Ontology type: schema:ScholarlyArticle Open Access: True
2010-02-03
AUTHORSLászló Bárándi, László Virág, Norbert Jost, Zoltán Horváth, István Koncz, Rita Papp, Gábor Harmati, Balázs Horváth, Norbert Szentandrássy, Tamás Bányász, János Magyar, Antonio Zaza, András Varró, Péter P. Nánási
ABSTRACTClass III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action potential duration (APD). In spite of the several theories developed so far to explain this reverse rate-dependency (RRD), its mechanism has not yet been clarified. The aim of the present work was to further elucidate the mechanisms responsible for RRD in mammalian ventricular myocardium. Action potentials were recorded using conventional sharp microelectrodes from human, canine, rabbit and guinea pig ventricular myocardium in a rate-dependent manner varying the cycle length (CL) between 0.3 and 5 s. Rate-dependent drug effects were studied using agents known to lengthen or shorten action potentials, and these drug-induced changes in APD were correlated with baseline APD values. Both drug-induced lengthening (by dofetilide, sotalol, E-4031, BaCl2, veratrine, BAY K 8644) and shortening (by mexiletine, tetrodotoxin, lemakalim) of action potentials displayed RRD, i.e., changes in APD were greater at longer than at shorter CLs. In rabbit, where APD is a biphasic function of CL, the drug-induced APD changes were proportional to baseline APD values but not to CL. Similar results were obtained when repolarization was modified by injection of inward or outward current pulses in isolated canine cardiomyocytes. In each case the change in APD was proportional to baseline APD (i.e., that measured before the superfusion of drug or injection of current). Also, the net membrane current (Inet), determined from the action potential waveform at the middle of the plateau, was inversely proportional to APD and consequently with to CL. The results indicate that RRD is a common characteristic of all the drugs tested regardless of the modified ion current species. Thus, drug-induced RRD can be considered as an intrinsic property of cardiac membranes based on the inverse relationship between Inet and APD. More... »
PAGES315-323
http://scigraph.springernature.com/pub.10.1007/s00395-009-0082-7
DOIhttp://dx.doi.org/10.1007/s00395-009-0082-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1030394942
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20127488
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Pharmacology and Pharmaceutical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Action Potentials",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Anti-Arrhythmia Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calcium Channel Agonists",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dogs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Guinea Pigs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Heart Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Potentials",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Animal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myocytes, Cardiac",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Patch-Clamp Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rabbits",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sodium Channel Blockers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tetrodotoxin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Time Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ventricular Function",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "B\u00e1r\u00e1ndi",
"givenName": "L\u00e1szl\u00f3",
"id": "sg:person.01145340003.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145340003.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary",
"id": "http://www.grid.ac/institutes/grid.9008.1",
"name": [
"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary"
],
"type": "Organization"
},
"familyName": "Vir\u00e1g",
"givenName": "L\u00e1szl\u00f3",
"id": "sg:person.01060330541.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060330541.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary",
"id": "http://www.grid.ac/institutes/grid.5018.c",
"name": [
"Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary"
],
"type": "Organization"
},
"familyName": "Jost",
"givenName": "Norbert",
"id": "sg:person.0640661174.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640661174.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary",
"id": "http://www.grid.ac/institutes/grid.5018.c",
"name": [
"Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary"
],
"type": "Organization"
},
"familyName": "Horv\u00e1th",
"givenName": "Zolt\u00e1n",
"id": "sg:person.01227371117.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227371117.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary",
"id": "http://www.grid.ac/institutes/grid.9008.1",
"name": [
"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary"
],
"type": "Organization"
},
"familyName": "Koncz",
"givenName": "Istv\u00e1n",
"id": "sg:person.0635020074.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635020074.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary",
"id": "http://www.grid.ac/institutes/grid.9008.1",
"name": [
"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary"
],
"type": "Organization"
},
"familyName": "Papp",
"givenName": "Rita",
"id": "sg:person.0677743226.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677743226.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "Harmati",
"givenName": "G\u00e1bor",
"id": "sg:person.01101345212.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101345212.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "Horv\u00e1th",
"givenName": "Bal\u00e1zs",
"id": "sg:person.01033572077.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033572077.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "Szentandr\u00e1ssy",
"givenName": "Norbert",
"id": "sg:person.0741603700.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741603700.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "B\u00e1ny\u00e1sz",
"givenName": "Tam\u00e1s",
"id": "sg:person.0772313221.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772313221.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "Magyar",
"givenName": "J\u00e1nos",
"id": "sg:person.01206027354.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206027354.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Dipartimento di Biotecnologie e Bioscienze, Universita di Milano-Bicocca, Milan, Italy",
"id": "http://www.grid.ac/institutes/grid.7563.7",
"name": [
"Dipartimento di Biotecnologie e Bioscienze, Universita di Milano-Bicocca, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Zaza",
"givenName": "Antonio",
"id": "sg:person.01314745214.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314745214.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary",
"id": "http://www.grid.ac/institutes/grid.5018.c",
"name": [
"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary",
"Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary"
],
"type": "Organization"
},
"familyName": "Varr\u00f3",
"givenName": "Andr\u00e1s",
"id": "sg:person.015203014040.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015203014040.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary",
"id": "http://www.grid.ac/institutes/grid.7122.6",
"name": [
"Department of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
],
"type": "Organization"
},
"familyName": "N\u00e1n\u00e1si",
"givenName": "P\u00e9ter P.",
"id": "sg:person.0724365203.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00395-008-0730-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005477760",
"https://doi.org/10.1007/s00395-008-0730-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00798257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082786426",
"https://doi.org/10.1007/bf00798257"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00717747",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031922050",
"https://doi.org/10.1007/bf00717747"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00395-003-0386-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018669470",
"https://doi.org/10.1007/s00395-003-0386-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s003950050236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019854705",
"https://doi.org/10.1007/s003950050236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00395-009-0019-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045147712",
"https://doi.org/10.1007/s00395-009-0019-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00424-005-1445-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028069154",
"https://doi.org/10.1007/s00424-005-1445-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1007784814823",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043450659",
"https://doi.org/10.1023/a:1007784814823"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002109900164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020774950",
"https://doi.org/10.1007/s002109900164"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00424-006-0077-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005301637",
"https://doi.org/10.1007/s00424-006-0077-2"
],
"type": "CreativeWork"
}
],
"datePublished": "2010-02-03",
"datePublishedReg": "2010-02-03",
"description": "Class III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action potential duration (APD). In spite of the several theories developed so far to explain this reverse rate-dependency (RRD), its mechanism has not yet been clarified. The aim of the present work was to further elucidate the mechanisms responsible for RRD in mammalian ventricular myocardium. Action potentials were recorded using conventional sharp microelectrodes from human, canine, rabbit and guinea pig ventricular myocardium in a rate-dependent manner varying the cycle length (CL) between 0.3 and 5\u00a0s. Rate-dependent drug effects were studied using agents known to lengthen or shorten action potentials, and these drug-induced changes in APD were correlated with baseline APD values. Both drug-induced lengthening (by dofetilide, sotalol, E-4031, BaCl2, veratrine, BAY K 8644) and shortening (by mexiletine, tetrodotoxin, lemakalim) of action potentials displayed RRD, i.e., changes in APD were greater at longer than at shorter CLs. In rabbit, where APD is a biphasic function of CL, the drug-induced APD changes were proportional to baseline APD values but not to CL. Similar results were obtained when repolarization was modified by injection of inward or outward current pulses in isolated canine cardiomyocytes. In each case the change in APD was proportional to baseline APD (i.e., that measured before the superfusion of drug or injection of current). Also, the net membrane current (Inet), determined from the action potential waveform at the middle of the plateau, was inversely proportional to APD and consequently with to CL. The results indicate that RRD is a common characteristic of all the drugs tested regardless of the modified ion current species. Thus, drug-induced RRD can be considered as an intrinsic property of cardiac membranes based on the inverse relationship between Inet and APD.",
"genre": "article",
"id": "sg:pub.10.1007/s00395-009-0082-7",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.4193655",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4192492",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3770920",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1016443",
"issn": [
"0300-8428",
"1435-1803"
],
"name": "Basic Research in Cardiology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "105"
}
],
"keywords": [
"action potential duration",
"action potentials",
"potential duration",
"cycle length",
"ventricular myocardium",
"class III antiarrhythmic agent",
"guinea pig ventricular myocardium",
"human ventricular preparations",
"mammalian ventricular myocardium",
"outward current pulses",
"baseline action potential duration",
"drug-induced changes",
"drug-induced lengthening",
"action potential waveform",
"shorter cycle lengths",
"rate-dependent drug effects",
"rate-dependent changes",
"antiarrhythmic agents",
"APD changes",
"conventional sharp microelectrodes",
"ventricular preparations",
"drug effects",
"canine cardiomyocytes",
"cardiac membranes",
"sharp microelectrodes",
"rate-dependent manner",
"RRD",
"APD values",
"myocardium",
"potential waveform",
"biphasic function",
"rabbits",
"inverse relationship",
"duration",
"lengthening",
"similar results",
"agents",
"repolarization",
"drugs",
"cardiomyocytes",
"canine",
"injection",
"changes",
"shortening",
"aim",
"mechanism",
"common characteristics",
"membrane",
"potential",
"cases",
"net membrane",
"microelectrodes",
"effect",
"current pulses",
"manner",
"results",
"spite",
"function",
"values",
"relationship",
"intrinsic properties",
"preparation",
"length",
"characteristics",
"plateau",
"middle",
"present work",
"waveforms",
"species",
"pulses",
"work",
"properties",
"current species",
"theory",
"INET"
],
"name": "Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations",
"pagination": "315-323",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1030394942"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00395-009-0082-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20127488"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00395-009-0082-7",
"https://app.dimensions.ai/details/publication/pub.1030394942"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_503.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00395-009-0082-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00395-009-0082-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00395-009-0082-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00395-009-0082-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00395-009-0082-7'
This table displays all metadata directly associated to this object as RDF triples.
355 TRIPLES
21 PREDICATES
128 URIs
110 LITERALS
25 BLANK NODES