Contribution of IKr and IK1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07-05

AUTHORS

Norbert Jost, Károly Acsai, Balázs Horváth, Tamás Bányász, István Baczkó, Miklós Bitay, Gábor Bogáts, Péter P. Nánási

ABSTRACT

BackgroundThe aim of the present work was to study the profile of the rapid delayed rectifier potassium current (IKr) and the inward rectifier potassium current (IK1) during ventricular repolarization as a function of action potential duration and rate of repolarization.MethodsWhole cell configuration of the patch clamp technique was used to monitor IKr and IK1 during the action potential plateau and terminal repolarization. Action potentials recorded at various cycle lengths (0.4–5 s) and repolarizing voltage ramps having various slopes (0.5–3 V/s) were used as command signals. IKr and IK1 were identified as difference currents dissected by E-4031 and BaCl2, respectively.ResultsNeither peak amplitudes nor mean values of IKr and IK1 recorded during the plateau of canine action potentials were influenced by action potential duration. The membrane potential where IKr and IK1 peaked during the terminal repolarization was also independent of action potential duration. Similar results were obtained in undiseased human ventricular myocytes, and also in canine cells when IKr and IK1 were evoked using repolarizing voltage ramps of various slopes. Action potential voltage clamp experiments revealed that the peak values of IKr, IK1, and net outward current during the terminal repolarization were independent of the pacing cycle length within the range of 0.4 and 5 s.ConclusionsThe results indicate that action potential configuration fails to influence the amplitude of IKr and IK1 during the ventricular action potential in dogs and humans, suggesting that rate-dependent changes in action potential duration are not likely related to rate-dependent alterations in IKr or IK1 kinetics in these species. More... »

PAGES

33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00395-008-0730-3

DOI

http://dx.doi.org/10.1007/s00395-008-0730-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005477760

