 schema:pagination 357
    146 schema:productId N58b23a08c8e34c27ad8280b62b57cfa3
    147 Na2b31fa571cb4d319b7f0e3fb13f16a2
    148 Nc3506295e74c4650bc07d75b8f5bfe8f
    149 Nea020d1b911848d98d8dd65c88419c20
    150 Nf1867965911c4098928d58cf2ed787c2
    151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038236580
    152 https://doi.org/10.1007/s00395-013-0357-x
    153 schema:sdDatePublished 2019-04-10T14:10
    154 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    155 schema:sdPublisher Nb7278e0f53c246938432984ea5e548df
    156 schema:url http://link.springer.com/10.1007%2Fs00395-013-0357-x
    157 sgo:license sg:explorer/license/
    158 sgo:sdDataset articles
    159 rdf:type schema:ScholarlyArticle
    160 N01ee5b820bf840358e2c223b0c4d8a6d rdf:first sg:person.01027600423.49
    161 rdf:rest Nc5f4185756324718a21aacd29adabc95
    162 N05278c3431854329b6c0c5cf115c78aa schema:issueNumber 4
    163 rdf:type schema:PublicationIssue
    164 N0db15ed089614b4295858efc43ead1d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name T-Lymphocytes
    166 rdf:type schema:DefinedTerm
    167 N28960312c386485ea082868e0c531ac1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Heart Failure
    169 rdf:type schema:DefinedTerm
    170 N293127b78df14c83bce287024d733aad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Cell Communication
    172 rdf:type schema:DefinedTerm
    173 N354c3aa528b34b4c97be74d7fa873720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Animals
    175 rdf:type schema:DefinedTerm
    176 N58b23a08c8e34c27ad8280b62b57cfa3 schema:name pubmed_id
    177 schema:value 23740215
    178 rdf:type schema:PropertyValue
    179 N7ad891000d614bc1b27cac126a3481e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Monocytes
    181 rdf:type schema:DefinedTerm
    182 N946c19b665a641b38ebc083fc5bf3b67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Fibroblasts
    184 rdf:type schema:DefinedTerm
    185 N951d563c8f0148aea640d521b7ce364f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Myocytes, Cardiac
    187 rdf:type schema:DefinedTerm
    188 Na2b31fa571cb4d319b7f0e3fb13f16a2 schema:name nlm_unique_id
    189 schema:value 0360342
    190 rdf:type schema:PropertyValue
    191 Na3e521f046854d8fbfce8569118fefa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Macrophages
    193 rdf:type schema:DefinedTerm
    194 Nb0e69057a7664339aceaa63c33772f65 schema:volumeNumber 108
    195 rdf:type schema:PublicationVolume
    196 Nb7278e0f53c246938432984ea5e548df schema:name Springer Nature - SN SciGraph project
    197 rdf:type schema:Organization
    198 Nc3506295e74c4650bc07d75b8f5bfe8f schema:name dimensions_id
    199 schema:value pub.1038236580
    200 rdf:type schema:PropertyValue
    201 Nc5f4185756324718a21aacd29adabc95 rdf:first sg:person.0772176333.38
    202 rdf:rest rdf:nil
    203 Ncd74934d87ef4a828b64edfc63c4f77e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Killer Cells, Natural
    205 rdf:type schema:DefinedTerm
    206 Ndb41e6cfb6a847c983e9f664e88d7a80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Humans
    208 rdf:type schema:DefinedTerm
    209 Ndff3b64deadf45de9d8c4592554f0363 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Disease Models, Animal
    211 rdf:type schema:DefinedTerm
    212 Nea020d1b911848d98d8dd65c88419c20 schema:name doi
    213 schema:value 10.1007/s00395-013-0357-x
    214 rdf:type schema:PropertyValue
    215 Nf1867965911c4098928d58cf2ed787c2 schema:name readcube_id
    216 schema:value b625946b254f01350349888a351e33e2f216bd0dcd321a4576cbb1bb1485983a
    217 rdf:type schema:PropertyValue
    218 Nfd9b856ca3d74d26bae383f2dcc6f46f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Dendritic Cells
    220 rdf:type schema:DefinedTerm
    221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Medical and Health Sciences
    223 rdf:type schema:DefinedTerm
    224 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Cardiorespiratory Medicine and Haematology
    226 rdf:type schema:DefinedTerm
    227 sg:grant.6078532 http://pending.schema.org/fundedItem sg:pub.10.1007/s00395-013-0357-x
    228 rdf:type schema:MonetaryGrant
    229 sg:journal.1016443 schema:issn 0300-8428
    230 1435-1803
    231 schema:name Basic Research in Cardiology
    232 rdf:type schema:Periodical
    233 sg:person.01027600423.49 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    234 schema:familyName Fujiu
    235 schema:givenName Katsuhito
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027600423.49
    237 rdf:type schema:Person
    238 sg:person.0772176333.38 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
    239 schema:familyName Nagai
    240 schema:givenName Ryozo
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38
    242 rdf:type schema:Person
    243 sg:pub.10.1007/978-1-59259-879-3_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040343879
    244 https://doi.org/10.1007/978-1-59259-879-3_8
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/s00281-009-0169-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047305303
    247 https://doi.org/10.1007/s00281-009-0169-0
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s00395-007-0674-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1030499865
    250 https://doi.org/10.1007/s00395-007-0674-z
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s00395-011-0204-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035159409
    253 https://doi.org/10.1007/s00395-011-0204-x
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s00395-011-0228-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006979184
    256 https://doi.org/10.1007/s00395-011-0228-2
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1007/s00395-011-0232-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053455835
    259 https://doi.org/10.1007/s00395-011-0232-6
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1007/s00395-012-0248-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037678994
    262 https://doi.org/10.1007/s00395-012-0248-6
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/s00395-012-0250-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007745831
    265 https://doi.org/10.1007/s00395-012-0250-z
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/s00395-012-0277-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026163746
    268 https://doi.org/10.1007/s00395-012-0277-1
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s00395-012-0278-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046554927
    271 https://doi.org/10.1007/s00395-012-0278-0
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1007/s00395-012-0287-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006032208
    274 https://doi.org/10.1007/s00395-012-0287-z
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/s00395-012-0325-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028297906
    277 https://doi.org/10.1007/s00395-012-0325-x
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1023/a:1009894007055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031444026
    280 https://doi.org/10.1023/a:1009894007055
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/75037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004288971
    283 https://doi.org/10.1038/75037
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nature05602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002654168
    286 https://doi.org/10.1038/nature05602
