EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-07

AUTHORS

Giovanni Esposito, Cinzia Perrino, Alessandro Cannavo, Gabriele G. Schiattarella, Francesco Borgia, Anna Sannino, Gianluigi Pironti, Giuseppe Gargiulo, Luigi Di Serafino, Anna Franzone, Laura Scudiero, Paolo Grieco, Ciro Indolfi, Massimo Chiariello

ABSTRACT

Urotensin II (UTII) and its seven trans-membrane receptor (UTR) are up-regulated in the heart under pathological conditions. Previous in vitro studies have shown that UTII trans-activates the epidermal growth factor receptor (EGFR), however, the role of such novel signalling pathway stimulated by UTII is currently unknown. In this study, we hypothesized that EGFR trans-activation by UTII might exert a protective effect in the overloaded heart. To test this hypothesis, we induced cardiac hypertrophy by transverse aortic constriction (TAC) in wild-type mice, and tested the effects of the UTII antagonist Urantide (UR) on cardiac function, structure, and EGFR trans-activation. After 7 days of pressure overload, UR treatment induced a rapid and significant impairment of cardiac function compared to vehicle. In UR-treated TAC mice, cardiac dysfunction was associated with reduced phosphorylation levels of the EGFR and extracellular-regulated kinase (ERK), increased apoptotic cell death and fibrosis. In vitro UTR stimulation induced membrane translocation of β-arrestin 1/2, EGFR phosphorylation/internalization, and ERK activation in HEK293 cells. Furthermore, UTII administration lowered apoptotic cell death induced by serum deprivation, as shown by reduced TUNEL/Annexin V staining and caspase 3 activation. Interestingly, UTII-mediated EGFR trans-activation could be prevented by UR treatment or knockdown of β-arrestin 1/2. Our data show, for the first time in vivo, a new UTR signalling pathway which is mediated by EGFR trans-activation, dependent by β-arrestin 1/2, promoting cell survival and cardioprotection. More... »

PAGES

577-589

References to SciGraph publications

  • 1999-12. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF in NATURE
  • 2011-05. Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats in BASIC RESEARCH IN CARDIOLOGY
  • 1996-02. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors in NATURE
  • 2010-09. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2 in BASIC RESEARCH IN CARDIOLOGY
  • 2002-05. ErbB2 is essential in the prevention of dilated cardiomyopathy in NATURE MEDICINE
  • 2011-05. Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab in BASIC RESEARCH IN CARDIOLOGY
  • 1999-09. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 in NATURE
  • 2002-01. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy in NATURE MEDICINE
  • 2008-01. Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8 in BASIC RESEARCH IN CARDIOLOGY
  • 2008-01. Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator in BASIC RESEARCH IN CARDIOLOGY
  • 2007-01. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol in ACTA PHARMACOLOGICA SINICA
  • 2007-10. Urotensin II acutely increases myocardial length and distensibility: potential implications for diastolic function and ventricular remodeling in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 2010-09. TGF-β1 improves cardiac performance via up-regulation of laminin receptor 37/67 in adult ventricular cardiomyocytes in BASIC RESEARCH IN CARDIOLOGY
  • 2011-03. Mitochondrial complex I and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused hearts in BASIC RESEARCH IN CARDIOLOGY
  • 2002-01. Seven-transmembrane-spanning receptors and heart function in NATURE
  • 2010-05. Blockage of Angiotensin II type 2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation in BASIC RESEARCH IN CARDIOLOGY
  • 2008-01. Translational activation of 5′-TOP mRNA in pressure overload myocardium in BASIC RESEARCH IN CARDIOLOGY
  • 2009-11. Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3β/mTOR signaling pathway in BASIC RESEARCH IN CARDIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00395-011-0163-2

    DOI

    http://dx.doi.org/10.1007/s00395-011-0163-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024314970

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21369867


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