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18604626


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Action Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Barium Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chlorides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophysiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "KATP Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patch-Clamp Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channels, Inwardly Rectifying", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reference Values", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Function", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.5018.c", 
          "name": [
            "Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary", 
            "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jost", 
        "givenName": "Norbert", 
        "id": "sg:person.0640661174.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640661174.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.5018.c", 
          "name": [
            "Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary", 
            "Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Acsai", 
        "givenName": "K\u00e1roly", 
        "id": "sg:person.0654503763.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654503763.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horv\u00e1th", 
        "givenName": "Bal\u00e1zs", 
        "id": "sg:person.01033572077.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033572077.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e1ny\u00e1sz", 
        "givenName": "Tam\u00e1s", 
        "id": "sg:person.0772313221.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772313221.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.9008.1", 
          "name": [
            "Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baczk\u00f3", 
        "givenName": "Istv\u00e1n", 
        "id": "sg:person.0740401737.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740401737.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. of Cardiac Surgery, University of Szeged, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.9008.1", 
          "name": [
            "Dept. of Cardiac Surgery, University of Szeged, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bitay", 
        "givenName": "Mikl\u00f3s", 
        "id": "sg:person.0623234751.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623234751.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. of Cardiac Surgery, University of Szeged, Szeged, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.9008.1", 
          "name": [
            "Dept. of Cardiac Surgery, University of Szeged, Szeged, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bog\u00e1ts", 
        "givenName": "G\u00e1bor", 
        "id": "sg:person.01062563421.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062563421.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00e1n\u00e1si", 
        "givenName": "P\u00e9ter P.", 
        "id": "sg:person.0724365203.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00395-006-0609-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027220416", 
          "https://doi.org/10.1007/s00395-006-0609-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052080725", 
          "https://doi.org/10.1038/325156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372366a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026055958", 
          "https://doi.org/10.1038/372366a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-007-0659-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044123291", 
          "https://doi.org/10.1007/s00395-007-0659-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07-05", 
    "datePublishedReg": "2008-07-05", 
    "description": "BackgroundThe aim of the present work was to study the profile of the rapid delayed rectifier potassium current (IKr) and the inward rectifier potassium current (IK1) during ventricular repolarization as a function of action potential duration and rate of repolarization.MethodsWhole cell configuration of the patch clamp technique was used to monitor IKr and IK1 during the action potential plateau and terminal repolarization. Action potentials recorded at various cycle lengths (0.4\u20135\u00a0s) and repolarizing voltage ramps having various slopes (0.5\u20133\u00a0V/s) were used as command signals. IKr and IK1 were identified as difference currents dissected by E-4031 and BaCl2, respectively.ResultsNeither peak amplitudes nor mean values of IKr and IK1 recorded during the plateau of canine action potentials were influenced by action potential duration. The membrane potential where IKr and IK1 peaked during the terminal repolarization was also independent of action potential duration. Similar results were obtained in undiseased human ventricular myocytes, and also in canine cells when IKr and IK1 were evoked using repolarizing voltage ramps of various slopes. Action potential voltage clamp experiments revealed that the peak values of IKr, IK1, and net outward current during the terminal repolarization were independent of the pacing cycle length within the range of 0.4 and 5\u00a0s.ConclusionsThe results indicate that action potential configuration fails to influence the amplitude of IKr and IK1 during the ventricular action potential in dogs and humans, suggesting that rate-dependent changes in action potential duration are not likely related to rate-dependent alterations in IKr or IK1 kinetics in these species.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00395-008-0730-3", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016443", 
        "issn": [
          "0300-8428", 
          "1435-1803"
        ], 
        "name": "Basic Research in Cardiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "104"
      }
    ], 
    "keywords": [
      "action potential duration", 
      "potential duration", 
      "terminal repolarization", 
      "action potentials", 
      "ventricular repolarization", 
      "inward rectifier potassium current", 
      "rectifier potassium current", 
      "action potential configuration", 
      "cycle length", 
      "patch-clamp technique", 
      "rate of repolarization", 
      "action potential plateau", 
      "ventricular action potential", 
      "net outward current", 
      "amplitude of IKr", 
      "contribution of IKr", 
      "human ventricular myocytes", 
      "voltage-clamp experiments", 
      "rate-dependent changes", 
      "rate-dependent alterations", 
      "rectifier potassium", 
      "human myocytes", 
      "potassium current", 
      "clamp technique", 
      "ventricular myocytes", 
      "IKr", 
      "outward currents", 
      "repolarization", 
      "IK1", 
      "clamp experiments", 
      "ConclusionsThe results", 
      "duration", 
      "canine cells", 
      "myocytes", 
      "membrane potential", 
      "peak amplitude", 
      "similar results", 
      "potential configuration", 
      "dogs", 
      "difference current", 
      "potential plateau", 
      "canine", 
      "alterations", 
      "cells", 
      "humans", 
      "aim", 
      "voltage ramp", 
      "potential", 
      "rate", 
      "potassium", 
      "peak value", 
      "length", 
      "profile", 
      "command signals", 
      "changes", 
      "results", 
      "BaCl2", 
      "amplitude", 
      "function", 
      "values", 
      "plateau", 
      "technique", 
      "influence", 
      "current", 
      "present work", 
      "slope", 
      "range", 
      "signals", 
      "contribution", 
      "kinetics", 
      "cell configuration", 
      "species", 
      "experiments", 
      "ramp", 
      "work", 
      "configuration", 
      "voltage"
    ], 
    "name": "Contribution of IKr and IK1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential duration?", 
    "pagination": "33", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005477760"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00395-008-0730-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18604626"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00395-008-0730-3", 
      "https://app.dimensions.ai/details/publication/pub.1005477760"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_455.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00395-008-0730-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00395-008-0730-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00395-008-0730-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00395-008-0730-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00395-008-0730-3'


 

This table displays all metadata directly associated to this object as RDF triples.