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/ni1439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049337093
    289 https://doi.org/10.1038/ni1439
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nm1613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050416284
    292 https://doi.org/10.1038/nm1613
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nm738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013852261
    295 https://doi.org/10.1038/nm738
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nri1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037702320
    298 https://doi.org/10.1038/nri1184
    299 rdf:type schema:CreativeWork
    300 https://app.dimensions.ai/details/publication/pub.1077519931 schema:CreativeWork
    301 https://app.dimensions.ai/details/publication/pub.1082398346 schema:CreativeWork
    302 https://app.dimensions.ai/details/publication/pub.1083228936 schema:CreativeWork
    303 https://doi.org/10.1002/jcp.10251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025274359
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/jcp.20197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048332476
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1002/jcp.20307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022998520
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1006/jmcc.1993.1104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006851400
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1006/jmcc.1999.1007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001277217
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1006/jmcc.2001.1383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031533353
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1006/jmcc.2001.1489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025992966
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/0014-5793(95)01238-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016216015
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/0735-1097(95)00589-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000871204
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.cardfail.2005.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011089772
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.ccr.2008.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033068785
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.cell.2006.12.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038330199
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.devcel.2008.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049455189
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.jacc.2011.10.863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033025934
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.pharmthera.2010.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029453413
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.yexmp.2009.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037187878
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.yexmp.2010.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020425557
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.yjmcc.2004.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038798282
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.yjmcc.2010.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019197912
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/s0002-9440(10)64824-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049303912
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/s0008-6363(02)00413-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578144
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/s0008-6363(02)00729-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578361
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/s0008-6363(98)00121-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580087
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/s0898-6568(98)00036-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011518450
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/s1471-4906(01)01863-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026324269
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1056/nejm199007263230405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487433
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1073/pnas.051625598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035834467
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1073/pnas.211086598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020550360
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1073/pnas.86.17.6753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035089772
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1074/jbc.m003128200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049857990
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1093/cvr/cvp040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003798894
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1093/cvr/cvp164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031481129
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1093/cvr/cvp208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037332168
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1093/cvr/cvs320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015263106
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1097/00005344-200201000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006644034
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1097/ccm.0b013e3181b4a854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035113208
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1111/j.1365-2249.2007.03356.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021406338
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1111/j.1440-1681.2007.04873.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000516368
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1111/j.1476-5381.1995.tb14901.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033117620
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1111/j.1749-6632.2009.05094.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050326839
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1113/expphysiol.2011.057612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037181993
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1126/science.1175202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032290342
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1126/science.1230719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467744
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1126/science.8140422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652919
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1152/ajpcell.00166.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003733796
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1152/ajpheart.00514.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027148578
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1152/ajpheart.00881.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001241321
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1152/ajpheart.00902.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063194671
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1152/ajpheart.00928.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016332200