268 TRIPLES      21 PREDICATES      120 URIs      108 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00395-008-0730-3 schema:about N07f3aa15a96f42be813e00e730fd7f57
2 N1498b01b62bd439ea849efb786573840
3 N19d18dc1881c47059ec9cd71d801ada0
4 N1e20f522322e4f5499e64e8466c87a74
5 N2874ba51838f48b49bd2450c61aa2c87
6 N31929d4337bd482db7bf982dcb217c50
7 N72aecc96aeaa4013a8aefe33cb52f6df
8 N8317eff569eb404c837225721308515b
9 N8ee872f275b142d28c272d712429afa7
10 N99522f1a78c84b51b751a56811688623
11 N9ae0f60ecb2944f7a7aea68fc8ec8ced
12 Nb7a00844b24c4808ae734f9ed359ca1d
13 Nc4a8f42f81a141b496f4ad0c9022cd8b
14 Nd5aa556c3de84344bef0c1e9cee8ed1c
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author N8aef2158538f4acba73372a2e3c3bcbb
18 schema:citation sg:pub.10.1007/s00395-006-0609-0
19 sg:pub.10.1007/s00395-007-0659-y
20 sg:pub.10.1038/325156a0
21 sg:pub.10.1038/372366a0
22 schema:datePublished 2008-07-05
23 schema:datePublishedReg 2008-07-05
24 schema:description BackgroundThe aim of the present work was to study the profile of the rapid delayed rectifier potassium current (IKr) and the inward rectifier potassium current (IK1) during ventricular repolarization as a function of action potential duration and rate of repolarization.MethodsWhole cell configuration of the patch clamp technique was used to monitor IKr and IK1 during the action potential plateau and terminal repolarization. Action potentials recorded at various cycle lengths (0.4–5 s) and repolarizing voltage ramps having various slopes (0.5–3 V/s) were used as command signals. IKr and IK1 were identified as difference currents dissected by E-4031 and BaCl2, respectively.ResultsNeither peak amplitudes nor mean values of IKr and IK1 recorded during the plateau of canine action potentials were influenced by action potential duration. The membrane potential where IKr and IK1 peaked during the terminal repolarization was also independent of action potential duration. Similar results were obtained in undiseased human ventricular myocytes, and also in canine cells when IKr and IK1 were evoked using repolarizing voltage ramps of various slopes. Action potential voltage clamp experiments revealed that the peak values of IKr, IK1, and net outward current during the terminal repolarization were independent of the pacing cycle length within the range of 0.4 and 5 s.ConclusionsThe results indicate that action potential configuration fails to influence the amplitude of IKr and IK1 during the ventricular action potential in dogs and humans, suggesting that rate-dependent changes in action potential duration are not likely related to rate-dependent alterations in IKr or IK1 kinetics in these species.
25 schema:genre article
26 schema:isAccessibleForFree false
27 schema:isPartOf N426bdedef9d34ae3b8ae7bc33b50e48a
28 Ncfd9c0172a2f48c19df00c8b83f1a379
29 sg:journal.1016443
30 schema:keywords BaCl2
31 ConclusionsThe results
32 IK1
33 IKr
34 action potential configuration
35 action potential duration
36 action potential plateau
37 action potentials
38 aim
39 alterations
40 amplitude
41 amplitude of IKr
42 canine
43 canine cells
44 cell configuration
45 cells
46 changes
47 clamp experiments
48 clamp technique
49 command signals
50 configuration
51 contribution
52 contribution of IKr
53 current
54 cycle length
55 difference current
56 dogs
57 duration
58 experiments
59 function
60 human myocytes
61 human ventricular myocytes
62 humans
63 influence
64 inward rectifier potassium current
65 kinetics
66 length
67 membrane potential
68 myocytes
69 net outward current
70 outward currents
71 patch-clamp technique
72 peak amplitude
73 peak value
74 plateau
75 potassium
76 potassium current
77 potential
78 potential configuration
79 potential duration
80 potential plateau
81 present work
82 profile
83 ramp
84 range
85 rate
86 rate of repolarization
87 rate-dependent alterations
88 rate-dependent changes
89 rectifier potassium
90 rectifier potassium current
91 repolarization
92 results
93 signals
94 similar results
95 slope
96 species
97 technique
98 terminal repolarization
99 values
100 ventricular action potential
101 ventricular myocytes
102 ventricular repolarization
103 voltage
104 voltage ramp
105 voltage-clamp experiments
106 work
107 schema:name Contribution of IKr and IK1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential duration?
108 schema:pagination 33
109 schema:productId Nae3b9d5438754c018d114079fac2d395
110 Nb34221cbbf5141cbb198d8532fe9e0f8
111 Nd2f6c2c86d1e444e951434a7c449617f
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005477760
113 https://doi.org/10.1007/s00395-008-0730-3
114 schema:sdDatePublished 2022-08-04T16:57
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher Ne85006b71107490b996b80f862a07f38
117 schema:url https://doi.org/10.1007/s00395-008-0730-3
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N07f3aa15a96f42be813e00e730fd7f57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Dogs
123 rdf:type schema:DefinedTerm
124 N1498b01b62bd439ea849efb786573840 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Electrophysiology
126 rdf:type schema:DefinedTerm
127 N19d18dc1881c47059ec9cd71d801ada0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Barium Compounds
129 rdf:type schema:DefinedTerm
130 N1e20f522322e4f5499e64e8466c87a74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Action Potentials
132 rdf:type schema:DefinedTerm
133 N2874ba51838f48b49bd2450c61aa2c87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Muscle Cells
135 rdf:type schema:DefinedTerm
136 N31929d4337bd482db7bf982dcb217c50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Potassium Channels, Inwardly Rectifying
138 rdf:type schema:DefinedTerm
139 N426bdedef9d34ae3b8ae7bc33b50e48a schema:volumeNumber 104
140 rdf:type schema:PublicationVolume
141 N5642c7ae5e1041f5bb948ad69145b1d1 rdf:first sg:person.01062563421.49
142 rdf:rest N9edc8db142a4424892c0d489f240b497
143 N5a47fc9927584a5387cf648dc419cb62 rdf:first sg:person.0654503763.80
144 rdf:rest N982f7daa6a7d4a6bbe6c5fd8c2df06df
145 N616e79f2353d4649aeca3f709a4d5afc rdf:first sg:person.0623234751.01
146 rdf:rest N5642c7ae5e1041f5bb948ad69145b1d1
147 N72aecc96aeaa4013a8aefe33cb52f6df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 N8317eff569eb404c837225721308515b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Kinetics
152 rdf:type schema:DefinedTerm
153 N8aef2158538f4acba73372a2e3c3bcbb rdf:first sg:person.0640661174.40
154 rdf:rest N5a47fc9927584a5387cf648dc419cb62
155 N8ee872f275b142d28c272d712429afa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Patch-Clamp Techniques
157 rdf:type schema:DefinedTerm
158 N982f7daa6a7d4a6bbe6c5fd8c2df06df rdf:first sg:person.01033572077.22
159 rdf:rest Ne578242c5f224a429c88077c70ef18d1
160 N99522f1a78c84b51b751a56811688623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name KATP Channels
162 rdf:type schema:DefinedTerm
163 N9ae0f60ecb2944f7a7aea68fc8ec8ced schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Animals
165 rdf:type schema:DefinedTerm
166 N9edc8db142a4424892c0d489f240b497 rdf:first sg:person.0724365203.35
167 rdf:rest rdf:nil
168 Nae3b9d5438754c018d114079fac2d395 schema:name doi
169 schema:value 10.1007/s00395-008-0730-3
170 rdf:type schema:PropertyValue
171 Nb34221cbbf5141cbb198d8532fe9e0f8 schema:name dimensions_id
172 schema:value pub.1005477760
173 rdf:type schema:PropertyValue
174 Nb7a00844b24c4808ae734f9ed359ca1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Chlorides
176 rdf:type schema:DefinedTerm
177 Nc4a8f42f81a141b496f4ad0c9022cd8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Ventricular Function
179 rdf:type schema:DefinedTerm
180 Ncfd9c0172a2f48c19df00c8b83f1a379 schema:issueNumber 1
181 rdf:type schema:PublicationIssue
182 Nd2f6c2c86d1e444e951434a7c449617f schema:name pubmed_id
183 schema:value 18604626
184 rdf:type schema:PropertyValue
185 Nd5aa556c3de84344bef0c1e9cee8ed1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Reference Values
187 rdf:type schema:DefinedTerm