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1152/ajpheart.01002.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041838981
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1152/ajpheart.01327.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042625731
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1152/ajpheart.01363.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007306930
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1152/ajpheart.2000.279.6.h3020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074731316
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1161/01.cir.0000057545.82749.ff schema:sameAs https://app.dimensions.ai/details/publication/pub.1025987601
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1161/01.cir.0000124490.27666.b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053255841
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1161/01.cir.0000147233.10318.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025483264
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1161/01.cir.101.20.2338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022791381
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1161/01.cir.102.25.3060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006113302
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1161/01.cir.93.4.704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336984
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1161/01.cir.95.5.1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337892
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1161/01.cir.99.3.427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033201084
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1161/01.hyp.0000118584.33350.7d schema:sameAs https://app.dimensions.ai/details/publication/pub.1045848863
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1161/01.hyp.0000227247.27111.b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018698428
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1161/01.res.0000014451.75415.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021426694
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1161/01.res.0000043825.01705.1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1026304018
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1161/01.res.0000117070.86556.9f schema:sameAs https://app.dimensions.ai/details/publication/pub.1052420241
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1161/01.res.0000185833.42544.06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008178357
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1161/01.res.0000255031.15793.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002075187
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1161/01.res.81.2.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341114
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1161/01.res.81.4.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341150
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1161/01.res.83.10.1035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041039067
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1161/01.res.86.12.1259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038895525
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1161/circheartfailure.108.823070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022013407
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1161/circheartfailure.109.931451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006874701
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1161/circresaha.108.180976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029720668
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1161/circresaha.109.207456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007465766
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1161/circresaha.111.240820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010380276
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1161/circresaha.112.270132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032135421
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1161/circulationaha.107.692764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049817998
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1161/circulationaha.108.832782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050326941
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1161/circulationaha.111.052126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045665588
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1172/jci119114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017088131
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1172/jci119509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024979688
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1172/jci14190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415253
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1172/jci39942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013929852
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1172/jci40295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025982428
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1172/jci41080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002170430
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1172/jci43569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012200470
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1172/jci44824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014352067
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1177/1074248408329860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039438051
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1253/jcj.63.951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024312791
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1369/jhc.4a6560.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004682861
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1371/journal.pone.0048910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012634955
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.2353/ajpath.2007.060547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013734622
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.2353/ajpath.2008.070974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032212725
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.4049/jimmunol.165.5.2798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074685498
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.4067/s0716-97602012000200012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052206046
    496 rdf:type schema:CreativeWork
    497 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    498 schema:name Department of Cardiovascular Medicine, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo, Tokyo, Japan
    499 Translational Systems Biology and Medicine Initiative (TSBMI), the University of Tokyo Graduate School of Medicine, Tokyo, Japan
    500 rdf:type schema:Organization
    501 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
    502 schema:name Department of Cardiovascular Medicine, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo, Tokyo, Japan
    503 Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program), Tokyo, Japan
    504 Jichi Medical University, Tochigi, Japan
    505 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...