188 Ne348e5c243eb43f5907724e13d6b6800 rdf:first sg:person.0740401737.78
189 rdf:rest N616e79f2353d4649aeca3f709a4d5afc
190 Ne578242c5f224a429c88077c70ef18d1 rdf:first sg:person.0772313221.04
191 rdf:rest Ne348e5c243eb43f5907724e13d6b6800
192 Ne85006b71107490b996b80f862a07f38 schema:name Springer Nature - SN SciGraph project
193 rdf:type schema:Organization
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
198 schema:name Cardiorespiratory Medicine and Haematology
199 rdf:type schema:DefinedTerm
200 sg:journal.1016443 schema:issn 0300-8428
201 1435-1803
202 schema:name Basic Research in Cardiology
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.01033572077.22 schema:affiliation grid-institutes:grid.7122.6
206 schema:familyName Horváth
207 schema:givenName Balázs
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033572077.22
209 rdf:type schema:Person
210 sg:person.01062563421.49 schema:affiliation grid-institutes:grid.9008.1
211 schema:familyName Bogáts
212 schema:givenName Gábor
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062563421.49
214 rdf:type schema:Person
215 sg:person.0623234751.01 schema:affiliation grid-institutes:grid.9008.1
216 schema:familyName Bitay
217 schema:givenName Miklós
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623234751.01
219 rdf:type schema:Person
220 sg:person.0640661174.40 schema:affiliation grid-institutes:grid.5018.c
221 schema:familyName Jost
222 schema:givenName Norbert
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640661174.40
224 rdf:type schema:Person
225 sg:person.0654503763.80 schema:affiliation grid-institutes:grid.5018.c
226 schema:familyName Acsai
227 schema:givenName Károly
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654503763.80
229 rdf:type schema:Person
230 sg:person.0724365203.35 schema:affiliation grid-institutes:grid.7122.6
231 schema:familyName Nánási
232 schema:givenName Péter P.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35
234 rdf:type schema:Person
235 sg:person.0740401737.78 schema:affiliation grid-institutes:grid.9008.1
236 schema:familyName Baczkó
237 schema:givenName István
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740401737.78
239 rdf:type schema:Person
240 sg:person.0772313221.04 schema:affiliation grid-institutes:grid.7122.6
241 schema:familyName Bányász
242 schema:givenName Tamás
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772313221.04
244 rdf:type schema:Person
245 sg:pub.10.1007/s00395-006-0609-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027220416
246 https://doi.org/10.1007/s00395-006-0609-0
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00395-007-0659-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1044123291
249 https://doi.org/10.1007/s00395-007-0659-y
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/325156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052080725
252 https://doi.org/10.1038/325156a0
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/372366a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026055958
255 https://doi.org/10.1038/372366a0
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.5018.c schema:alternateName Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary
258 schema:name Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary
259 Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary
260 rdf:type schema:Organization
261 grid-institutes:grid.7122.6 schema:alternateName Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary
262 schema:name Dept. of Physiology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary
263 rdf:type schema:Organization
264 grid-institutes:grid.9008.1 schema:alternateName Dept. of Cardiac Surgery, University of Szeged, Szeged, Hungary
265 Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary
266 schema:name Dept. of Cardiac Surgery, University of Szeged, Szeged, Hungary
267 Dept. of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary
268 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...